COVID-19 Evidence Reviews
as of 10/21/20
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Today's Feature

10/21/2020
The Center for Evidence Based Medicine at Oxford University has been producing high quality evidence reviews and commentaries on COVID-19 topics. Many of their publications are updated regularly with new evidence.



Completed Reviews
 
= living review
= meets mimimum quality standards   |  

A review with this mark was peer-reviewed, described systematic search and study selection, and included critical appraisal of primary studies.
latest update
date
report
select
10/21/20
Leisman DE, Ronner L, Pinotti R, et al. | Lancet Respir Med
Aim: To synthesise and describe the reported pattern of inflammatory cytokines in COVID-19-induced respiratory failure and to compare this profile with those of other acute inflammatory syndromes.
RECENTLY UPDATED
10/21/20
Cheng L, Li H, Li L, et al. | J Clin Lab Anal
Aim: To determine the role of ferritin in COVID?19.
10/21/20
Agstam S, Yadav A, Kumar MP, et al. | Indian Pacing Electrophysiol J
Aim: To study the risk of QTc prolongation and Torsades de pointes (TdP) by a well-defined criterion for HCQ, CQ alone, and in combination with Azithromycin in patients with COVID-19.
10/21/20
Kefale B, Tegegne GT, Degu A, et al. | Clin Appl Thromb Hemost
Aim: To investigate the extent and risk factors of thromboembolism among COVID-19 patients.
RECENTLY UPDATED
10/21/20
Bhattacharyya A, Kumar S, Sarma P, et al. | Indian J Pharmacol
Aim: To evaluate the safety as well as efficacy of L/R combination therapy in the management of COVID-19.
10/21/20
Xu J, Teng Y, Shang L, et al. | Clin Infect Dis
Aim: To provide a comprehensive summarization of current evidence to answer two major clinical questions: (1) Does the prior treatment of ACEI/ARB alter the susceptibility of SARS-CoV-2 infection in general population? (2) Does the prior treatment of ACEI/ARB affect risk of mortality and severe outcomes in COVID-19 patients?
RECENTLY UPDATED
10/20/20
da Silva PG, Nascimento MSJ, Soares RRG, et al. | Sci Total Environ
Aim: To review the evidence on the viability/stability of aerosols containing SARS-CoV and MERS-CoV viruses.
10/20/20
Yonas E, Alwi I, Pranata R, et al. | Am J Emerg Med
Aim: To investigate the association between heart failure (HF) and poor outcome in patients with COVID-19.
10/20/20
Gungor B, Atici A, Baycan OF, et al. | Am J Emerg Med
Aim: To investigate the correlation of D-dimer levels measured on admission with disease severity and the risk of death in patients with coronavirus disease 2019 (COVID-19) pneumonia.
10/20/20
Tan E, Song J, Deane AM, et al. | Chest
Aim: To review the evidence on the global point estimate of mortality and risk factors for patients admitted to intensive care units (ICUs) with severe COVID-19.
10/20/20
Wassie GT, Azene AG, Bantie GM, et al. | Curr Ther Res Clin Exp
Aim: To estimate the pooled average incubation period of SARS-CoV-2.
10/20/20
Chua TH, Xu Z, King NKK | Brain Inj
Aim: To determine the clinical characteristics of neurological manifestations in COVID-19.
10/20/20
Kotecha P, Light A, Checcucci E, et al. | Panminerva Med
Aim: To evaluate the data currently available regarding the repurposing of different drugs for Covid-19 treatment. 
RECENTLY UPDATED
10/20/20
Sun C, Sun Y, Li X | Am J Emerg Med
Aim: To evaluate the clinical efficacy and safety of CM in the treatment of COVID-19 pneumonia.
10/20/20
Hossein H, Ali KM, Hosseini M, et al. | Clin Transl Imaging
Aim: To answer to the question whether CT scan can be used in diagnosis of COVID-19 or not.
10/19/20
Fram G, Wang D, Malette K, et al. | Curr Cardiol Rev
Aim: To evaluate the incidence of cardiotoxicity associated with hydroxychloroquine prior to onset of the COVID-19 pandemic.
10/19/20
Liu Y, Lu H, Wang W, et al. | Expert Rev Anticancer Ther
Aim: To identify the risk factors for death in patients with cancer and COVID-19.
RECENTLY UPDATED
10/19/20
Mulchandani R, Lyngdoh T, Kakkar AK | Eur J Clin Invest
Aim: To quantify the differences in the circulating levels of major inflammatory and immunological markers between severe and non?severe COVID?19 patients.
RECENTLY UPDATED
10/19/20
Ortega KL, Rech BO, El Haje GLC, et al. | J Hosp Infect
Aim: To review the evidence on whether hydrogen peroxide mouthwash has a virucidal effect.
RECENTLY UPDATED
10/19/20
Tasar R, Wiegand C, Elsner P | Contact Dermatitis
Aim: To review the evidence on the irritant effects of alcoholic hand rubs.
10/19/20
Cantini F, Goletti D, Petrone L, et al. | Drugs
Aim: To assess the clinical impact of different therapies for COVID-19.
10/19/20
July J, Pranata R | J Stroke Cerebrovasc Dis
Aim: To evaluate the impact of the coronavirus disease (COVID-19) pandemic on stroke care, including the number of stroke alerts/codes, number of reperfusions, and number of thrombectomies during the pandemic compared to those during the pre-pandemic period.
10/19/20
 | CADTH
Aim: To review the various strategies being used to increase the availability of N95 masks.
10/19/20
Abate SM, Mantefardo B, Basu B | Patient Saf Surg
Aim: To provide the global prevalence of perioperative outcomes of patients with COVID-19.
RECENTLY UPDATED
10/19/20
Chamseddine RS, Wahbeh F, Chervenak F, et al. | J Pregnancy
Aim: To review the evidence on preinatal and obstetric management in patients with COVID-19.
RECENTLY UPDATED
10/19/20
Raschetti R, Vivanti AJ, Vauloup-Fellous C, et al. | Nat Commun
Aim: To clarify the main transmission route, clinical features and outcomes of neonatal SARS-CoV-2 infections
RECENTLY UPDATED
10/19/20
Ramaraj P, Super JT, Doyle R, et al. | BMJ Open
Aim: To review the evidence behind UK Government PPE guidance on surgical masks versus respirators for SARS-CoV-2 protection.
RECENTLY UPDATED
10/16/20
Bhatia R, Pedapati R, Komakula S, et al. | J Stroke
Aim: To report the characteristics of stroke in patients with COVID-19.
CLINICAL CHARACTERISTICS
10/15/20
Gonzalez-Rubio J, Navarro-Lopez C, Lopez-Najera E, et al. | Int J Environ Res Public Health
Aim: To review the evidence on the epidemiologic relationship between smoking and COVID-19.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
10/15/20
Apostolopoulou A, Garrigos ZE, Vijayvargiya P, et al. | Diagnostics
Aim: To investigate the epidemiology, pathogenesis, risk factors, clinical manifestations, diagnosis, treatment and prognosis of COVID-19 associated pulmonary aspergillosis (CAPA).
CLINICAL CHARACTERISTICS
10/15/20
 | NSW Health COVID-19 Critical Intelligence Unit
10/15/20
Akiyama S, Hamdeh S, Micic D, et al. | Ann Rheum Dis
Aim: To assess the prevalence and clinical outcomes of COVID-19 in autoimmune diseases.
CLINICAL CHARACTERISTICS
10/15/20
Chu IY, Alam P, Larson H, et al. | J Travel Med
Aim: To identify: 1) the social consequences of mass quarantine—community-wide movement restrictions—during previous and current infectious disease outbreaks, and 2) recommended strategies to mitigate the negative social implications of COVID-19 lockdowns. 
RECENTLY UPDATED
10/15/20
Walsh KA, Spillane S, Comber L, et al. | J Infect
Aim: To summarise the evidence on the duration of infectiousness of individuals in whom SARS-CoV-2 ribonucleic acid is detected.
CLINICAL CHARACTERISTICS
10/14/20
Dehaghi BF, Ghodrati-Torbati A, Teimori G, et al. | Invest Educ Enferm
Aim: To assess the effectiveness of face masks against the novel coronavirus. 
INFECTION CONTROL
10/14/20
Pang KW, Chee J, Subramaniam S, Ng CL | Curr Allergy Asthma Rep
Aim: To quantify the clinical utility of identifying OD in the diagnosis of COVID-19 and determine an estimate of the frequency of OD amongst these patients.
CLINICAL CHARACTERISTICS
10/14/20
Fung HF, Martinez L, Alarid-Escudero F, et al. | Clin Infect Dis
Aim: To review the evidence on the transmission of SARS-CoV-2 within households.
INFECTION CONTROL
10/13/20
Bansal A, Singh AD, Jain V, et al. | Heart Lung
Aim: To determine if D-dimers are elevated in individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who have adverse clinical outcomes including all-cause mortality, intensive care unit (ICU) admission or acute respiratory distress syndrome (ARDS).
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Jackson T, Deibert D, Wyatt G, et al. | BMJ Open Respir Res
Aim: To review how official guidance documents and academic publications have classified procedures in terms of whether or not they are aerosol-generating. 
INFECTION CONTROL
10/13/20
Pormohammad A, Ghorbani S, Khatami A, et al. | Rev Med Virol
Aim: To compare clinical symptoms, laboratory findings, radiographic signs and outcomes of COVID?19 and influenza to identify unique features.
CLINICAL CHARACTERISTICS
10/13/20
Chai KL, Valk SJ, Piechotta V, et al. | Cochrane Database Syst Rev
Aim: To assess whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in the treatment of people with COVID?19.
RECENTLY UPDATED
CANDIDATE THERAPEUTICS
10/13/20
Banakar M, Lankarani KB, Jafarpour D, et al. | BMC Oral Health
Aim: To examine the risk of the transmission of the COVID–19 during dental treatments and provides pathways and protective protocols to minimize them, bearing in mind the long-term necessity of actions and realistic, practical measures.
RECENTLY UPDATED
INFECTION CONTROL
10/13/20
Singh H, Kaur H, Singh K, et al. | Adv Wound Care
Aim: To review the evidence on cutaneous manifestations reported in COVID-19 patients.
CLINICAL CHARACTERISTICS
10/13/20
Aggarwal N, Garg M, Dwarakanathan V, et al. | J Travel Med
Aim: To review the evidence on the diagnostic accuracy of infrared thermal screening via handheld non-contact infrared thermometers and thermal scanners.
DIAGNOSTICS
10/13/20
Roshandel R, Nateqi M, Lak R, et al. | Cell Mol Biol
Aim: To review the evidence on the diagnostic and methodological evaluation of urinary shedding of SARS-CoV-2.
RECENTLY UPDATED
DIAGNOSTICS
10/13/20
Kashour ZT, Riaz M, Garbati M, et al. | J Antimicrob Chemother
Aim: To systematically evaluate the effect of CQ and HCQ with or without azithromycin (AZ) on outcomes of COVID-19 patients.
RECENTLY UPDATED
CANDIDATE THERAPEUTICS
10/13/20
Prodromos C, Rumschlag T | New Microbes New Infect
Aim: To review the efficacy of HCQ against COVID-19.
CANDIDATE THERAPEUTICS
10/13/20
Sathian B, Asim M, Banerjee I, et al. | Nepal J Epidemiol
Aim: To assess the impact of the COVID-19 pandemic on the conduction of clinical trials and research.
INFECTION CONTROL
10/13/20
Sajid MI, Awais S, Salar K, et, al. | Biomedica
Aim: To evaluate the pathogenesis, risk factors, diagnosis and management strategies in pregnant women suspected or confirmed with COVID-19 infection.
CLINICAL CHARACTERISTICS
10/13/20
Han SM, Greenfield G, Majeed A, et al. | J Med Internet Res
Aim: To summarize evidence on the impact of remote consultation in primary care on antibiotic prescribing.
INFECTION CONTROL
10/13/20
Tamuzi JL, Ayele BT, Shumba CS, et al. | BMC Infect Dis
Aim: To review different studies on SARS-CoV, MERS-CoV or COVID-19 associated with HIV/TB co-infection or only TB and to understand the interactions between HIV, TB and COVID-19 and its implications on the burden of the COVID-19 among HIV/TB co-infected or TB patients, screening algorithm and clinical management.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Malaty M, Kayes T, Amarasekera AT, et al. | Eur J Clin Invest
Aim: To examine the current incidence and available treatment for arrhythmias in hospitalized patients with SARS-CoV-2 infection.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Gidari A, Nofri M, Saccarelli L, et al. | Eur J Clin Microbiol Infect Dis
Aim: To review the evidence on the recurrence of coronavirus disease 2019.
CLINICAL CHARACTERISTICS
10/13/20
Hariri LP, North CM, Shih AR, et al. | Chest
Aim: To review the evidence on the lung histopathology described in COVID-19 compared to SARS and H1N1 influenza.
CLINICAL CHARACTERISTICS
10/13/20
Nopp S, Moik F, Jilma B, et al. | Res Pract Thromb Haemost
Aim: To evaluate available data and estimating the prevalence of VTE in COVID?19 patients.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Singh S, Desai R, Gandhi Z, et al. | SN Compr Clin Med
Aim: To identify COVID-19-associated TTS case reports and evaluate patient-level demographics, clinical attributes, and outcomes. 
CLINICAL CHARACTERISTICS
10/13/20
Elsayed S, Reddy M, Murthy PM, et al. | Cureus
Aim: To identify the trends of COVID-19 relapse, the effects of co-morbidities on it, and associated mortality rates.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Koh WC, Naing L, Chaw L, et al. | PLoS One
Aim:  To estimate the secondary attack rate (SAR) in various settings and to examine whether household transmission differed by symptom status of index case, adult and children (< 18 years old), and relationship to index case.
INFECTION CONTROL
10/9/20
Li Y, Li J, Zhang Y, et al. | Chin J Integr Med
Aim: To systematically review the clinical practice guidelines for the treatment of coronavirus disease 2019 (COVID-19) patients with Chinese herbal medicine (CHM), summarize their recommendations and evaluate their qualities.
CANDIDATE THERAPEUTICS
10/9/20
Toomey E, Conway Y, Burton C, et al. | Infect Control Hosp Epidemiol
Aim: To review the evidence on the extended use or re-use of single-use respirators and surgical masks by frontline healthcare workers.
INFECTION CONTROL
10/9/20
Abate BB, Kassie AM, Kassaw MW, et al. | BMJ Open
Aim: To assess the sex difference in the prevalence of COVID-19 confirmed cases.
CLINICAL CHARACTERISTICS
10/8/20
Maiese A, Manetti AC, La Russa R, et al. | Forensic Sci Med Pathol
Aim: To collect the currently available pathological data on COVID-19 and review the international literature on the postmortem findings of patients with COVID-19.
CLINICAL CHARACTERISTICS
10/8/20
Gianola S, Jesus TS, Bargeri S, et al. | PLoS One
Aim: To take a snapshot of the amount of scientific development devoted to COVID-19 and gain an idea of the current status of global research. 
10/8/20
Quesada JA, López-Pineda A, Gil-Guillén VF, et al. | Rev Clin Esp
Aim: To provide a more accurate estimate of the incubation period of COVID-19.
CLINICAL CHARACTERISTICS
10/8/20
Ehaideb SN, Abdullah ML, Abuyssin B, et al. | Crit Care
Aim: To assess whether the newly created models reproduce the full spectrum of human COVID-19.
10/8/20
Oliveira CB, Lima CAB, Vajgel G, et al. | J Clin Pathol
Aim: To describe the incidence of AKI, need for renal replacement therapy (RRT) and mortality among patients with COVID-19-associated AKI.
CLINICAL CHARACTERISTICS
10/8/20
Henssler J, Stock F, van Bohemen J, et al. | Eur Arch Psychiatry Clin Neurosci
Aim: To assess the psychological effects in both quarantined and isolated persons compared to non-quarantined and non-isolated persons. 
RECENTLY UPDATED
10/8/20
Choi GJ, Kim HM, Kang H, et al. | J Lipid Atheroscler
Aim: To analyze the available knowledge about the potential association between dyslipidemia and the severity of coronavirus disease 2019 (COVID-19) as reported in previous published systematic reviews.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
10/7/20
Leochico CFD, Espiritu AI, Ignacio SD, et al. | Front Neurol
Aim: To determine the challenges faced by telerehabilitation in the Philippines.
INFECTION CONTROL
10/7/20
Miller L, Bhattacharyya R, Miller AL | Medicine
Aim: To determine the mortality rate of hospitalized patients with Covid-19 in China and to identify factors that may potentially influence this rate.
CLINICAL CHARACTERISTICS
10/7/20
 | NSW Health COVID-19 Critical Intelligence Unit
10/7/20
Ferner RE, Aronson JK | Oxford COVID-19 Evidence Service
10/7/20
Setiati S, Harimurti K, Safitri ED, et al | Acta Med Indones
Aim: To systematically review all relevant studies related to the risk factors and laboratory test results associated with severe illness and mortality in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
10/7/20
Betancourt JA, Rosenberg MA, Zevallos A, et al. | Healthcare
Aim: To review the evidence on the impact of the COVID-19 pandemic on the provision of care through telemedicine across unique health service lines that include dermatology, oncology, obstetrics/gynecology, and mental health.
INFECTION CONTROL
10/7/20
Magill E, Siegel Z, Pike KM | Psychiatr Serv
Aim: To review the evidence on the anticipated mental health sequelae for frontline health workers and best practices to address those mental health needs.
10/7/20
 | NSW Health COVID-19 Critical Intelligence Unit
10/6/20
Mandal A, Nandi S, Chhebbi M, et al. | Indian J Otolaryngol Head Neck Surg
Aim: To review the current guidelines and safety measures to be followed during tracheostomy in COVID-19 infected patients.
CLINICAL CHARACTERISTICS
10/6/20
Olorunsaiye CZ, Yusuf KK, Reinhart K, et al. | Int J MCH AIDS
Aim: To review the evidence on the immunization landscape since the COVID-19 pandemic.
INFECTION CONTROL
10/6/20
Cheng W, Li Y, Cui L, et al. | Front Pharmacol
Aim: To evaluate the efficacy and safety of corticosteroid therapy in patients with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
10/6/20
Sharma SK, Mishra M, Mudgal SK | J Educ Health Promot
Aim: To update the available most recent evidences on efficacy of cloth face masks in prevention of viral infection transmission.
10/6/20
Cheong KX | Curr Ophthalmol Rep
Aim: To summarise and discuss the current literature regarding ocular involvement of SARS-CoV-2 in COVID-19.
CLINICAL CHARACTERISTICS
10/6/20
Jena A, Singh AK, Kumar-M P, et al. | Dig Liver Dis
Aim: To identify the frequency and reasons for the disruption of care for IBD patients and attempted to identify regional differences in patterns of adherence to IBD therapies.
10/5/20
Meyerowitz-Katz G, Merone L | Int J Infect Dis
Aim: To review the evidence on infection-fatality rates for COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/5/20
Noorimotlagh Z, Mirzaee SA, Jaafarzadeh N, et al. | Environ Sci Pollut Res Int
Aim: To collect all available studies concerning inactivation methods, environmental survival, and control and prevention strategies related to SARS-CoV-2. 
INFECTION CONTROL
10/5/20
Tlayjeh H, Mhish O, Enani M, et al. | J Infect Public Health
Aim: To systematically review the literature about the association between systemic corticosteroid therapy (CST) and outcomes of COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
10/5/20
Moutchia J, Pokharel P, Kerri A, et al. | PLoS One
Aim: To assess clinical laboratory parameters which may serve as markers or predictors of severe or critical COVID-19.
UPDATED
DIAGNOSTICS
10/5/20
Soeroto AY, Soetedjo NN, Purwiga A, et al. | Diabetes Metab Syndr
Aim: To evaluate the association between obesity and composite poor outcome in coronavirus disease 2019 (COVID-19) patients.
UPDATED
CLINICAL CHARACTERISTICS
10/5/20
Chaudhry H, Nadeem S, Mundi R | Clin Orthop Relat Res
Aim: To review the evidence on patient and surgeon satisfaction with the use of telemedicine, differences in outcomes compared to in-person visits and the difference in time commitment.
INFECTION CONTROL
10/5/20
Huang Y, Yao L, Huang Y, et al. | Metabolism
Aim: To review the evidence on the effects of obesity with the risk of severe disease among patients with COVID-19.
CLINICAL CHARACTERISTICS
10/5/20
Simons D, Shahab L, Brown J, et al. | Addiction
Aim: To estimate the association of smoking status with rates of i) infection, ii) hospitalisation, iii) disease severity, and iv) mortality from SARS?CoV?2/COVID?19 disease.
CLINICAL CHARACTERISTICS
10/5/20
Jarrom D, Elston L, Washington J, et al. | BMJ Evid Based Med
Aim: To identify evidence on: (1) the clinical effectiveness of tests that detect the presence of severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) to inform COVID?19 diagnosis? and (2) the clinical effectiveness of tests that detect the presence of antibodies to the SARS?CoV?2 virus to inform COVID?19 diagnosis.
UPDATED
DIAGNOSTICS
10/5/20
Deng J, Zhou F, Hou W, et al. | Ann N Y Acad Sci
Aim: To assess the prevalence of depression, anxiety, and sleep disturbances in COVID-19 patients.
CLINICAL CHARACTERISTICS
10/2/20
Simoni P, Bazzocchi A, Boitsios G, et al. | J Med Imaging Radiat Oncol
Aim: To describe the chest CT features reported in children with confirmed COVID?19 infection.
CLINICAL CHARACTERISTICS
10/2/20
Jahangir M, Nawaz M, Nanjiani D, et al. | Hong Kong Med J
Aim: To review the characteristics and presentation of COVID-19 among children and describe any subtle characteristics that may strengthen the clinical suspicion of infection and prompt further testing. 
CLINICAL CHARACTERISTICS
10/2/20
Carrillo-Larco RM, Altez-Rodriguez C, Ravaglia S, et al. | Wellcome Open Res
Aim: To understand the characteristics of patients with COVID-19 and GBS, and to identify potential patterns.
UPDATED
CLINICAL CHARACTERISTICS
10/2/20
Mhango M, Dzobo M, Chitungo I, et al. | Saf Health Work
Aim: To map available evidence on Covid-19 risk factors among HWs to guide future research and policy.
CLINICAL CHARACTERISTICS
10/2/20
Rostami M, Mansouritorghabeh H | Expert Rev Hematol
Aim: To analyze the levels of D-dimer in patients with COVID-19.
CLINICAL CHARACTERISTICS
10/2/20
Oliviera Silva DF, Cunha Lima SC, Mauricio Sena-Evangelista KC, et al. | Nutrients
Aim: To identify the screening instruments that can be used to assess nutritional risk in older adults with COVID-19, and to clarify their measurement properties.
UPDATED
CLINICAL CHARACTERISTICS
10/2/20
Flumignan RLG, de Sa Tinoco JD, Pascoal PIF, et al. | Cochrane Database Syst Rev
Aim: To assess the effects of prophylactic anticoagulants versus active comparator, placebo or no intervention, on mortality and the need for respiratory support in people hospitalised with COVID?19.
UPDATED
CANDIDATE THERAPEUTICS
10/2/20
Yang S, Li A, Eshaghpour A, et al. | BMJ Evid Based Med
Aim: To review the trends and quality of evidence in early SARS-CoV-2 publications.
10/2/20
Negrini F, De Sire A, Andrenelli E, et al. | Eur J Phys Rehabil Med
Aim: To report data of a systematic search performed on papers published in July 2020.
UPDATED
CLINICAL CHARACTERISTICS
10/2/20
Salari N, Khazaie H, Hosseinian-Far A, et al. | Global Health
Aim: To investigate the prevalence of sleep disturbances in hospital nurses and physicians facing the COVID-19 patients.
10/2/20
Antikchi MH, Neamatzadeh H, Ghelmani Y, et al. | J Gastrointest Cancer
Aim: To estimate the risk and prevalence of COVID-19 infection in CRC patients using all available data.
INFECTION CONTROL
10/2/20
Li WT, Ma J, Shende N, et al. | BMC Med Inform Decis Mak
Aim: To investigate correlations between clinical variables, cluster COVID-19 patients into subtypes, and generate a computational classification model for discriminating between COVID-19 patients and influenza patients based on clinical variables alone.
DIAGNOSTICS
9/30/20
Salameh JP, Leeflang MMG, Hooft L, et al. | Cochrane Database Syst Rev
Aim: To determine the diagnostic accuracy of chest imaging (computed tomography (CT), X?ray and ultrasound) in people with suspected or confirmed COVID?19.
DIAGNOSTICS
9/29/20
Hussain N, Chung E, Heyl JJ, et al. | Cureus
Aim: To assess the effects of HCQ on patients with COVID-19.
CLINICAL CHARACTERISTICS
9/29/20
Oliveira LV, Silva C, Lopes LP, et al. | Rev Assoc Med Bras
Aim: To review the current scientific evidence of vertical transmission related to coronavirus disease 2019 (COVID-19).
9/29/20
Bhattacharjee S, Banerjee M | SN Compr Clin Med
Aim: To analyze the clinical profile and outcomes in a total of 45 cases of new-onset ITP in COVID-19 patients described in literature until date.
9/29/20
Morone G, Palomba A, Iosa M, et al.  | Front Med
Aim: To correlate the presence and the relevant temporal patterns of SARS-CoV-2 viral RNA in biological specimens (stool, urine, blood, and tears) of the transmission with clinical/epidemiological features in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/29/20
Abuelgasim E, Dona ACM, Sondh RS, et al. | Dermatol Ther
Aim: To review the current literature on urticaria in COVID-19 patients and to provide insight into urticarial pathogenesis and management in such patients.
9/29/20
de Araujo LA, Veloso CF, de Campos Souza M, et al. | J Pediatr
Aim: To examine the impact of epidemics or social restriction on mental and developmental health in parents and children/adolescents.
9/28/20
Sheleme T, Bekele F, Ayela T | Infect Dis
Aim: To summarize clinical presentations of this newly emerging coronavirus disease.
9/28/20
Shrestha DB, Pudhathoki P, Khadka S, et al. | Virol J
Aim: To review the efficacy and safety of favipiravir triphosphate as a treatment for COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
9/28/20
Malik P, Patel U, Patel K, et al. | J Med Virol
Aim: To assess the association of obesity and outcomes in COVID?19 hospitalized patients.
9/28/20
Rios P, Radhakrishnan A, Williams C, et al. | Syst Rev
Aim: to examine the current guidelines for infection prevention and control (IPAC) of coronavirus disease-19 (COVID-19) or other coronaviruses in adults 60 years or older living in long-term care facilities (LTCF).
UPDATED
INFECTION CONTROL
9/28/20
 | Public Health Agency of Canada
Aim: Not provided
9/28/20
de Assis GG, Murawksa-Cialowicz E, Cieszczyk P, et wl. | Front Neurol
Aim: To review the evidence on the implications and mechanisms of infections by respiratory CoVs.
9/28/20
Viner RM, Mytton OT, Bonell C, et al. | JAMA Pediatr
Aim: To review the evidence on the susceptibility to and transmission of SARS-CoV-2 by children and adolescents compared with adults.
UPDATED
INFECTION CONTROL
9/25/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence that CPR is aerosol generating and current advice for CPR in patients with suspected or confirmed COVID-19.
9/25/20
Singh B, Gornet M, Sims H, et al. | Am J Reprod Immunol
Aim: To analyze the available evidence on SARS-CoV-2 infection, early pregnancy, and reproductive tissues.
CLINICAL CHARACTERISTICS
9/24/20
Bennett S, Tafuro J, Mayer J, et al. | Int J Clin Pract
Aim: To identify the symptoms, comorbidities present, radiological features and outcomes for adults testing positive for COVID?19 admitted to hospital.
CLINICAL CHARACTERISTICS
9/24/20
Lim MA, Pranata R | J Clin Orthop Trauma
Aim: To evaluate the prevalence of coronavirus disease 2019 (COVID-19) and its impact on mortality in patients with hip fracture.
UPDATED
CLINICAL CHARACTERISTICS
9/24/20
Malgie J, Schoones JW, Pijls BG | Clin Infect Dis
Aim: To review the evidence on the use of IL-6 (receptor) antagonist therapy in reducing mortality in COVID-19 patients.
CANDIDATE THERAPEUTICS
9/24/20
Wang Y, Chen J, Chen W, et al. | Int Arch Allergy Immunol
Aim: To explore the literature and collate data comparing the mortality of coronavirus disease 2019 (COVID-19) patients with and without asthma.
CLINICAL CHARACTERISTICS
9/24/20
Wang M, Wu T, Zuo Z, et al. | BMJ Support Palliat Care
Aim: To summarize the efficacy and safety of antiviral agents currently in use for COVID-19 treatment.
UPDATED
CANDIDATE THERAPEUTICS
9/24/20
Berling I, King JD, Shepherd G, et al. | J Am Soc Nephrol
Aim: To determine the effect of and indications for extracorporeal treatments in cases of poisoning with chloroquine, hydroxychloroquine, and quinine.
9/24/20
Murchu EO, Byrne P, Walsh KA, et al. | Rev Med Virol
Aim: To summarize the evidence on the immune response and reinfection rate following SARS?CoV?2 infection. 
CLINICAL CHARACTERISTICS
9/24/20
Roncon L, Zuin M, Barco S, et al. | Eur J Intern Med
Aim: To perform a systematic review and meta-analysis of the in-hospital incidence of acute PE among COVID-19 patients based on studies published within four months of COVID-19 outbreak.
CLINICAL CHARACTERISTICS
9/24/20
Goncalves LF, Gonzales AI, Patatt FSA, et al. | Rev Assoc Med Bras
Aim: To present scientific evidence evaluating the association of Kawasaki Disease (DK) and COVID-19 in children.
CLINICAL CHARACTERISTICS
9/24/20
Buitrago-Garcia D, Egli-Gany D, Counotte MJ, et al. | PLoS Med
Aim: To review the evidence on asymptomatic SARS-CoV-2 transmission.
CLINICAL CHARACTERISTICS
9/24/20
Nogueira SAR, de Oliveira SCS, de Carvalho AFM, et al. | Rev Assoc Med Bras
Aim: To present a review of renal changes in patients with COVID-19.
CLINICAL CHARACTERISTICS
9/24/20
Ibekew TS, Fasunla AJ, Orimadegun AE | OTO Open
Aim: To estimate prevalence of smell and taste loss among COVID-19 patients.
CLINICAL CHARACTERISTICS
9/24/20
Gulsen A, Yigitbas BA, Uslu B, et al. | Pulm Med
Aim: To determine the relationship between smoking and clinical COVID-19 severity via a systematic meta-analysis approach.
UPDATED
CLINICAL CHARACTERISTICS
9/24/20
Cabarkapa S, Nadjidai SE, Murgier J, et al. | Brain Behav Immun Health
Aim: To explore the main findings from the literature examining the psychological impact on HCWs in times of severe epidemics, and to identify strategies to address this.
9/23/20
O'Reilly A, Tibbs M, Booth A, et al. | Ir J Psychol Med
Aim: To summarise existing evidence on the potential impact of a pandemic on the mental health of 12-25-year-olds.
UPDATED
9/23/20
Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the medium-term and long-term health impacts of COVID-19 on infection survivors.
9/22/20
Li X, Xu Z, Wang T, et al. | Clin Epidemiol Glob Health
Aim: To identify clinical characteristics of severe patients with COVID-19.
CLINICAL CHARACTERISTICS
9/22/20
van Boekel L, Stoop A, Luijkx KG | Tijdschr Gerontol Geriatr
Aim: To understand what we can learn from previous crises or disasters worldwide to optimize the care for older adults in long term care facilities during the outbreak of COVID-19. 
9/22/20
 | CADTH
Aim: To review evidence related to airflow transmission of SARS-CoV-2 and the risk associated with the use of heating, ventilation, and air conditioning (HVAC) systems.
9/22/20
Melo-Oliveira ME, Sa-Caputo D, Bachur JA, et al. | Expert Rev Respir Med
Aim: To summarize effects of the COVID-19 in the QoL of the studied populations.
CLINICAL CHARACTERISTICS
9/22/20
Boyce L, Nicolaides M, Hanrahan JG, et al. | J Plast Reconstr Aesthet Surg
Aim:  To identify all published literature on plastic surgery and COVID-19, in an effort to summarise the evidence for future reference.
INFECTION CONTROL
9/21/20
Huang AT, Garcia Carreras B, Hitchings MDT, et al. | Nat Commun
Aim: To review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). 
UPDATED
CLINICAL CHARACTERISTICS
9/21/20
Marinaki S, Tsiakas S, Korogiannou M, et al. | J Clin Med
Aim: To analyze the data of studies reporting on adult KTx recipients with confirmed COVID-19.
CLINICAL CHARACTERISTICS
9/21/20
Lo KB, Bhargav R, Salacup G, et al. | Expert Rev Cardiovasc Ther
Aim: To investigate the impact of ACEI/ARB on COVID-19 associated disease severity and mortality through a systematic review and meta-analysis of existing literature.
CLINICAL CHARACTERISTICS
9/21/20
Moosavi MS, Aminishakib P, Ansari M | J Oral Microbiol
Aim: To review the evidence on the effects of different types of mouthwashes to reduce viral load.
INFECTION CONTROL
9/21/20
Chen J, See KC | J Med Internet Res
Aim: To review AI applications for COVID-19.
DIAGNOSTICS
9/21/20
Yoon S, Li H, Lee KH, et al. | Medicina
Aim: To compare characteristics among: (1) asymptomatic versus symptomatic and (2) less than 10 versus greater or equal to 10 years old pediatric COVID-19 patients. 
CLINICAL CHARACTERISTICS
9/21/20
Cabrera MA, Karamsetty L, Simpson SA | Psychosomatics
Aim: To provide a critical synthesis of the scientific literature on the pandemic's implications for psychiatric practice.
INFECTION CONTROL
9/21/20
Trevisanuto D, Cavallin F, Cavicchiolo ME, et al. | Arch Dis Child Fetal Neonatal Ed
Aim: To summarise currently reported neonatal cases of SARS-CoV-2 infection.
CLINICAL CHARACTERISTICS
9/21/20
Singh S, Fong HK, Mercedes BR, et al. | Resuscitation
Aim: To review the evidence on the change in out-of-hospital cardiac arrest indicence and mortality during the COVID-19 outbreak in various countries.
9/21/20
Mecenas P, da Rose Moreira Bastos RT, Vallinoto ACR, et al. | PLoS One
Aim: To describe current knowledge about the emergence and replicability of the virus and its connection with different weather factors such as temperature and relative humidity.
UPDATED
INFECTION CONTROL
9/21/20
Acheampong DO, Barffour IK, Boye A, et al. | Biomed Pharmacother
Aim: To review the evidence on the possible biological reasons which underpin the differences observed in the outcome of COVID-19 among males and females.
CLINICAL CHARACTERISTICS
9/21/20
Luigi B, Francesco B, Giovanni B, et al. | Oral Dis
Aim: To review the evidence on surfaces decontamination and protection masks for SARS-CoV-2 in dental practice.
INFECTION CONTROL
9/21/20
Yang T, Chou C, Yang Y, et al. | J Chin Med Assoc
Aim: To address not only the benefits and safety issues of HCQ in COVID-19 treatment and to evaluate the effects in combination with the use of macrolide, especially AZI in therapy.
CANDIDATE THERAPEUTICS
9/21/20
Khalaj K, Figueira RL, Antounians L, et al. | J Extracell Vesicles
Aim: To analyse whether EV-based therapies could be effective in treating severe pulmonary conditions that affect COVID-19 patients and to understand their relevance for an eventual therapeutic application to human patients. 
CANDIDATE THERAPEUTICS
9/21/20
Hamedani S, Farshidfar N, Ziaei A, et al. | European Oral Research
Aim: To review relevant current evidence in literature that has addressed the role of saliva and the threats that may be inherent in transmission of the disease during dental procedures.
INFECTION CONTROL
9/18/20
WHO REACT Working Group | JAMA
Aim: To estimate the association between administration of corticosteroids compared with usual care or placebo and 28-day all-cause mortality.
WHO COLLABORATIVE
CANDIDATE THERAPEUTICS
9/18/20
Malik P, Patel U, Mehta D, et al. | BMJ Evid Based Med
Aim: To evaluate association between biomarkers and outcomes in COVID-19 hospitalised patients.
CLINICAL CHARACTERISTICS
9/18/20
Zahra SA, Iddawela S, Pillai K, et al. | Brain Behav
Aim: To investigate the diagnostic value of symptoms of anosmia and dysgeusia for COVID?19.
DIAGNOSTICS
9/18/20
Bornstein S | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the effectiveness of reducing prison populations to reduce the spread of COVID-19.
9/18/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on whether domestic animals can become infected with and transmit COVID-19.
9/18/20
Pranata R, Huang I, Lim MA, et al. | J Stroke Cerebrovasc Dis
Aim: To evaluate the latest evidence on the association between cerebrovascular, and cardiovascular diseases and poor outcome in patients with Coronavirus Disease 2019 (COVID-19) pneumonia.
CLINICAL CHARACTERISTICS
9/18/20
Mojtabavi H, Saghazadeh A, Rezaei N | Eur Cytokine Netw
Aim: To investigate whether the circulating levels of IL-6 is a reliable indicator of disease severity among patients affected with COVID-19.
DIAGNOSTICS
9/18/20
Lagzian M, Dadkhah M, Mehraeen A | Eur J Clin Invest
Aim: To recognize the challenges policymakers have typically experienced during pandemic diseases, including Covid-19, and, accordingly, new information technology capabilities to encounter with them.
9/18/20
Orru G, Conversano C, Malloggi E, et al. | Int J Environ Res Public Health
Aim: To review the evidence on the neurological complications of possible neuroinvasion related to SARS-CoV-2.
CLINICAL CHARACTERISTICS
9/18/20
Paknahad Z, Moravejolahkami AR | Endocr Metab Immune Disord Drug Targets
Aim: To review the evidence on the effects of probiotics on incidence, severity, duration, and other clinical manifestations of viral infections especially SARS-CoV-2-induced.
CANDIDATE THERAPEUTICS
9/18/20
Campbell CM, Guha A, Haque T, et al. | J Clin Med
Aim: To characterize the current state of immunotherapy trials in COVID-19, and focuses on associated cardiotoxicities, given the importance of pharmacovigilance.
CANDIDATE THERAPEUTICS
9/18/20
Leung T, Chan A, Chan EW, et al. | Emerg Microbes Infect
Aim: To summarize the current evidence on the short-term adverse health outcomes and assess the risk of potential long-term adverse outcomes of COVID-19. 
CLINICAL CHARACTERISTICS
9/18/20
Fridman S, Bullrich MB, Jimenez-Ruiz A, et al. | Neurology
Aim: To investigate the hypothesis that strokes occurring in patients with COVID-19 have distinctive features.
CLINICAL CHARACTERISTICS
9/18/20
Rajan MB, Kumar P, Bhardwaj A | Int J Dermatol
Aim: To estimate the prevalence of cutaneous manifestations in COVID?19 patients.
CLINICAL CHARACTERISTICS
9/17/20
Pastick KA, Nicol MR, Smyth E, et al. | Open Forum Infect Dis
Aim: To review the available evidence on COVID-19 cases during pregnancy and summarize clinical trials enrolling this population.
CLINICAL CHARACTERISTICS
9/17/20
Macaluso FS, Orlando A | Dig Liver Dis
Aim: To review the evidence on published COVID-19 cases ocurring in patients with IBD.
CLINICAL CHARACTERISTICS
9/17/20
Dambha-Miller H, Albasri A, Hodgson S, et al. | BMJ Open
Aim: To review evidence on routinely prescribed drugs in the UK that could upregulate or downregulate ACE2 and potentially affect COVID-19 disease.
UPDATED
CANDIDATE THERAPEUTICS
9/17/20
Chang T, Chou C, Chang L | Obes Rev
Aim: To examine the effects of body mass index (BMI) and obesity (BMI ? 30 kg/m2) on coronavirus disease 2019 (COVID?19).
CLINICAL CHARACTERISTICS
9/17/20
Juul S, Nielsen N, Feinberg J, et al. | PLoS Med
Aim: To compare the effects of all treatment interventions for participants in all age groups with COVID-19. 
UPDATED
CANDIDATE THERAPEUTICS
9/17/20
Lasheras I, Gracia-Garcia P, Lipnicki DM, et al. | Int J Environ Res Public Health
Aim: To investigate the prevalence of anxiety in medical students during this pandemic.
9/17/20
Wang Y, Ao G, Qi X, et al  | Clin Exp Allergy
Aim: To review the evidence on the association of asthma with risk of severe or fatal COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/16/20
Du Y, Lv Y, Zha W et al. | Metabolism
Aim: To explore the association between BMI and COVID-19 severity and mortality
CLINICAL CHARACTERISTICS
9/16/20
 | CADTH
Aim: To provide information on ongoing randomized controlled trials of drugs being investigated to treat or prevent COVID-19.
9/15/20
da Silva ML, Rocha RSB, Buheji M, et al. | J Health Psychol
Aim: To assess the prevalence of generalized anxiety disorder (GAD) in pandemic survivors and the general population.
9/15/20
Cheruiyot I, Henry B, Lippi G, et al. | Acta Biomed
Aim: To assess whether AKI may be associated with worse prognosis and increased mortality in COVID-19 patients
UPDATED
9/15/20
Peres KC, Riera R, Martimbianco ALC, et al. | Front Endocrinol
Aim: To investigate a possible association between body weight and prognosis among patients diagnosed with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/15/20
Muhammad SZ, Ahmed A, Shahid I, et al. | Infez Med
Aim: To systematically review these studies and to conduct a meta-analysis of their results to provide a well-powered assessment of chest CT findings in patients with COVID-19.
CLINICAL CHARACTERISTICS
9/15/20
Ciuca IM | Risk Manag Healthc Policy
Aim: To describe the current knowledge about coronavirus disease 2019 (COVID-19, which is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) in children, from epidemiological, clinical, and laboratory perspectives, including knowledge on the disease course, treatment, and prognosis.
CLINICAL CHARACTERISTICS
9/15/20
Bizzoca ME, Campisi G, Lo Muzio L | Int J Environ Res Public Health
Aim: To illustrate the most accepted models of safety protocols in dentistry and oral medicine, and to propose an easy view of the problem and a comparison (pre- vs post-COVID19) for the most common dental procedures.
INFECTION CONTROL
9/15/20
Fiorillo L, Cervino G, Matarese M, et al. | Int J Environ Res Public Health
Aim: To highlight all the sources currently present in the literature concerning the persistence of the different coronaviruses in the environment as well as in medical and dental settings. 
INFECTION CONTROL
9/15/20
Yamamoto V, Bolanos JF, Fiallos J, et al. | J Alzheimers Dis
Aim: To provide a comprehensive review of SARS-CoV-2-induced disease, its mechanism of infection, diagnostics, therapeutics, and treatment strategies, while also focusing on less attended aspects by previous studies, including nutritional support, psychological, and rehabilitation of the pandemic and its management.
CANDIDATE THERAPEUTICS
9/15/20
Aziz H, Lashkari N, Yoon YC, et al. | Transplant Proc
Aim: To assess currently published literature relating to the management, clinical course and outcomes of SARS-Cov-2 infection in liver, kidney and heart SOT recipients.
CLINICAL CHARACTERISTICS
9/15/20
Roberto KT, Espiritu AI, Fernandez MLL, et al. | Seizure
Aim: To review the EEG findings in patients diagnosed with COVID-19 infection through a systematic review of published articles.
CLINICAL CHARACTERISTICS
9/15/20
Siepmann T, Sedghi A, Simon E, et al. | Eur J Neurol
Aim: To define the risk of acute stroke in patients with severe and non-severe COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/15/20
Zhang A, Leng Y, Zhang Y et al. | Int J Infect Dis
Aim: To figure out whether abnormal coagulation parameters are associated with disease severity and poor prognosis in patients with 2019 Corona Virus Disease (COVID-19)
CLINICAL CHARACTERISTICS
9/15/20
Ahmed M, Advani S, Moreira A, et al. | EClinicalMedicine
Aim: To describe the typical presentation and outcomes of children diagnosed with this hyperinflammatory condition.
UPDATED
CLINICAL CHARACTERISTICS
9/15/20
 | Quebec National Institute of Public Health
Aim: To review the evidence on risk factors for severe infections and potential for transmission in children.
9/15/20
Sharpe H | Alberta Health Services
Aim: To review the evidence on different methods, completion rates, and costs for self-collected samples for SARS-CoV-2 RT-PCR.
9/15/20
Ricco M, Ranzieri S, Peruzzi S, et al. | Acta Biomed
Aim: To conduct a meta-analysis on the sensitivity and specificity of SARS-CoV-2 viral RNA detection through RT-qPCR based on salivary specimens compared to conventional nasopharyngeal swabs.
DIAGNOSTICS
9/15/20
Banerjee I, Robinson J, Kashyap A, et al. | Nepal J Epidemiol
Aim: To assess the impact of COVID-19 on the younger age group in terms of the Global mortality of COVID-19 in comparison to Nepal. 
CLINICAL CHARACTERISTICS
9/15/20
Aronoff SC, Hall A, Del Vecchio MT | J Pediatric Infect Dis Soc
Aim: To provide a detailed clinical description and natural history of MIS-C.
CLINICAL CHARACTERISTICS
9/15/20
Viswanathan M, Kahwati L, Jahn B, et al. | Cochrane Database Syst Rev
Aim: To assess (1) the effectiveness of universal screening for SARS?CoV?2 infection compared with no screening and (2) the accuracy of universal screening in people who have not presented to clinical care for symptoms of COVID?19.
INFECTION CONTROL
9/14/20
Lee JC, Nallani R, Cass L, et al. | Am J Rhinol Allergy
Aim: To synthesize the existing primary literature related to olfactory dysfunction secondary to viral infection, detail the underlying pathophysiological mechanisms, highlight relevance for the current COVID-19 pandemic, and identify high impact areas of future research.
CLINICAL CHARACTERISTICS
9/14/20
Mark EG, Golden WC, Gilmore MM, et al. | J Pediatr
Aim: To summarize and evaluate current reports on community-onset severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in young infants.
CLINICAL CHARACTERISTICS
9/14/20
Jimenez-Ruiz CA, Lopez-Padilla D, Alonso-Arroyo A, et al. | Arch Bronconeumol
Aim: To review the evidence on the association between tobacco use in patients with COVID-19 and negative progression and adverse outcome of the disease.
CLINICAL CHARACTERISTICS
9/14/20
Klein MG, Cheng CJ, Lii E, et al. | Disaster Med Public Health Prep
Aim: To highlight models that project both caseload and hospital capacity requirements over time.
9/14/20
Williams N, Radia T, Harman K, et al. | Eur J Pediatr
Aim: To identify and describe which underlying comorbidities may be associated with severe SARS-CoV-2 disease and death in children.
CLINICAL CHARACTERISTICS
9/14/20
Siemieniuk RAC, Bartoszko JJ, Ge L, et al. | BMJ
Aim: To compare the effects of treatments for coronavirus disease 2019 (covid-19).
UPDATED
CANDIDATE THERAPEUTICS
9/14/20
Aziz M, Haghbin H, Sitta EA, et al. | J Med Virol
Aim: To compare the efficacy of addition of TOC to standard of care (SOC) versus SOC in patients with COVID?19.
CANDIDATE THERAPEUTICS
9/14/20
Di Maria E, Latini A, Borgiani P, et al. | Human Genomics
Aim: To review the evidence on genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS, and COVID-19).
UPDATED
CLINICAL CHARACTERISTICS
9/14/20
Fernandez R, Lord H, Halcomb E, et al. | Int J Nurs Stud
Aim: To synthesize and present the best available evidence on the experiences of nurses working in acute hospital settings during a pandemic.
9/14/20
Hasan SS, Kow CS, Hadi MA, et al. | Am J Cardiovasc Drugs
Aim: To critically examine the association of RAS inhibitors use with mortality and disease severity in COVID-19.
CANDIDATE THERAPEUTICS
9/14/20
Panda PK, Sharawat IK, Panda P, et al. | J Trop Pediatr
Aim: To review the evidence on the neurological manifestations of COVID-19 in children.
UPDATED
CLINICAL CHARACTERISTICS
9/14/20
Amorim dos Santos J, Normando AGC, Carvalho da Silva RL, et al. | J Dent Res
Aim: To provide a comprehensive up-to-date summary of oral manifestations in patients with COVID-19.
9/14/20
Nino G, Zember J, Sanchez-Jacob R, et al. | Pediatr Pulmonol
Aim: To provide the first comprehensive summary of the findings of published studies thus far describing COVID-19 lung imaging data in the pediatric population.
CLINICAL CHARACTERISTICS
9/14/20
Cozzupoli GM, Savastano MC, Galsini B, et al. | J Ophthalmol
Aim: To review and analyze previous studies conducted on ritonavir administration and retinal impairment in a narrative synthesis. 
CANDIDATE THERAPEUTICS
9/14/20
Nussbaumer-Streit B, Mayr V, Dobrescu AI, et al. | Cochrane Database of Systematic Reviews
Aim: To assess the effects of quarantine (alone or in combination with other measures) of individuals who had contact with confirmed cases of COVID19, who travelled from countries with a declared outbreak, or who live in regions with high transmission of the disease.
UPDATED
WHO COLLABORATIVE
INFECTION CONTROL
9/14/20
Florez-Perdomo WA, Serrato-Vargas SA, Bosque-Varela P, et al. | Clin Neurol Neurosurg
Aim: To evaluate and summarize the level of evidence on past history of stroke in COVID19 patients.
CLINICAL CHARACTERISTICS
9/14/20
Patoulias D, Katsimardou A, Stavropoulos K, et a. | Curr Hypertens Rep
Aim: To evaluate the association between the use of either ACE inhibitors or ARBs and the risk for major clinical endpoints (infection, hospitalization, admission to ICU, death) in adult patients during the COVID-19 pandemic. 
CLINICAL CHARACTERISTICS
9/14/20
Elhabyan A, El Yaacoub S, Sanad E, et al. | Virus Res
Aim: To identify the candidate genes that are likely to aid in explaining severe COVID-19 and provide insights to understand severe COVID-19.
CLINICAL CHARACTERISTICS
9/14/20
Zeng M, Li L, Wu Z | PLoS ONE
Aim: To review the evidence on the clinical efficacy and safety of the traditional Chinese medicine Lianhua Qingwen in the treatment of new coronavirus pneumonia (COVID-19). 
CANDIDATE THERAPEUTICS
9/12/20
Noor FM, Islam MM | J Community Health
Aim: To find the prevalence of mortality among hospitalized COVID-19 infected patients and associated risk factors for death.
CLINICAL CHARACTERISTICS
9/12/20
Hussain N, Yoganathan A, Hewage S, et al. | Expert Rev Anti Infect Ther
Aim: To identify studies pertaining to antivirals, both as sole and combined therapies, in COVID-19 patients and review the clinical outcomes of these treatment methods.
CANDIDATE THERAPEUTICS
9/11/20
Usman AS, Siddiqi TJ, Khan MS, et al. | Am J Cardiol
Aim: To conduct a meta-analysis of all available data on the relationship between renin-angiotensin aldosterone system of inhibitors and COVID-19.
CANDIDATE THERAPEUTICS
9/11/20
Sun M, Xu Y, He H, et al. | Int J Infect Dis
Aim: To explore the effectiveness of treatment and predict the potential effects of CP with COVID-19.
CANDIDATE THERAPEUTICS
9/11/20
Sun Z, Zhang N, Li Y, et al. | Quant Imaging Med Surg
Aim: To analyze the currently available studies documenting radiologic findings and aim to clarify the role of CT imaging in the diagnosis of patients with COVID-19.
DIAGNOSTICS
9/11/20
Brienza N, Puntillo F, Romagnoli S, et al. | Blood Purif
Aim: To clarify the incidence and the impact of COVID-19-related AKI on mortality.
CLINICAL CHARACTERISTICS
9/11/20
Ng JJ, Luo Y, Phua K, et al. | J Infect
Aim: To quantitatively synthesized available literature and performed a single-arm meta-analysis of proportions to report the pooled incidence rate of AKI and renal replacement therapy (RRT) use in hospitalized patients with COVID-19.
CLINICAL CHARACTERISTICS
9/11/20
Patel U, Malik P, Usman MS, et al. | SN Compr Clin Med
Aim: To identify risk factors associated with poor outcomes (IMV and mortality) of COVID-19 hospitalized patients.
CLINICAL CHARACTERISTICS
9/11/20
Bakhtawar N, Usman M, Khan MMU | Cureus
Aim: To evaluate the efficacy of convalescent plasma (CP) therapy and its effects on COVID-19 patient outcomes.
CANDIDATE THERAPEUTICS
9/11/20
Paliogiannis P, Mangoni AA, Dettori P, et al. | Front Public Health
Aim: To investigate differences in serum D-dimer concentrations in patients with and without severe COVID-19 disease. 
CLINICAL CHARACTERISTICS
9/11/20
Pathak SK, Salunke AA, Thivari P, et al. | Diabets Metab Syndr
Aim: To evaluate the efficacy of hydroxychloroquine and its related formulations in COVID-19 patients.
CANDIDATE THERAPEUTICS
9/11/20
Zhao G, Huang P, Du B, et al. | Nutr Metab Cardiovasc Dis
Aim: To 1) explore the prevalence of cardiac injury in different types of COVID-19 patients and 2) evaluate the association between cardiac injury and worse prognosis (severe disease, admission to ICU, and mortality) in patients with COVID-19.
CLINICAL CHARACTERISTICS
9/11/20
Lenferink LIM, Meyerbroker K, Boelen PA | Psychiatry Res
Aim: To review the evidence on online Eye Movement Desensitization and Reprocessing (EMDR) treatment for PTSD.
9/11/20
Czumbel LM, Kiss S, Farkas N, et al. | Front Med
Aim: To conduct a meta-analysis on the reliability and consistency of SARS-CoV-2 viral RNA detection in saliva specimens.
UPDATED
DIAGNOSTICS
9/11/20
Abdoul-Azize HT, El Gamil R | Glob Soc Welf
Aim: To explore the current implementation of social protection programs during the COVID-19 pandemic in the most affected countries as well as to provide learned lessons from countries that had not previously considered implementing social protection programs up until the COVID-19 crisis. 
9/11/20
Heidary F, Gharebaghi R | Expert Rev Clin Immunol
Aim: To review the evidence on the antiviral effects of TRIM56.
9/11/20
Seidu S, Gillies C, Zaccardi F, et al. | Endocrinol Diabetes Metab
Aim: To determine whether people with overweight or obesity and with SARS?CoV?2 have different outcomes compared to those within normal weight thresholds.
UPDATED
CLINICAL CHARACTERISTICS
9/10/20
Neishaboori AM, Moshrefiaraghi D, Ali KM, et al. | Arch Acad Emerg Med
Aim: To investigate the current evidence regarding central nervous system (CNS) complications in patients with confirmed COVID-19.
CLINICAL CHARACTERISTICS
9/10/20
Chastain DB, Stitt TM, Ly PR, et al. | Open Forum Infect Dis
Aim: To assess potential proinflammatory targets and review the safety and efficacy of immunomodulatory therapies in managing patients with acute respiratory distress syndrome associated with coronavirus disease 2019.
CANDIDATE THERAPEUTICS
9/10/20
Flumignan RLG, Nakano LCU, Pascoal PIF, et al. | Sao Paulo Med J
Aim: To identify and summarize the evidence from Cochrane systematic reviews (SRs) regarding measures for controlling the dissemination of COVID-19 infection.
INFECTION CONTROL
9/10/20
Housing for Health Project | University of Alberta
Aim: To review the evidence on the built environment factors associated with physical activity among older adults during the acute and recovery phases of the COVID-19 and future pandemics.
9/10/20
Tricco A | Drug Safety and Effectiveness Network
Aim: To review the evidence on the safety and effectiveness of using fractional dosing strategies to deliver intramuscular seasonal influenza vaccines.
9/10/20
Serban D, Smarandache CG, Tudor C, et al. | Diagnostics
Aim: To review the available evidence regarding the health risk of the aerosolization induced by laparoscopy induced and impact of the COVID-19 pandemic upon minimally invasive surgery.
INFECTION CONTROL
9/10/20
Cyr G, Gabet M | Centre de Recherche en Sante Publique
Aim: To review the evidence on the best practices for managing a regional coordination center in a crisis situation.
9/10/20
Bondini CM, Sage S, Wilson BP, et al. | Int Wound J
Aim: To explore the existing evidence around alternative service delivery modalities for treating complex wounds.
INFECTION CONTROL
9/10/20
García Ron A, Cuéllar-Flores I | An Pediatr
Aim: To review the available evidence on the psychological impact of confinement in children, seeking to identify the main stressors and protective factors at play.
9/10/20
Lester S, Khatwa M, Sutcliffe K | JAMA Intern Med
Aim: To gain a deeper understanding of the kinds of services that young people exposed to ACEs feel they need.
9/10/20
Seyedpour S, Khodaei B, Loghman AH, et al. | J Cell Physiol
Aim: To provide a systematic evaluation of the most recent in vitro and in vivo investigations targeting SARS?CoV?2 cell entry. 
CLINICAL CHARACTERISTICS
9/10/20
Major R, Selvaskandan H, Makkeyah YM, et al. | J Am Soc Nephrol
Aim:  To assess the CKD-related inclusion and exclusion criteria for COVID-19 trials.
9/10/20
Bornstein S | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the long-term impacts of COVID-19 on infection survivors.
9/9/20
Fu EL, Janse RJ, de Jong Y, et al. | Clin Kidney J
Aim: To review the evidence on incidence, mortality and risk factors for acute kidney injury in hospitalized COVID-19 patients.
CLINICAL CHARACTERISTICS
9/9/20
Razmi M, Hashemi F, Gheytanchi E, et al. | Int Immunopharmacol
Aim: To assess the available data regarding the efficacy of the immunomodulatory drugs used to manage COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
9/9/20
Kow CS, Hasan SS | J Med Virol
Aim: To explore whether the use of metformin was associated with decreased mortality in COVID-19 patients.
CANDIDATE THERAPEUTICS
9/9/20
Chauhan N, Soni S, Gupta A, et al. | Expert Rev Mol Diagn
Aim: To review the evidence on diagnostic methods for COVID-19 detection.
DIAGNOSTICS
9/9/20
Gitterman LMT, Feris SNV, von Oetinger Giocoman A | Neurologia
Aim: To analyze the available evidence on patients with Guillain-Barre syndrome associated with COVID-19.
CLINICAL CHARACTERISTICS
9/9/20
Seyedpour S, Khodaei B, Loghman AH, et al. | J Cell Physiol
Aim: To provide a systematic evaluation of the most recent in vitro and in vivo investigations targeting SARS?CoV?2 cell entry.
CANDIDATE THERAPEUTICS
9/8/20
Wong Y, Tan M, Zheng Q, et al. | Ann Hepatol
Aim: To assess the prevalence and degree of liver injury between patients with severe and non-severe COVID-19.
CLINICAL CHARACTERISTICS
9/8/20
Miller MA, Cappuccio F | Sleep Med Rev
Aim: To review the rapidly emerging COVID-19 literature to determine (a) the relationship between obstructive sleep apnoea (OSA) and adverse COVID-19 outcomes and, (b) potential causal mechanisms (c) what effect COVID-19 has had on OSA diagnosis and (d) what effect COVID-19 has had on treatment and management of OSA during this period. 
CLINICAL CHARACTERISTICS
9/8/20
Kaushik A, Gupta S, Sood M, et al. | Pediatr Infect Dis J
Aim: To review the evidence on multisystem inflammatory syndrome in children (MIS-C).
CLINICAL CHARACTERISTICS
9/8/20
Hartmann-Boyce J, Gunnell J, Drake J, et al. | BMJ Evid Based Med
Aim: To assess the risks and management considerations of COVID-19 in people with asthma (PWA).
CLINICAL CHARACTERISTICS
9/8/20
Elavarasi A, Prasad M, Seth T, et al. | J Gen Intern Med
Aim: To synthesize the available data on the efficacy and safety of CQ and HCQ for the treatment of COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
9/8/20
Fraser J, Mousley J, Testro A, et al. | Transplant Proc
Aim: To review the evidence on the clinical presentation, treatments, and outcomes in liver transplant recipients with COVID-19.
CLINICAL CHARACTERISTICS
9/8/20
Zang Y, Han X, He M, et al. | Naunyn Schmiedebergs Arch Pharmacol
Aim: To systematically assess the benefits and harms of HCQ for the treatment of COVID-19.
CANDIDATE THERAPEUTICS
9/8/20
Vargas M, Servillo G, Einav S | Eur Rev Med Pharmacol Sci
Aim: To review the evidence on the use of lopinavir/ritonavir for the treatment of SARS, MERS, and SARS-CoV-2.
CANDIDATE THERAPEUTICS
9/8/20
Shoar S, Hosseini F, Naderan M, et al. | Am J Cardiol
Aim: To review the evidence on cardiovascular complications associated with COVID-19.
CLINICAL CHARACTERISTICS
9/8/20
Radia T, Williams N, Agrawal P, et al. | Paediatr Respir Rev
Aim: To evaluate reported cases of MIS-C in children and adolescents.
CLINICAL CHARACTERISTICS
9/8/20
Wittmeier K, Parsons J, Webber S, et al. | Phys Ther
Aim: To provide a review of the pandemic and physical disaster management literature to summarize physical therapy–specific operational considerations to assist hospital-based leadership teams in planning and response efforts during the COVID-19 pandemic.
INFECTION CONTROL
9/8/20
Barbosa MT, Sousa CS, Morais-Almeida M, et al. | COPD
Aim: To review the effectiveness of telemedicine to treat COPD during the COVID-19 pandemic.
INFECTION CONTROL
9/8/20
Diriba K, Awulachew E, Getu E | Eur J Med Res
Aim: To assess the effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and its possibility of vertical maternal–fetal transmission.
CLINICAL CHARACTERISTICS
9/8/20
Samaranayake LP, Fakhruddin KS, Ngo HC, et al. | Acta Odontol Scand
Aim: To review the data on the effectiveness and efficacy of facemasks and respirators, including protective eyewear, with particular emphasis on dental healthcare.
INFECTION CONTROL
9/8/20
Barello S, Falco-Pegueroles A, Rose D, et al. | Int J Public Health
Aim: To assess available literature on perceived stress and psychological responses to influenza pandemics in HCWs and identify implications for healthcare practice and future research.
9/8/20
Kashi AH, De la Rosette J, Amini E, et al. | Urol J
Aim: To review the current literature on the presence of COVID-19 virus in the urine of infected patients and to explore the clinical features that can predict the presence of COVID-19 in urine.
INFECTION CONTROL
9/7/20
Simadibrata DM, Lubis AM | Epidemiol Infect
Aim: To review and evaluate currently available evidence to establish the association between D-dimer levels on admission and all-cause mortality risk in patients with COVID-19.
CLINICAL CHARACTERISTICS
9/4/20
Sarkar S, Khanna P, Soni KD | J Med Virol
Aim: To evaluate the impact of glucocorticoid therapy in COVID-19 patients based on the publications reported to date.
CANDIDATE THERAPEUTICS
9/4/20
Keller KG, Reangsing C, Schneider JK | J Adv Nurs
Aim: To 1) determine the clinical presentation and 2) outcomes of adult hospitalized patients with COVID-19 to provide practicing nurses with a cogent and concise clinical impression of COVID-19 patients.
CLINICAL CHARACTERISTICS
9/4/20
Rees EM, Nightingale ES, Jafari Y, et al. | BMC Med
Aim: To review estimates of how long patients with COVID-19 need different levels of hospital care.
UPDATED
CLINICAL CHARACTERISTICS
9/4/20
Ghoda A, Ghoda M | Cureus
Aim: To ascertain whether liver enzyme derangement is a common feature in adult patients with confirmed COVID-19 infection, determine the relation of deranged liver enzymes with outcome or mortality in COVID-19, and determine if liver failure is a common feature of COVID-19.
CLINICAL CHARACTERISTICS
9/4/20
Stavridou A, Stergiopoulou A, Panagouli E, et al. | Psychiatry Clin Neurosci
Aim: To review the evidence on psychosocial consequences of COVID-19 in children, adolescents and young adults.
9/3/20
Giorli A, Ferretti F, Biagini C, et al. | Curr Treat Options Neurol
Aim: To investigate the association between the olfactory dysfunction and the more typical symptoms (fever, cough, dyspnoea) within the Sars-CoV-2 infection (COVID-19) in hospitalized and non-hospitalized patients.
CLINICAL CHARACTERISTICS
9/3/20
Martin A, Blom IM, Whyatt G, et al. | Disaster Med Public Health Prep
Aim: To explore the involvement of medical students in past global health emergencies, to help inform current and future scenarios.
UPDATED
9/3/20
Caldeira D, Alves M, Melo RGE, et al. | Int J Cardiol Heart Vasc
Aim: To systematically evaluate the risk of COVID-19 infection and the risk of severe COVID-19 disease associated with previous exposure to (ACEi) and/or ARB).
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
Liu C, He Y, Liu L, et al. | BMC Pediatr
Aim: To review the evidence on the characteristics of children with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
Zhang Z, Zhang L, Zha D, et al. | Ren Fail
Aim: To evaluate the clinical characteristics and possible risk factors affecting the progression of disease in COVID-19 patients with AKI.
CLINICAL CHARACTERISTICS
9/3/20
Allotey J, Stallings E, Bonet M, et al. | BMJ
Aim: To determine the clinical manifestations, risk factors, and maternal and perinatal outcomes in pregnant and recently pregnant women with suspected or confirmed coronavirus disease 2019 (covid-19).
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
de Camargo MC, Martinez-Silveira MS, Lima AA, et al. | Cien Saude Colet
Aim: To evaluate the effectiveness of non-woven face masks for the prevention of respiratory infections (MERS CoV, SARS-CoV, and SARS-CoV-2) in the population.
INFECTION CONTROL
9/3/20
Sergeant A, van Reekum EA, Sanger N, et al. | BMJ Open
Aim: To study the effect of pandemics and epidemics on mental health outcomes for people with premorbid mental disorders.
UPDATED
9/3/20
de Andrade KRC, da Silva Carvalho VK, Farinasso CM, et al. | Cien Saude Colet
Aim: To evaluate the effects of drug therapies for coronavirus infections. 
CANDIDATE THERAPEUTICS
9/3/20
Bendezu-Quispe G, Rodirquez-Zuniga MJM, Roman YM, et al. | Rev Peru Med Exp Salud Publica
Aim: To review the evidence on chloroquine/hydroxychloroquine, lopinavir/ritonavir, tocilizumab, oseltamivir, interferon, atazanavir and anti SARS-CoV-2 serum as therapeutic agents for COVID-19.
CANDIDATE THERAPEUTICS
9/3/20
Bentlage E, Ammar A, How D, et al. | Int J Environ Res Public Health
Aim: To provide practical recommendations for maintaining active lifestyles during pandemics.
INFECTION CONTROL
9/3/20
de Barcelos Ubaldo Martins L, Jabour LGPP, Vieira CC, et al. | Curr Med Chem
Aim: To describe the particularities of the RAS and the immune system profile of particular subgroups of patients.
CLINICAL CHARACTERISTICS
9/3/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the volume-outcome relationship for surgical interventions.
9/3/20
Costenaro P, Minotti C, Barbieri E, et al. | Rev Med Virol
Aim: To review the current knowledge on SARS-CoV-2 cases in PLWHA.
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
de Almeida-Pititto B, Dualib PM, Zajdenverg L, et al. | Diabetol Metab Syndr
Aim: To evaluate the association of diabetes, hypertension, cardiovascular disease and ACEI/ARBs exposure with severity–intensive care unit treatment or mechanical ventilation necessity or O2 saturation?
UPDATED
CLINICAL CHARACTERISTICS
9/2/20
Cheruiyot I, Kipkorir V, Ngure B, et al. | Ann Vasc Surg
Aim: To identify and consolidate evidence of AT in COVID-19 patients.
CLINICAL CHARACTERISTICS
9/2/20
Saini KS, Tagliamento M, Lambertini M, et al. | Eur J Cancer
Aim: To provide precise estimates of the mortality rate among patients with both cancer and COVID-19.
CLINICAL CHARACTERISTICS
9/2/20
Cumpstey AF, Oldman AH, Smith AF, et al. | Cochrane Database of Systematic Reviews
Aim: To address how oxygen therapy should be targeted in adults with ARDS (particularly ARDS secondary to COVID?19 or other respiratory viruses) and requiring mechanical ventilation in an intensive care unit, and the impact oxygen therapy has on mortality, days ventilated, days of catecholamine use, requirement for renal replacement therapy, and quality of life.
CANDIDATE THERAPEUTICS
9/2/20
Chan CK, Huang YS, Liao HW, et al  | Hypertension
Aim: To review the evidence on the impact of the use of ACEi or ARBs on SARS-CoV-2 infection.
CANDIDATE THERAPEUTICS
9/2/20
Gebru AA, Birhanu T, Wendimu E, et al. | Hum Antibodies
Aim: To identify and review a published level of risk, effects response to potential health emergencies, prevention, and control methods of Coronavirus Disease 2019 at the global level.
INFECTION CONTROL
9/1/20
Sakka M, Conners JM, Hekimian G, et al. | J Med Vasc
Aim: To review current available data on the association between D-Dimer levels and mortality in patients admitted to hospital for COVID-19.
CLINICAL CHARACTERISTICS
9/1/20
Vafea MT, Atalla E, Kalligeros M, et al. | Clin Radiol
Aim: To determine the overall rate of chest imaging findings in asymptomatic cases, describe the most common patterns found, and determine the rate of later symptom development in these initially asymptomatic cases.
CLINICAL CHARACTERISTICS
9/1/20
Ahmed J, Rizwan T, Malik F, et al. | Cureus
Aim: To derive generalizable, well-powered estimates of liver injury prevalence in COVID-19 patients. 
CLINICAL CHARACTERISTICS
9/1/20
Leal J, Gagnon H | Alberta Health Services
Aim: To review the evidence on transmission of COVID-19 in condos, apartments, and/or hotels.
9/1/20
Gagnon MP | Universite Laval
Aim: To review the evidence on effective digital health interventions to prevent, detect, and manage mental health problems in individuals with a pre-existing chronic diseases.
9/1/20
Liu M, Ya G, Yuan Y, et al. | Integr Med Res
Aim: To evaluate the efficacy and safety of LH for treating patients with COVID-19 by a systematic review and meta-analysis.
CANDIDATE THERAPEUTICS
9/1/20
Lapid MI, Seiner S, Heintz H, et al. | Am J Geriatr Psychiatry
Aim: To provide a consensus statement on the clinical practice changes in ECT specific to older adults based on expert group discussions of ECT practitioners across the country and a systematic review of the literature. 
INFECTION CONTROL
9/1/20
Sharpe H | Alberta Health Services
Aim: To review the evidence on the harm of mask use in specific patient populations.
9/1/20
Allison P, de Souza RF, Aboud L, et al. | Public Health Agency of Canada
Aim: To review the evidence on safe dental practices during the COVID-19 pandemic.
9/1/20
Clements F | University of Calgary, Health Technology Assessment Unit
Aim: To review the evidence on the immunogenicity and safety of the influenza vaccine at reduced or regular intradermal doses compared with a full intramuscular dose.
9/1/20
Smale J | Timiskamig Health Unit
Aim: To review the harms being experienced by community dwelling low income populations from staying at home for long periods of time during current or past pandemics.
9/1/20
Baroutjian A, Sanchez C, Boneva D, et al. | Am J Emerg Med
Aim: To evaluate the safety and effectiveness of SARS-CoV-2 pharmacologic therapies as of August 2, 2020 according to study level of evidence.
CANDIDATE THERAPEUTICS
9/1/20
Park R, Chidharla A, Mehta K, et al. | EClinicalMedicine
Aim: To synthesize the evidence behind sex-bias within COVID-19 associated illness severity and death specifically within the cancer patient population.
CLINICAL CHARACTERISTICS
9/1/20
Erdmann R | Alberta Health Services
Aim: To review the evidence on the risk factors associated with the development of severe outcomes in COVID-19.
9/1/20
Carroll A, Hicks A, Saxinger L, et al. | Alberta Health Services
Aim: To review the evidence on the role of children in community SARS-CoV-2 transmission.
8/31/20
Usher K, Jackson D, Durkin J, et al. | Int J Ment Health Nurs
Aim: To systematically examine, synthesise and critically appraise the available evidence on the relationship between pandemic-related behaviours and psychological outcomes.
8/31/20
McBane RD, Roldan VDT, Niven AS, et al. | Mayo Clin Proc
Aim: To synthesize current data on thrombosis risk, prognostic implications, and anticoagulation effects in COVID-19.
CLINICAL CHARACTERISTICS
8/31/20
Ssentongo P, Ssentongo AE, Heilbrunn ES, et al. | PLoS ONE
Aim: To estimate the association of pre-existing comorbidities with COVID-19 mortality.
UPDATED
CLINICAL CHARACTERISTICS
8/31/20
Dhir SK, Kumar J, Meena J, et al. | J Trop Pediatr
Aim: To systematically synthesize the currently available literature on various modes of transmission (congenital, intrapartum, and postpartum), clinical features and outcomes of SARS-CoV-2 infection in neonates.
INFECTION CONTROL
8/31/20
Chi H, Chiu N, Tai Y, et al. | J Microbiol Immunol Infect
Aim: To investigate the outcomes of neonates born to mothers with COVID-19.
CLINICAL CHARACTERISTICS
8/31/20
Pal R, Banerjee M, Yadav U, et al. | Diabetes Metab Syndr
Aim: To conduct a systematic literature review and analyze the demographic/biochemical parameters and clinical outcomes of COVID-19 patients with diabetic ketoacidosis (DKA) and combined DKA/HHS (hyperglycemic hyperosmolar syndrome).
CLINICAL CHARACTERISTICS
8/31/20
Bakhtawar N, Usman M, Khan MHU | Cureus
Aim: To provide an insight into the clinical effectiveness of convalescent plasma as a potential therapy for COVID-19 patients.
CANDIDATE THERAPEUTICS
8/31/20
Mousavi E, Kananizadeh N, Martinello R, et al. | Environ Sci Technol
Aim:  To review the evidence on the safety of air filtration and air recirculation in healthcare premises. 
INFECTION CONTROL
8/31/20
Rego GNA, Nucci MP, Alves AH, et al. | Vaccines
Aim: To summarize the global race for vaccine development against COVID-19. 
INFECTION CONTROL
8/31/20
Gordon M, Patricio M, Horne L, et al. | Med Teach
Aim: To synthesize published reports of medical educational developments in response to the pandemic, considering descriptions of interventions, evaluation data and lessons learned.
INFECTION CONTROL
8/31/20
Fiolet T, Guihur A, Rebeaud M, et al. | Clin Microbiol Infect
Aim: To assess whether chloroquine or hydroxychloroquine with or without azithromycin decreased COVID-19 mortality compared to the standard of care.
UPDATED
CANDIDATE THERAPEUTICS
8/31/20
Das RR, Jaiswal N, Dev N, et al. | Front Med
Aim: To review the evidence on the efficacy and safety of using anti-malarial drugs to treat COVID-19.
CANDIDATE THERAPEUTICS
8/31/20
Del Sole F, Farcomeni A, Loffredo L, et al. | Eur J Clin Invest
Aim: To systematically review clinical and biochemical characteristics associated with the severity of the novel severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2)?related disease (COVID?19).
CLINICAL CHARACTERISTICS
8/31/20
Uncini A, Vallat J, Jacobs BC | J Neurol Neurosurg Psychiatry
Aim: To clarify the clinical and electrophysiological phenotype, and to discuss, on the basis of the available data, whether the disease mechanism could be parainfective or postinfective and to speculate on the possible pathogenesis.
CLINICAL CHARACTERISTICS
8/31/20
Lei H, Xu X, Xiao S, et al. | J Infect
Aim: To assess the secondary attack rate of household COVID-19 transmission.
INFECTION CONTROL
8/31/20
Zhang C, Shen L, Le K, et al. | Front Cardiovasc Med
Aim: To summarize all available evidence for a comprehensive and rigorous systematic review focused on VTE incidence in hospitalized COVID-19 patients.
CLINICAL CHARACTERISTICS
8/31/20
Popkin BM, Du S, Green WD, et al. | Obes Rev
Aim: To review the evidence on the linkage between obesity and COVID-19.
CLINICAL CHARACTERISTICS
8/31/20
El Boghdady M, Ewalds-Kvist B | Surgeon
Aim: To systematically review the literature regarding the safe use of laparoscopy during COVID-19.
INFECTION CONTROL
8/31/20
Shorey S, Chan V, et al. | Midwifery
Aim: To consolidate qualitative research studies that examined the experiences and needs of pregnant women, midwives, and nurses of maternity units to provide a way forward for future research and practices during the current pandemic and future epidemics and pandemics.
INFECTION CONTROL
8/31/20
Soklaridis S, Lin E, Lalani Y, et al. | Gen Hosp Psychiatry
Aim: To provide an up-to-date and robust synthesis of the evidence by reporting on implementation, evaluation, and outcomes regarding mental health interventions during medical pandemics within the last two decades.
8/31/20
Almqvist J, Granberg T, Tzortzakakis A, et al. | Ann Clin Transl Neurol
Aim: To optimize diagnostic workup of the current severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) pandemic.
DIAGNOSTICS
8/31/20
Chi H, Chiu N, Peng C, et al. | Life
Aim: To investigate the prevalence of OGA in COVID-19 patients.
CLINICAL CHARACTERISTICS
8/31/20
Daphine J, Hebert PC, Ziegler D, et al. | Crit Care Med
Aim: To identify and appraise articles describing criteria used to prioritize or withhold a critical care admission.
INFECTION CONTROL
8/31/20
Bueno-Notivol J, Gracia-Garcia P, Olaya B, et al. | Int J Clin Health Psychol
Aim: To systematically review community-based studies on depression conducted during the COVID-19 and estimate the pooled prevalence of depression.
8/31/20
Derraik JGB, Anderson WA, Connelly EA, et al. | Int J Environ Res Public Health
Aim: To summarize the existing literature on the viability of SARS-CoV-2, the efficacy of key potential disinfection procedures against the virus (specifically ultraviolet light and heat), and the impact of these procedures on FFR performance, material integrity, and/or fit.
INFECTION CONTROL
8/31/20
Jani BD, Pell JP, McGagh D, et al. | BJGP Open
Aim: To collate a comprehensive list of symptoms, assessment items, demographics, and lifestyle and health conditions associated with COVID-19, with proposed corresponding SNOMED CT clinical terms. 
CLINICAL CHARACTERISTICS
8/31/20
Duarte ML, Dos Santos LR, de Souza Contencas AC, et al. | Sao Paulo Med J
Aim: To compare accuracy between RT-PCR and computed tomography (CT) for detecting COVID-19 in the first week of its symptoms during the pandemic.
DIAGNOSTICS
8/31/20
Ullah W, Abdullah HM, Roomi S, et al. | J Clin Med Res
Aim: To review the evidence on the use of hydroxycholorquine to treat COVID-19.
CANDIDATE THERAPEUTICS
8/31/20
Sawalha K, Abozenah M, Kadado AJ, et al. | Cardiovasc Revasc Med
Aim: To describe the clinical characteristics and management of currently published COVID-19 myocarditis patients.
CLINICAL CHARACTERISTICS
8/31/20
Nasir M, Perveen RA, Saha SK, et al. | Mymensingh Med J
Aim: To evaluate the role of favipiravir along with its safety and efficacy for the patients who are suffering from severe acute respiratory distress syndrome due to CoronaVirus-2 (SARS-CoV-2) as re-purposeful use.
CANDIDATE THERAPEUTICS
8/31/20
Hasani H, Mardi S, Shakerian S, et al. | Biomed Res Int
Aim: To assess the frequency of clinical, laboratory, and imaging featues of COVID-19.
CLINICAL CHARACTERISTICS
8/31/20
Copat C, Cristaldi A, Fiore M, et al. | Environ Res
Aim: To provide an update state of art relating the role of air pollution, in particular PM2.5, PM10 and NO2, in COVID-19 spread and lethality.
INFECTION CONTROL
8/31/20
Centeno-Tablante E, Medina-Rivera M, Finkelstein J, et al. | Ann N Y Acad Sci
Aim: To capture information that might necessitate changes in the guidance on breast milk and breastfeeding given the uncertainty in this area.
8/31/20
Porfidia A, Valeriani E, Pola R, et al. | Thromb Res
Aim: To evaluate the incidence of VTE in patients with COVID-19.
CLINICAL CHARACTERISTICS
8/29/20
Kelada M, Anto A, Dave K, et al. | Cureus
Aim: To assess the role of sex in the risk of mortality from COVID-19 in adult patients through comparison of clinical markers and inflammatory indexes.? 
UPDATED
CLINICAL CHARACTERISTICS
8/28/20
Yu J, Wu B, Yang J, et al. | Biol Res Nurs
Aim: To explore whether cardio-cerebrovascular disease would increase the risk of COVID-19 patients. 
CLINICAL CHARACTERISTICS
8/27/20
Braithwaite I, Callender T, Bullock M, et al. | Lancet Digit Health
Aim: To assess the effectiveness of automated and semi-automated digital tools for contact tracing, and identify key considerations for successful implementation, to inform the control of COVID-19. 
UPDATED
INFECTION CONTROL
8/27/20
Prodromos CC | New Microbes New Infect
Aim: To review the evidence on cardiac arrhythmic mortality caused by the use of hydroxychloroquine and azithromycin.
CANDIDATE THERAPEUTICS
8/27/20
Coomes EA, Haghbayan H | Rev Med Virol
Aim: To assess the evidence describing IL-6 response in patients with COVID-19 and the existing and planned studies investigating the efficacy of tocilizumab to guide patient management, clarify guideline development, and inform future trials in this field.
UPDATED
CLINICAL CHARACTERISTICS
8/27/20
Gertsman S, Agarwal A, O'Hearn K, et al. | J Hosp Infect
Aim: To collect and synthesize existing information on decontamination of N95 filtering facepiece respirators (FFRs) using microwave and heat-based treatments, with special attention to impact on mask function (aerosol penetration, airflow resistance), fit, and physical traits.
UPDATED
INFECTION CONTROL
8/27/20
Laufs J, Waseem Z | Int J Disaster Risk Reduct
Aim: To explore the short- and long-term effects of epidemics on policing.
INFECTION CONTROL
8/26/20
Zou F, Qian Z, Wang Y, et al. | CJC Open
Aim: To conduct a comprehensive review and meta-analysis of the incidence, comorbidities, outcomes and possible mechanisms of acute cardiac injury in COVID-19 patients.
CLINICAL CHARACTERISTICS
8/26/20
Pang W, Liu Z, Li Y, et al. | Integr Med Res
Aim: To evaluate the efficacy and safety of CMD for COVID-19.
CANDIDATE THERAPEUTICS
8/26/20
Arentz S, Yang G, Goldenberg J, et al. | Adv Integr Med
Aim: To assess the effects of zinc on the incidence, duration and severity of acute upper or lower respiratory tract infections caused by SARS-CoV-2 infection in people of any age and of any zinc status when used as a preventive supplement or as a therapy.
CANDIDATE THERAPEUTICS
8/26/20
Schloss J, Lauche R, Harnett J, et al. | Adv Integr Med
Aim: To review the evidence on the effect of Vitamin C on acute respiratory tract infections in adults when administered at the onset of symptoms.
CANDIDATE THERAPEUTICS
8/26/20
Kaur N, Gupta I, Singh H, et al. | SN Compr Clin Med
Aim: To evaluate the epidemiological and clinical characteristics of COVID-19 patients while also highlighting the comorbidities and radiological findings.
CLINICAL CHARACTERISTICS
8/26/20
Rai B, Shukla A, Dwivedi LK | Clin Epidemiol Glob Health
Aim: To review the qualitative and quantitative synthesis of the currently available evidence for the serial interval of COVID-19.
INFECTION CONTROL
8/26/20
Abu-Rumeileh S, Abdelhak A, Foschi M, et al. | J Neurol
Aim: To provide a comprehensive and updated overview of all case reports and series of COVID-19-related GBS to identify predominant clinical, laboratory, and neurophysiological patterns and to discuss the possible underlying pathophysiology.
CLINICAL CHARACTERISTICS
8/26/20
Bansal A, Prasad JB | Z Gesundh Wiss
Aim: To quantify the overall risk of liver damage in COVID-19 patients and also find the overall variation in risk outcome.
CLINICAL CHARACTERISTICS
8/26/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the medium- and long-term health sequelae of COVID-19 infection among survivors.
8/26/20
Said M, Ngo V, Hwang J, et al. | Laryngoscope Investig Otolaryngol
Aim: To review applications of telemedicine for the evaluation of facial trauma to better direct utilization of these methods and technologies during times of limited access to clinical resources such as the COVID?19 pandemic.
INFECTION CONTROL
8/26/20
Correia AO, Feitosa PWG, Moreira JLS, et al. | Neurol Psychiatry Brain Res
Aim: To describe the main neurological manifestations related to coronavirus infection in humans.
CLINICAL CHARACTERISTICS
8/26/20
D'Ambrosi R | Indian J Orthop
Aim: To analyze all the articles related to COVID-19 and orthopedics and to shed light on the scientific evidence that has actually been found.
CLINICAL CHARACTERISTICS
8/26/20
Kotwal A, Yadav A, Kotwal J | Med J Armed Forces India
Aim: To assess correlation between predicted and actual values of cases in India.
8/26/20
Dinnes J, Deeks JJ, Adriano A et al. | Cochrane Database Syst Rev
Aim: To assess the diagnostic accuracy of point-of-care antigen and molecular-based tests to determine if a person presenting in the community or in primary or secondary care has current SARS-CoV-2 infection
DIAGNOSTICS
8/26/20
Frediansyah A, Nainu F, Dhama K, et al. | Clin Epidemiol Glob Health
Aim: To summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19.
CANDIDATE THERAPEUTICS
8/26/20
Khalil A, Kalafat E, Benlioglu C, et al. | EClinicalMedicine
Aim: To systematically review the available literature on COVID-19 and pregnancy, to provide comprehensive data to care-providers, pregnant women and their families, inform national and international guidelines, and direct the course of ongoing and future studies
CLINICAL CHARACTERISTICS
8/26/20
Hariyanto TI, Kurniawan A | Diabetes Metab Syndr
Aim: To analyze the association between statin use and in-hospital outcomes of COVID-19 infection.
CANDIDATE THERAPEUTICS
8/26/20
Siordia JA, Bernaba M, Yoshino K, et al. | SN Compr Clin Med
Aim: To compile the current data regarding human controlled COVID-19 treatment trials.
CANDIDATE THERAPEUTICS
8/26/20
Leeson CE, Ismail A, Hashad MM, et al. | SN Compr Clin Med
Aim: To review and summarize what is known about COVID-19 and the current implications of intravesical BCG with regard to the disease.
CANDIDATE THERAPEUTICS
8/26/20
Aucoin M, Cooley K, Saunders PR, et al. | Adv Integr Med
Aim: To review the role of quercetin in the treatment and recovery of COVID-19 and other respiratory tract infections.
CANDIDATE THERAPEUTICS
8/26/20
Aucoin M, Cooley K, Saunders PR, et al. | Adv Integr Med
Aim: To review the role of Echinacea in the prevention and treatment of COVID-19 and other respiratory tract infections.
CANDIDATE THERAPEUTICS
8/26/20
Nieto I, Navas JF, Vazquez C | Brain Behav Immun Health
Aim: To examine compliance with basic methodological quality criteria and open scientific research practices on the mental health effects of the COVID-19 pandemic.
8/26/20
Davis B, Rothrock AN, Swetland S, et al. | J Am Coll Emerg Physicians Open
Aim: To analyze the prevalence of respiratory pathogens (viruses and atypical bacteria) in COVID?19 patients.
CLINICAL CHARACTERISTICS
8/25/20
Chirico F, Sacco A, Bragazzi NL, et al. | Int J Environ Res Public Health
Aim: To evaluate the COVID-19 risk associated with the presence of air-conditioning systems.
INFECTION CONTROL
8/25/20
Baral R, White M, Vassiliou VS | Curr Atheroscler Rep
Aim: To review the evidence on the impact RAAS inhibitor use has in antihypertensive COVID-19 hospitalised patients.
UPDATED
CANDIDATE THERAPEUTICS
8/25/20
Kunutsor SK, Laukkanen JA | Thromb Res
Aim: To review the evidence on the thromboembolic complications associated with COVID-19 and the incidence of severe disease.
CLINICAL CHARACTERISTICS
8/25/20
Krishnamoorthy Y, Nagarajan R, Saya GK, et al. | Psychiatry Res
Aim: To quantify the prevalence of various psychological morbidities among general population, healthcare workers and COVID-19 patients amidst the COVID-19 pandemic.
8/25/20
van Doorn AS, Meijer B, Frampton CMA, et al. | Aliment Pharmacol Ther
Aim: To critically assess the clinical relevance of testing stool samples and anal swabs and provide an overview of the potential faecal-oral transmission of SARS-CoV-2.
DIAGNOSTICS
8/24/20
Puli S, Baig M, Walayat S | Cureus
Aim: To assess gastrointestinal symptoms and liver enzymes trend in corona virus infection.
CLINICAL CHARACTERISTICS
8/24/20
Patanavanich R & Glantz SA | Nicotine & Tobacco Research
Aim: To review the evidence on the association between smoking and progression of the infectious disease COVID-19.
CLINICAL CHARACTERISTICS
8/23/20
Jovic TH, Ali SR, Ibrahim N, et al. | Nutrients
Aim: To investigate whether vitamin supplementation is beneficial in COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
8/23/20
Starke KR, Petereit-Haack G, Schubert M, et al. | Int J Environ Res Public Health
Aim: To quantify the isolated effect of age on severe COVID-19 outcomes
CLINICAL CHARACTERISTICS
8/23/20
Murphy RP, Dennehy KA, Costello MM, et al. | Age Ageing
Aim: To describe the satisfaction, clinic productivity, clinical benefit, satisfaction and costs associated with the virtual geriatric clinic model of care.
INFECTION CONTROL
8/21/20
Karlsen APH, Wiberg S, Laigaard J, et al. | PLoS One
Aim: To provide a global snapshot overview of interventions and main methodological aspects of planned and initiated randomised clinical trials on COVID-19 prevention and treatment. 
CANDIDATE THERAPEUTICS
8/21/20
Lechien JR, Radulesco T, Calvo-Henriquez C, et al. | Head Neck Pathol
Aim: To review the data regarding the expression of angiotensin converting enzyme-2 (ACE2) and transmembrane protease serine-2 (TMPRSS2) in head and neck tissue.
8/21/20
Taneri PE, Ochoa S, Llanaj E, et al. | Eur J Epidemiol
Aim: To evaluate biomarkers of anemia and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and prevalence of anemia) in patients diagnosed with COVID-19, and explore their prognostic value. 
UPDATED
CLINICAL CHARACTERISTICS
8/21/20
Turan O, Hakim A, Dashraath P, et al. | Int J Gynaecol Obstet
Aim: To summarize clinical characteristics and outcomes among pregnant women hospitalized with COVID-19.
CLINICAL CHARACTERISTICS
8/21/20
Shang L, Shao M, Guo Q, et al. | Arch Med Res
Aim: To assess whether diabetes mellitus (DM) would increase the risk of severe infection and death in patients with COVID-19.
CLINICAL CHARACTERISTICS
8/21/20
Deshmukh V, Motwani R, Kumar A, et al. | J Clin Pathol
Aim: To review and summarise the latest histopathological changes in different organs observed after autopsy of COVID-19 cases.
CLINICAL CHARACTERISTICS
8/21/20
Pranata R, Huang I, Raharjo SB | Indian Pacing Electrophysiol J
Aim: To evaluate the incidence of cardiac arrhythmias in patients with COVID-19 and their implications on patient prognosis.
CLINICAL CHARACTERISTICS
8/21/20
Talaie H, Hosseini SM, Nazari M, et al. | Daru
Aim: To synthesize the results of well-done observational studies and clinical trials to estimate the value of some clinical managements to confront COVID-19.
CANDIDATE THERAPEUTICS
8/21/20
Khalili MA, Leisegang K, Majzoub A, et al. | World J Mens Health
Aim: To investigate the current evidence of SARS-CoV-2 impact on male reproduction and pregnancy outcomes, discussing them in light of the evidence published on other coronaviruses.
CLINICAL CHARACTERISTICS
8/21/20
Abdel-Maboud M, Menshawy A, Elgebaly A, et al. | J Thromb Thrombolysis
Aim: To investigate whether prophylactic heparin use is associated with reduction in thromboembolic events. 
CANDIDATE THERAPEUTICS
8/20/20
Misra S, Nath M, Hadda V, et al. | Eur J Clin Invest
Aim: To assess the efficacy of various treatment modalities in nCOV-2019 patients.
CANDIDATE THERAPEUTICS
8/20/20
 | Public Health Agency of Canada
Aim: Not provided
8/20/20
Mahumud RA, Kamara JK, Renzaho AMN | Infection
Aim: To examine the overall distribution of chronic comorbidities in coronavirus disease-19 (COVID-19) infected populations and the risk of the underlying burden of disease in terms of the case fatality ratio (CFR).
CLINICAL CHARACTERISTICS
8/19/20
Selman L, Lapwood S, Jones N, et al. | Oxford COVID-19 Evidence Service
Aim: To review the evidence on advance care planning in community settings during the COVID-19 pandemic.
8/19/20
Remillard L, Perras C, Pant S, et al. | CADTH
Aim: To review the current scientific evidence on the potential benefits and harms of chloroquine and hydroxychloroquine for the prevention or treatment of COVID-19. 
8/19/20
Ortolan A, Lorenzin M, Felicetti M, et al. | Int J Infect Dis
Aim: To analyse the influence of gender on COVID-19 mortality, severity and disease outcomes. 
CLINICAL CHARACTERISTICS
8/19/20
 | Public Health Agency of Canada
8/19/20
 | Public Health Agency of Canada
Aim: To review the evidence on the difference in risk of transmission from persons who are pre- and asymptomatic infected cases compared to symptomatic cases?
8/19/20
 | Public Health Agency of Canada
Aim: To examine the evidence on whether pregnant women at higher risk of severe COVID-19 disease than non-pregnant women of reproductive age.
8/19/20
 | Public Health Agency of Canada
Aim: To review the evidence on the impact of physical distancing of 1 meter, 1.5 meters and 2 meters on SARS-CoV-2 virus transmission risk.
8/19/20
 | Public Health Agency of Canada
8/19/20
Kumar D, Spry C | CADTH
Aim: To review the evidence on the effectiveness of face shields at preventing SARS-CoV-2 virus transmission.
8/19/20
Elsawah H, Elsokary MA, Elrazzaz M, et al. | J Med Virol
Aim: To assess the evidence strength of hydroxychloroquine efficacy in treating COVID-19 arising from clinical trials and to update the practice with the most reliable clinical evidence.
CANDIDATE THERAPEUTICS
8/19/20
Xiong J, Lipsitz O, Nasri F, et al. | J Affect Disord
Aim: To synthesize extant literature that reports on the effects of COVID-19 on psychological outcomes of the general population and its associated risk factors.
8/19/20
McAloon C, Collins A, Barber A, et al. | BMJ Open
Aim: To conduct a rapid systematic review and meta-analysis of estimates of the incubation period of COVID-19.
CLINICAL CHARACTERISTICS
8/19/20
Guentcheva I | Centre de Recherche en Sante Publique
Aim: To review the effectiveness of the obligation to wear a mask in a population without concrete social acceptability measures having been deployed beforehand.
8/19/20
Chtourou H, Trabelsi K, H'Mida C, et al. | Front Psychol
Aim: To summarize the existing literature regarding the effect of quarantine and social distancing on psychology and well-being, while providing possible practical recommendations for being more physically active during isolation periods.
8/19/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effectiveness of wearing a surgical mask at the same time as an oxygen mask.
8/19/20
Topfer L | CADTH
Aim: To identify a list of potential technologies that may be used to address the negative effects of social isolation on older adults living in long-term care.
8/19/20
Luo X, Ni X, Lin J, et al. | Phytomedicine
Aim: To investigate the efficacy and safety of CHM or CHM combination therapy for COVID-19.
CANDIDATE THERAPEUTICS
8/19/20
Vaja R, chan J, Ferreira P, et al. | Br J Clin Pharmacol
Aim: To evaluate cardiovascular and respiratory complications in patients taking NSAIDs during acute lower respiratory tract infections.
CLINICAL CHARACTERISTICS
8/19/20
Birkeland K, Zimmer R, Kimchi A, et al. | Interact J Med Res
Aim: To estimate VTE incidence in hospitalized patients and to analyze characteristic factors in the VTE cohort.
CLINICAL CHARACTERISTICS
8/17/20
Inomata T, Kitazawa K, Kuno T, et al. | Invest Ophthalmol Vis Sci
Aim: To determine currently reported clinical and prodromal ocular symptoms in patients with coronavirus disease 2019 (COVID-19).
CLINICAL CHARACTERISTICS
8/17/20
Labenz C, Toenges G, Worns M, et al. | Eur J Gastroenterol Hepatol
Aim: To review the evidence on published data on liver injury in patients with COVID-19 infection.
CLINICAL CHARACTERISTICS
8/17/20
Dubey P, Reddy SY, Manuel S, et al. | Eur J Obstet Gynecol Reprod Biol
Aim: To estimate the adverse maternal and neonatal characteristics and outcomes among COVID-19 infected women and determine heterogeneity in the estimates and associated factors.
CLINICAL CHARACTERISTICS
8/17/20
Thomson DJ, Yom SS, Saeed H, et al. | Int J Radiat Oncol Biol Phys
Aim: To aggregate changes in the quality of the evidence supporting these schedules to establish a comprehensive evidence base for future reference and highlight aspects for future study.
INFECTION CONTROL
8/16/20
Hessami K, Homayoon N, Hashemi A, et al. | J Matern Fetal Neonatal Med
Aim: To review the evidence regarding maternal, fetal and neonatal mortality cases associated with COVID-19 infection.
CLINICAL CHARACTERISTICS
8/15/20
Fan AF, Gu S, Alemi AF, et al. | J Integr Med
Aim: To summarize contemporary studies that report the use of Chinese herbal medicine (CHM) to treat COVID-19.
CANDIDATE THERAPEUTICS
8/15/20
Nasiri MJ, Haddadi S, Tahvildari A, et al.  | Front Med
Aim: To better understand role of the sex in mortality of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
8/15/20
Rakedzon S, Khoury Y, Rozenberg G, et al. | Rambam Maimonides Med J
Aim: To review the existing clinical evidence of HCQ use for the prevention and treatment of COVID-19.
CANDIDATE THERAPEUTICS
8/15/20
Lv H, Chen T, Pan Y, et al. | Ann Transl Med
Aim: To estimate the prevalence and identify the underlying differential diagnostic value of VES.
DIAGNOSTICS
8/15/20
Boregowda U, Aloysius M, Perisetti A, et al. | Front Med
Aim: To compare the serum liver chemistries such as hepatic transaminases, total bilirubin, albumin, and prothrombin time to evaluate whether they can predict severity and mortality in COVID-19.
CLINICAL CHARACTERISTICS
8/14/20
Knisely A, Wu J, Kaplan SJ, et al. | Cancer Invest
Aim: To examine the patterns of clinical presentations and outcomes in patients with cancer with coronavirus-spectrum illness to offer guidance on detection and management of COVID-19 disease in this particularly susceptible cohort of patients.
CLINICAL CHARACTERISTICS
8/14/20
Manchanda ECC, Sanky C, Appel JM | J Racial Ethn Health Disparities
Aim: To identify and review all publicly available state-level CSC in the USA and to compare the ways in which CSC prioritize patients for the allocation of scarce resources such as ventilators, and to consider the ethical and equity implications of these decisions.
8/14/20
de Moura DTH, McCarty TR, Ribeiro IB, et al. | Clinics (Sao Paulo)
Aim: To perform a structured systematic review and meta-analysis to evaluate the diagnostic characteristics of serological-based COVID-19 testing.
UPDATED
DIAGNOSTICS
8/14/20
Li J, Huang DQ, Zou B, et al. | J Med Virol
Aim: To determine pooled estimates for clinical characteristics and outcomes in COVID-19 patients including subgroups by disease severity (based on WHO Interim Guidance Report or IDSA/ATS criteria) and by country/region.
CLINICAL CHARACTERISTICS
8/14/20
Luo W, Sun J, Zhang W, et al. | BMJ Open
Aim: To determine the quality of recommendations for optimising management in paediatric wards and provide suggestions to hospital managers for the adjustment of existing hospital prevention and control strategies, and also to offer recommendations for further research.
INFECTION CONTROL
8/12/20
Davalbhakta S, Advani S, Kumar S, et al. | J Med Syst
Aim: To provide an overview of mobile applications being currently utilized for COVID-19 related activities.
UPDATED
INFECTION CONTROL
8/12/20
Samanta A, Shetty A, Nelson PC | J Telemed Telecare
Aim: To conduct a systematic literature review of the accuracy and effectiveness of available portable automated refractors compared to the current standard of care, subjective refraction (SR).
INFECTION CONTROL
8/12/20
Moosavi SA, Mashhadiagha A, Hashemazar A, et al. | Transpl Infect Dis
Aim: to conduct a systematic review on COVID?19 clinical manifestations and treatment strategies in SOT recipients.
UPDATED
CLINICAL CHARACTERISTICS
8/12/20
Kasperkiewicz M | J Am Acad Dermatol
Aim: To review the evidence on how the COVID-19 pandemic affects patients with autoimmune bullous diseases.
CLINICAL CHARACTERISTICS
8/12/20
Kow CS, Hasan SS | Am J Cardiol
Aim: To summarise the existing evidence on the effect of statins on the clinical outcomes of COVID-19 from adjusted analyses.
CANDIDATE THERAPEUTICS
8/11/20
Sarkar S, Soni KD, Khanna P | J Med Virol
Aim: To evaluate the impact of CPT in COVID-19 patients based on the publications reported to date.
CANDIDATE THERAPEUTICS
8/11/20
Almutairi A, Alfaleh M, Alasheikh M | Cureus
Aim: To evaluate the medical literature and explore the dermatological clinical manifestations in patients with SARS-CoV-2.
CLINICAL CHARACTERISTICS
8/11/20
Jain VK, Lal H, Patralekh MT, et al. | J Clin Orthop Trauma
Aim: To evaluate the fracture types, presentation, treatment, complications, and early outcomes of fractures occurring amidst COVID-19 pandemic.
INFECTION CONTROL
8/11/20
Jones L, Candy B, Roberts N, Ondruskova T, et al | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the management of delirium in patients with COVID-19 and the use of non-pharmacological approaches outside of critical care settings.
UPDATED
8/11/20
Katal S, Johnston SK, Johnston JH, et al. | Acad Radiol
Aim: To review the radiological characteristics of COVID-19 in pediatrics.
CLINICAL CHARACTERISTICS
8/11/20
Mahendiratta S, Batra G, Sarma P, et al. | Life Sci
Aim: To evaluate the effectiveness of the molecular detection techniques in COVID-19. 
INFECTION CONTROL
8/11/20
Robbins-Jaurez SY, Qian L, King KL, et al. | Kidney Int Rep
Aim: To assess the incidence of AKI among patients with COVID-19 and examine their associations with patient outcomes as reported in the available literature thus far.
CLINICAL CHARACTERISTICS
8/11/20
da Silva FCT, Neto MLR | Prog Neuropsychopharmacol Biol Psychiatry
Aim: To review the evidence on the psychiatric repercussions in health professionals that work in health systems to fight the clinical implications caused by COVID-19.
8/11/20
da Silva FCT, Neto MLR | Prog Neuropsychopharmacol Biol Psychiatry
Aim: To analyze the main psychological effects caused by the COVID-19 pandemic in health professionals.
8/11/20
Sheraton M, Deo N, Dutt T, et al. | Psychiatry Res
Aim: To compare the incidences of psychological issues during the COVID-19 pandemic, such as anxiety, depression, occupational stress, PTSD and insomnia, in healthcare workers (HCW) and non-healthcare workers (NHCW). 
8/11/20
Chen C, Pan K, Wu B, et al. | Eur J Clin Pharmacol
Aim: To evaluate the safety of HCQ in the treatment of COVID-19 and other diseases by performing a systematic review and meta-analysis.
8/11/20
D'Amico F, Danese S, Peyrin-Biroulet L | Clin Gastroenterol Hepatol
Aim: To investigate symptoms and diagnostic-therapeutic management of IBD patients with COVID-19.
CLINICAL CHARACTERISTICS
8/11/20
Licina A, Silvers A, Stuart RL  | Syst Rev
Aim: To evaluate the effect of powered air-purifying respirators (PAPRs) as part of respiratory protection versus another device (egN95/FFP2) on HCW infection rates and contamination.
UPDATED
8/10/20
Abrams JY, Godfred-Cato SE, Oster ME, et al. | J Pediatr
Aim: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C).
CLINICAL CHARACTERISTICS
8/9/20
Cui X, Zhao Z, Zhang T, et al. | J Med Virol
Aim: To provide a comprehensive and systematic analysis of demographic characteristics, clinical symptoms, laboratory findings and imaging features of coronavirus disease 2019 (COVID-19) in pediatric patients.
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Jutzeler CR, Bourguignon L, Weis CV, et al. | Travel Med Infect Dis
Aim: To gather all available information regarding comorbidities, clinical signs and symptoms, outcomes, laboratory findings, imaging features, and treatments in patients with coronavirus disease 2019 (COVID-19).
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Neumann-Podczaska A, Al-Saad SR, Karbowski LM, et al. | Aging Dis
Aim: To concisely summarize the clinical features, comorbidities, radiological/laboratory findings, and outcomes in the older adults. 
CLINICAL CHARACTERISTICS
8/9/20
Hoang A, Chorath K, Moreira A, et al. | EClinicalMedicine
Aim: To characterize clinical symptoms, laboratory, and imaging findings, as well as therapies provided to confirmed pediatric cases of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Xu X, Shi Y, Wang R, et al. | Integr Med Res
Aim: To comprehensively summarize and analyze the current guidelines on home-based traditional Chinese medicine (TCM) nursing interventions for discharged patients with COVID-19.
CANDIDATE THERAPEUTICS
8/9/20
Wu T, Zuo Z, Deng M | Aging Dis
Aim: To provide systematic evidence for the association between multiorgan dysfunction and COVID-19 development.
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Cooke JE, Eirich R, Racine N, et al. | Psychiatry Res
Aim: To review the evidence on posttraumatic stress and general psychological stress symptoms during COVID-19.
8/9/20
Samaranayake L, Fakhruddin K, Panduwawala C | Acta Odontol Scand
Aim: To evaluate the contemporary evidence on dysgeusia and anosmia as trigger prodromal symptoms, and their prevalence in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Haider Z, Aweid B, Subramanian P, et al. | J Telemed Telecare
Aim: To explore evidence for telemedicine in orthopaedics to determine its advantages, validity, effectiveness and utilisation.
INFECTION CONTROL
8/9/20
Sanchez-Ramirez DC, Mackey D | Respir Med
Aim: To explore the association of underlying respiratory diseases and smoking with severe outcomes in patients with COVID-19 infection.
CLINICAL CHARACTERISTICS
8/9/20
Barochiner J, Martinez R | J Clin Pharm Ther
Aim: To compare the occurrence of severe and fatal COVID-19 in infected patients who were under treatment with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) vs no treatment or other antihypertensives.
UPDATED
CANDIDATE THERAPEUTICS
8/9/20
Baladia E, Pizarro AB, Ortiz-Munoz L, et al. | Medwave
Aim: To provide a timely, rigorous, and continuously updated summary of the available evidence on the role of vitamin C in treating patients with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
8/7/20
Zheng B, Wang H, Yu C | Pediatr Pulmonol
Aim: To systematically review the current situation and public health burden associated with children infected with SARS-CoV2.
CLINICAL CHARACTERISTICS
8/7/20
Liu X, Long C, Ziong Q, et al. | Clin Cardiol
Aim: To review the current evidence and assess the clinical prognosis of COVID?19 patients with or without hypertension treated with ACEs/ARBs.
CANDIDATE THERAPEUTICS
8/7/20
Wu X, Liu L, Jiao J, et al. | Ann Med
Aim: To review the evidence on clinical, laboratory and imaging factors related to mild vs. severe COVID-19 infection.
CLINICAL CHARACTERISTICS
8/7/20
De Sanctis P, Doneddu PE, Vigano L, et al. | Eur J Neurol
Aim: To identify specific clinical features of GBS associated with COVID-19.
CLINICAL CHARACTERISTICS
8/7/20
Salunke AA, Nandy K, Pathak PK, et al. | Diabetes Metab Syndr
Aim: To evaluate the impact of cancer on serious events including ICU admission rate and mortality in COVID 19.
CLINICAL CHARACTERISTICS
8/7/20
Sharifian-Dorche M, Huot P, Osherov M, et al. | J Neurol Sci
Aim: To review the neurological complications of CoV infection in humans.
CLINICAL CHARACTERISTICS
8/7/20
Chi G, Lee JJ, Jamil A, et al. | J Clin Med
Aim: To offer benchmark data on the incidence of VTE and to examine the difference in D-dimer levels among anticoagulated COVID-19 patients with and without VTE incident. 
UPDATED
CANDIDATE THERAPEUTICS
8/6/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the extended use or re-use of personal protective equipment (PPE) during COVID-19.
UPDATED
8/6/20
Tariq R, Saha S, Furqan F, et al. | Mayo Clin Proc
Aim: To evaluate the prevalence of gastrointestinal (GI) symptoms and mortality in patients with coronavirus disease 2019 (COVID-19) diagnosed.
8/6/20
Agyeman AA, Chin KL, Landersdorfer CB, et al. | Mayo Clin Proc
Aim: To estimate the prevalence of olfactory and gustatory dysfunctions (OGDs) among patients infected with novel coronavirus disease 2019 (COVID-19).
8/5/20
Kariyanna PT, Sutarjono B, Grewal E, et al. | Am J Med Case Rep
Aim: To identify the clinical features of myocarditis in COVID-19 patients.
8/5/20
Pei L, Zhang S, Huang L, et al. | Pol Arch Intern Med
Aim: To evaluate the impact of drug therapy on the risk of death in patients with COVID-19.
8/5/20
 | Public Health Agency of Canada
Aim: To review the evidence for age-dependent transmission of SARS-CoV-2.
8/5/20
Kumar A, Arora A, Sharma P, et al. | Indian J Gastroenterol
Aim: To determine the frequency of GI and hepatic manifestations of COVID-19 and to explore their relationship with severe clinical course.
UPDATED
8/5/20
Ghahramani S, Tabrizi R, Lankarani KB, et al. | Eur J Med Res
Aim: To understand the common laboratory features of COVID-19 in severe cases versus non-severe patients could be quite useful for clinicians and might help to predict the model of disease progression.
UPDATED
8/5/20
Reddy RK, Charles WN, Sklavounos A, et al. | J Med Virol
Aim: To rigorously and definitively quantify the effects of smoking on COVID-19 severity.
UPDATED
8/5/20
Mansourabadi AH, Sadeghalvad M, Mohammadi-Motlagh H, et al. | Life Sci
Aim: To describe the role of the immune system in response to COVID-19.
8/5/20
Desiato VM, Levy DA, Byun YJ, et al. | Am J Rhinol Allergy
Aim: To perform a systematic review and meta-analysis of the prevalence of OD in the healthy general population, review the various assessment metrics used, and compare pooled OD prevalence rates.
8/5/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the symptoms and incidence for vascular events in patients with COVID-19.
8/5/20
Hasan SS, Radford S, Kow CS, et al. | J Thromb Thrombolysis
Aim: To systematically review the available evidence to help guide clinicians weighing up decisions regarding the anticoagulation approach for COVID-19 patients admitted to intensive care units.
8/4/20
Gao Y, Ye L, Zhang J, et al. | BMC Infect Dis
Aim: To systematically review the clinical features and outcomes of pregnant women with COVID-19.
UPDATED
8/4/20
Yoon SH, Kang J, Ahn JG | Eur Rev Med Pharmacol Sci
Aim: To evaluate the clinical manifestations and outcomes of neonates born to women who had Coronavirus Disease 2019 (COVID-19) during pregnancy.
8/4/20
Kay JK, Parsel SM, Marsh JJ, et al. | JAMA Otolaryngol Head Neck Surg
Aim: To review evidence on the risks of aerosolization and transmission of SARS-CoV-2 from patients to health care personnel during endoscopy of the upper aerodigestive tract.
8/4/20
Elgohary G | Hematol Oncol Stem Cell Ther
Aim: To evaluate the impact of COVID-19 infection on cancer patients. 
8/4/20
Khan S, Gionfriddo MR, Cortes-Penfield N, et al. | Expert Opin Pharmacother
Aim: To synthesize the literature on COVID-19 pharmacotherapy to inform practice and policymaking.
8/3/20
Shao M, Li X, Liu F, et al. | Pharmacol Res
Aim: To investigate whether the presence of acute kidney injury (AKI) might increase the risk of severe infection and fatality in COVID-19 patients.
CLINICAL CHARACTERISTICS
8/3/20
Putman M, Chock YPE, Tam H, et al. | Arthritis Rheumatol
Aim: To identify and summarize research that describes the use of antirheumatic disease therapies for the treatment of COVID-19.
CANDIDATE THERAPEUTICS
8/3/20
Wu B, Gu D, Yu J, et al. | Infect Genet Evol
Aim: To delve into the association between ABO blood group and COVID-19 infection, severity and demise.
CLINICAL CHARACTERISTICS
8/3/20
Carlo D, Montemurro N, Petrella G, et al. | J Neurol
Aim: To review the evidence on the spectrum of neurological symptoms experienced by COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
8/3/20
Zuin M, Rigatelli G, Zuliani G, et al. | J Cardiovasc Med
Aim: To investigate the relationship between ACI and mortality risk in COVID-19 patients.
CLINICAL CHARACTERISTICS
8/3/20
Rocke J, Hopkins C, Philpott C, et al. | Clin Otolaryngol
Aim: To systematically review the currently available evidence investigating the association between olfactory dysfunction (OD) and the novel coronavirus (COVID-19).
CLINICAL CHARACTERISTICS
8/3/20
Kotlyar A, Grechukihina O, Chen A, et al | Am J Obstet Gynecol
Aim: To determine estimates of vertical transmission of COVID-19 based upon early RNA detection of SARS-CoV-2 after birth from various neonatal/fetal sources and neonatal serology.
CLINICAL CHARACTERISTICS
8/2/20
Sahu AK, Amrithanand VT, Mathew R, et al. | Am J Emerg Med
Aim: To determine the proportion of HCW who were COVID-19 positive among all the COVID-19 patients. 
8/2/20
de Siqueira JVV, Almeida LG, Zico BO | Obes Res Clin Pract
Aim: To assess whether there was an association between obesity and higher levels of hospitalization, poor outcomes and mortality due to the disease of novel coronavirus (COVID-19).
CLINICAL CHARACTERISTICS
8/2/20
Rooney S, Webster A, Paul L | Phys Ther
Aim: To 1) compare physical function and fitness outcomes in people infected with SARS-CoV to healthy controls; 2) quantify the recovery of physical function and fitness following SARS-CoV infection; 3) determine the effects of exercise following SARS-CoV infection.
CLINICAL CHARACTERISTICS
8/2/20
Volpe M, Battistoni A | Int J Cardiol
Aim: To review the evidence on the potential role of renin-angiotensin system inhibitors, specifically angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, with regard to COVID-19 disease and mortality.
CANDIDATE THERAPEUTICS
8/2/20
Harrop E, Mann M, Semedo L, et al. | Palliat Med
Aim: To synthesise the evidence regarding system-level responses to mass bereavement events, including natural and human-made disasters as well as pandemics, to inform service provision and policy during the COVID-19 pandemic and beyond.
8/1/20
Qiu P, Zhou Y, Wang F, et al. | Aging Clin Exp Res
Aim: To find risk factors for the COVID-19-related death, helping to enhance the efficacy and reduce the mortality of COVID-19.
CLINICAL CHARACTERISTICS
8/1/20
Awulachew E, Diriba K, Anja A, et al. | Radiol Res Pract
Aim: To systematically analyze the existing literature on CT imaging features of patients with COVID-19 pneumonia.
CLINICAL CHARACTERISTICS
8/1/20
Mirzaei H, McFarland W, Karamouzian M, et al. | AIDS Behav
Aim: To review the evidence on the earliest patients with COVID-19-HIV co-infection.
CLINICAL CHARACTERISTICS
8/1/20
Pranata R, Soeroto AY, Huang I, et al. | Int J Tuberc Lung Dis
Aim: To investigate the association between chronic obstructive pulmonary disease (COPD) and smoking with outcome in patients with COVID-19.
CLINICAL CHARACTERISTICS
8/1/20
Hasan SS, Capstick T, Ahmed R, et al. | Expert Rev Respair Med
Aim: To review ARDS-associated mortality and the potential role of systemic corticosteroids in COVID-19 patients.
CANDIDATE THERAPEUTICS
8/1/20
Baradaran A, Ebrahimzadeh MH, Baradaran A, et al. | Arch Bone Jt Surg
Aim: To assess the prevalence of comorbidities in the confirmed COVID-19 patients.
CLINICAL CHARACTERISTICS
8/1/20
Liu H, Gai S, Wang X et al. | Cardiovasc Res
Aim: To analyse ACE2 and SARS-CoV-2 spike (S) protein proteases at the single-cell level, to explore the cardiac involvement in COVID-19 and improve our understanding of the potential cardiovascular implications of COVID-19.
CLINICAL CHARACTERISTICS
8/1/20
Akbari H, Tabrizi R, Lankarani KB, et al. | Life Sci
Aim: To make a comparison between the clinical laboratory-related factors, complete blood count (CBC) indices, cytokines, and lymphocyte subsets in order to distinguish severe coronavirus disease 2019 (COVID-19) cases from the non-severe ones.
UPDATED
CLINICAL CHARACTERISTICS
8/1/20
Monaghesh E, Hajizadeh A | BMC Public Health
Aim: To identify the role of telehealth services during COVID-19 outbreak.
UPDATED
INFECTION CONTROL
7/31/20
Akhtar H, Patel C, Abuelgasim E, et al. | Gynecol Obstet Invest
Aim: To review published studies related to the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections with pregnancy, foetal, and neonatal outcomes during coronavirus disease 2019 (COVID-19) pandemic.
CLINICAL CHARACTERISTICS
7/31/20
Clark EG, Hiremath S, Soroka SD, et al. | Can J Kidney Health Dis
Aim: To synthesize guidance documents from the broader nephrology community in an effort to provide the best possible care to the largest number of patients with kidney disease while also ensuring the safety of the health care team.
INFECTION CONTROL
7/31/20
Seresirikachorn K, Phoophiboon V, Chobarporn T, et al. | Infect Control Hosp Epidemiol
Aim: To evaluate the effectiveness of existing decontamination methods of surgical masks and N95 FFRs and provide evidence-based recommendations for selecting an appropriate decontamination method.
INFECTION CONTROL
7/31/20
Tng XJJ, Chew QH, Sim K | Singapore Med J
Aim: To examine and summarise existing studies to date regarding the psychological impact of COVID-19 on various populations.
7/31/20
Mitchell S, Maynard V, Lyons V, et al | Palliat Med
Aim: To synthesise existing evidence related to the delivery of palliative and end-of-life care by primary healthcare professionals in epidemics and pandemics.
UPDATED
7/30/20
Zhou Y, Yang Q, Chi J, et al. | Int J Infect Dis
Aim: To evaluate the association between different comorbidities and the severity of Covid-19.
CLINICAL CHARACTERISTICS
7/30/20
Hadeler E, Gitlow H, Nouri K | Arch Dermatol Res
Aim: To evaluate recent studies that have analyzed patient satisfaction with teledermatology. 
7/30/20
Figliozzi S, Masci P, Ahmadi N, et al. | Eur J Clin Invest
Aim: To review available evidence and provide pooled estimates on predictors of clinical outcomes in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/30/20
Musa A, Pendi K, Hashemi A, et al. | West J Emerg Med
Aim: To review the evidence on the use of remdesivir for the treatment of COVID-19.
CANDIDATE THERAPEUTICS
7/30/20
Shah K, Saxena D, Mavalankar D | QJM
Aim: To assess global statistics and characteristics of household secondary attack rate (SAR) of COVID-19.
INFECTION CONTROL
7/29/20
Yasuhara J, Kuno T, Takagi H, et al. | Pediatr Pulmonol
Aim: To investigate the clinical characteristics of COVID-19 in children.
CLINICAL CHARACTERISTICS
7/29/20
Chakravarti A, Upadhyay S, Bharara T, et al. | Indian J Med Microbiol
Aim: To provide an insight about the current understanding, knowledge gaps and a perspective on the future of coronavirus disease 2019 (COVID-19) infections. 
7/29/20
Liao S, Shao S, Chen Y, et al. | Crit Care
Aim: To review the evidence on severe complications of COVID-19 associated with coagulation changes, mainly characterized by increased D-dimer and fibrinogen levels with higher thrombosis risk, in particular pulmonary embolism (PE).
CLINICAL CHARACTERISTICS
7/29/20
Shulte PA, Streit JMK, Sheriff F, et al. | Ann Work Expo Health
Aim: To identify and characterize scenarios and hazards in the future of work after a global pandemic.
7/28/20
Rao SN, Manissero D, Steele VR, et al. | Infect Dis Ther
Aim: To review available knowledge on correlations between SARS-COV-2 Ct values and patient- or healthcare-related outcomes to determine whether Ct values provide useful clinical information.
CLINICAL CHARACTERISTICS
7/28/20
Langford B, So M, Raybardhan S, et al. | Clin Microbiol Infect
Aim: To determine the prevalence of bacterial co-infection (at presentation) and secondary infection (after presentation) in patients with COVID-19.
CLINICAL CHARACTERISTICS
7/28/20
Li X, Pan X, Li Y, et al. | Crit Care
Aim: To comprehensively evaluate the impact of cardiac injury and its related biomarkers on mortality and other prognosis in patients infected with SARS-CoV-2.
CLINICAL CHARACTERISTICS
7/28/20
Capobianco G, Saderi L, Aliberti S, et al. | Eur J Obstet Gynecol Reprod Biol
Aim: To assess the risk of clinical complications in pregnant women and neonates infected with SARS-CoV-2.
CLINICAL CHARACTERISTICS
7/28/20
Abdi A, Jalilian M, Sarbarzeh PA, et al. | Diabetes Res Clin Pract
Aim: To summarize the evidence about diabetes and COVID-19 outbreak through a systematic review and meta-analysis approach.
CLINICAL CHARACTERISTICS
7/28/20
Jin X, Chua HZ, Wang K, et al. | Integr Med Res
Aim: To summarize all the clinical studies to generate reliable evidence for decision-making on the medicinal value of Squama Manitis.
CANDIDATE THERAPEUTICS
7/28/20
Malik VS, Ravindra K, Attri SV, et al. | Environ Sci Pollut Res Int
Aim: To examine the emerging evidence to identify an association between body mass index (BMI) and COVID-19 disease outcome.
CLINICAL CHARACTERISTICS
7/28/20
Wu Y, Li H, Guo X, et al. | Hepatol Int
Aim: To explore the incidence, risk factors, and prognosis of abnormal liver biochemical tests in COVID-19 patients.
CLINICAL CHARACTERISTICS
7/28/20
Kovalic AJ, Satapathy SK, Thuluvath PJ | Hepatol Int
Aim: To determine the prevalence of CLD in patients with COVID-19 and their clinical outcomes.
CLINICAL CHARACTERISTICS
7/28/20
Cortegiani A, Ippolito M, Greco M, et al. | Pulmonology
Aim: To describe the rationale for the use of tocilizumab for the treatment of COVID-19 and to summarize the available evidence regarding its efficacy. and safety.
CANDIDATE THERAPEUTICS
7/28/20
Haiduc AA, Alom S, Melamed N, Harky A | J Card Surg
Aim:  To examine the literature evidence behind using extracorporeal membrane oxygenation in COVID?19 patients in a systematic review manner.
CANDIDATE THERAPEUTICS
7/28/20
Radulesco T, Lechien JR, Sowerby L, et al. | Eur Arch Otorhinolaryngol
Aim: To summarize recommendations for sinus and anterior skull base surgery during the COVID-19 pandemic.
UPDATED
INFECTION CONTROL
7/28/20
Weiss A, Jellingso M, Sommer MOA | EBioMedicine
Aim: To conduct a coherent overview of the duration of viral detection and viral RNA load in COVID-19 patients, stratified by specimen type, clinical severity, and age.
CLINICAL CHARACTERISTICS
7/28/20
Lan S, Lai C, Huang H, et al. | Int J Antimicrob Agents
Aim: To assess the efficacy of tocilizumab for the treatment of severe coronavirus disease-2019 (COVID-19).
CANDIDATE THERAPEUTICS
7/27/20
Cabrera-Tasayco FDP, Rivera-Carhuavilca JM, Atoche-Socola KJ, et al. | Disaster Med Public Health Prep
Aim: To determine biosecurity measures at the dental office after the appearance of COVID-19.
INFECTION CONTROL
7/27/20
Bwire GM, Majigo MV, Nijiro BJ, et al. | J Med Virol
Aim: To profile the positive detection rate from different clinical specimens using PCR to guide the selection of specimens for clinical diagnosis of COVID-19.
UPDATED
DIAGNOSTICS
7/27/20
Goldstein KM, Ghadimi K, Mystakelis H, et al. | VA Evidence Synthesis Program
Aim: To review the evidence on the risk of transmitting SARS-CoV-2, SARS, MERS, and influenza with administration of drugs via nebulizer
UPDATED
VA ESP
7/27/20
Elsner P | J of the German Society of Derm
Aim: To answer the questions i) to which extent teledermatological procedures were used by dermatologists in the course of the COVID?19 pandemic and ii) which experiences with the application of teledermatological procedures in dermatological practices and clinics were reported in the literature
INFECTION CONTROL
7/25/20
Solis-Garcia Del Pozo J, Galindo MF, Nava E, et al. | Eur Rev Med Pharmacol Sci
Aim: To review the evidence on the role of IL-6 in treating COVID-19.
CANDIDATE THERAPEUTICS
7/25/20
Racine N, Cooke JE, Eirich R, et al. | Psychiatry Res
Aim: To conduct a rapid review of child and adolescent anxiety, depression, and traumatic stress experienced during the COVID-19 pandemic. 
7/25/20
Rahman J, Mumin J, Fakhruddin B | Ann Glob Health
Aim: To appraise the frequency of T-zone (eyes, nose, mouth, chin) touching in humans to comprehend the challenge of its restriction, and thus support public health professionals to produce evidence synthesis guidance for public.
INFECTION CONTROL
7/25/20
Imran N, Aamer I, Sharif MI, et al. | Pak J Med Sci
Aim: To examine the impact of quarantine on mental health of children and adolescents, and proposes measures to improve psychological outcomes of isolation.
7/25/20
Katims AB, Razdan S, Eilender BM, et al. | Urol Oncol
Aim: To provide a review of high-risk urologic cancers and the feasibility of delaying surgery without impacting oncologic or mortality outcomes.
INFECTION CONTROL
7/24/20
Lin J, Yan H, Chen H, et al. | J Med Virol
Aim: To review the blood coagulation indicators in severe COVID?19 patients.
CLINICAL CHARACTERISTICS
7/24/20
PHAC Emerging Science Group, Public Health Agency of Canada  | Public Health Agency of Canada
Aim: To review the evidence on the effectiveness of face shields at preventing SARS-CoV-2 virus transmission, with and without additional mask wearing.
7/24/20
PHAC Emerging Science Group, Public Health Agency of Canada  | Public Health Agency of Canada
Aim: To review the evidence on the aerodynamic properties of SARS-CoV-2 virus and travel distance, and the implications on transmission risk.
7/24/20
Venkatesulu BP, Chandrasekar VT, Giridhar P, et al. | J Med Virol
Aim: To do a systematic review and critical appraisal of the ongoing clinical trials that are assessing various therapeutic interventions against SARS-CoV-2 with an aim to provide insight into the various interventions tested, clinical rationale, geographical distribution of the trials as well as the endpoints assessed in the studies.
UPDATED
CANDIDATE THERAPEUTICS
7/24/20
 | Sante Publique France
7/24/20
 | Sante Publique France
7/23/20
de Melo GC, de Araujo KCGM | Cad Saude Publica
Aim: To analyze whether COVID-19 in pregnant women is related to premature birth and birth weight, and to summarize the diagnostic results of neonates born to mothers with COVID-19 for investigating the possibility of vertical transmission.
CLINICAL CHARACTERISTICS
7/23/20
James HK, Pattison GTR | J Surg Educ
Aim: To synthesise the current evidence of pandemic-related impact on surgical training internationally and describe strategies that have been put in place to mitigate disruption.
7/23/20
 | Public Health Agency of Canada
Aim: To review the evidence on determinants of individual adherence to public health interventions to prevent COVID-19.
7/23/20
Garcia-Iglesias JJ, Gomez-Salgado J, Martin-Pereira J, et al. | Rev Esp Salud Publica
Aim: To analyze the impact of the SARS-CoV-2 outbreak on healthcare professionals' mental health.
7/23/20
Taherifard E, Taherifard E | Neurol Res
Aim: To systematically review the neurological complications in patients with SARS-CoV-2 infection and the methods used to diagnose both neurological complications and coronavirus infection.
CLINICAL CHARACTERISTICS
7/23/20
Deniz M, Tezer H | J Matern Fetal Neonatal Med
Aim: To review the current evidence on the vertical transmission of SARS CoV-2.
CLINICAL CHARACTERISTICS
7/22/20
Chen X, Laurent S, Onur OA, et al. | J Neurol
Aim: To study the frequency of neurological symptoms and complications in COVID-19 patients in a systematic review of the literature.
CLINICAL CHARACTERISTICS
7/22/20
Patterson TJ, Currie PJ, Beck J, et al. | Surgeon
Aim: To conduct an objective, systematic review of studies reporting on viral transmission risk comparing laparoscopic and open surgery.
INFECTION CONTROL
7/22/20
Sorrentino S, Cacia M, Leo I et al. | J. Clin. Med.
Aim: To investigate whether the measurement of NT-proBNP may help discriminate clinical severity in patients with COVID-19
CLINICAL CHARACTERISTICS
7/22/20
PHAC Emerging Science Group, Public Health Agency of Canada  | Public Health Agency of Canada
Aim: To review the evidence on the de-escelation of "household bubbles" during the COVID-19 pandemic.
7/22/20
PHAC Emerging Science Group, Public Health Agency of Canada  | Public Health Agency of Canada
Aim: To review the evidence on the thresholds or allowable sizes of gatherings or events during the COVID-19 pandemic.
7/22/20
Bertrand K, Camire M, Milot D, et al. | University of Sherbrooke
Aim: To review the evidence on gender and sexual diversity in the adaptation of services in the context of the COVID-19 pandemic.
7/21/20
Ashraf MA, Keshavarz P, Hosseinpour P, et al. | J Reprod Infertil
Aim: To demonstrate the effects of COVID-19 on pregnant women and the possibility of vertical transmission.
CLINICAL CHARACTERISTICS
7/21/20
Vidali S, Morosetti D, Cossu E, et al. | ERJ Open Res
Aim: To highlight the correlation between elevated D-dimer (an indirect thrombosis marker) and the increased rate of poor prognosis-associated conditions, and to introduce D-dimer-labelled anticoagulant administration as a potentially useful tool to prevent complications and positively influence coronavirus disease 2019 (COVID-19) course.
CANDIDATE THERAPEUTICS
7/21/20
Kovalic AJ, Huang G, Thuluvath PJ, et al. | Hepatology
Aim: To further characterize liver injury and other unique clinical characteristics across COVID-19 severity.
CLINICAL CHARACTERISTICS
7/21/20
Lim MA, Pranata R, Huang I, et al. | Can J Kidney Health Dis
Aim: To investigate the association between several complications, including acute kidney injury (AKI), acute liver injury (ALI), and coagulopathy, with poor outcomes in COVID-19.
CLINICAL CHARACTERISTICS
7/21/20
He J, Guo Y, Mao R, et al. | J Med Virol
Aim: To systematically review the characteristics of asymptomatic infection in the coronavirus disease 2019 (COVID-19).
CLINICAL CHARACTERISTICS
7/21/20
Kumar J, Meena J, Yadav A, et al. | J Trop Pediatr
Aim: To compile the radiological findings of COVID-19 pneumonia in children in a systematic manner.
CLINICAL CHARACTERISTICS
7/21/20
Wynants L, Van Calster B, Bonten MMJ | BMJ
Aim: To review and critically appraise published and preprint reports of models that aim to predict either (i) presence of existing COVID-19 infection, or (ii) future complications in individuals already diagnosed with COVID-19
UPDATED
7/21/20
Bajwa H, Riaz Y, Ammar M, et al. | Cureus
Aim: To analyze the published data on kidney injuries in COVID-19 and mortality rates in these patients.
CLINICAL CHARACTERISTICS
7/20/20
Cortegiani A, Ingoglia G, Ippolito M, et al. | J Crit Care
Aim: To evaluate the efficacy and safety of chloroquine and chloroquine-related formulations in patients with SARS-CoV-2 pneumonia and articles describing related in-vitro studies.
UPDATED
CANDIDATE THERAPEUTICS
7/20/20
Gao Y, Liu M, Chen Y, et al. | J Med Virol
Aim: To assess whether tuberculosis is associated with an increased risk of severe disease and death in patients with COVID-19.
CLINICAL CHARACTERISTICS
7/20/20
Egbert AR, Cankurtaran S, Karpiak S | Brain Behav Immun
Aim: To synthesize early data on typology and topography of brain abnormalities in adults with COVID-19 in acute/subacute phase.
CLINICAL CHARACTERISTICS
7/20/20
Tian Y, Qiu X, Wang C, et al. | Int J Cancer
Aim: To review the evidence on cancer prevalence in patients with COVID-19, and examine the association of cancer with severe events.
CLINICAL CHARACTERISTICS
7/20/20
Pei Y, Liu W, Masokano IB, et al. | J Infect Public Health
Aim: To investigate the differences in the clinical manifestations and imaging characteristics between Chinese children and adults with COVID-19 by systematically analyzing the data derived from some latest literatures.
CLINICAL CHARACTERISTICS
7/20/20
O'Hearn K, Gertsman S, Sampson M, et al. | J Hosp Infect
Aim: To synthesize existing data on the effectiveness of ultraviolet germicidal irradiation (UVGI) for N95 FFR decontamination.
INFECTION CONTROL
7/20/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the efficacy of face masks in helping to prevent the spread of COVID-19.
UPDATED
7/20/20
Noorimotlagh Z, Karami C, Mirzaee SA, et al. | Int Immunopharmacol
Aim: To help researchers to produce vaccine by collecting data for the control and prevention of SARS-CoV-2 and the immune and bioinformatic identification of T-cell and B-cell epitopes.
INFECTION CONTROL
7/20/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of adverse post-operative outcomes on patients with COVID-19 or who have previously had COVID-19.
7/20/20
Eichberg DG, Basil GW, Di L, et al. | Neurosurgery
Aim: To conduct a systematic literature review investigating treatment of neurosurgical patients via telemedicine, and to evaluate barriers and challenges.
7/20/20
Shield KD, Chrystoja BR, Ali S, et al. | CMH Initiative
Aim: To review the evidence on how economic crises and natural disasters impact alcohol consumption and its harms.
7/19/20
Pormohammad A, Ghorbani S, Baradaran B, et al. | Microb Pathog
Aim: To evaluate the clinical features and laboratory findings using a large sample size of COVID-19 infected patients in order to assist in its understanding, prevention and treatment.
UPDATED
CLINICAL CHARACTERISTICS
7/19/20
Zarifian A, Birdary MZ, Arekhi S, et al. | J Med Virol
Aim: To review the evidence on gastrointestinal and liver manifestations of COVID-19 patients.
CLINICAL CHARACTERISTICS
7/19/20
Chen Y, Shao S, Lai EC, et al. | Crit Care
Aim: To compare the mortality rate in patients with SARS, MERS, and COVID-19 who developed acute kidney injury.
CLINICAL CHARACTERISTICS
7/19/20
Abdullahi A, Candan SA, Abba MA, et al. | Front Neurol
Aim: To summarize the evidence on the neurological and musculoskeletal symptoms of the disease.
CLINICAL CHARACTERISTICS
7/19/20
Foldi M, Farkas N, Kiss S, et al. | Obes Rev
Aim: To examine whether obesity is a risk factor for the critical condition in COVID?19 patients by performing a meta?analysis.
CLINICAL CHARACTERISTICS
7/18/20
Cooper TJ, Woodward BL, Harky A | HIV Med
Aim: To systematically review current studies reporting on clinical outcomes in people living with HIV (PLHIV) infected with severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2).
CLINICAL CHARACTERISTICS
7/18/20
Ghayda RA, Lee J, Lee JY, et al. | Int J Environ Res Public Health
Aim: To perform a novel systematic review and meta-analysis focusing on findings about correlations between clinical characteristics and laboratory features of patients with COVID-19.
CLINICAL CHARACTERISTICS
7/18/20
Yadav DK, Singh A, Zhang Q, et al. | Gut
Aim: To perform a meta-analysis to estimate the prognosis of patients with COVID-19 stratified according to liver injury. 
CLINICAL CHARACTERISTICS
7/18/20
Verdugo-Paiva F, Izcovich A, Ragusa M, et al. | Medwave
Aim: To provide a timely, rigorous, and continuously updated summary of the evidence on the role of lopinavir/ritonavir in the treatment of patients with COVID-19.
UPDATED
7/17/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on whether cardiac stress testing is an aerosol generating procedure and its risk to healthcare workers.
7/17/20
Greco A, Buccheri S, D'Arrigo P, et al. | Eur Heart J Cardiovasc Pharmacother
Aim: To review the evidence on the impact of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on the clinical outcomes of COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
7/17/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on post-surgery innovations in an outpatient setting, such as virtual follow up and rehabilitation, in improving outcomes for patients who have undergone surgery.
7/17/20
Galbadage T, Peterson BM, Awada J, et al. | Front Med
Aim: To examine the association between male sex and COVID-19 severity.
UPDATED
CLINICAL CHARACTERISTICS
7/16/20
Liu J, Cui M, Yang T, et al. | BMJ Open Gastroenterol
Aim: To study the correlation between gastrointestinal (GI) symptoms and disease severity in patients with COVID-19.
CLINICAL CHARACTERISTICS
7/16/20
Garg PK, Kaul P, Choudary D, et al. | J Surg Oncol
Aim: To systematically evaluate the available literature on the impact of COVID-19 on cancer care and to critically analyze the diagnostic and therapeutic strategies suggested by various healthcare providers, societies, and institutions. 
7/16/20
Shah S, Shah K, Patel SB, et al. | Cardiol Rev
Aim: To investigate the prognostic role of D-dimer in COVID-19 infected patients. 
UPDATED
CLINICAL CHARACTERISTICS
7/16/20
Blair B | Simcoe Muskoka District Health Unit
Aim: To review the evidence on whether staying at home for long periods of time during current or past pandemics worsens the rates of mental and social health outcomes.
7/15/20
Zaki N, Alashwal H, Ibrahim S | Diabetes Metab Syndr
Aim: To undertake a review and critical appraisal of published/preprint reports that offer methods of determining the effects of hypertension, diabetes, stroke, cancer, kidney issues, and high-cholesterol on COVID-19 disease severity. 
CLINICAL CHARACTERISTICS
7/15/20
Collantes ME, Espiritu AI, Sy MCC, et al. | Can J Neurol Sci
Aim: To determine the neurological 48 manifestations and complications in COVID-19.
CLINICAL CHARACTERISTICS
7/15/20
Chandrasekar VT, Venkatesalu B, Patel HK, et al. | J Med Virol
Aim: To assess if any intervention provides mortality benefit, other clinically relevant outcomes and also ascertain the safety profile.
UPDATED
CANDIDATE THERAPEUTICS
7/14/20
Murphy E, Fenelon C, Murphy RP, et al. | Clin Orthop Relat Res
Aim: To describe (1) adverse outcomes, (2) cost reductions, and (3) efficiencies associated with the virtual fracture clinic model.
INFECTION CONTROL
7/14/20
Patel RS, Patel N, Baksh M, et al. | Cureus
Aim: To summarize the transmission and pathology of 2019-nCoV, and demographics, clinical presentation, laboratory, and chest imaging findings, along with treatment and outcomes in 2019-nCoV pneumonia patients.
CLINICAL CHARACTERISTICS
7/14/20
Oltean M, Softeland JM, Bagge J, et al. | Infect Dis
Aim: To pool the individual and aggregated data from available case-series on kidney transplant patients and the risk of COVID-19.
INFECTION CONTROL
7/14/20
Fang X, Li S, Yu H, et al. | Aging
Aim: To systematically collect and evaluate the associations of epidemiological, comorbidity factors with the severity and prognosis of coronavirus disease 2019 (COVID-19).
CLINICAL CHARACTERISTICS
7/14/20
de Pablo GS, Vaquerizo-Serrano J, Catalan A, et al. | J Affect Disord
Aim: To review the evidence on the impact of SARS/MERS/COVID-19 on physical and mental health outcomes of health care workers.
UPDATED
INFECTION CONTROL
7/14/20
Bajgain KT, Badal S, Bajgain BB, et al. | Am J Infect Control
Aim: To explore the prevalence of top global comorbidities (CVD, Diabetes, COPD, Cancer, and CKD) among individuals with COVID-19, as well as investigate any significant associations.
CLINICAL CHARACTERISTICS
7/14/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the resumption of elective surgery following cancellation and deferment of routine services during COVID-19.
7/14/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on low-value surgery and how to reduce it.
7/14/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on post-surgery innovations in hospital such as enhanced recovery, early mobilisation and early discharge in improving outcomes for patients who have undergone surgery?
7/14/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on ways to increase productivity or efficiency in operating theatres and managing elective surgery waiting lists?
7/14/20
Boger B, Fachi MM, Vilhena RO, et al. | Am J Infect Control
Aim: To collate the evidence on the accuracy parameters of all available diagnostic methods for detecting SARS-CoV-2.
DIAGNOSTICS
7/14/20
Ning AY, Cabrera CI, D'Anza B | Ann Otol Rhinol Laryngol
Aim: To evaluate existing literature on telemedicine and assess overall image quality, diagnostic concordance, and patient and provider satisfaction with telemedicine technologies.
INFECTION CONTROL
7/14/20
La Marca A, Capuzzo M, Paglia T, et al. | Reprod Biomed Online
Aim: To provide an overview of current diagnostic approaches for SARS-CoV-2 and in particular highlight issues with serological testing, with the objective of providing a clear guide to clinicians on the assays currently available.
DIAGNOSTICS
7/14/20
Gavriilidis P, Pai M | J Clin Med Res
Aim: To summarise the existing evidence of impact of COVID-19 global pandemic on liver transplant recipients.
7/13/20
Momtazmanesh S, Shobeiri P, Hanaei S, et al. | Egypt Heart J
Aim: To define the clinical, electrocardiographic, and pathologic spectrum of cardiovascular disease (CVD), frequency of elevated cardiac and inflammatory biomarkers, and their frequency and relationship with severity of the disease and mortality in COVID-19 patients and to develop a triage risk stratification tool (TRST) that can serve as a guide for the timely recognition of the high-risk patients and mechanism-targeted therapy. 
CLINICAL CHARACTERISTICS
7/13/20
Tan Y, Goh C, Leow AST, et al. | J Thromb Thrombolysis
Aim: To characterize the clinical characteristics, neuroimaging findings, and outcomes of AIS in COVID-19 patients. 
CLINICAL CHARACTERISTICS
7/13/20
Koletsi D, Belibasakis GN, Eliades T | J Dent Res
Aim: To identify and rank the effectiveness of different interventions used in dental practice to reduce microbial load in aerosolized compounds.
INFECTION CONTROL
7/13/20
Nepal G, Rehrig JH, Shrestha GS, et al. | Crit Care
Aim: To inform and improve decision-making among the physicians treating COVID-19 by presenting a systematic analysis of the neurological manifestations experienced within these patients.
CLINICAL CHARACTERISTICS
7/13/20
Preti E, Di Mattei V, Perego G, et al. | Curr Psychiatry Rep
Aim: To provide quantitative evidence on the psychological impact of epidemic/pandemic outbreaks (i.e., SARS, MERS, COVID-19, ebola, and influenza A) on healthcare workers (HCWs).
7/13/20
Manabe T, Akatsu H, Kotani K, et al. | Respir Investig
Aim: To elucidate the clinical features of COVID-19 using a meta-analysis with a stratified analysis according to the timeline and the changes in the exposure risks before the disease was declared as a pandemic.
CLINICAL CHARACTERISTICS
7/11/20
Shafi AMA, Shaikh SA, Shirke MM, et al. | J Card Surg
Aim: To systematically review the current published literature on the different cardiac manifestations and the use of cardiac?specific biomarkers in terms of their prognostic value in determining clinical outcomes and correlation to disease severity.
CLINICAL CHARACTERISTICS
7/11/20
Abate S, Ali S, Mantedafro B, et al. | PLoS One
Aim: To investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus.
UPDATED
CLINICAL CHARACTERISTICS
7/11/20
Albahri OS, Zaidan AA, Albahri AS, et al. | J Infect Public Health
Aim: To review the evidence on artificial intelligence (AI) techniques used in the detection and classification of coronavirus disease 2019 (COVID-19) medical images in terms of evaluation and benchmarking.
DIAGNOSTICS
7/11/20
Moreno G, Carbonell R, Bodi M, et al. | Med Intensiva
Aim: To define the role of D-dimer in the disease, the prevalence of DIC and the usefulness of anticoagulant treatment in these patients.
CLINICAL CHARACTERISTICS
7/10/20
 | Public Health Agency of Canada
Aim: To review the evidence on the risk of SARS-CoV-2 virus transmission from singing or playing a wood instrument in a choir, orchestra and/or practice setting with other people.
7/10/20
Yu C, Kang L, Chen J, et al. | Int Immunopharmacol
Aim: To recapitulate relevant studies to evaluate the safety, efficacy, tolerability and treatment-related outcomes of type I IFNs for coronavirus infection in clinical practice, with expectation to provide more robust evidence whether IFNs should be served as first-line agents for coronavirus infection, including the SARS-CoV-2.
CANDIDATE THERAPEUTICS
7/10/20
Bornstein S | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the impacts of COVID-19 mitigation on non-COVID-19 populations with pre-existing mental health conditions.
7/10/20
Kunutsor S, Laukkanen J | Ann Med
Aim: To evaluate renal complications of COVID-19 and their incidence using a systematic meta-analysis.
UPDATED
CLINICAL CHARACTERISTICS
7/10/20
Lewis J, Mackey K | VA Evidence Synthesis Program
Aim: To critically appraise the identified study and provide additional context for study findings.
VA ESP
7/10/20
Kernohan A, Calderon M | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on risk factors or management of VTE.
UPDATED
7/9/20
Shao JM, Ayuso SA, Deerenberg EB, et al. | Colorectal Dis
Aim: To investigate the sensitivity and utility of computed tomography (CT) of the chest in diagnosing active Coronavirus 2019 (COVID?19) infection, and its potential application to the surgical setting.
DIAGNOSTICS
7/9/20
Farsalinos K, Barbouni A, Poulas K, et al. | Ther Adv Chronic Dis
Aim: To examine the prevalence and effects of current smoking on adverse outcomes among hospitalized COVID-19 patients.
CLINICAL CHARACTERISTICS
7/9/20
Mackey S, Warren C | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the impacts of COVID-19 mitigation on non-COVID-19 populations with pre-existing substance use and addictions issues.
7/9/20
Trocado V, Silvestre-Machado J, Azevedo L, et al. | J Matern Fetal Neonatal Med
Aim: To evaluate the impact of COVID-19 during pregnancy.
CLINICAL CHARACTERISTICS
7/9/20
Fontana P, Casini A, Robert-Ebadi H, et al. | Swiss Med Wkly
Aim: To summarise the reported risk of VTE associated with COVID-19 infections and to summarise guidance documents on thromboprophylaxis in COVID-19 patients, in a systematic review.
CLINICAL CHARACTERISTICS
7/9/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the role of daycares and schools in the transmission of COVID-19.
7/8/20
Lvliang L, Zhong W, Bian Z, et al. | J Infect
Aim: To compare mortality risk factors of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) to provide new strategies for COVID-19 prevention and treatment.
CLINICAL CHARACTERISTICS
7/8/20
Nandy K, Salunke A, Pathak SK, et al. | Diabetes Metab Syndr
Aim: To evaluate the impact of various morbidities on serious events in COVID 19.
CLINICAL CHARACTERISTICS
7/8/20
Seirafianpour F, Sodagar S, Mohammad AP, et al. | Dermatol Ther
Aim: To present an overview of suggestive skin manifestations of the COVID-19 and to address several considerations in the dermatological issues practices, during this pandemic.
CLINICAL CHARACTERISTICS
7/8/20
Rodriguez-Martinez CE, Sossa-Briceno MP, Cortes-Luna JA | Am J Infect Control
Aim: To summarize all of the available evidence on the different decontamination methods that might allow disposable N95 FFRs to be reused, with emphasis on decontamination from SARS-CoV-2.
INFECTION CONTROL
7/8/20
Sun M, Xu Y, He H, et al. | Int J Infect Dis
Aim: To explore the effectiveness of treatment and predict the potential effect of convalescent plasma for COVID-19.
CANDIDATE THERAPEUTICS
7/8/20
Salari N, Hosseinian-Far A, Jalali R, et al. | Global Health
Aim: To analyze the existing research works and findings in relation to the prevalence of stress, anxiety and depression in the general population during the COVID-19 pandemic.
7/8/20
Ravani P, Saxinger L, Chandran U, et al. | Alberta Health Services
Aim: To evaluate the current prevalence of COVID-19 infection among asymptomatic patients presenting to Emergency Rooms and requiring hospital admission.
7/8/20
Zhu R, Gao Y, Robert S, et al. | J Transl Med
Aim: To summarize the characteristics of clinical trials for COVID-19.
CANDIDATE THERAPEUTICS
7/8/20
Kulkarni A, Kumar P, Tevethia HV, et al. | Aliment Pharmacol Ther
Aim: To assess the prevalence of CLD, the incidence of elevated liver chemistries and the outcomes of patients with and without underlying CLD/elevated liver chemistries in COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/8/20
Pan D, Sze S, Minhas J, et al. | EClinicalMedicine
Aim: To assess whether ethnicity has been reported in patients with COVID-19 and its relation to clinical outcomes.
UPDATED
CLINICAL CHARACTERISTICS
7/7/20
Rokkas T | Ann Gastroenterol
Aim: To review the evidence on the involvement of the digestive system in COVID-19.
CLINICAL CHARACTERISTICS
7/7/20
Struyf T, Deeks JJ, Dinnes J et al. | Cochrane Database Syst Rev
Aim: To assess the diagnostic accuracy of signs and symptoms to determine if a person presenting in primary care or to hospital outpatient settings, such as the emergency department or dedicated COVID?19 clinics, has COVID?19 disease or COVID?19 pneumonia.
DIAGNOSTICS
7/7/20
Lin Y, Duan Q, Zhou Y, et al. | Front Med
Aim: To review existing mathematical and statistical models and build a mathematical model to estimate the transmission capacity, epidemiological characteristics, potential peak time and size, and elimination time of COVID-19.
7/6/20
Xiong X, Wang P, Su K, et al. | Pharmacol Res
Aim: To evaluate the current clinical evidence on Chinese herbal medicine for the treatment of COVID-19.
CANDIDATE THERAPEUTICS
7/6/20
Kumar-M P, Mishra S, Jha DK, et al. | Hepatol Int
Aim: To systematically study the occurrence of liver injury in COVID-19 and also determine the frequency of liver involvement in COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/6/20
Laperriere H, Bendevis C, et al. | CIHR IRSC
Aim: To review the evidence on how COVID-19 is affecting the mental health of indigenous community members in Ottawa-Gatineau who are living with or affected by HIV or related issues.
7/6/20
Kania-Richmond A, Saxinger L, Manns B | Alberta Health Services
Aim: To review the evidence for the effectiveness of remdesivir as a treatment for COVID-19.
7/6/20
Borsetto D, Hopkins C, Philips V, et al. | Rhinology
Aim: To systematically assess the prevalence of self-reported altered sense of smell or taste in patients with confirmed SARS-CoV-2 infection.
CLINICAL CHARACTERISTICS
7/6/20
Al-Sadeq DW, Nasrallah GK | Int J Infect Dis
Aim: To systematically review the published literature on SARS-CoV-2 in the asymptomatic patients to estimate the incidence of COVID-19 among asymptomatic cases, as well as describe its epidemiological and clinical significance.
CLINICAL CHARACTERISTICS
7/4/20
Aziz M, Fatima R, Haghbin H, et al. | Inflamm Bowel Dis
Aim: To better understand the incidence and outcomes of COVID-19 in infammatory bowel disease (IBD) patients.
CLINICAL CHARACTERISTICS
7/3/20
Bastos M, Tavaziva G, Abidi SK, et al. | BMJ
Aim: To determine the diagnostic accuracy of serological tests for coronavirus disease-2019 (covid-19).
UPDATED
DIAGNOSTICS
7/3/20
Huang D, Yu H, Wang T, et al. | J Med Virol
Aim: To evaluate the efficacy and safety of umifenovir in COVID?19.
CANDIDATE THERAPEUTICS
7/3/20
Spencer EA, Brassey J, Jefferson T, et al. | Oxford COVID-19 Evidence Service Team
Aim: To explore if climate conditions may influence the spread of SARS-CoV-2.
UPDATED
7/3/20
Russo B, Iudici M | Infect Control Hosp Epidemiol
Aim: To provide a summary of preventative or therapeutic interventions specifically designed for healthcare workers facing with COVID-19 pandemic.
INFECTION CONTROL
7/3/20
Amaefule CE, Sasitharan A, Kalra P, et al. | Curr Opin Obstet Gynecol
Aim: To review the evidence on the screening and diagnostic accuracy of the haemoglobin A1c (HbA1c) test in women with and without risk factors for gestational diabetes.
INFECTION CONTROL
7/3/20
Pranata R, Permana H, Huang I, et al. | Diabetes Metab Syndr
Aim: To investigate the association between use of angiotensin-converting enzyme inhibitor (ACEI)/angiotensin-receptor blocker (ARB) and outcomes of hypertensive COVID-19 patients.
7/2/20
Potere N, Valeriani E, Candeloro M, et al. | Crit Care
Aim: To summarize the evidence on clinically relevant outcomes in hospitalized patients with COVID-19.
CLINICAL CHARACTERISTICS
7/2/20
Dorfman R, Saadat S, Gupta N et al. | Plast Reconstr Surg
Aim: To provide clear recommendations for plastic surgeons to follow during the COVID-19 pandemic.
INFECTION CONTROL
7/1/20
Altmayer S, Zanon M, Pacini GS, et al. | Eur Radiol
Aim: To compare the chest computed tomography (CT) findings of coronavirus disease 2019 (COVID-19) to other non-COVID viral pneumonia.
CLINICAL CHARACTERISTICS
7/1/20
Koh J, Shah SU, Chua PEY, et al. | Front Med
Aim: To review the epidemiological and clinical characteristics of COVID-19 cases in the early phase of the COVID-19 pandemic.
CLINICAL CHARACTERISTICS
7/1/20
Katal S, Balakrishnan S, Gholamrexanezhad A | J Neuroradiol
Aim: To review the available imaging findings of patients diagnosed with neurological symptoms associated with coronavirus infections.
CLINICAL CHARACTERISTICS
7/1/20
Yang J, Hu J, Zhu C | J Med Virol
Aim: To explore the relationship between obesity and COVID-19.
CLINICAL CHARACTERISTICS
7/1/20
Greaves L, Brabete AC, Wolfson L, et al. | Centre of Excellence for Women's Health
Aim: To review the evidence on the role of natural disasters and pandemics in intimate partner violence among women and the role of substance use in intimate partner violence among women.
7/1/20
Alizadeh F, Khodavandi A | IEEE Trans Nanobioscience
Aim: To summarize the available evidence on the efficacy of nanoscale materials against coronaviruses in vitro and in animal models.
CANDIDATE THERAPEUTICS
7/1/20
Flacco ME, Martellucci CA, Bravi F et al. | Heart
Aim: To summarise the existing evidence on the association between these medications and severe/lethal COVID-19.
CANDIDATE THERAPEUTICS
6/30/20
Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the best practices for personal care workers providing home care in the context of COVID-19.
6/30/20
Hu CLH, Raval M, Schnall JA, et al. | Pediatr Infect Dis J
Aim: To determine the average shedding times of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via the respiratory and gastrointestinal tracts in children.
CLINICAL CHARACTERISTICS
6/30/20
Khalili M, Karamouzian M, Nasiri N, et al. | Epidemiol Infect
Aim: To synthesize case fatality rate (CFR) among confirmed COVID-19 patients, incubation period, and time from onset of COVID-19 symptoms to first medical visit, intensive care unit (ICU) admission, recovery and death.
CLINICAL CHARACTERISTICS
6/30/20
Armstrong RA, Kane AD, Cook TM | Anaesthesia
Aim: To assess the reported ICU mortality for patients with confirmed COVID?19.
UPDATED
CLINICAL CHARACTERISTICS
6/30/20
Beesoon S, Jelinski S | Alberta Health Services
Aim: To review the evidence on the risks of infection transmission related to aerosol generation through dental procedures.
6/29/20
Khalili M, Karamouzian M, Nasiri N et al. | Epidemiol Infect
Aim: To synthesise case fatality rate (CFR) among confirmed COVID-19 patients, incubation period and time from onset of COVID-19 symptoms to first medical visit, intensive care unit (ICU) admission, recovery, and death.
CLINICAL CHARACTERISTICS
6/29/20
Dube L, Paquet C, Cisneros-Franco M, et al. | McGill University
Aim: To identify and examine the effectiveness of social connectedness interventions at reducing feelings of social isolation and loneliness and promoting wellbeing, resilience, and coping in the context of infection control-related social and physical distancing measures.
6/29/20
Li X, Xu W, Dozier M, et al. | J Glob Health
Aim: To synthesise the latest evidence in relation to the role of children in the transmission of SARS-CoV-2.
INFECTION CONTROL
6/28/20
Zhao Q, Fang X, Pang Z, et al. | J Eur Acad Dermatol Venereol
Aim: To gain an in-depth understanding of COVID-19 by summarizing publications related to the cutaneous manifestations of the disease and the ACE2 expression in skin tissues.
CLINICAL CHARACTERISTICS
6/27/20
Matar R, Oules B, Sohier P, et al. | J Eur Acad Dermatol Venereol
Aim: To analyze our experience in a French referral center and to perform a systematic review of the literature to evaluate the incidence and prognosis of cutaneous lesions observed in COVID?19 patients. 
CLINICAL CHARACTERISTICS
6/27/20
Schnitzbauer AA, Kempf VAJ, Hack D, et al. | Surgeon
Aim: To summarize the evidence on standards for personal protective equipment (PPE) for the employees in the central emergency rooms and in the operating area as well as restructuring measures for the operations in the operating area in a COVID-plus area.
INFECTION CONTROL
6/27/20
Gengler I, Wang JC, Speth MM, et al. | Laryngoscope Investig Otolaryngol
Aim: To synthesize existing scientific evidence on the role of sinonasal pathophysiology in COVID?19.
CLINICAL CHARACTERISTICS
6/26/20
Meena J, Yadav J, Saini L, et al. | Indian Pediatr
Aim: To synthesize the information on clinical manifestations, laboratory findings, and outcome of COVID-19 among the pediatric population.
CLINICAL CHARACTERISTICS
6/26/20
Hanrahan JG, Burford C, Adegboyega G, et al. | World Neurosurg
Aim: To detail early experiences and changes to neurosurgical practice in response to the COVID-19 pandemic.
6/26/20
Feng X, Li S, Sun Q, et al. | Front Med
Aim: To explore the effect of risk factors on the severity of the disease, focusing on immune-inflammatory parameters, which represent the immune status of patients.
CLINICAL CHARACTERISTICS
6/26/20
da Costa KVT, Carnauba ATL, Rocha KW, et al. | Braz J Otorhinolaryngol
Aim: To identify evidence in the scientific literature about olfactory/gustatory disorders, their clinical presentation, prevalence and possible specific treatments associated with COVID-19.
CLINICAL CHARACTERISTICS
6/26/20
Helfand M | VA Evidence Synthesis Program
Aim: To review the evidence for using corticosteroids to treat acute respiratory distress syndrome in patients with COVID-19.
VA ESP
6/26/20
Duan-Porter W | VA Evidence Synthesis Program
Aim: To explore the length of stay in the intensive care unit (ICU) and time on invasive mechanical ventilation for adult patients with COVID-19.
UPDATED
VA ESP
6/25/20
Tahvildari A, Arbabi M, Farsi Y, et al. | Front Med
Aim: To characterize the clinical, diagnostic, and treatment characteristics of patients presenting with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
6/25/20
 | ECRI
Aim: To provide guidance on ways to protect staff, measures to limit transmission, recommendations for COVID-19 testing for pregnant women and for infants born to infected mothers, and optimal maternal care and breastfeeding recommendations.
6/25/20
Saleem H, Rahman J, Aslam N, et al. | Cureus
Aim: To review the evidence on COVID-19 severity in children.
6/25/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of acquiring COVID-19 on an aircraft.
6/25/20
Pelland-St-Pierre L, Duquesne L | Center for Research in Public Health
Aim: To review the evidence on COVID-19 outbreaks in childcare centers and schools, including risk factors, symptoms, and attack rates.
6/25/20
Espinosa OA, Dos Santos Zanetti A, Antunes EF, et al. | Rev Inst Med Trop Sao Paulo
Aim: To calculate the prevalence and geographical distribution of comorbidities in all patients admitted to intensive care units (ICUs), and the mortality rate of COVID-19.
6/25/20
Qureshi Z, Jones N, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify the evidence behind the 2-metre social distancing rule in the context of the still used large vs. small (droplet vs airborne) droplet size dichotomy in route of transmission.
UPDATED
6/24/20
Polak SB, Van Gool IC, Cohen D, et al. | Mod Pathol
Aim: To increase our understanding of COVID-19 pathophysiology by constructing a timeline and correlating histopathological findings with clinical stages of COVID-19. 
CLINICAL CHARACTERISTICS
6/24/20
Matar R, Alrahamani L, Monzer N, et al. | Clin Infect Dis
Aim: To describe the clinical characteristics and perinatal outcomes of COVID-19 in pregnancy.
CLINICAL CHARACTERISTICS
6/24/20
Trippella G, Ciarcia M, Ferrari M, et al. | Pathogens
Aim: To provide a comprehensive overview of all the available data regarding clinical features, outcomes, and management of pregnant women with COVID-19. 
CLINICAL CHARACTERISTICS
6/24/20
Chou R, Dana T, Jungbauer R, et al. | Ann Intern Med
Aim: To examine the effectiveness of N95, surgical, and cloth masks in community and health care settings for preventing respiratory virus infections, and effects of reuse or extended use of N95 masks.
UPDATED
6/24/20
Pinzon RT, Wijaya VO, Buana RB, et al. | Front Neurol
Aim: To understand the neurologic characteristic of the disease and help physicians with early diagnosis and management.
CLINICAL CHARACTERISTICS
6/24/20
Gordon M, Kagalwala T, Rezk K, et al. | BMJ Paediatr Open
Aim: To carry out a systematic review of the available studies on COVID-19 (coronavirus disease 2019) in neonates seen globally since the onset of the COVID-19 global pandemic in 2020.
6/24/20
Xu L, Mao Y, Chen G, et al. | Aging
Aim: To systematically review evidence for the risk factors of COVID-19 patients progressing to critical illness.
6/24/20
Grant MC, Geoghegan L, Arbyn M, et al. | PLoS One
Aim: To determine the prevalence of symptoms associated with COVID-19 worldwide.
CLINICAL CHARACTERISTICS
6/24/20
Jones P, Roberts S, Hotu C, et al. | Emerg Med Australas
Aim: To determine the carriage of respiratory viruses on facemasks used by HCW.
6/23/20
Baksh M, Ravat V, Zaidi A, et al. | Cureus
Aim: To summarize the clinical presentation, laboratory and chest imaging findings, management protocols, and outcome of ARDS in COVID-19-positive patients.
CLINICAL CHARACTERISTICS
6/23/20
Gao Y, Liu R, Zhou Q, et al. | Ann Transl Med
Aim: To assess the effectiveness of telemedicine in reducing transmission of COVID-19 and reducing pressure on medical institutions.
UPDATED
6/23/20
Yang N, Che S, Zhang J, et al. | Ann Transl Med
Aim: To conduct a rapid review of mother-to-child transmission of COVID-19 during breastfeeding.
UPDATED
6/23/20
Ofori-Asenso R, Ogundipe O, Agyeman AA, et al. | Ecancermedicalscience
Aim: To examine the prevalence of cancer and its association with disease severity in patients with novel coronavirus disease 2019 (COVID-19).
6/23/20
Lv M, Wang M, Yang N, et al. | Ann Transl Med
Aim: To understand the role of CT for the diagnosis and the main imaging manifestations of patients with COVID-19.
UPDATED
DIAGNOSTICS
6/23/20
Wang Z, Zhou Q, Wang C, et al. | Ann Transl Med
Aim: To review the clinical characteristics of children with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
6/23/20
Huang D, Lian X, Song F, et al. | Ann Transl Med
Aim: To identify and treat the severe and critical patients with COVID-19 is the key clinical problem to be solved.
CLINICAL CHARACTERISTICS
6/23/20
Gold MS, Sehayek D, Gabrielli S, et al. | Postgrad Med
Aim: To evaluate comorbidities associated with severe and fatal cases of COVID-19.
6/23/20
Lu S, Zhou Q, Huang L, et al. | Ann Transl Med
Aim: To review the evidence on the use of glucocorticoids in treating COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Zhang J, Yang Y, Yang N, et al. | Ann Transl Med
Aim: To explore the clinical effectiveness and safety of IVIG in the treatment of children with severe COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Wang J, Tang Y, Ma Y, et al. | Ann Transl Med
Aim: To evaluate the efficacy and safety of antibiotic agents in children with COVID-19, as well as to introduce the present situation of antibiotics use and bacterial coinfections in COVID-19 patients. 
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Montesanti S, Silverstone P, Wells L, et al. | CIHR IRSC
Aim: To specifically understand the potential of trauma-focused virtual interventions that can rapidly be used to support domestic violence and sexual assault populations.
6/23/20
Alnor A, Sandberg MB, Gils C, et al. | J Appl Lab Med
Aim: To examine which routine laboratory tests are associated with severe COVID-19 disease.
CLINICAL CHARACTERISTICS
6/23/20
Zhou Q, Gao Y, Wang X, et al. | Ann Transl Med
Aim: To understand nosocomial infection in patients with COVID-19, SARS, and MERS.
UPDATED
6/23/20
Thulien N, Noble A, Daley M, et al. | CIHR IRSC
Aim: To review the evidence on promising mental health and substance use practices utilized by front-line providers serving young people who are experiencing or have experienced homelessness during the COVID-19 pandemic.
6/23/20
Shi Q, Zhou Q, Wang X, et al. | Ann Transl Med
Aim: To assess the potential effectiveness and safety of antiviral agents for COVID-19 in children. 
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Singh AK, Gillies CL, Singh R, et al. | Diabetes Obes Metab
Aim: To estimate the prevalence of both cardiometabolic and other co?morbidities in patients with COVID?19 infection, and to estimate the increased risk of severity and mortality in people with co?morbidities.
CLINICAL CHARACTERISTICS
6/23/20
Li W, Liao J, Li Q, et al. | Ann Transl Med
Aim: To review the evidence on how health providers should advise families and parents to obtain health education information during the COVID-19 pandemic.
6/23/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the effect of the COVID-19 pandemic on alcohol use and alcohol-related harms.
6/23/20
Prajapat M, Sarma P, Shekhar N, Avti P, Sinha S, Kaur H, Kumar S, Bhattacharyya A, Kumar H, Bansal S, Medhi B | Indian J Pharmacol
Aim: To review the structural basis of different target proteins of SARS-corona virus (CoV2) from a viral life cycle and from drug design perspective.
6/22/20
Goodarzi Z, Watt J, Kirkham J, et al | CIHR IRSC
Aim: To review the evidence on the effect of telehealth interventions on depression or depressive symptoms in older adults.
UPDATED
6/22/20
Best MW, Grossman M, Bowie C, et al. | TIP Research Lab
Aim: To review the evidence on interventions for schizophrenia-spectrum disorders for virtual delivery.
6/22/20
Lam R, Murphy J, Michalak E, et al. | CIHR IRSC
Aim: To review the evidence on at-risk groups and their mental health needs in the context of COVID-19 in the Asia Pacific Region and recommendations for improving access to digital mental health support.
6/22/20
Weiss J, Lee V, Aubaum C, et al. | CIHR IRSC
Aim: To review the evidence on the impact of the COVID-19 pandemic on caregiver and family functioning, and on mental health services response.
6/22/20
Karanasos A, Aznaouridis K, Latsios G, et al. | Nicotine Tob Res
Aim: To summarize relevant studies and quantify the impact of smoking on disease severity and mortality of hospitalized COVID-19 patients.
6/22/20
Armitage LC, Brettel R | Oxford COVID-19 Evidence Service Team
Aim: To review the current evidence on the use of inhaled corticosteroids to prevent the development of acute respiratory distress syndrome.
6/22/20
Carroll S, Collins B, Dolce M, et al. | CIHR IRSC
Aim: To review the evidence on how to prevent or mitigate mental health and substance use responses for those at risk of severe COVID-19 infection.
6/22/20
Hoang MP, Kanjanaumporn J, Aeumjaturapat S, et al. | Asian Pac J Allergy Immunol
Aim: To review the associations of olfactory and gustatory dysfunctions with COVID-19 which will be useful for early diagnosis and self-isolation. 
CLINICAL CHARACTERISTICS
6/22/20
Birnie KA, Noel M, Stinson J, et al. | CIHR IRSC
Aim: To review the evidence on virtual care solutions for pain, mental health, and substance use in youth with pre-existing and new onset pain actross the stepped care model during the COVID-19 pandemic.
6/22/20
Luo M, Guo L, Yu M, et al. | Psychiatry Res
Aim: To assess the psychological and mental impact of COVID-19 among healthcare workers, the general population, and patients with higher COVID-19 risk.
6/21/20
Kronbichler A, Kresse D, Yoon S, et al. | Int J Infect Dis
Aim: To summarize the presentation of asymptomatic COVID-19 infections.
CLINICAL CHARACTERISTICS
6/21/20
Parohan M, Yaghoubi S, Seraji A | Eur Heart J Acute Cardiovasc Care
Aim: To summarize available findings on the association between cardiac injury and severity of COVID-19 infection.
6/21/20
Kunustor SK, Laukkanen JA | J Infect
Aim: To review the evidence on the characteristics and prevalence of hepatic manifestations and complications of COVID-19
6/21/20
Ghannam MG, Alshaer QA, Al-Chalabi MAC, et al. | J Neurol
Aim: To clarify the neurological complications of SARS-CoV-2 infection including the potential mechanisms and therapeutic options.
UPDATED
6/21/20
Montana M, Montero V, Khoumeri O, et al. | Molecules
Aim: To compile and discuss recently published studies concerning the therapeutic potential of the antiviral activity of quinoxaline derivatives.
6/21/20
Bienvenu A, Marty AM, Jones MK, et al. | One Health
Aim: To analyze studies registered on ClinicalTrials.gov that study hydroxycholorquine as a COVID-19 prophylaxis.
6/20/20
Maldonado E, Tao D, Mackey K | J Gen Intern Med
Aim: To synthesize evidence on thromboembolism incidence and outcomes with antithrombotic therapies in COVID-19.
UPDATED
VA ESP
CANDIDATE THERAPEUTICS
6/20/20
Castro-Rodriguez JA, Forno E | Pediatr Pulmonol
Aim: To review the evidence on the role of asthma in children with COVID-19 and the risk of infection.
UPDATED
6/20/20
Shelmerdine S, Lovrenski J, Caro-Dominguez P, et al. | Pediatr Radiol
Aim: To systematically review available literature regarding imaging findings in paediatric cases of COVID-19.
CLINICAL CHARACTERISTICS
6/20/20
Raba AA, Abobaker A, Elgenaidi IS, et al. | Acta Pediatr
Aim: To evaluate the clinical characteristics of COVID?19 in neonates and children under one year of age.
CLINICAL CHARACTERISTICS
6/20/20
Nobar NN, Goodarzi A | Dermatol Ther
Aim: To review the evidence on the course of COVID-19 in patients with dermatologic disorders, and the most effective management strategies.
6/20/20
 | Health Technology, Wales
Aim: To reivew the evidence on the use of point-of-care ultrasound imaging for suspected and confirmed cases of COVID-19.
6/20/20
Yang X, Jin Y, Li R, et al. | Crit Care
Aim: To assess the prevalence of abnormal urine analysis and kidney dysfunction in COVID-19 patients and to determine the association of acute kidney injury (AKI) with the severity and prognosis of COVID-19 patients.
CLINICAL CHARACTERISTICS
6/20/20
Sacco G, Briere O, Asfar M, et al. | Geriatr Psychol Neurosychiatr Vieil
Aim: To identify, from international literature, the most common symptoms met in older adults infected with the SARS-CoV-2 virus.
CLINICAL CHARACTERISTICS
6/20/20
Xuefeng M, Shouseng L, Chen L, Zhuang L, et al. | J Med Virol
Aim: To investigate the clinical features of pediatric inpatients with SARS-CoV-2 infection.
CLINICAL CHARACTERISTICS
6/20/20
Waller JV, Allen IE, Lin KK, et al. | Invest Radiol
Aim: To stratify studies as high or low risk of bias to determine the true sensitivity of CT for severe acute respiratory syndrome coronavirus-2 infection
6/20/20
Piscitello GM, Kapania EM, Miller WD, et al. | JAMA Netw Open
Aim: To evaluate the number of publicly available US state guidelines for ventilator allocation and the variation in state recommendations for how ventilator allocation decisions should occur and to assess whether unique criteria exist for pediatric patients.
6/19/20
Prato AP, Conforti A, Almstrom M, et al. | Front Pediatr
Aim: To propose technical strategies to assist the pediatric surgeons to minimize the potential aerosolization of viral particles in COVID-19 patients undergoing urgent or emergent surgical treatment using laparoscopic approaches, based on the currently available literature.
6/19/20
Althobaiti S, Alharthi S, Moosa A, et al. | Int J Qual Res
Aim: To review the studies on patient perceptions of nursing care quality.
6/19/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the effect of the COVID-19 pandemic on opioid and substance use and related harms.
6/19/20
Lakhani HV, Pillai SS, Zehra M, et al. | Int J Environ Res Public Health
Aim: To provide insight on the pathogenesis and the transmission dynamics of CoVID-19 along with pharmacological and non-pharmacological intervention strategies to mitigate the clinical manifestation of this virus.
6/19/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the impact of COVID-19 on the mode and content of clinical education and current recommendations to address the impact.
6/19/20
Latalska M, Mackiewicz J | Ann Agric Environ Med
Aim: To review the evidence of ocular pathologies in asymptomatic COVID-19 patients.
CLINICAL CHARACTERISTICS
6/19/20
Gkiouras K, Nigdelis MP, Grammatikopoulou MG, et al. | Eur J Clin Invest
Aim: To assess the availability of open data and metrics and of articles pertaining to the COVID?19 outbreak in five high?impact journals.
6/18/20
Jameleddine M, Harzallah N, Jebali MC, et al. | Department of Evaluation Interventions and Health Technologies
Aim: To review the effectiveness and value of the use of spray booths for disinfectants on humans as a preventive measure at the entrance to establishments, with the aim of reducing the spread of SARS-CoV-2.
INFECTION CONTROL
6/18/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the safe use of pools for hydrotherapy or aquatic physiotherapy during COVID-19.
6/18/20
Chen Y, Shao S, Hsu C, et al. | Crit Care
Aim: To quantify the incidence of acute kidney injury in COVID-19 patients.
CLINICAL CHARACTERISTICS
6/18/20
Tabari P, Amini M, Moghadami M, et al. | Iran J Med Sci
Aim: To determine countries’ public responses to the epidemic of COVID-19 and how they developed administrative approaches towards the outbreak.
UPDATED
6/18/20
Chung TW, Sridhar S, Zhang AZ, et al. | Open Forum Infect Dis
Aim: To review the evidence on olfactory disturbances in COVID-19 patients.
CLINICAL CHARACTERISTICS
6/18/20
Novara G, Checcucci E, Crestani A, et al. | Eur Urol
Aim: To perform a systematic review of the literature and evaluate all the available studies on urological applications of telehealth.
INFECTION CONTROL
6/17/20
Grover A, Oberoi M | Eur Heart J Cardiovasc Pharmacother
Aim: To review the evidence on the continued use of angiotensin converting enzyme inhibitors (ACEI) and angtiotensin receptor blockers (ARBs) in patients with COVID-19.
UPDATED
6/17/20
Di Lorenzo G, Di Trolio R, Kozlakidis Z, et al. | Crit Rev Oncol Hematol
Aim: To review the evidence on the clinical outcomes of COVID-19-positive patients and the possible interactions between drugs used in experimental therapy of COVID-19 and commonly used antineoplastic drugs.
CANDIDATE THERAPEUTICS
6/17/20
Agarwal A, Basmaji J, Muttalib F, et al. | Can J Anaesth
Aim: To describe the efficacy and safety of HFNC in acute hypoxemic respiratory failure; and to determine the risk of dispersion, aerosol generation and associated transmission of COVID-19 with HFNC.
UPDATED
WHO COLLABORATIVE
6/17/20
Sharpe H | Alberta Health Services
Aim: To review the evidence on the safety and efficacy of video laryngoscopy in intubating patients with suspected or confirmed COVID-19.
6/17/20
Galang RR, Chang K, Strid P, et al. | Obstet Gynecol
Aim: To summarize the clinical presentation, course of illness, and pregnancy and neonatal outcomes in pregnant women with MERS-CoV, SARS-CoV, or SARS-CoV-2.
6/17/20
Lauvrak V, Juvet L | Norwegian Institute of Public Health
Aim: To identify any reported associations between increased severity of COVID-19 disease, and infection rates in populations postulated to be socially or economic vulnerable.
6/15/20
Souza, T, Nadal JA, Nogueira RJ, et al. | Pediatr Pulmonol
Aim: To describe the clinical, laboratorial and radiological characteristics of children with COVID-19. 
CLINICAL CHARACTERISTICS
6/15/20
Raymond C, Loshak H | CADTH
Aim: To describe the trial characteristics and estimated primary completion dates of the ongoing phase II, phase III, and phase IV studies evaluating IVIg and hyperimmune globulin to treat COVID-19.
6/15/20
Pavan N, Crestani A, Abrate A, et al. | Eur Urol Focus
Aim: To evaluate the risk of virus spread due to surgical smoke during surgical procedures.
6/15/20
Barbosa DJ, Gomes MP, Souza BA, et al. | Comun. ciênc. saúde
Aim: To identify the main psychological effects of the COVID-19 pandemic on nursing professionals; describe the main factors capable of generating psychological stress in nursing professionals, describe the coping strategies to combat emotional stress.
6/15/20
Bornstein S | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the psychological impact of self-isolation on older adults living in the community.
6/15/20
Wang B & Huang Y | Crit Rev Oncol Hematol
Aim: This study will explore which type of cancer patients are more susceptible to the SARS-COX-2
CLINICAL CHARACTERISTICS
6/15/20
Wang B, Huang Y | Crit Rev Oncol Hematol
Aim: To explore which type of cancer patients are more susceptible to the SARS-CoV-2.
CLINICAL CHARACTERISTICS
6/14/20
Heldwein FL, Loeb S, Wroclawski ML, et al. | Eur Urol Focus
Aim: To summarize guidelines and recommendations on the urology standard of care during the COVID-19 pandemic.
6/14/20
Velev V, Popov M, Velikov P, et al. | Infez Med
Aim: To describe the incidence and type of the gastrointestinal injury (GI) in COVID-19, as well as their prognostic value.
CLINICAL CHARACTERISTICS
6/14/20
Heidary F, Gharebaghi R | J Antibiot (Tokyo)
Aim: To summarize the antiviral effects of ivermectin by reviewing available in vivo and in vitro studies over the past 50 years.
CANDIDATE THERAPEUTICS
6/14/20
Bonilla-Aldana DK, Cardona-Trujillo MC, García-Barco A, et al. | Infez Med
Aim: To review the evidence on the role of animals as potential reservoirs for MERS-CoV and SARS-CoV.
UPDATED
6/14/20
Samidoust P, Samidoust A, Samadani AA, et al. | Infez Med
Aim: To investigate the incidence of liver injury among published literature from 2019-Jan-01 to 2020-April-03 to provide an outline for further studies on the liver injury of COVID-19. 
6/14/20
Yamada T, Wakabayashi M, Yamaji T, et al. | Clin Chim Acta
Aim: To investigate the association between severe COVID-19 and a change in white blood cell (WBC) count, an elevation of C-reactive protein (CRP), and fever, and to evaluate the diagnostic accuracy of leukocytosis and an elevation of CRP.
CLINICAL CHARACTERISTICS
6/13/20
Xin S, Xu J, Yu Y | J Gastrointestin Dis
Aim: To compare the risk of abnormal liver function tests between severe and non-severe patients with coronavirus disease 2019 (COVID-19) by meta-analysis.
CLINICAL CHARACTERISTICS
6/13/20
Wang L, Shen Y, Li M, et al. | J Neurol
Aim: To systematically collect and investigate the clinical manifestations and evidence of neurological involvement in COVID-19.
CLINICAL CHARACTERISTICS
6/13/20
Zhu T, Xu A, Bai X, et al. | Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Aim: To systematically review evidence for the effect of convalescent plasma and immunoglobulin on treatment of severe acute respiratory syndrome (SARS), and further provide advice on the treatment of coronavirus disease 2019 (COVID-19).
CANDIDATE THERAPEUTICS
6/13/20
Walker KF, O'Donoghue K, Grace N, et al. | BJOG
Aim: To estimate the risk of the neonate becoming infected with SARS-COV-2 by mode of delivery, type of infant feeding and mother-infant interaction. 
6/13/20
Patel NA | Am J Otolaryngol
Aim: To elucidate a better understanding of the global impact of COVID-19 on the pediatric population.
6/12/20
Almufarrij I, Uus K, Munro KJ | Int J Audiol
Aim: To investigate audio-vestibular symptoms associated with coronavirus.
UPDATED
CLINICAL CHARACTERISTICS
6/12/20
 | Public Health Agency of Canada
Aim: To summarize the literature on associations of ethnicity with risk of infection, severity and mortality to COVID-19.
6/12/20
 | Public Health Agency of Canada
Aim: To review the evidence on characteristics of the workplace that can increase the risk of COVID-19 transmission.
6/12/20
Parasa S, Desai M, Chandrasekar VT, et al. | JAMA Netw Open
Aim: To provide a pooled estimate of GI symptoms, liver enzyme levels outside reference ranges, and fecal tests positive for SARS-CoV-2 among patients with COVID-19.
CLINICAL CHARACTERISTICS
6/12/20
Erdmann R | Alberta Health Services
Aim: To review the evidence on the effectivness of workplace screening programs for reducing the spread of COVID-19 in healthcare settings.
6/12/20
 | National Collaborating Centre for Methods and Tools
Aim: To identify, appraise, and summarize emerging research evidence on the efficacy and cost-effectiveness of copper materials to reduce transmission of the virus.
6/12/20
 | National Collaborating Centre for Methods and Tools
Aim: To identify, appraise, and summarize emerging research evidence on the effectiveness of cohorting virus-positive residents to shared rooms in care facilities.
6/12/20
Chiesa-Estomba CM, Lechien JR, Calvo-Henriquez C, et al. | Oral Oncol
Aim: To summarize in a systematic way the available recommendations from 18 guidelines from all over the world.
UPDATED
6/12/20
 | Malaysian Health Technology Assessment Section
Aim: To provide scientific evidence on the use of XPEL® RX silver ion protection film for COVID-19 based on a request from the Medical Care Quality Section (MOH) following a proposal from a company to introduce the technology.
6/11/20
 | Public Health Agency of Canada
Aim: To review the evidence on SARS-CoV-2 transmission in dental settings, and the infection transmission risk from aerosol generating procedures use in dental care?
6/11/20
Bresee L, MacDougall D | CADTH
Aim: To describe the epidemiology of venous thromboembolism (VTE), review the evidence on the use of pharmacologic thromboprophylaxis for the prevention of VTE, and list ongoing trials.
6/10/20
Bhaumik S, Moola S, Tyagi J, et al. | BMJ Glob Health
Aim: To examine the evidence to inform the potential role, enablers and barriers for community health workers during COVID-19 prevention and control from the National Health Systems Resource Centre (NHSRC), India.
6/10/20
 | ECRI
Aim: To review the evidence on the optimal timing for performing tracheotomy in patients with acute respiratory failure.
6/10/20
Iversen BG, Vestrheim DF, Flottorp S, et al. | Norwegian Institute of Public Health
Aim: To review the evidence on the use of face masks by people in the community to reduce the spread of COVID-19.
6/10/20
Pelland-St-Pierre L, Cortes JB | Center for Research in Public Health
Aim: To review the evidence on the impact of contact time, distance between contacts, and the environment on the probablity of transmission of the coronavirus between humans.
6/10/20
Marra DE, Hamlet KM, Bauer RM, et al. | Clin Neuropsychol
Aim: To review the evidence on the effectiveness of teleneuropsychology for older adults.
UPDATED
INFECTION CONTROL
6/10/20
Waddell K, Wilson MG, Bullock HL, et al. | McMaster University Health Forum
Aim: To review the evidence on pandemic-related mental health and addictions issues have emerged and what indicators and strategies can be used to monitor and address them.
6/10/20
Zhang L, Peres TG, Silva MVF, et al. | Pediatr Pulmonol
Aim: To summarize what we know so far about coronavirus disease (COVID?19) in children.
CLINICAL CHARACTERISTICS
6/9/20
MacIntyre CR, Chughtai AA | Int J Nurs Stud
Aim: To review the evidence around the efficacy of masks and respirators for healthcare workers, sick patients and the general public.
INFECTION CONTROL
6/9/20
Wan S, Li M, Ye Z, et al. | Acad Radiol
Aim: To assess the prevalence of significant computed tomographic(CT) manifestations and describe some notable features based on chest CT images, as well as the main clinical features of patients with coronavirus disease 2019(COVID-19).
CLINICAL CHARACTERISTICS
6/9/20
Patel TK, Barvaliya M, Kevadiya BD, et al. | J Neuroimmune Pharmacol
Aim: To find out early trends of mortality in COVID-19 patients treated with hydroxychloroquine based on published literature.
CANDIDATE THERAPEUTICS
6/9/20
 | Health Information and Quality Authority, Ireland
Aim: To review the international evidence on immunity and the spread of the virus by children.
UPDATED
6/9/20
Ashcroft J, Byrne MHV, Brennan PA, et al. | Postgrad Med J
Aim: To identify pandemic and disaster medicine-themed training programmes aimed at medical students and to assess whether these interventions had an effect on objective measures of disaster preparedness and clinical outcomes.
6/9/20
Huntley BJF, Huntley ES, Di Mascio D, et al. | Obstet Gynecol
Aim: To ascertain the frequency of maternal and neonatal complications, as well as maternal disease severity, in pregnancies affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
UPDATED
6/9/20
Nasir M, Talha KA, Islam T, et al. | Mymensingh Med J
Aim:  To evaluate the available evidence on efficacy, safety to identify any promising role for compassionate use of remdesivir in patient suffered for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as re-purposeful use. 
CANDIDATE THERAPEUTICS
6/8/20
Carver C, Jones N | Oxford COVID-19 Evidence Service Team
Aim: To determine if there are any known risk factors for ARDS in this infection and whether there are any interventions to prevent ARDS developing.
6/8/20
Parohan M, Yaghoubi S, Seraj A, et al. | Aging Male
Aim: To summarize available findings on the association between age, gender, comorbidities and risk of death from COVID-19 infection.
UPDATED
6/8/20
Lima WG, Brito J, Overhage J, et al. | Arch Virol
Aim: To describe the drug repositioning strategy against SARS-CoV-2 and to discuss the clinical impact of this approach in the current pandemic context. 
CANDIDATE THERAPEUTICS
6/8/20
Williams S | Newfoundland and Laborador Centre for Applied Health Research
6/7/20
Kunutsor S, Laukkanen | J Infect
Aim: To review the evidence on cardiovascular complications associated with COVID-19.
UPDATED
6/7/20
Dedeilia A, Sotiropoulos MG, Hanrahan JG, et al. | In Vivo
Aim: To identify the challenges imposed on medical and surgical education by the COVID-19 pandemic, and the proposed innovations enabling the continuation of medical student and resident training. 
6/7/20
Loades ME, Chatburn E, Higson-Sweeney N, et al. | J Am Acad Child Adolesc Psychiatry
Aim: To establish what is known about how loneliness and disease containment measures impact on the mental health in children and adolescents.
6/6/20
Romoli M, Jelcic I, Bernard-Valnet R, et al. | Eur J Neurol
Aim: To  review available evidence for reports of neurological signs and symptoms in Coronavirus disease (COVID)-19 patients to identify cases with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection or immune-mediated reaction in the nervous system.
CLINICAL CHARACTERISTICS
6/6/20
Alimohamadi Y, Taghdir M, Sepandi M | J Prev Med Public Health
Aim: To estimate the pooled R0 for COVID-19 in the current outbreak.
6/6/20
Mohamed MFH, A-Shokri S, Yousaf Z, et al. | Am J Trop Med Hyg
Aim: To pool the proportion of various reported lung abnormalities detected by LUS in symptomatic COVID-19 patients. 
CLINICAL CHARACTERISTICS
6/6/20
Quah P, Li A, Phua J | Crit Care
Aim: To review the outcomes of ICU patients with COVID-19 from the existing literature.
6/5/20
Pormohammad A, Ghorbani S, Baradaran B, et al. | Rev Med Virol
Aim: To review the evidence on clinical and laboratory characteristics of COVID-19 infected patients.
UPDATED
CLINICAL CHARACTERISTICS
6/5/20
Lahiri A, Jha SS, Bhattacharya S, et al. | Indian J Public Health
Aim: To understand the effectiveness of NPIs reported in the contemporary literatures describing prediction models for prevention of the ongoing pandemic of SARS-CoV-2 specifically in Indian population.
6/5/20
Aggarwal N, Dwarakanathan V, Gautam N, et al. | Indian J Public Health
Aim: To estimate the effectiveness of facemask use alone or along with hand hygiene in community settings in reducing the transmission of viral respiratory illness.
INFECTION CONTROL
6/5/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the transmission of COVID-19 to and from healthcare professionals and strategies to reduce risk of nosocomial infections of COVID-19.
6/5/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on isolation periods other than 14 days in response to COVID-19 in various jurisdictions.
6/5/20
Leal J | Alberta Health Services
Aim: To review the evidence on the transmission of SARS-CoV-2 virus through heating, ventiliation, and air conditioning (HVAC) systems in hospitals or non-hospital settings.
6/5/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the duration from expsoure to symptoms or diagnosis for COVID-19.
6/5/20
Mackey S, Warren C, Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the approaches being taken to mitigate the risks associated with reopening establishments that provide personal services.
6/5/20
Bhagavathula AS, Aldhaleei WA, Rovetta A, et al. | Cureus
Aim: To extract and summarize information on potential vaccines and therapeutic agents against COVID-19 at different stages of clinical trials from January to March 2020.
CANDIDATE THERAPEUTICS
6/5/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence regarding temporary workforce reconfigurations such as splitting of teams and establishing social distancing protocols within teams to minimise staff exposure to COVID-19.
UPDATED
6/4/20
Rosenwohl-Mack A, Schumacher K, Fang ML, et al. | Int J Nurs Stud
Aim: To synthesize the evidence on experiences of aging in place in the United States.
6/4/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the use of computed tomography in patients with COVID-19.
6/4/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the infection rate, infectivity and transmission of COVID-19 in children?
6/4/20
Ye Z, Wang Y, Colunga-Lozano LE, et al. | CMAJ
Aim: To examine the impact of corticosteroids in COVID-19 and related severe acute respiratory illnesses to support a guideline for managing COVID-19.
CANDIDATE THERAPEUTICS
6/4/20
Byambasuren O, Cardona M, Bell K, et al. | medRxiv
Aim: To synthesize all available research on the asymptomatic rates and transmission rates where possible. 
6/4/20
Pranata R, Lim MA, Huang I, et al. | J Renin Angiotensin Aldosterone Syst
Aim: To investigate the association between hypertension and outcome in patients with Coronavirus Disease 2019 (COVID-19) pneumonia.
6/4/20
Pranata R, Huang I, Lim MA, et al. | J Stroke Cerebrovasc Dis
Aim: To evaluate the latest evidence on the association between cerebrovascular, cardiovascular disease, and poor outcome in patients with Coronavirus Disease 2019 (COVID-19) pneumonia.
6/4/20
Abdollahpour S, Khadivzadeh T | J Matern Fetal Neonatal Med
Aim: To improve the quality of care by health providers through what they need to know about coronavirus during pregnancy and childbirth.
6/4/20
Smith V, Deo D, Warty R, et al. | PLoS One
Aim: To systematically evaluate the literature and report the maternal and neonatal outcomes associated with COVID-19.
6/4/20
Santos VS, Gurgel RQ, Cuevas LE, et al. | J Pediatr Gastroenterol Nutr
Aim: To investigate differences in viral shedding in respiratory and fecal samples from children with COVID-19.
6/4/20
Zhang JJY, Lee KS, Ang LW, et al. | Clin Infect Dis
Aim: To review the evidence on predictors of severe disease and the efficacy of different treatments for COVID-19.
6/4/20
 | Health Technology, Wales
Aim: To review the evidence on the safety of personal protective equipment gowns for health and social care workers.
6/4/20
Mitchell S, Maynard V, Lyons V et al. | Oxford COVID-19 Evidence Service
Aim: To review the evidence on the role and response of primary care and community nursing services in the delivery of palliative care in epidemics and pandemics.
6/3/20
Yang M, Shang Y, Tian Z, et al. | Integr Med Res
Aim: To review the study characteristics of registered clinical trials on COVID-19 and provide guidance for future trials to avoid duplicated effort.
6/3/20
Nacif LS, Zanini LY, Waisberg DR, et al. | Clinics (Sao Paulo)
Aim: To collate available data on COVID-19 infection in solid organ transplantation (SOT) patients.
6/3/20
Vindegaard N, Benros ME | Brain Behav Immun
Aim: To systematically review the literature in order to provide an overview of the psychiatric complications to COVID-19 infection (direct effect) and how COVID-19 are currently affecting mental health among psychiatric patients and general public (indirect effect) alongside with factors altering the risk of psychiatric symptoms in both groups.
6/3/20
Liu W, Zhou P, Chen K, et al. | CMAJ
Aim: To support the development of a COVID-19 management guideline by reviewing evidence that addressed the benefits and harms of 7 antiviral treatments for COVID-19.
CANDIDATE THERAPEUTICS
6/3/20
Huang I, Pranata R | J Intensive Care
Aim: To investigate the association of lymphocyte count on admission and the severity of COVID-19.
CLINICAL CHARACTERISTICS
6/3/20
 | INESSS Quebec
6/3/20
Vestrheim DF, Iversen BG, Flottorp S, et al. | Norwegian Institute of Public Health
Aim: To review the evidence on the use of facemasks by asymptomatic personnel in long-term care facilities for primary prevention of COVID-19 infection.
6/3/20
Iannone P, Castellini G, Coclite D, et al. | PLoS One
Aim: To assess the efficacy of N95 respirators versus surgical masks for the prevention of respiratory tract infections transmission among HCWs.
UPDATED
6/3/20
LoPresti M, Beck DB, Duggal P, et al. | Am J Hum Genet
Aim: To review the literature on host genetic factors related to coronaviruses, with a systematic focus on human studies.
CLINICAL CHARACTERISTICS
6/2/20
Raymond M, Ching-A-Sue G, Van Hecke O | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on mast cell stabilizers, leukotriene antagonists, and antihistimines in COVID-19.
UPDATED
6/2/20
Hossain M, Sultana A, Purohit N | Epidemiol Health
Aim: To synthesize the available evidence on mental health outcomes of quarantine and isolation for preventing infectious diseases.
UPDATED
6/2/20
Boyd J, Davis A | Alberta Health Services
Aim: To review the various models, scenarios and thresholds that have been used internationally from past pandemics.
6/2/20
Liu M, Gao Y, Zhang Y, et al. | J Infect
Aim: To review the evidence on the assocation between severe or death COVID-19 and autoimmune disease.
6/1/20
Bolton L, Mills C, Wallace S, et al. | Int J Lang Commun Disord
Aim: To review the evidence underpinning the current healthcare policies in relation to AGPs, dysphagia assessment, and risk of transmission of and infection with COVID?19 in response to urgent clinical information needs.
6/1/20
Sanna G, Serrau G, Bassareo PP, et al. | Eur J Pediatr
Aim: To summarize all COVID-19 cases with a cardiac involvement published in paediatric age and explain the underlying mechanisms responsible for COVID-19-related myocardial damage.