COVID-19 Evidence Reviews
as of 8/13/20
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Our goal of cataloging COVID-19 evidence reviews is to capture the work of evidence synthesis groups in the US and around the world to maximize our collective contributions to patients, frontline clinicians, researchers, and policymakers during the COVID-19 pandemic and avoid duplicating efforts. This catalog is maintained by staff at the VA Evidence Synthesis Program based in Portland, OR. We identify new evidence reviews and reviews in progress through literature searching and through correspondence with colleagues and content experts. You can download data on selected files by following the instructions on the About Us page. We welcome your feedback and questions; please reach out to us at covid19reviews@gmail.com
Completed Reviews
 
= living review
= meets mimimum quality standards   |  

A review with this mark was peer-reviewed, described systematic search and study selection, and included critical appraisal of primary studies.
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8/12/20
Davalbhakta S, Advani S, Kumar S, et al. | J Med Syst
Aim: To provide an overview of mobile applications being currently utilized for COVID-19 related activities.
RECENTLY UPDATED
8/12/20
Samanta A, Shetty A, Nelson PC | J Telemed Telecare
Aim: To conduct a systematic literature review of the accuracy and effectiveness of available portable automated refractors compared to the current standard of care, subjective refraction (SR).
8/12/20
Moosavi SA, Mashhadiagha A, Hashemazar A, et al. | Transpl Infect Dis
Aim: to conduct a systematic review on COVID?19 clinical manifestations and treatment strategies in SOT recipients.
RECENTLY UPDATED
8/12/20
Kasperkiewicz M | J Am Acad Dermatol
Aim: To review the evidence on how the COVID-19 pandemic affects patients with autoimmune bullous diseases.
8/11/20
Sarkar S, Soni KD, Khanna P | J Med Virol
Aim: To evaluate the impact of CPT in COVID-19 patients based on the publications reported to date.
8/11/20
Almutairi A, Alfaleh M, Alasheikh M | Cureus
Aim: To evaluate the medical literature and explore the dermatological clinical manifestations in patients with SARS-CoV-2.
8/11/20
Jain VK, Lal H, Patralekh MT, et al. | J Clin Orthop Trauma
Aim: To evaluate the fracture types, presentation, treatment, complications, and early outcomes of fractures occurring amidst COVID-19 pandemic.
8/11/20
Jones L, Candy B, Roberts N, Ondruskova T, et al | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the management of delirium in patients with COVID-19 and the use of non-pharmacological approaches outside of critical care settings.
RECENTLY UPDATED
8/11/20
Katal S, Johnston SK, Johnston JH, et al. | Acad Radiol
Aim: To review the radiological characteristics of COVID-19 in pediatrics.
8/11/20
Mahendiratta S, Batra G, Sarma P, et al. | Life Sci
Aim: To evaluate the effectiveness of the molecular detection techniques in COVID-19. 
8/11/20
Robbins-Jaurez SY, Qian L, King KL, et al. | Kidney Int Rep
Aim: To assess the incidence of AKI among patients with COVID-19 and examine their associations with patient outcomes as reported in the available literature thus far.
8/11/20
da Silva FCT, Neto MLR | Prog Neuropsychopharmacol Biol Psychiatry
Aim: To review the evidence on the psychiatric repercussions in health professionals that work in health systems to fight the clinical implications caused by COVID-19.
8/11/20
da Silva FCT, Neto MLR | Prog Neuropsychopharmacol Biol Psychiatry
Aim: To analyze the main psychological effects caused by the COVID-19 pandemic in health professionals.
8/11/20
Sheraton M, Deo N, Dutt T, et al. | Psychiatry Res
Aim: To compare the incidences of psychological issues during the COVID-19 pandemic, such as anxiety, depression, occupational stress, PTSD and insomnia, in healthcare workers (HCW) and non-healthcare workers (NHCW). 
8/11/20
Chen C, Pan K, Wu B, et al. | Eur J Clin Pharmacol
Aim: To evaluate the safety of HCQ in the treatment of COVID-19 and other diseases by performing a systematic review and meta-analysis.
8/11/20
D'Amico F, Danese S, Peyrin-Biroulet L | Clin Gastroenterol Hepatol
Aim: To investigate symptoms and diagnostic-therapeutic management of IBD patients with COVID-19.
8/11/20
Licina A, Silvers A, Stuart RL  | Syst Rev
Aim: To evaluate the effect of powered air-purifying respirators (PAPRs) as part of respiratory protection versus another device (egN95/FFP2) on HCW infection rates and contamination.
RECENTLY UPDATED
8/10/20
Abrams JY, Godfred-Cato SE, Oster ME, et al. | J Pediatr
Aim: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C).
8/9/20
Cui X, Zhao Z, Zhang T, et al. | J Med Virol
Aim: To provide a comprehensive and systematic analysis of demographic characteristics, clinical symptoms, laboratory findings and imaging features of coronavirus disease 2019 (COVID-19) in pediatric patients.
RECENTLY UPDATED
8/9/20
Jutzeler CR, Bourguignon L, Weis CV, et al. | Travel Med Infect Dis
Aim: To gather all available information regarding comorbidities, clinical signs and symptoms, outcomes, laboratory findings, imaging features, and treatments in patients with coronavirus disease 2019 (COVID-19).
RECENTLY UPDATED
8/9/20
Neumann-Podczaska A, Al-Saad SR, Karbowski LM, et al. | Aging Dis
Aim: To concisely summarize the clinical features, comorbidities, radiological/laboratory findings, and outcomes in the older adults. 
8/9/20
Hoang A, Chorath K, Moreira A, et al. | EClinicalMedicine
Aim: To characterize clinical symptoms, laboratory, and imaging findings, as well as therapies provided to confirmed pediatric cases of COVID-19.
RECENTLY UPDATED
8/9/20
Xu X, Shi Y, Wang R, et al. | Integr Med Res
Aim: To comprehensively summarize and analyze the current guidelines on home-based traditional Chinese medicine (TCM) nursing interventions for discharged patients with COVID-19.
8/9/20
Wu T, Zuo Z, Deng M | Aging Dis
Aim: To provide systematic evidence for the association between multiorgan dysfunction and COVID-19 development.
RECENTLY UPDATED
8/9/20
Cooke JE, Eirich R, Racine N, et al. | Psychiatry Res
Aim: To review the evidence on posttraumatic stress and general psychological stress symptoms during COVID-19.
8/9/20
Samaranayake L, Fakhruddin K, Panduwawala C | Acta Odontol Scand
Aim: To evaluate the contemporary evidence on dysgeusia and anosmia as trigger prodromal symptoms, and their prevalence in COVID-19 patients.
RECENTLY UPDATED
8/9/20
Haider Z, Aweid B, Subramanian P, et al. | J Telemed Telecare
Aim: To explore evidence for telemedicine in orthopaedics to determine its advantages, validity, effectiveness and utilisation.
8/9/20
Sanchez-Ramirez DC, Mackey D | Respir Med
Aim: To explore the association of underlying respiratory diseases and smoking with severe outcomes in patients with COVID-19 infection.
8/9/20
Barochiner J, Martinez R | J Clin Pharm Ther
Aim: To compare the occurrence of severe and fatal COVID-19 in infected patients who were under treatment with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) vs no treatment or other antihypertensives.
RECENTLY UPDATED
8/9/20
Baladia E, Pizarro AB, Ortiz-Munoz L, et al. | Medwave
Aim: To provide a timely, rigorous, and continuously updated summary of the available evidence on the role of vitamin C in treating patients with COVID-19.
RECENTLY UPDATED
8/7/20
Zheng B, Wang H, Yu C | Pediatr Pulmonol
Aim: To systematically review the current situation and public health burden associated with children infected with SARS-CoV2.
8/7/20
Liu X, Long C, Ziong Q, et al. | Clin Cardiol
Aim: To review the current evidence and assess the clinical prognosis of COVID?19 patients with or without hypertension treated with ACEs/ARBs.
8/7/20
Wu X, Liu L, Jiao J, et al. | Ann Med
Aim: To review the evidence on clinical, laboratory and imaging factors related to mild vs. severe COVID-19 infection.
8/7/20
De Sanctis P, Doneddu PE, Vigano L, et al. | Eur J Neurol
Aim: To identify specific clinical features of GBS associated with COVID-19.
8/7/20
Salunke AA, Nandy K, Pathak PK, et al. | Diabetes Metab Syndr
Aim: To evaluate the impact of cancer on serious events including ICU admission rate and mortality in COVID 19.
8/7/20
Chi G, Lee JJ, Jamil A, et al. | J Clin Med
Aim: To offer benchmark data on the incidence of VTE and to examine the difference in D-dimer levels among anticoagulated COVID-19 patients with and without VTE incident. 
RECENTLY UPDATED
8/6/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the extended use or re-use of personal protective equipment (PPE) during COVID-19.
RECENTLY UPDATED
8/6/20
Tariq R, Saha S, Furqan F, et al. | Mayo Clin Proc
Aim: To evaluate the prevalence of gastrointestinal (GI) symptoms and mortality in patients with coronavirus disease 2019 (COVID-19) diagnosed.
8/6/20
Agyeman AA, Chin KL, Landersdorfer CB, et al. | Mayo Clin Proc
Aim: To estimate the prevalence of olfactory and gustatory dysfunctions (OGDs) among patients infected with novel coronavirus disease 2019 (COVID-19).
8/5/20
Kariyanna PT, Sutarjono B, Grewal E, et al. | Am J Med Case Rep
Aim: To identify the clinical features of myocarditis in COVID-19 patients.
8/5/20
Pei L, Zhang S, Huang L, et al. | Pol Arch Intern Med
Aim: To evaluate the impact of drug therapy on the risk of death in patients with COVID-19.
8/5/20
 | Public Health Agency of Canada
Aim: To review the evidence for age-dependent transmission of SARS-CoV-2.
8/5/20
Kumar A, Arora A, Sharma P, et al. | Indian J Gastroenterol
Aim: To determine the frequency of GI and hepatic manifestations of COVID-19 and to explore their relationship with severe clinical course.
RECENTLY UPDATED
8/5/20
Ghahramani S, Tabrizi R, Lankarani KB, et al. | Eur J Med Res
Aim: To understand the common laboratory features of COVID-19 in severe cases versus non-severe patients could be quite useful for clinicians and might help to predict the model of disease progression.
RECENTLY UPDATED
8/5/20
Reddy RK, Charles WN, Sklavounos A, et al. | J Med Virol
Aim: To rigorously and definitively quantify the effects of smoking on COVID-19 severity.
RECENTLY UPDATED
8/5/20
Mansourabadi AH, Sadeghalvad M, Mohammadi-Motlagh H, et al. | Life Sci
Aim: To describe the role of the immune system in response to COVID-19.
8/5/20
Desiato VM, Levy DA, Byun YJ, et al. | Am J Rhinol Allergy
Aim: To perform a systematic review and meta-analysis of the prevalence of OD in the healthy general population, review the various assessment metrics used, and compare pooled OD prevalence rates.
8/5/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the symptoms and incidence for vascular events in patients with COVID-19.
8/5/20
Hasan SS, Radford S, Kow CS, et al. | J Thromb Thrombolysis
Aim: To systematically review the available evidence to help guide clinicians weighing up decisions regarding the anticoagulation approach for COVID-19 patients admitted to intensive care units.
8/4/20
Gao Y, Ye L, Zhang J, et al. | BMC Infect Dis
Aim: To systematically review the clinical features and outcomes of pregnant women with COVID-19.
RECENTLY UPDATED
8/4/20
Yoon SH, Kang J, Ahn JG | Eur Rev Med Pharmacol Sci
Aim: To evaluate the clinical manifestations and outcomes of neonates born to women who had Coronavirus Disease 2019 (COVID-19) during pregnancy.
8/4/20
Kay JK, Parsel SM, Marsh JJ, et al. | JAMA Otolaryngol Head Neck Surg
Aim: To review evidence on the risks of aerosolization and transmission of SARS-CoV-2 from patients to health care personnel during endoscopy of the upper aerodigestive tract.
8/4/20
Elgohary G | Hematol Oncol Stem Cell Ther
Aim: To evaluate the impact of COVID-19 infection on cancer patients. 
8/4/20
Khan S, Gionfriddo MR, Cortes-Penfield N, et al. | Expert Opin Pharmacother
Aim: To synthesize the literature on COVID-19 pharmacotherapy to inform practice and policymaking.
8/3/20
Shao M, Li X, Liu F, et al. | Pharmacol Res
Aim: To investigate whether the presence of acute kidney injury (AKI) might increase the risk of severe infection and fatality in COVID-19 patients.
CLINICAL CHARACTERISTICS
8/3/20
Putman M, Chock YPE, Tam H, et al. | Arthritis Rheumatol
Aim: To identify and summarize research that describes the use of antirheumatic disease therapies for the treatment of COVID-19.
CANDIDATE THERAPEUTICS
8/3/20
Wu B, Gu D, Yu J, et al. | Infect Genet Evol
Aim: To delve into the association between ABO blood group and COVID-19 infection, severity and demise.
CLINICAL CHARACTERISTICS
8/3/20
Carlo D, Montemurro N, Petrella G, et al. | J Neurol
Aim: To review the evidence on the spectrum of neurological symptoms experienced by COVID-19 patients.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
8/3/20
Zuin M, Rigatelli G, Zuliani G, et al. | J Cardiovasc Med
Aim: To investigate the relationship between ACI and mortality risk in COVID-19 patients.
CLINICAL CHARACTERISTICS
8/3/20
Rocke J, Hopkins C, Philpott C, et al. | Clin Otolaryngol
Aim: To systematically review the currently available evidence investigating the association between olfactory dysfunction (OD) and the novel coronavirus (COVID-19).
CLINICAL CHARACTERISTICS
8/3/20
Kotlyar A, Grechukihina O, Chen A, et al | Am J Obstet Gynecol
Aim: To determine estimates of vertical transmission of COVID-19 based upon early RNA detection of SARS-CoV-2 after birth from various neonatal/fetal sources and neonatal serology.
CLINICAL CHARACTERISTICS
8/2/20
Sahu AK, Amrithanand VT, Mathew R, et al. | Am J Emerg Med
Aim: To determine the proportion of HCW who were COVID-19 positive among all the COVID-19 patients. 
8/2/20
de Siqueira JVV, Almeida LG, Zico BO | Obes Res Clin Pract
Aim: To assess whether there was an association between obesity and higher levels of hospitalization, poor outcomes and mortality due to the disease of novel coronavirus (COVID-19).
CLINICAL CHARACTERISTICS
8/2/20
Rooney S, Webster A, Paul L | Phys Ther
Aim: To 1) compare physical function and fitness outcomes in people infected with SARS-CoV to healthy controls; 2) quantify the recovery of physical function and fitness following SARS-CoV infection; 3) determine the effects of exercise following SARS-CoV infection.
CLINICAL CHARACTERISTICS
8/2/20
Volpe M, Battistoni A | Int J Cardiol
Aim: To review the evidence on the potential role of renin-angiotensin system inhibitors, specifically angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, with regard to COVID-19 disease and mortality.
CANDIDATE THERAPEUTICS
8/2/20
Harrop E, Mann M, Semedo L, et al. | Palliat Med
Aim: To synthesise the evidence regarding system-level responses to mass bereavement events, including natural and human-made disasters as well as pandemics, to inform service provision and policy during the COVID-19 pandemic and beyond.
8/1/20
Qiu P, Zhou Y, Wang F, et al. | Aging Clin Exp Res
Aim: To find risk factors for the COVID-19-related death, helping to enhance the efficacy and reduce the mortality of COVID-19.
CLINICAL CHARACTERISTICS
8/1/20
Awulachew E, Diriba K, Anja A, et al. | Radiol Res Pract
Aim: To systematically analyze the existing literature on CT imaging features of patients with COVID-19 pneumonia.
CLINICAL CHARACTERISTICS
8/1/20
Mirzaei H, McFarland W, Karamouzian M, et al. | AIDS Behav
Aim: To review the evidence on the earliest patients with COVID-19-HIV co-infection.
CLINICAL CHARACTERISTICS
8/1/20
Siemieniuk RAC, Bartoszko JJ, Ge L, et al. | BMJ
Aim: To compare the effects of treatments for coronavirus disease 2019 (covid-19).
CANDIDATE THERAPEUTICS
8/1/20
Hasan SS, Capstick T, Ahmed R, et al. | Expert Rev Respair Med
Aim: To review ARDS-associated mortality and the potential role of systemic corticosteroids in COVID-19 patients.
CANDIDATE THERAPEUTICS
8/1/20
Baradaran A, Ebrahimzadeh MH, Baradaran A, et al. | Arch Bone Jt Surg
Aim: To assess the prevalence of comorbidities in the confirmed COVID-19 patients.
CLINICAL CHARACTERISTICS
8/1/20
Akbari H, Tabrizi R, Lankarani KB, et al. | Life Sci
Aim: To make a comparison between the clinical laboratory-related factors, complete blood count (CBC) indices, cytokines, and lymphocyte subsets in order to distinguish severe coronavirus disease 2019 (COVID-19) cases from the non-severe ones.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
8/1/20
Monaghesh E, Hajizadeh A | BMC Public Health
Aim: To identify the role of telehealth services during COVID-19 outbreak.
RECENTLY UPDATED
INFECTION CONTROL
7/31/20
Akhtar H, Patel C, Abuelgasim E, et al. | Gynecol Obstet Invest
Aim: To review published studies related to the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections with pregnancy, foetal, and neonatal outcomes during coronavirus disease 2019 (COVID-19) pandemic.
CLINICAL CHARACTERISTICS
7/31/20
Clark EG, Hiremath S, Soroka SD, et al. | Can J Kidney Health Dis
Aim: To synthesize guidance documents from the broader nephrology community in an effort to provide the best possible care to the largest number of patients with kidney disease while also ensuring the safety of the health care team.
INFECTION CONTROL
7/31/20
Seresirikachorn K, Phoophiboon V, Chobarporn T, et al. | Infect Control Hosp Epidemiol
Aim: To evaluate the effectiveness of existing decontamination methods of surgical masks and N95 FFRs and provide evidence-based recommendations for selecting an appropriate decontamination method.
INFECTION CONTROL
7/31/20
Tng XJJ, Chew QH, Sim K | Singapore Med J
Aim: To examine and summarise existing studies to date regarding the psychological impact of COVID-19 on various populations.
7/31/20
Mitchell S, Maynard V, Lyons V, et al | Palliat Med
Aim: To synthesise existing evidence related to the delivery of palliative and end-of-life care by primary healthcare professionals in epidemics and pandemics.
RECENTLY UPDATED
7/30/20
Zhou Y, Yang Q, Chi J, et al. | Int J Infect Dis
Aim: To evaluate the association between different comorbidities and the severity of Covid-19.
CLINICAL CHARACTERISTICS
7/30/20
Hadeler E, Gitlow H, Nouri K | Arch Dermatol Res
Aim: To evaluate recent studies that have analyzed patient satisfaction with teledermatology. 
7/30/20
Figliozzi S, Masci P, Ahmadi N, et al. | Eur J Clin Invest
Aim: To review available evidence and provide pooled estimates on predictors of clinical outcomes in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/30/20
Musa A, Pendi K, Hashemi A, et al. | West J Emerg Med
Aim: To review the evidence on the use of remdesivir for the treatment of COVID-19.
CANDIDATE THERAPEUTICS
7/30/20
Shah K, Saxena D, Mavalankar D | QJM
Aim: To assess global statistics and characteristics of household secondary attack rate (SAR) of COVID-19.
INFECTION CONTROL
7/29/20
Yasuhara J, Kuno T, Takagi H, et al. | Pediatr Pulmonol
Aim: To investigate the clinical characteristics of COVID-19 in children.
CLINICAL CHARACTERISTICS
7/29/20
Chakravarti A, Upadhyay S, Bharara T, et al. | Indian J Med Microbiol
Aim: To provide an insight about the current understanding, knowledge gaps and a perspective on the future of coronavirus disease 2019 (COVID-19) infections. 
7/29/20
Liao S, Shao S, Chen Y, et al. | Crit Care
Aim: To review the evidence on severe complications of COVID-19 associated with coagulation changes, mainly characterized by increased D-dimer and fibrinogen levels with higher thrombosis risk, in particular pulmonary embolism (PE).
CLINICAL CHARACTERISTICS
7/29/20
Shulte PA, Streit JMK, Sheriff F, et al. | Ann Work Expo Health
Aim: To identify and characterize scenarios and hazards in the future of work after a global pandemic.
7/28/20
Rao SN, Manissero D, Steele VR, et al. | Infect Dis Ther
Aim: To review available knowledge on correlations between SARS-COV-2 Ct values and patient- or healthcare-related outcomes to determine whether Ct values provide useful clinical information.
CLINICAL CHARACTERISTICS
7/28/20
Langford B, So M, Raybardhan S, et al. | Clin Microbiol Infect
Aim: To determine the prevalence of bacterial co-infection (at presentation) and secondary infection (after presentation) in patients with COVID-19.
CLINICAL CHARACTERISTICS
7/28/20
Li X, Pan X, Li Y, et al. | Crit Care
Aim: To comprehensively evaluate the impact of cardiac injury and its related biomarkers on mortality and other prognosis in patients infected with SARS-CoV-2.
CLINICAL CHARACTERISTICS
7/28/20
Capobianco G, Saderi L, Aliberti S, et al. | Eur J Obstet Gynecol Reprod Biol
Aim: To assess the risk of clinical complications in pregnant women and neonates infected with SARS-CoV-2.
CLINICAL CHARACTERISTICS
7/28/20
Abdi A, Jalilian M, Sarbarzeh PA, et al. | Diabetes Res Clin Pract
Aim: To summarize the evidence about diabetes and COVID-19 outbreak through a systematic review and meta-analysis approach.
CLINICAL CHARACTERISTICS
7/28/20
Malik VS, Ravindra K, Attri SV, et al. | Environ Sci Pollut Res Int
Aim: To examine the emerging evidence to identify an association between body mass index (BMI) and COVID-19 disease outcome.
CLINICAL CHARACTERISTICS
7/28/20
Wu Y, Li H, Guo X, et al. | Hepatol Int
Aim: To explore the incidence, risk factors, and prognosis of abnormal liver biochemical tests in COVID-19 patients.
CLINICAL CHARACTERISTICS
7/28/20
Kovalic AJ, Satapathy SK, Thuluvath PJ | Hepatol Int
Aim: To determine the prevalence of CLD in patients with COVID-19 and their clinical outcomes.
CLINICAL CHARACTERISTICS
7/28/20
Cortegiani A, Ippolito M, Greco M, et al. | Pulmonology
Aim: To describe the rationale for the use of tocilizumab for the treatment of COVID-19 and to summarize the available evidence regarding its efficacy. and safety.
CANDIDATE THERAPEUTICS
7/28/20
Haiduc AA, Alom S, Melamed N, Harky A | J Card Surg
Aim:  To examine the literature evidence behind using extracorporeal membrane oxygenation in COVID?19 patients in a systematic review manner.
CANDIDATE THERAPEUTICS
7/28/20
Radulesco T, Lechien JR, Sowerby L, et al. | Eur Arch Otorhinolaryngol
Aim: To summarize recommendations for sinus and anterior skull base surgery during the COVID-19 pandemic.
UPDATED
INFECTION CONTROL
7/28/20
Weiss A, Jellingso M, Sommer MOA | EBioMedicine
Aim: To conduct a coherent overview of the duration of viral detection and viral RNA load in COVID-19 patients, stratified by specimen type, clinical severity, and age.
CLINICAL CHARACTERISTICS
7/28/20
Lan S, Lai C, Huang H, et al. | Int J Antimicrob Agents
Aim: To assess the efficacy of tocilizumab for the treatment of severe coronavirus disease-2019 (COVID-19).
CANDIDATE THERAPEUTICS
7/27/20
Cabrera-Tasayco FDP, Rivera-Carhuavilca JM, Atoche-Socola KJ, et al. | Disaster Med Public Health Prep
Aim: To determine biosecurity measures at the dental office after the appearance of COVID-19.
INFECTION CONTROL
7/27/20
Bwire GM, Majigo MV, Nijiro BJ, et al. | J Med Virol
Aim: To profile the positive detection rate from different clinical specimens using PCR to guide the selection of specimens for clinical diagnosis of COVID-19.
UPDATED
DIAGNOSTICS
7/27/20
Goldstein KM, Ghadimi K, Mystakelis H, et al. | VA Evidence Synthesis Program
Aim: To review the evidence on the risk of transmitting SARS-CoV-2, SARS, MERS, and influenza with administration of drugs via nebulizer
UPDATED
VA ESP
7/25/20
Solis-Garcia Del Pozo J, Galindo MF, Nava E, et al. | Eur Rev Med Pharmacol Sci
Aim: To review the evidence on the role of IL-6 in treating COVID-19.
CANDIDATE THERAPEUTICS
7/25/20
Racine N, Cooke JE, Eirich R, et al. | Psychiatry Res
Aim: To conduct a rapid review of child and adolescent anxiety, depression, and traumatic stress experienced during the COVID-19 pandemic. 
7/25/20
Rahman J, Mumin J, Fakhruddin B | Ann Glob Health
Aim: To appraise the frequency of T-zone (eyes, nose, mouth, chin) touching in humans to comprehend the challenge of its restriction, and thus support public health professionals to produce evidence synthesis guidance for public.
INFECTION CONTROL
7/25/20
Imran N, Aamer I, Sharif MI, et al. | Pak J Med Sci
Aim: To examine the impact of quarantine on mental health of children and adolescents, and proposes measures to improve psychological outcomes of isolation.
7/25/20
Katims AB, Razdan S, Eilender BM, et al. | Urol Oncol
Aim: To provide a review of high-risk urologic cancers and the feasibility of delaying surgery without impacting oncologic or mortality outcomes.
INFECTION CONTROL
7/24/20
Lin J, Yan H, Chen H, et al. | J Med Virol
Aim: To review the blood coagulation indicators in severe COVID?19 patients.
CLINICAL CHARACTERISTICS
7/24/20
PHAC Emerging Science Group, Public Health Agency of Canada  | Public Health Agency of Canada
Aim: To review the evidence on the effectiveness of face shields at preventing SARS-CoV-2 virus transmission, with and without additional mask wearing.
7/24/20
PHAC Emerging Science Group, Public Health Agency of Canada  | Public Health Agency of Canada
Aim: To review the evidence on the aerodynamic properties of SARS-CoV-2 virus and travel distance, and the implications on transmission risk.
7/24/20
Venkatesulu BP, Chandrasekar VT, Giridhar P, et al. | J Med Virol
Aim: To do a systematic review and critical appraisal of the ongoing clinical trials that are assessing various therapeutic interventions against SARS-CoV-2 with an aim to provide insight into the various interventions tested, clinical rationale, geographical distribution of the trials as well as the endpoints assessed in the studies.
UPDATED
CANDIDATE THERAPEUTICS
7/24/20
 | Sante Publique France
7/24/20
Ceravolo MG, Arienti C, De Sire A, et al. | Eur J Phys Rehabil Med
Aim: To gather and present the current evidence informing rehabilitation of patients with COVID-19 and/or describing the consequences due to the disease and its treatment.
CLINICAL CHARACTERISTICS
7/24/20
 | Sante Publique France
7/23/20
de Melo GC, de Araujo KCGM | Cad Saude Publica
Aim: To analyze whether COVID-19 in pregnant women is related to premature birth and birth weight, and to summarize the diagnostic results of neonates born to mothers with COVID-19 for investigating the possibility of vertical transmission.
CLINICAL CHARACTERISTICS
7/23/20
James HK, Pattison GTR | J Surg Educ
Aim: To synthesise the current evidence of pandemic-related impact on surgical training internationally and describe strategies that have been put in place to mitigate disruption.
7/23/20
 | Public Health Agency of Canada
Aim: To review the evidence on determinants of individual adherence to public health interventions to prevent COVID-19.
7/23/20
Garcia-Iglesias JJ, Gomez-Salgado J, Martin-Pereira J, et al. | Rev Esp Salud Publica
Aim: To analyze the impact of the SARS-CoV-2 outbreak on healthcare professionals' mental health.
7/23/20
Taherifard E, Taherifard E | Neurol Res
Aim: To systematically review the neurological complications in patients with SARS-CoV-2 infection and the methods used to diagnose both neurological complications and coronavirus infection.
CLINICAL CHARACTERISTICS
7/23/20
Deniz M, Tezer H | J Matern Fetal Neonatal Med
Aim: To review the current evidence on the vertical transmission of SARS CoV-2.
CLINICAL CHARACTERISTICS
7/22/20
Chen X, Laurent S, Onur OA, et al. | J Neurol
Aim: To study the frequency of neurological symptoms and complications in COVID-19 patients in a systematic review of the literature.
CLINICAL CHARACTERISTICS
7/22/20
Patterson TJ, Currie PJ, Beck J, et al. | Surgeon
Aim: To conduct an objective, systematic review of studies reporting on viral transmission risk comparing laparoscopic and open surgery.
INFECTION CONTROL
7/22/20
PHAC Emerging Science Group, Public Health Agency of Canada  | Public Health Agency of Canada
Aim: To review the evidence on the de-escelation of "household bubbles" during the COVID-19 pandemic.
7/22/20
PHAC Emerging Science Group, Public Health Agency of Canada  | Public Health Agency of Canada
Aim: To review the evidence on the thresholds or allowable sizes of gatherings or events during the COVID-19 pandemic.
7/22/20
Bertrand K, Camire M, Milot D, et al. | University of Sherbrooke
Aim: To review the evidence on gender and sexual diversity in the adaptation of services in the context of the COVID-19 pandemic.
7/21/20
Ashraf MA, Keshavarz P, Hosseinpour P, et al. | J Reprod Infertil
Aim: To demonstrate the effects of COVID-19 on pregnant women and the possibility of vertical transmission.
CLINICAL CHARACTERISTICS
7/21/20
Vidali S, Morosetti D, Cossu E, et al. | ERJ Open Res
Aim: To highlight the correlation between elevated D-dimer (an indirect thrombosis marker) and the increased rate of poor prognosis-associated conditions, and to introduce D-dimer-labelled anticoagulant administration as a potentially useful tool to prevent complications and positively influence coronavirus disease 2019 (COVID-19) course.
CANDIDATE THERAPEUTICS
7/21/20
Kovalic AJ, Huang G, Thuluvath PJ, et al. | Hepatology
Aim: To further characterize liver injury and other unique clinical characteristics across COVID-19 severity.
CLINICAL CHARACTERISTICS
7/21/20
Lim MA, Pranata R, Huang I, et al. | Can J Kidney Health Dis
Aim: To investigate the association between several complications, including acute kidney injury (AKI), acute liver injury (ALI), and coagulopathy, with poor outcomes in COVID-19.
CLINICAL CHARACTERISTICS
7/21/20
He J, Guo Y, Mao R, et al. | J Med Virol
Aim: To systematically review the characteristics of asymptomatic infection in the coronavirus disease 2019 (COVID-19).
CLINICAL CHARACTERISTICS
7/21/20
Kumar J, Meena J, Yadav A, et al. | J Trop Pediatr
Aim: To compile the radiological findings of COVID-19 pneumonia in children in a systematic manner.
CLINICAL CHARACTERISTICS
7/21/20
Wynants L, Van Calster B, Bonten MMJ | BMJ
Aim: To review and critically appraise published and preprint reports of models that aim to predict either (i) presence of existing COVID-19 infection, or (ii) future complications in individuals already diagnosed with COVID-19
UPDATED
7/21/20
Bajwa H, Riaz Y, Ammar M, et al. | Cureus
Aim: To analyze the published data on kidney injuries in COVID-19 and mortality rates in these patients.
CLINICAL CHARACTERISTICS
7/20/20
Cortegiani A, Ingoglia G, Ippolito M, et al. | J Crit Care
Aim: To evaluate the efficacy and safety of chloroquine and chloroquine-related formulations in patients with SARS-CoV-2 pneumonia and articles describing related in-vitro studies.
UPDATED
CANDIDATE THERAPEUTICS
7/20/20
Gao Y, Liu M, Chen Y, et al. | J Med Virol
Aim: To assess whether tuberculosis is associated with an increased risk of severe disease and death in patients with COVID-19.
CLINICAL CHARACTERISTICS
7/20/20
Egbert AR, Cankurtaran S, Karpiak S | Brain Behav Immun
Aim: To synthesize early data on typology and topography of brain abnormalities in adults with COVID-19 in acute/subacute phase.
CLINICAL CHARACTERISTICS
7/20/20
Tian Y, Qiu X, Wang C, et al. | Int J Cancer
Aim: To review the evidence on cancer prevalence in patients with COVID-19, and examine the association of cancer with severe events.
CLINICAL CHARACTERISTICS
7/20/20
Pei Y, Liu W, Masokano IB, et al. | J Infect Public Health
Aim: To investigate the differences in the clinical manifestations and imaging characteristics between Chinese children and adults with COVID-19 by systematically analyzing the data derived from some latest literatures.
CLINICAL CHARACTERISTICS
7/20/20
O'Hearn K, Gertsman S, Sampson M, et al. | J Hosp Infect
Aim: To synthesize existing data on the effectiveness of ultraviolet germicidal irradiation (UVGI) for N95 FFR decontamination.
INFECTION CONTROL
7/20/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the efficacy of face masks in helping to prevent the spread of COVID-19.
UPDATED
7/20/20
Noorimotlagh Z, Karami C, Mirzaee SA, et al. | Int Immunopharmacol
Aim: To help researchers to produce vaccine by collecting data for the control and prevention of SARS-CoV-2 and the immune and bioinformatic identification of T-cell and B-cell epitopes.
INFECTION CONTROL
7/20/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of adverse post-operative outcomes on patients with COVID-19 or who have previously had COVID-19.
7/20/20
Eichberg DG, Basil GW, Di L, et al. | Neurosurgery
Aim: To conduct a systematic literature review investigating treatment of neurosurgical patients via telemedicine, and to evaluate barriers and challenges.
7/20/20
Shield KD, Chrystoja BR, Ali S, et al. | CMH Initiative
Aim: To review the evidence on how economic crises and natural disasters impact alcohol consumption and its harms.
7/19/20
Pormohammad A, Ghorbani S, Baradaran B, et al. | Microb Pathog
Aim: To evaluate the clinical features and laboratory findings using a large sample size of COVID-19 infected patients in order to assist in its understanding, prevention and treatment.
UPDATED
CLINICAL CHARACTERISTICS
7/19/20
Zarifian A, Birdary MZ, Arekhi S, et al. | J Med Virol
Aim: To review the evidence on gastrointestinal and liver manifestations of COVID-19 patients.
CLINICAL CHARACTERISTICS
7/19/20
Chen Y, Shao S, Lai EC, et al. | Crit Care
Aim: To compare the mortality rate in patients with SARS, MERS, and COVID-19 who developed acute kidney injury.
CLINICAL CHARACTERISTICS
7/19/20
Abdullahi A, Candan SA, Abba MA, et al. | Front Neurol
Aim: To summarize the evidence on the neurological and musculoskeletal symptoms of the disease.
CLINICAL CHARACTERISTICS
7/19/20
Foldi M, Farkas N, Kiss S, et al. | Obes Rev
Aim: To examine whether obesity is a risk factor for the critical condition in COVID?19 patients by performing a meta?analysis.
CLINICAL CHARACTERISTICS
7/18/20
Cooper TJ, Woodward BL, Harky A | HIV Med
Aim: To systematically review current studies reporting on clinical outcomes in people living with HIV (PLHIV) infected with severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2).
CLINICAL CHARACTERISTICS
7/18/20
Ghayda RA, Lee J, Lee JY, et al. | Int J Environ Res Public Health
Aim: To perform a novel systematic review and meta-analysis focusing on findings about correlations between clinical characteristics and laboratory features of patients with COVID-19.
CLINICAL CHARACTERISTICS
7/18/20
Yadav DK, Singh A, Zhang Q, et al. | Gut
Aim: To perform a meta-analysis to estimate the prognosis of patients with COVID-19 stratified according to liver injury. 
CLINICAL CHARACTERISTICS
7/18/20
Verdugo-Paiva F, Izcovich A, Ragusa M, et al. | Medwave
Aim: To provide a timely, rigorous, and continuously updated summary of the evidence on the role of lopinavir/ritonavir in the treatment of patients with COVID-19.
UPDATED
7/17/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on whether cardiac stress testing is an aerosol generating procedure and its risk to healthcare workers.
7/17/20
Greco A, Buccheri S, D'Arrigo P, et al. | Eur Heart J Cardiovasc Pharmacother
Aim: To review the evidence on the impact of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on the clinical outcomes of COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
7/17/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on post-surgery innovations in an outpatient setting, such as virtual follow up and rehabilitation, in improving outcomes for patients who have undergone surgery.
7/17/20
Galbadage T, Peterson BM, Awada J, et al. | Front Med
Aim: To examine the association between male sex and COVID-19 severity.
UPDATED
CLINICAL CHARACTERISTICS
7/16/20
Liu J, Cui M, Yang T, et al. | BMJ Open Gastroenterol
Aim: To study the correlation between gastrointestinal (GI) symptoms and disease severity in patients with COVID-19.
CLINICAL CHARACTERISTICS
7/16/20
Garg PK, Kaul P, Choudary D, et al. | J Surg Oncol
Aim: To systematically evaluate the available literature on the impact of COVID-19 on cancer care and to critically analyze the diagnostic and therapeutic strategies suggested by various healthcare providers, societies, and institutions. 
7/16/20
Shah S, Shah K, Patel SB, et al. | Cardiol Rev
Aim: To investigate the prognostic role of D-dimer in COVID-19 infected patients. 
UPDATED
CLINICAL CHARACTERISTICS
7/16/20
Blair B | Simcoe Muskoka District Health Unit
Aim: To review the evidence on whether staying at home for long periods of time during current or past pandemics worsens the rates of mental and social health outcomes.
7/15/20
Zaki N, Alashwal H, Ibrahim S | Diabetes Metab Syndr
Aim: To undertake a review and critical appraisal of published/preprint reports that offer methods of determining the effects of hypertension, diabetes, stroke, cancer, kidney issues, and high-cholesterol on COVID-19 disease severity. 
CLINICAL CHARACTERISTICS
7/15/20
Collantes ME, Espiritu AI, Sy MCC, et al. | Can J Neurol Sci
Aim: To determine the neurological 48 manifestations and complications in COVID-19.
CLINICAL CHARACTERISTICS
7/15/20
Chandrasekar VT, Venkatesalu B, Patel HK, et al. | J Med Virol
Aim: To assess if any intervention provides mortality benefit, other clinically relevant outcomes and also ascertain the safety profile.
UPDATED
CANDIDATE THERAPEUTICS
7/14/20
Murphy E, Fenelon C, Murphy RP, et al. | Clin Orthop Relat Res
Aim: To describe (1) adverse outcomes, (2) cost reductions, and (3) efficiencies associated with the virtual fracture clinic model.
INFECTION CONTROL
7/14/20
Patel RS, Patel N, Baksh M, et al. | Cureus
Aim: To summarize the transmission and pathology of 2019-nCoV, and demographics, clinical presentation, laboratory, and chest imaging findings, along with treatment and outcomes in 2019-nCoV pneumonia patients.
CLINICAL CHARACTERISTICS
7/14/20
Oltean M, Softeland JM, Bagge J, et al. | Infect Dis
Aim: To pool the individual and aggregated data from available case-series on kidney transplant patients and the risk of COVID-19.
INFECTION CONTROL
7/14/20
Fang X, Li S, Yu H, et al. | Aging
Aim: To systematically collect and evaluate the associations of epidemiological, comorbidity factors with the severity and prognosis of coronavirus disease 2019 (COVID-19).
CLINICAL CHARACTERISTICS
7/14/20
de Pablo GS, Vaquerizo-Serrano J, Catalan A, et al. | J Affect Disord
Aim: To review the evidence on the impact of SARS/MERS/COVID-19 on physical and mental health outcomes of health care workers.
UPDATED
INFECTION CONTROL
7/14/20
Bajgain KT, Badal S, Bajgain BB, et al. | Am J Infect Control
Aim: To explore the prevalence of top global comorbidities (CVD, Diabetes, COPD, Cancer, and CKD) among individuals with COVID-19, as well as investigate any significant associations.
CLINICAL CHARACTERISTICS
7/14/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the resumption of elective surgery following cancellation and deferment of routine services during COVID-19.
7/14/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on low-value surgery and how to reduce it.
7/14/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on post-surgery innovations in hospital such as enhanced recovery, early mobilisation and early discharge in improving outcomes for patients who have undergone surgery?
7/14/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on ways to increase productivity or efficiency in operating theatres and managing elective surgery waiting lists?
7/14/20
Boger B, Fachi MM, Vilhena RO, et al. | Am J Infect Control
Aim: To collate the evidence on the accuracy parameters of all available diagnostic methods for detecting SARS-CoV-2.
DIAGNOSTICS
7/14/20
Ning AY, Cabrera CI, D'Anza B | Ann Otol Rhinol Laryngol
Aim: To evaluate existing literature on telemedicine and assess overall image quality, diagnostic concordance, and patient and provider satisfaction with telemedicine technologies.
INFECTION CONTROL
7/14/20
La Marca A, Capuzzo M, Paglia T, et al. | Reprod Biomed Online
Aim: To provide an overview of current diagnostic approaches for SARS-CoV-2 and in particular highlight issues with serological testing, with the objective of providing a clear guide to clinicians on the assays currently available.
DIAGNOSTICS
7/14/20
Gavriilidis P, Pai M | J Clin Med Res
Aim: To summarise the existing evidence of impact of COVID-19 global pandemic on liver transplant recipients.
7/13/20
Momtazmanesh S, Shobeiri P, Hanaei S, et al. | Egypt Heart J
Aim: To define the clinical, electrocardiographic, and pathologic spectrum of cardiovascular disease (CVD), frequency of elevated cardiac and inflammatory biomarkers, and their frequency and relationship with severity of the disease and mortality in COVID-19 patients and to develop a triage risk stratification tool (TRST) that can serve as a guide for the timely recognition of the high-risk patients and mechanism-targeted therapy. 
CLINICAL CHARACTERISTICS
7/13/20
Tan Y, Goh C, Leow AST, et al. | J Thromb Thrombolysis
Aim: To characterize the clinical characteristics, neuroimaging findings, and outcomes of AIS in COVID-19 patients. 
CLINICAL CHARACTERISTICS
7/13/20
Koletsi D, Belibasakis GN, Eliades T | J Dent Res
Aim: To identify and rank the effectiveness of different interventions used in dental practice to reduce microbial load in aerosolized compounds.
INFECTION CONTROL
7/13/20
Nepal G, Rehrig JH, Shrestha GS, et al. | Crit Care
Aim: To inform and improve decision-making among the physicians treating COVID-19 by presenting a systematic analysis of the neurological manifestations experienced within these patients.
CLINICAL CHARACTERISTICS
7/13/20
Preti E, Di Mattei V, Perego G, et al. | Curr Psychiatry Rep
Aim: To provide quantitative evidence on the psychological impact of epidemic/pandemic outbreaks (i.e., SARS, MERS, COVID-19, ebola, and influenza A) on healthcare workers (HCWs).
7/13/20
Manabe T, Akatsu H, Kotani K, et al. | Respir Investig
Aim: To elucidate the clinical features of COVID-19 using a meta-analysis with a stratified analysis according to the timeline and the changes in the exposure risks before the disease was declared as a pandemic.
CLINICAL CHARACTERISTICS
7/11/20
Shafi AMA, Shaikh SA, Shirke MM, et al. | J Card Surg
Aim: To systematically review the current published literature on the different cardiac manifestations and the use of cardiac?specific biomarkers in terms of their prognostic value in determining clinical outcomes and correlation to disease severity.
CLINICAL CHARACTERISTICS
7/11/20
Piechotta V, Chai KL, Valk SJ, et al. | Cochrane Database Syst Rev
Aim: To assess whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in the treatment of people with COVID?19.
UPDATED
CANDIDATE THERAPEUTICS
7/11/20
Abate S, Ali S, Mantedafro B, et al. | PLoS One
Aim: To investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus.
UPDATED
CLINICAL CHARACTERISTICS
7/11/20
Albahri OS, Zaidan AA, Albahri AS, et al. | J Infect Public Health
Aim: To review the evidence on artificial intelligence (AI) techniques used in the detection and classification of coronavirus disease 2019 (COVID-19) medical images in terms of evaluation and benchmarking.
DIAGNOSTICS
7/11/20
Moreno G, Carbonell R, Bodi M, et al. | Med Intensiva
Aim: To define the role of D-dimer in the disease, the prevalence of DIC and the usefulness of anticoagulant treatment in these patients.
CLINICAL CHARACTERISTICS
7/10/20
 | Public Health Agency of Canada
Aim: To review the evidence on the risk of SARS-CoV-2 virus transmission from singing or playing a wood instrument in a choir, orchestra and/or practice setting with other people.
7/10/20
Yu C, Kang L, Chen J, et al. | Int Immunopharmacol
Aim: To recapitulate relevant studies to evaluate the safety, efficacy, tolerability and treatment-related outcomes of type I IFNs for coronavirus infection in clinical practice, with expectation to provide more robust evidence whether IFNs should be served as first-line agents for coronavirus infection, including the SARS-CoV-2.
CANDIDATE THERAPEUTICS
7/10/20
Bornstein S | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the impacts of COVID-19 mitigation on non-COVID-19 populations with pre-existing mental health conditions.
7/10/20
Kunutsor S, Laukkanen J | Ann Med
Aim: To evaluate renal complications of COVID-19 and their incidence using a systematic meta-analysis.
UPDATED
CLINICAL CHARACTERISTICS
7/10/20
Lewis J, Mackey K | VA Evidence Synthesis Program
Aim: To critically appraise the identified study and provide additional context for study findings.
VA ESP
7/10/20
Kernohan A, Calderon M | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on risk factors or management of VTE.
UPDATED
7/9/20
Shao JM, Ayuso SA, Deerenberg EB, et al. | Colorectal Dis
Aim: To investigate the sensitivity and utility of computed tomography (CT) of the chest in diagnosing active Coronavirus 2019 (COVID?19) infection, and its potential application to the surgical setting.
DIAGNOSTICS
7/9/20
Farsalinos K, Barbouni A, Poulas K, et al. | Ther Adv Chronic Dis
Aim: To examine the prevalence and effects of current smoking on adverse outcomes among hospitalized COVID-19 patients.
CLINICAL CHARACTERISTICS
7/9/20
Mackey S, Warren C | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the impacts of COVID-19 mitigation on non-COVID-19 populations with pre-existing substance use and addictions issues.
7/9/20
Trocado V, Silvestre-Machado J, Azevedo L, et al. | J Matern Fetal Neonatal Med
Aim: To evaluate the impact of COVID-19 during pregnancy.
CLINICAL CHARACTERISTICS
7/9/20
Fontana P, Casini A, Robert-Ebadi H, et al. | Swiss Med Wkly
Aim: To summarise the reported risk of VTE associated with COVID-19 infections and to summarise guidance documents on thromboprophylaxis in COVID-19 patients, in a systematic review.
CLINICAL CHARACTERISTICS
7/9/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the role of daycares and schools in the transmission of COVID-19.
7/8/20
Lvliang L, Zhong W, Bian Z, et al. | J Infect
Aim: To compare mortality risk factors of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) to provide new strategies for COVID-19 prevention and treatment.
CLINICAL CHARACTERISTICS
7/8/20
Nandy K, Salunke A, Pathak SK, et al. | Diabetes Metab Syndr
Aim: To evaluate the impact of various morbidities on serious events in COVID 19.
CLINICAL CHARACTERISTICS
7/8/20
Seirafianpour F, Sodagar S, Mohammad AP, et al. | Dermatol Ther
Aim: To present an overview of suggestive skin manifestations of the COVID-19 and to address several considerations in the dermatological issues practices, during this pandemic.
CLINICAL CHARACTERISTICS
7/8/20
Rodriguez-Martinez CE, Sossa-Briceno MP, Cortes-Luna JA | Am J Infect Control
Aim: To summarize all of the available evidence on the different decontamination methods that might allow disposable N95 FFRs to be reused, with emphasis on decontamination from SARS-CoV-2.
INFECTION CONTROL
7/8/20
Sun M, Xu Y, He H, et al. | Int J Infect Dis
Aim: To explore the effectiveness of treatment and predict the potential effect of convalescent plasma for COVID-19.
CANDIDATE THERAPEUTICS
7/8/20
Salari N, Hosseinian-Far A, Jalali R, et al. | Global Health
Aim: To analyze the existing research works and findings in relation to the prevalence of stress, anxiety and depression in the general population during the COVID-19 pandemic.
7/8/20
Ravani P, Saxinger L, Chandran U, et al. | Alberta Health Services
Aim: To evaluate the current prevalence of COVID-19 infection among asymptomatic patients presenting to Emergency Rooms and requiring hospital admission.
7/8/20
Zhu R, Gao Y, Robert S, et al. | J Transl Med
Aim: To summarize the characteristics of clinical trials for COVID-19.
CANDIDATE THERAPEUTICS
7/8/20
Kulkarni A, Kumar P, Tevethia HV, et al. | Aliment Pharmacol Ther
Aim: To assess the prevalence of CLD, the incidence of elevated liver chemistries and the outcomes of patients with and without underlying CLD/elevated liver chemistries in COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/8/20
Pan D, Sze S, Minhas J, et al. | EClinicalMedicine
Aim: To assess whether ethnicity has been reported in patients with COVID-19 and its relation to clinical outcomes.
UPDATED
CLINICAL CHARACTERISTICS
7/7/20
Rokkas T | Ann Gastroenterol
Aim: To review the evidence on the involvement of the digestive system in COVID-19.
CLINICAL CHARACTERISTICS
7/7/20
Lin Y, Duan Q, Zhou Y, et al. | Front Med
Aim: To review existing mathematical and statistical models and build a mathematical model to estimate the transmission capacity, epidemiological characteristics, potential peak time and size, and elimination time of COVID-19.
7/6/20
Xiong X, Wang P, Su K, et al. | Pharmacol Res
Aim: To evaluate the current clinical evidence on Chinese herbal medicine for the treatment of COVID-19.
CANDIDATE THERAPEUTICS
7/6/20
Kumar-M P, Mishra S, Jha DK, et al. | Hepatol Int
Aim: To systematically study the occurrence of liver injury in COVID-19 and also determine the frequency of liver involvement in COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/6/20
Laperriere H, Bendevis C, et al. | CIHR IRSC
Aim: To review the evidence on how COVID-19 is affecting the mental health of indigenous community members in Ottawa-Gatineau who are living with or affected by HIV or related issues.
7/6/20
Kania-Richmond A, Saxinger L, Manns B | Alberta Health Services
Aim: To review the evidence for the effectiveness of remdesivir as a treatment for COVID-19.
7/6/20
Borsetto D, Hopkins C, Philips V, et al. | Rhinology
Aim: To systematically assess the prevalence of self-reported altered sense of smell or taste in patients with confirmed SARS-CoV-2 infection.
CLINICAL CHARACTERISTICS
7/6/20
Al-Sadeq DW, Nasrallah GK | Int J Infect Dis
Aim: To systematically review the published literature on SARS-CoV-2 in the asymptomatic patients to estimate the incidence of COVID-19 among asymptomatic cases, as well as describe its epidemiological and clinical significance.
CLINICAL CHARACTERISTICS
7/4/20
Aziz M, Fatima R, Haghbin H, et al. | Inflamm Bowel Dis
Aim: To better understand the incidence and outcomes of COVID-19 in infammatory bowel disease (IBD) patients.
CLINICAL CHARACTERISTICS
7/3/20
Bastos M, Tavaziva G, Abidi SK, et al. | BMJ
Aim: To determine the diagnostic accuracy of serological tests for coronavirus disease-2019 (covid-19).
UPDATED
DIAGNOSTICS
7/3/20
Huang D, Yu H, Wang T, et al. | J Med Virol
Aim: To evaluate the efficacy and safety of umifenovir in COVID?19.
CANDIDATE THERAPEUTICS
7/3/20
Spencer EA, Brassey J, Jefferson T, et al. | Oxford COVID-19 Evidence Service Team
Aim: To explore if climate conditions may influence the spread of SARS-CoV-2.
UPDATED
7/3/20
Russo B, Iudici M | Infect Control Hosp Epidemiol
Aim: To provide a summary of preventative or therapeutic interventions specifically designed for healthcare workers facing with COVID-19 pandemic.
INFECTION CONTROL
7/3/20
Amaefule CE, Sasitharan A, Kalra P, et al. | Curr Opin Obstet Gynecol
Aim: To review the evidence on the screening and diagnostic accuracy of the haemoglobin A1c (HbA1c) test in women with and without risk factors for gestational diabetes.
INFECTION CONTROL
7/3/20
Pranata R, Permana H, Huang I, et al. | Diabetes Metab Syndr
Aim: To investigate the association between use of angiotensin-converting enzyme inhibitor (ACEI)/angiotensin-receptor blocker (ARB) and outcomes of hypertensive COVID-19 patients.
7/2/20
Potere N, Valeriani E, Candeloro M, et al. | Crit Care
Aim: To summarize the evidence on clinically relevant outcomes in hospitalized patients with COVID-19.
CLINICAL CHARACTERISTICS
7/1/20
Altmayer S, Zanon M, Pacini GS, et al. | Eur Radiol
Aim: To compare the chest computed tomography (CT) findings of coronavirus disease 2019 (COVID-19) to other non-COVID viral pneumonia.
CLINICAL CHARACTERISTICS
7/1/20
Koh J, Shah SU, Chua PEY, et al. | Front Med
Aim: To review the epidemiological and clinical characteristics of COVID-19 cases in the early phase of the COVID-19 pandemic.
CLINICAL CHARACTERISTICS
7/1/20
Katal S, Balakrishnan S, Gholamrexanezhad A | J Neuroradiol
Aim: To review the available imaging findings of patients diagnosed with neurological symptoms associated with coronavirus infections.
CLINICAL CHARACTERISTICS
7/1/20
Yang J, Hu J, Zhu C | J Med Virol
Aim: To explore the relationship between obesity and COVID-19.
CLINICAL CHARACTERISTICS
7/1/20
Greaves L, Brabete AC, Wolfson L, et al. | Centre of Excellence for Women's Health
Aim: To review the evidence on the role of natural disasters and pandemics in intimate partner violence among women and the role of substance use in intimate partner violence among women.
7/1/20
Alizadeh F, Khodavandi A | IEEE Trans Nanobioscience
Aim: To summarize the available evidence on the efficacy of nanoscale materials against coronaviruses in vitro and in animal models.
CANDIDATE THERAPEUTICS
6/30/20
Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the best practices for personal care workers providing home care in the context of COVID-19.
6/30/20
Hu CLH, Raval M, Schnall JA, et al. | Pediatr Infect Dis J
Aim: To determine the average shedding times of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via the respiratory and gastrointestinal tracts in children.
CLINICAL CHARACTERISTICS
6/30/20
Khalili M, Karamouzian M, Nasiri N, et al. | Epidemiol Infect
Aim: To synthesize case fatality rate (CFR) among confirmed COVID-19 patients, incubation period, and time from onset of COVID-19 symptoms to first medical visit, intensive care unit (ICU) admission, recovery and death.
CLINICAL CHARACTERISTICS
6/30/20
Armstrong RA, Kane AD, Cook TM | Anaesthesia
Aim: To assess the reported ICU mortality for patients with confirmed COVID?19.
UPDATED
CLINICAL CHARACTERISTICS
6/30/20
Beesoon S, Jelinski S | Alberta Health Services
Aim: To review the evidence on the risks of infection transmission related to aerosol generation through dental procedures.
6/29/20
Dube L, Paquet C, Cisneros-Franco M, et al. | McGill University
Aim: To identify and examine the effectiveness of social connectedness interventions at reducing feelings of social isolation and loneliness and promoting wellbeing, resilience, and coping in the context of infection control-related social and physical distancing measures.
6/29/20
Li X, Xu W, Dozier M, et al. | J Glob Health
Aim: To synthesise the latest evidence in relation to the role of children in the transmission of SARS-CoV-2.
INFECTION CONTROL
6/28/20
Zhao Q, Fang X, Pang Z, et al. | J Eur Acad Dermatol Venereol
Aim: To gain an in-depth understanding of COVID-19 by summarizing publications related to the cutaneous manifestations of the disease and the ACE2 expression in skin tissues.
CLINICAL CHARACTERISTICS
6/27/20
Matar R, Oules B, Sohier P, et al. | J Eur Acad Dermatol Venereol
Aim: To analyze our experience in a French referral center and to perform a systematic review of the literature to evaluate the incidence and prognosis of cutaneous lesions observed in COVID?19 patients. 
CLINICAL CHARACTERISTICS
6/27/20
Schnitzbauer AA, Kempf VAJ, Hack D, et al. | Surgeon
Aim: To summarize the evidence on standards for personal protective equipment (PPE) for the employees in the central emergency rooms and in the operating area as well as restructuring measures for the operations in the operating area in a COVID-plus area.
INFECTION CONTROL
6/27/20
Gengler I, Wang JC, Speth MM, et al. | Laryngoscope Investig Otolaryngol
Aim: To synthesize existing scientific evidence on the role of sinonasal pathophysiology in COVID?19.
CLINICAL CHARACTERISTICS
6/26/20
Meena J, Yadav J, Saini L, et al. | Indian Pediatr
Aim: To synthesize the information on clinical manifestations, laboratory findings, and outcome of COVID-19 among the pediatric population.
CLINICAL CHARACTERISTICS
6/26/20
Hanrahan JG, Burford C, Adegboyega G, et al. | World Neurosurg
Aim: To detail early experiences and changes to neurosurgical practice in response to the COVID-19 pandemic.
6/26/20
Feng X, Li S, Sun Q, et al. | Front Med
Aim: To explore the effect of risk factors on the severity of the disease, focusing on immune-inflammatory parameters, which represent the immune status of patients.
CLINICAL CHARACTERISTICS
6/26/20
da Costa KVT, Carnauba ATL, Rocha KW, et al. | Braz J Otorhinolaryngol
Aim: To identify evidence in the scientific literature about olfactory/gustatory disorders, their clinical presentation, prevalence and possible specific treatments associated with COVID-19.
CLINICAL CHARACTERISTICS
6/26/20
Helfand M | VA Evidence Synthesis Program
Aim: To review the evidence for using corticosteroids to treat acute respiratory distress syndrome in patients with COVID-19.
UPDATED
VA ESP
6/26/20
Duan-Porter W | VA Evidence Synthesis Program
Aim: To explore the length of stay in the intensive care unit (ICU) and time on invasive mechanical ventilation for adult patients with COVID-19.
UPDATED
VA ESP
6/25/20
Tahvildari A, Arbabi M, Farsi Y, et al. | Front Med
Aim: To characterize the clinical, diagnostic, and treatment characteristics of patients presenting with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
6/25/20
 | ECRI
Aim: To provide guidance on ways to protect staff, measures to limit transmission, recommendations for COVID-19 testing for pregnant women and for infants born to infected mothers, and optimal maternal care and breastfeeding recommendations.
6/25/20
Saleem H, Rahman J, Aslam N, et al. | Cureus
Aim: To review the evidence on COVID-19 severity in children.
6/25/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of acquiring COVID-19 on an aircraft.
6/25/20
Pelland-St-Pierre L, Duquesne L | Center for Research in Public Health
Aim: To review the evidence on COVID-19 outbreaks in childcare centers and schools, including risk factors, symptoms, and attack rates.
6/25/20
Espinosa OA, Dos Santos Zanetti A, Antunes EF, et al. | Rev Inst Med Trop Sao Paulo
Aim: To calculate the prevalence and geographical distribution of comorbidities in all patients admitted to intensive care units (ICUs), and the mortality rate of COVID-19.
6/25/20
Qureshi Z, Jones N, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify the evidence behind the 2-metre social distancing rule in the context of the still used large vs. small (droplet vs airborne) droplet size dichotomy in route of transmission.
UPDATED
6/24/20
Polak SB, Van Gool IC, Cohen D, et al. | Mod Pathol
Aim: To increase our understanding of COVID-19 pathophysiology by constructing a timeline and correlating histopathological findings with clinical stages of COVID-19. 
CLINICAL CHARACTERISTICS
6/24/20
Matar R, Alrahamani L, Monzer N, et al. | Clin Infect Dis
Aim: To describe the clinical characteristics and perinatal outcomes of COVID-19 in pregnancy.
CLINICAL CHARACTERISTICS
6/24/20
Trippella G, Ciarcia M, Ferrari M, et al. | Pathogens
Aim: To provide a comprehensive overview of all the available data regarding clinical features, outcomes, and management of pregnant women with COVID-19. 
CLINICAL CHARACTERISTICS
6/24/20
Chou R, Dana T, Jungbauer R, et al. | Ann Intern Med
Aim: To examine the effectiveness of N95, surgical, and cloth masks in community and health care settings for preventing respiratory virus infections, and effects of reuse or extended use of N95 masks.
UPDATED
6/24/20
Pinzon RT, Wijaya VO, Buana RB, et al. | Front Neurol
Aim: To understand the neurologic characteristic of the disease and help physicians with early diagnosis and management.
CLINICAL CHARACTERISTICS
6/24/20
Gordon M, Kagalwala T, Rezk K, et al. | BMJ Paediatr Open
Aim: To carry out a systematic review of the available studies on COVID-19 (coronavirus disease 2019) in neonates seen globally since the onset of the COVID-19 global pandemic in 2020.
6/24/20
Xu L, Mao Y, Chen G, et al. | Aging
Aim: To systematically review evidence for the risk factors of COVID-19 patients progressing to critical illness.
6/24/20
Grant MC, Geoghegan L, Arbyn M, et al. | PLoS One
Aim: To determine the prevalence of symptoms associated with COVID-19 worldwide.
CLINICAL CHARACTERISTICS
6/24/20
Jones P, Roberts S, Hotu C, et al. | Emerg Med Australas
Aim: To determine the carriage of respiratory viruses on facemasks used by HCW.
6/23/20
Baksh M, Ravat V, Zaidi A, et al. | Cureus
Aim: To summarize the clinical presentation, laboratory and chest imaging findings, management protocols, and outcome of ARDS in COVID-19-positive patients.
CLINICAL CHARACTERISTICS
6/23/20
Gao Y, Liu R, Zhou Q, et al. | Ann Transl Med
Aim: To assess the effectiveness of telemedicine in reducing transmission of COVID-19 and reducing pressure on medical institutions.
UPDATED
6/23/20
Yang N, Che S, Zhang J, et al. | Ann Transl Med
Aim: To conduct a rapid review of mother-to-child transmission of COVID-19 during breastfeeding.
UPDATED
6/23/20
Ofori-Asenso R, Ogundipe O, Agyeman AA, et al. | Ecancermedicalscience
Aim: To examine the prevalence of cancer and its association with disease severity in patients with novel coronavirus disease 2019 (COVID-19).
6/23/20
Lv M, Wang M, Yang N, et al. | Ann Transl Med
Aim: To understand the role of CT for the diagnosis and the main imaging manifestations of patients with COVID-19.
UPDATED
DIAGNOSTICS
6/23/20
Wang Z, Zhou Q, Wang C, et al. | Ann Transl Med
Aim: To review the clinical characteristics of children with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
6/23/20
Huang D, Lian X, Song F, et al. | Ann Transl Med
Aim: To identify and treat the severe and critical patients with COVID-19 is the key clinical problem to be solved.
CLINICAL CHARACTERISTICS
6/23/20
Gold MS, Sehayek D, Gabrielli S, et al. | Postgrad Med
Aim: To evaluate comorbidities associated with severe and fatal cases of COVID-19.
6/23/20
Lu S, Zhou Q, Huang L, et al. | Ann Transl Med
Aim: To review the evidence on the use of glucocorticoids in treating COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Zhang J, Yang Y, Yang N, et al. | Ann Transl Med
Aim: To explore the clinical effectiveness and safety of IVIG in the treatment of children with severe COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Wang J, Tang Y, Ma Y, et al. | Ann Transl Med
Aim: To evaluate the efficacy and safety of antibiotic agents in children with COVID-19, as well as to introduce the present situation of antibiotics use and bacterial coinfections in COVID-19 patients. 
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Montesanti S, Silverstone P, Wells L, et al. | CIHR IRSC
Aim: To specifically understand the potential of trauma-focused virtual interventions that can rapidly be used to support domestic violence and sexual assault populations.
6/23/20
Alnor A, Sandberg MB, Gils C, et al. | J Appl Lab Med
Aim: To examine which routine laboratory tests are associated with severe COVID-19 disease.
CLINICAL CHARACTERISTICS
6/23/20
Zhou Q, Gao Y, Wang X, et al. | Ann Transl Med
Aim: To understand nosocomial infection in patients with COVID-19, SARS, and MERS.
UPDATED
6/23/20
Thulien N, Noble A, Daley M, et al. | CIHR IRSC
Aim: To review the evidence on promising mental health and substance use practices utilized by front-line providers serving young people who are experiencing or have experienced homelessness during the COVID-19 pandemic.
6/23/20
Shi Q, Zhou Q, Wang X, et al. | Ann Transl Med
Aim: To assess the potential effectiveness and safety of antiviral agents for COVID-19 in children. 
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Singh AK, Gillies CL, Singh R, et al. | Diabetes Obes Metab
Aim: To estimate the prevalence of both cardiometabolic and other co?morbidities in patients with COVID?19 infection, and to estimate the increased risk of severity and mortality in people with co?morbidities.
CLINICAL CHARACTERISTICS
6/23/20
Li W, Liao J, Li Q, et al. | Ann Transl Med
Aim: To review the evidence on how health providers should advise families and parents to obtain health education information during the COVID-19 pandemic.
6/23/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the effect of the COVID-19 pandemic on alcohol use and alcohol-related harms.
6/23/20
Prajapat M, Sarma P, Shekhar N, Avti P, Sinha S, Kaur H, Kumar S, Bhattacharyya A, Kumar H, Bansal S, Medhi B | Indian J Pharmacol
Aim: To review the structural basis of different target proteins of SARS-corona virus (CoV2) from a viral life cycle and from drug design perspective.
6/22/20
Goodarzi Z, Watt J, Kirkham J, et al | CIHR IRSC
Aim: To review the evidence on the effect of telehealth interventions on depression or depressive symptoms in older adults.
UPDATED
6/22/20
Best MW, Grossman M, Bowie C, et al. | TIP Research Lab
Aim: To review the evidence on interventions for schizophrenia-spectrum disorders for virtual delivery.
6/22/20
Lam R, Murphy J, Michalak E, et al. | CIHR IRSC
Aim: To review the evidence on at-risk groups and their mental health needs in the context of COVID-19 in the Asia Pacific Region and recommendations for improving access to digital mental health support.
6/22/20
Weiss J, Lee V, Aubaum C, et al. | CIHR IRSC
Aim: To review the evidence on the impact of the COVID-19 pandemic on caregiver and family functioning, and on mental health services response.
6/22/20
Karanasos A, Aznaouridis K, Latsios G, et al. | Nicotine Tob Res
Aim: To summarize relevant studies and quantify the impact of smoking on disease severity and mortality of hospitalized COVID-19 patients.
6/22/20
Armitage LC, Brettel R | Oxford COVID-19 Evidence Service Team
Aim: To review the current evidence on the use of inhaled corticosteroids to prevent the development of acute respiratory distress syndrome.
6/22/20
Carroll S, Collins B, Dolce M, et al. | CIHR IRSC
Aim: To review the evidence on how to prevent or mitigate mental health and substance use responses for those at risk of severe COVID-19 infection.
6/22/20
Hoang MP, Kanjanaumporn J, Aeumjaturapat S, et al. | Asian Pac J Allergy Immunol
Aim: To review the associations of olfactory and gustatory dysfunctions with COVID-19 which will be useful for early diagnosis and self-isolation. 
CLINICAL CHARACTERISTICS
6/22/20
Birnie KA, Noel M, Stinson J, et al. | CIHR IRSC
Aim: To review the evidence on virtual care solutions for pain, mental health, and substance use in youth with pre-existing and new onset pain actross the stepped care model during the COVID-19 pandemic.
6/22/20
Luo M, Guo L, Yu M, et al. | Psychiatry Res
Aim: To assess the psychological and mental impact of COVID-19 among healthcare workers, the general population, and patients with higher COVID-19 risk.
6/21/20
Kronbichler A, Kresse D, Yoon S, et al. | Int J Infect Dis
Aim: To summarize the presentation of asymptomatic COVID-19 infections.
CLINICAL CHARACTERISTICS
6/21/20
Parohan M, Yaghoubi S, Seraji A | Eur Heart J Acute Cardiovasc Care
Aim: To summarize available findings on the association between cardiac injury and severity of COVID-19 infection.
6/21/20
Kunustor SK, Laukkanen JA | J Infect
Aim: To review the evidence on the characteristics and prevalence of hepatic manifestations and complications of COVID-19
6/21/20
Ghannam MG, Alshaer QA, Al-Chalabi MAC, et al. | J Neurol
Aim: To clarify the neurological complications of SARS-CoV-2 infection including the potential mechanisms and therapeutic options.
UPDATED
6/21/20
Montana M, Montero V, Khoumeri O, et al. | Molecules
Aim: To compile and discuss recently published studies concerning the therapeutic potential of the antiviral activity of quinoxaline derivatives.
6/21/20
Bienvenu A, Marty AM, Jones MK, et al. | One Health
Aim: To analyze studies registered on ClinicalTrials.gov that study hydroxycholorquine as a COVID-19 prophylaxis.
6/20/20
Maldonado E, Tao D, Mackey K | J Gen Intern Med
Aim: To synthesize evidence on thromboembolism incidence and outcomes with antithrombotic therapies in COVID-19.
UPDATED
VA ESP
CANDIDATE THERAPEUTICS
6/20/20
Castro-Rodriguez JA, Forno E | Pediatr Pulmonol
Aim: To review the evidence on the role of asthma in children with COVID-19 and the risk of infection.
UPDATED
6/20/20
Shelmerdine S, Lovrenski J, Caro-Dominguez P, et al. | Pediatr Radiol
Aim: To systematically review available literature regarding imaging findings in paediatric cases of COVID-19.
CLINICAL CHARACTERISTICS
6/20/20
Raba AA, Abobaker A, Elgenaidi IS, et al. | Acta Pediatr
Aim: To evaluate the clinical characteristics of COVID?19 in neonates and children under one year of age.
CLINICAL CHARACTERISTICS
6/20/20
Nobar NN, Goodarzi A | Dermatol Ther
Aim: To review the evidence on the course of COVID-19 in patients with dermatologic disorders, and the most effective management strategies.
6/20/20
 | Health Technology, Wales
Aim: To reivew the evidence on the use of point-of-care ultrasound imaging for suspected and confirmed cases of COVID-19.
6/20/20
Yang X, Jin Y, Li R, et al. | Crit Care
Aim: To assess the prevalence of abnormal urine analysis and kidney dysfunction in COVID-19 patients and to determine the association of acute kidney injury (AKI) with the severity and prognosis of COVID-19 patients.
CLINICAL CHARACTERISTICS
6/20/20
Sacco G, Briere O, Asfar M, et al. | Geriatr Psychol Neurosychiatr Vieil
Aim: To identify, from international literature, the most common symptoms met in older adults infected with the SARS-CoV-2 virus.
CLINICAL CHARACTERISTICS
6/20/20
Xuefeng M, Shouseng L, Chen L, Zhuang L, et al. | J Med Virol
Aim: To investigate the clinical features of pediatric inpatients with SARS-CoV-2 infection.
CLINICAL CHARACTERISTICS
6/20/20
Waller JV, Allen IE, Lin KK, et al. | Invest Radiol
Aim: To stratify studies as high or low risk of bias to determine the true sensitivity of CT for severe acute respiratory syndrome coronavirus-2 infection
6/20/20
Piscitello GM, Kapania EM, Miller WD, et al. | JAMA Netw Open
Aim: To evaluate the number of publicly available US state guidelines for ventilator allocation and the variation in state recommendations for how ventilator allocation decisions should occur and to assess whether unique criteria exist for pediatric patients.
6/19/20
Prato AP, Conforti A, Almstrom M, et al. | Front Pediatr
Aim: To propose technical strategies to assist the pediatric surgeons to minimize the potential aerosolization of viral particles in COVID-19 patients undergoing urgent or emergent surgical treatment using laparoscopic approaches, based on the currently available literature.
6/19/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the effect of the COVID-19 pandemic on opioid and substance use and related harms.
6/19/20
Lakhani HV, Pillai SS, Zehra M, et al. | Int J Environ Res Public Health
Aim: To provide insight on the pathogenesis and the transmission dynamics of CoVID-19 along with pharmacological and non-pharmacological intervention strategies to mitigate the clinical manifestation of this virus.
6/19/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the impact of COVID-19 on the mode and content of clinical education and current recommendations to address the impact.
6/19/20
Latalska M, Mackiewicz J | Ann Agric Environ Med
Aim: To review the evidence of ocular pathologies in asymptomatic COVID-19 patients.
CLINICAL CHARACTERISTICS
6/18/20
Jameleddine M, Harzallah N, Jebali MC, et al. | Department of Evaluation Interventions and Health Technologies
Aim: To review the effectiveness and value of the use of spray booths for disinfectants on humans as a preventive measure at the entrance to establishments, with the aim of reducing the spread of SARS-CoV-2.
INFECTION CONTROL
6/18/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the safe use of pools for hydrotherapy or aquatic physiotherapy during COVID-19.
6/18/20
Chen Y, Shao S, Hsu C, et al. | Crit Care
Aim: To quantify the incidence of acute kidney injury in COVID-19 patients.
CLINICAL CHARACTERISTICS
6/18/20
Tabari P, Amini M, Moghadami M, et al. | Iran J Med Sci
Aim: To determine countries’ public responses to the epidemic of COVID-19 and how they developed administrative approaches towards the outbreak.
UPDATED
6/18/20
Chung TW, Sridhar S, Zhang AZ, et al. | Open Forum Infect Dis
Aim: To review the evidence on olfactory disturbances in COVID-19 patients.
CLINICAL CHARACTERISTICS
6/18/20
Novara G, Checcucci E, Crestani A, et al. | Eur Urol
Aim: To perform a systematic review of the literature and evaluate all the available studies on urological applications of telehealth.
INFECTION CONTROL
6/17/20
Grover A, Oberoi M | Eur Heart J Cardiovasc Pharmacother
Aim: To review the evidence on the continued use of angiotensin converting enzyme inhibitors (ACEI) and angtiotensin receptor blockers (ARBs) in patients with COVID-19.
UPDATED
6/17/20
Di Lorenzo G, Di Trolio R, Kozlakidis Z, et al. | Crit Rev Oncol Hematol
Aim: To review the evidence on the clinical outcomes of COVID-19-positive patients and the possible interactions between drugs used in experimental therapy of COVID-19 and commonly used antineoplastic drugs.
CANDIDATE THERAPEUTICS
6/17/20
Agarwal A, Basmaji J, Muttalib F, et al. | Can J Anaesth
Aim: To describe the efficacy and safety of HFNC in acute hypoxemic respiratory failure; and to determine the risk of dispersion, aerosol generation and associated transmission of COVID-19 with HFNC.
UPDATED
WHO COLLABORATIVE
6/17/20
Sharpe H | Alberta Health Services
Aim: To review the evidence on the safety and efficacy of video laryngoscopy in intubating patients with suspected or confirmed COVID-19.
6/17/20
Galang RR, Chang K, Strid P, et al. | Obstet Gynecol
Aim: To summarize the clinical presentation, course of illness, and pregnancy and neonatal outcomes in pregnant women with MERS-CoV, SARS-CoV, or SARS-CoV-2.
6/17/20
Lauvrak V, Juvet L | Norwegian Institute of Public Health
Aim: To identify any reported associations between increased severity of COVID-19 disease, and infection rates in populations postulated to be socially or economic vulnerable.
6/15/20
Raymond C, Loshak H | CADTH
Aim: To describe the trial characteristics and estimated primary completion dates of the ongoing phase II, phase III, and phase IV studies evaluating IVIg and hyperimmune globulin to treat COVID-19.
6/15/20
Pavan N, Crestani A, Abrate A, et al. | Eur Urol Focus
Aim: To evaluate the risk of virus spread due to surgical smoke during surgical procedures.
6/15/20
Barbosa DJ, Gomes MP, Souza BA, et al. | Comun. ciênc. saúde
Aim: To identify the main psychological effects of the COVID-19 pandemic on nursing professionals; describe the main factors capable of generating psychological stress in nursing professionals, describe the coping strategies to combat emotional stress.
6/15/20
Bornstein S | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the psychological impact of self-isolation on older adults living in the community.
6/14/20
Heldwein FL, Loeb S, Wroclawski ML, et al. | Eur Urol Focus
Aim: To summarize guidelines and recommendations on the urology standard of care during the COVID-19 pandemic.
6/14/20
Velev V, Popov M, Velikov P, et al. | Infez Med
Aim: To describe the incidence and type of the gastrointestinal injury (GI) in COVID-19, as well as their prognostic value.
CLINICAL CHARACTERISTICS
6/14/20
Heidary F, Gharebaghi R | J Antibiot (Tokyo)
Aim: To summarize the antiviral effects of ivermectin by reviewing available in vivo and in vitro studies over the past 50 years.
CANDIDATE THERAPEUTICS
6/14/20
Bonilla-Aldana DK, Cardona-Trujillo MC, García-Barco A, et al. | Infez Med
Aim: To review the evidence on the role of animals as potential reservoirs for MERS-CoV and SARS-CoV.
UPDATED
6/14/20
Samidoust P, Samidoust A, Samadani AA, et al. | Infez Med
Aim: To investigate the incidence of liver injury among published literature from 2019-Jan-01 to 2020-April-03 to provide an outline for further studies on the liver injury of COVID-19. 
6/14/20
Yamada T, Wakabayashi M, Yamaji T, et al. | Clin Chim Acta
Aim: To investigate the association between severe COVID-19 and a change in white blood cell (WBC) count, an elevation of C-reactive protein (CRP), and fever, and to evaluate the diagnostic accuracy of leukocytosis and an elevation of CRP.
CLINICAL CHARACTERISTICS
6/13/20
Xin S, Xu J, Yu Y | J Gastrointestin Dis
Aim: To compare the risk of abnormal liver function tests between severe and non-severe patients with coronavirus disease 2019 (COVID-19) by meta-analysis.
CLINICAL CHARACTERISTICS
6/13/20
Wang L, Shen Y, Li M, et al. | J Neurol
Aim: To systematically collect and investigate the clinical manifestations and evidence of neurological involvement in COVID-19.
CLINICAL CHARACTERISTICS
6/13/20
Zhu T, Xu A, Bai X, et al. | Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Aim: To systematically review evidence for the effect of convalescent plasma and immunoglobulin on treatment of severe acute respiratory syndrome (SARS), and further provide advice on the treatment of coronavirus disease 2019 (COVID-19).
CANDIDATE THERAPEUTICS
6/13/20
Walker KF, O'Donoghue K, Grace N, et al. | BJOG
Aim: To estimate the risk of the neonate becoming infected with SARS-COV-2 by mode of delivery, type of infant feeding and mother-infant interaction. 
6/13/20
Patel NA | Am J Otolaryngol
Aim: To elucidate a better understanding of the global impact of COVID-19 on the pediatric population.
6/12/20
Almufarrij I, Uus K, Munro KJ | Int J Audiol
Aim: To investigate audio-vestibular symptoms associated with coronavirus.
UPDATED
CLINICAL CHARACTERISTICS
6/12/20
 | Public Health Agency of Canada
Aim: To summarize the literature on associations of ethnicity with risk of infection, severity and mortality to COVID-19.
6/12/20
 | Public Health Agency of Canada
Aim: To review the evidence on characteristics of the workplace that can increase the risk of COVID-19 transmission.
6/12/20
Parasa S, Desai M, Chandrasekar VT, et al. | JAMA Netw Open
Aim: To provide a pooled estimate of GI symptoms, liver enzyme levels outside reference ranges, and fecal tests positive for SARS-CoV-2 among patients with COVID-19.
CLINICAL CHARACTERISTICS
6/12/20
Erdmann R | Alberta Health Services
Aim: To review the evidence on the effectivness of workplace screening programs for reducing the spread of COVID-19 in healthcare settings.
6/12/20
 | National Collaborating Centre for Methods and Tools
Aim: To identify, appraise, and summarize emerging research evidence on the efficacy and cost-effectiveness of copper materials to reduce transmission of the virus.
6/12/20
 | National Collaborating Centre for Methods and Tools
Aim: To identify, appraise, and summarize emerging research evidence on the effectiveness of cohorting virus-positive residents to shared rooms in care facilities.
6/12/20
Chiesa-Estomba CM, Lechien JR, Calvo-Henriquez C, et al. | Oral Oncol
Aim: To summarize in a systematic way the available recommendations from 18 guidelines from all over the world.
UPDATED
6/12/20
 | Malaysian Health Technology Assessment Section
Aim: To provide scientific evidence on the use of XPEL® RX silver ion protection film for COVID-19 based on a request from the Medical Care Quality Section (MOH) following a proposal from a company to introduce the technology.
6/11/20
 | Public Health Agency of Canada
Aim: To review the evidence on SARS-CoV-2 transmission in dental settings, and the infection transmission risk from aerosol generating procedures use in dental care?
6/11/20
Bresee L, MacDougall D | CADTH
Aim: To describe the epidemiology of venous thromboembolism (VTE), review the evidence on the use of pharmacologic thromboprophylaxis for the prevention of VTE, and list ongoing trials.
6/10/20
Bhaumik S, Moola S, Tyagi J, et al. | BMJ Glob Health
Aim: To examine the evidence to inform the potential role, enablers and barriers for community health workers during COVID-19 prevention and control from the National Health Systems Resource Centre (NHSRC), India.
6/10/20
 | ECRI
Aim: To review the evidence on the optimal timing for performing tracheotomy in patients with acute respiratory failure.
6/10/20
Iversen BG, Vestrheim DF, Flottorp S, et al. | Norwegian Institute of Public Health
Aim: To review the evidence on the use of face masks by people in the community to reduce the spread of COVID-19.
6/10/20
Pelland-St-Pierre L, Cortes JB | Center for Research in Public Health
Aim: To review the evidence on the impact of contact time, distance between contacts, and the environment on the probablity of transmission of the coronavirus between humans.
6/10/20
Waddell K, Wilson MG, Bullock HL, et al. | McMaster University Health Forum
Aim: To review the evidence on pandemic-related mental health and addictions issues have emerged and what indicators and strategies can be used to monitor and address them.
6/9/20
MacIntyre CR, Chughtai AA | Int J Nurs Stud
Aim: To review the evidence around the efficacy of masks and respirators for healthcare workers, sick patients and the general public.
INFECTION CONTROL
6/9/20
Razmi M, Madjd Z, Ghods R, et al | PROSPERO
6/9/20
Wan S, Li M, Ye Z, et al. | Acad Radiol
Aim: To assess the prevalence of significant computed tomographic(CT) manifestations and describe some notable features based on chest CT images, as well as the main clinical features of patients with coronavirus disease 2019(COVID-19).
CLINICAL CHARACTERISTICS
6/9/20
Patel TK, Barvaliya M, Kevadiya BD, et al. | J Neuroimmune Pharmacol
Aim: To find out early trends of mortality in COVID-19 patients treated with hydroxychloroquine based on published literature.
CANDIDATE THERAPEUTICS
6/9/20
 | Health Information and Quality Authority, Ireland
Aim: To review the international evidence on immunity and the spread of the virus by children.
UPDATED
6/9/20
Ashcroft J, Byrne MHV, Brennan PA, et al. | Postgrad Med J
Aim: To identify pandemic and disaster medicine-themed training programmes aimed at medical students and to assess whether these interventions had an effect on objective measures of disaster preparedness and clinical outcomes.
6/9/20
Huntley BJF, Huntley ES, Di Mascio D, et al. | Obstet Gynecol
Aim: To ascertain the frequency of maternal and neonatal complications, as well as maternal disease severity, in pregnancies affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
UPDATED
6/9/20
Nasir M, Talha KA, Islam T, et al. | Mymensingh Med J
Aim:  To evaluate the available evidence on efficacy, safety to identify any promising role for compassionate use of remdesivir in patient suffered for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as re-purposeful use. 
CANDIDATE THERAPEUTICS
6/8/20
Carver C, Jones N | Oxford COVID-19 Evidence Service Team
Aim: To determine if there are any known risk factors for ARDS in this infection and whether there are any interventions to prevent ARDS developing.
6/8/20
Parohan M, Yaghoubi S, Seraj A, et al. | Aging Male
Aim: To summarize available findings on the association between age, gender, comorbidities and risk of death from COVID-19 infection.
UPDATED
6/8/20
Lima WG, Brito J, Overhage J, et al. | Arch Virol
Aim: To describe the drug repositioning strategy against SARS-CoV-2 and to discuss the clinical impact of this approach in the current pandemic context. 
CANDIDATE THERAPEUTICS
6/8/20
Williams S | Newfoundland and Laborador Centre for Applied Health Research
6/7/20
Kunutsor S, Laukkanen | J Infect
Aim: To review the evidence on cardiovascular complications associated with COVID-19.
UPDATED
6/7/20
Dedeilia A, Sotiropoulos MG, Hanrahan JG, et al. | In Vivo
Aim: To identify the challenges imposed on medical and surgical education by the COVID-19 pandemic, and the proposed innovations enabling the continuation of medical student and resident training. 
6/7/20
Loades ME, Chatburn E, Higson-Sweeney N, et al. | J Am Acad Child Adolesc Psychiatry
Aim: To establish what is known about how loneliness and disease containment measures impact on the mental health in children and adolescents.
6/6/20
Romoli M, Jelcic I, Bernard-Valnet R, et al. | Eur J Neurol
Aim: To  review available evidence for reports of neurological signs and symptoms in Coronavirus disease (COVID)-19 patients to identify cases with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection or immune-mediated reaction in the nervous system.
CLINICAL CHARACTERISTICS
6/6/20
Alimohamadi Y, Taghdir M, Sepandi M | J Prev Med Public Health
Aim: To estimate the pooled R0 for COVID-19 in the current outbreak.
6/6/20
Mohamed MFH, A-Shokri S, Yousaf Z, et al. | Am J Trop Med Hyg
Aim: To pool the proportion of various reported lung abnormalities detected by LUS in symptomatic COVID-19 patients. 
CLINICAL CHARACTERISTICS
6/6/20
Quah P, Li A, Phua J | Crit Care
Aim: To review the outcomes of ICU patients with COVID-19 from the existing literature.
6/5/20
Pormohammad A, Ghorbani S, Baradaran B, et al. | Rev Med Virol
Aim: To review the evidence on clinical and laboratory characteristics of COVID-19 infected patients.
UPDATED
CLINICAL CHARACTERISTICS
6/5/20
Lahiri A, Jha SS, Bhattacharya S, et al. | Indian J Public Health
Aim: To understand the effectiveness of NPIs reported in the contemporary literatures describing prediction models for prevention of the ongoing pandemic of SARS-CoV-2 specifically in Indian population.
6/5/20
Toomey E, Conway Y, et al. | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the extended use or re-use of single-use respirators and surgical masks by frontline healthcare workers.
6/5/20
Aggarwal N, Dwarakanathan V, Gautam N, et al. | Indian J Public Health
Aim: To estimate the effectiveness of facemask use alone or along with hand hygiene in community settings in reducing the transmission of viral respiratory illness.
INFECTION CONTROL
6/5/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the transmission of COVID-19 to and from healthcare professionals and strategies to reduce risk of nosocomial infections of COVID-19.
6/5/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on isolation periods other than 14 days in response to COVID-19 in various jurisdictions.
6/5/20
Leal J | Alberta Health Services
Aim: To review the evidence on the transmission of SARS-CoV-2 virus through heating, ventiliation, and air conditioning (HVAC) systems in hospitals or non-hospital settings.
6/5/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the duration from expsoure to symptoms or diagnosis for COVID-19.
6/5/20
Mackey S, Warren C, Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the approaches being taken to mitigate the risks associated with reopening establishments that provide personal services.
6/5/20
Bhagavathula AS, Aldhaleei WA, Rovetta A, et al. | Cureus
Aim: To extract and summarize information on potential vaccines and therapeutic agents against COVID-19 at different stages of clinical trials from January to March 2020.
CANDIDATE THERAPEUTICS
6/5/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence regarding temporary workforce reconfigurations such as splitting of teams and establishing social distancing protocols within teams to minimise staff exposure to COVID-19.
UPDATED
6/4/20
Rosenwohl-Mack A, Schumacher K, Fang ML, et al. | Int J Nurs Stud
Aim: To synthesize the evidence on experiences of aging in place in the United States.
6/4/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the use of computed tomography in patients with COVID-19.
6/4/20
 | ECRI
Aim: Guidance on ways to protect staff, measures to limit transmission, recommendations for COVID-19 testing for pregnant women and for infants born to infected mothers, and optimal maternal care and breastfeeding recommendations.
6/4/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the infection rate, infectivity and transmission of COVID-19 in children?
6/4/20
Ye Z, Wang Y, Colunga-Lozano LE, et al. | CMAJ
Aim: To examine the impact of corticosteroids in COVID-19 and related severe acute respiratory illnesses to support a guideline for managing COVID-19.
CANDIDATE THERAPEUTICS
6/4/20
Byambasuren O, Cardona M, Bell K, et al. | medRxiv
Aim: To synthesize all available research on the asymptomatic rates and transmission rates where possible. 
6/4/20
Pranata R, Lim MA, Huang I, et al. | J Renin Angiotensin Aldosterone Syst
Aim: To investigate the association between hypertension and outcome in patients with Coronavirus Disease 2019 (COVID-19) pneumonia.
6/4/20
Pranata R, Huang I, Lim MA, et al. | J Stroke Cerebrovasc Dis
Aim: To evaluate the latest evidence on the association between cerebrovascular, cardiovascular disease, and poor outcome in patients with Coronavirus Disease 2019 (COVID-19) pneumonia.
6/4/20
Abdollahpour S, Khadivzadeh T | J Matern Fetal Neonatal Med
Aim: To improve the quality of care by health providers through what they need to know about coronavirus during pregnancy and childbirth.
6/4/20
Smith V, Deo D, Warty R, et al. | PLoS One
Aim: To systematically evaluate the literature and report the maternal and neonatal outcomes associated with COVID-19.
6/4/20
Santos VS, Gurgel RQ, Cuevas LE, et al. | J Pediatr Gastroenterol Nutr
Aim: To investigate differences in viral shedding in respiratory and fecal samples from children with COVID-19.
6/4/20
Zhang JJY, Lee KS, Ang LW, et al. | Clin Infect Dis
Aim: To review the evidence on predictors of severe disease and the efficacy of different treatments for COVID-19.
6/4/20
 | Health Technology, Wales
Aim: To review the evidence on the safety of personal protective equipment gowns for health and social care workers.
6/3/20
Yang M, Shang Y, Tian Z, et al. | Integr Med Res
Aim: To review the study characteristics of registered clinical trials on COVID-19 and provide guidance for future trials to avoid duplicated effort.
6/3/20
Nacif LS, Zanini LY, Waisberg DR, et al. | Clinics (Sao Paulo)
Aim: To collate available data on COVID-19 infection in solid organ transplantation (SOT) patients.
6/3/20
Vindegaard N, Benros ME | Brain Behav Immun
Aim: To systematically review the literature in order to provide an overview of the psychiatric complications to COVID-19 infection (direct effect) and how COVID-19 are currently affecting mental health among psychiatric patients and general public (indirect effect) alongside with factors altering the risk of psychiatric symptoms in both groups.
6/3/20
Liu W, Zhou P, Chen K, et al. | CMAJ
Aim: To support the development of a COVID-19 management guideline by reviewing evidence that addressed the benefits and harms of 7 antiviral treatments for COVID-19.
CANDIDATE THERAPEUTICS
6/3/20
Huang I, Pranata R | J Intensive Care
Aim: To investigate the association of lymphocyte count on admission and the severity of COVID-19.
CLINICAL CHARACTERISTICS
6/3/20
 | INESSS Quebec
6/3/20
Vestrheim DF, Iversen BG, Flottorp S, et al. | Norwegian Institute of Public Health
Aim: To review the evidence on the use of facemasks by asymptomatic personnel in long-term care facilities for primary prevention of COVID-19 infection.
6/3/20
Iannone P, Castellini G, Coclite D, et al. | PLoS One
Aim: To assess the efficacy of N95 respirators versus surgical masks for the prevention of respiratory tract infections transmission among HCWs.
UPDATED
6/2/20
Raymond M, Ching-A-Sue G, Van Hecke O | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on mast cell stabilizers, leukotriene antagonists, and antihistimines in COVID-19.
UPDATED
6/2/20
Boyd J, Davis A | Alberta Health Services
Aim: To review the various models, scenarios and thresholds that have been used internationally from past pandemics.
6/2/20
Liu M, Gao Y, Zhang Y, et al. | J Infect
Aim: To review the evidence on the assocation between severe or death COVID-19 and autoimmune disease.
6/1/20
Bolton L, Mills C, Wallace S, et al. | Int J Lang Commun Disord
Aim: To review the evidence underpinning the current healthcare policies in relation to AGPs, dysphagia assessment, and risk of transmission of and infection with COVID?19 in response to urgent clinical information needs.
6/1/20
Sanna G, Serrau G, Bassareo PP, et al. | Eur J Pediatr
Aim: To summarize all COVID-19 cases with a cardiac involvement published in paediatric age and explain the underlying mechanisms responsible for COVID-19-related myocardial damage.
6/1/20
Wang Y, Fang R, Zhang H, et al. | Dermatol Ther
Aim: To reveal the contribution of dermatologists in COVID-19 research.
6/1/20
Ojha V, Mani A, Pandey NN, et al. | Eur Radiol
Aim: To evaluate the key imaging manifestations of COVID-19 on chest CT in adult patients by providing a comprehensive review of the published literature.
CLINICAL CHARACTERISTICS
6/1/20
Liu M, Gao Y, Shi S, et al  | J Infect
Aim: To quantitatively assess whether drinking is associated with the severity of COVID-19.
6/1/20
Kunutsor S, Laukkanen J | J Infect
Aim: To review the evidence on clinical characteristics and outcomes of liver injury in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
6/1/20
Chu DK, Akl EA, Duda S, et al. | Lancet
Aim: To investigate the effects of physical distance, face masks, and eye protection on virus transmission in health-care and non-health-care (eg, community) settings.
UPDATED
6/1/20
Adams HJA, Kwee TC, Yakar D, et al. | AJR Am J Roentgenol
Aim: To systematically review and meta-analyze the diagnostic accuracy of chest CT in detecting coronavirus disease (COVID-19).
DIAGNOSTICS
5/31/20
Lansbury L, Lim WS, Baskaran V, et al. | J Infect
Aim: To evaluate the burden of co-infections in patients with COVID-19.
UPDATED
5/29/20
Qu W, Wang Z, Hare JM, et al. | Stem Cells Transl Med
Aim: To review the available literature on safety, efficacy, and cytokine responses to MSC therapies in patients with ARDS.
5/29/20
Li X, Guan B, Su T, et al. | Heart
Aim: To assess the impact of underlying cardiovascular comorbidities and acute cardiac injury on in-hospital mortality risk.
5/29/20
 | INESSS Quebec
5/29/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on how affected jurisdictions handled previously positive COVID-19 cases in the context of re-exposure/re-infection.
5/29/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the potential for COVID-19 re-infection, including new transmission after recovery.
5/29/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on what serological tests are available and their sensitivities and specificities.
5/28/20
Das S, Bhowmick S, Tiwari S, et al. | Clin Drug Investig
Aim: To systematically review the therapeutic role of HCQ in COVID-19 from the available literature.
CANDIDATE THERAPEUTICS
5/28/20
Hartmann-Boyce J, et al. | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the risk and management of people of asthma during the COVID-19 pandemic.
5/28/20
Sutherland AE, Stickland J, Wee B | BMJ Support Palliat Care
Aim: To identify the highest currently available level of evidence to inform this major change in clinical practice.
5/28/20
Williams S, Walsh C | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the standards and practices that non-medical first responders should use in all activities with potential for exposure to high risk populations.
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on risk stratification approaches to identify risk level in diabetes patients and clinical pathways to support diabetes management and service delivery.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of domestic and family violence during the COVID-19 pandemic.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on fibrinolysis versus primary percutaneous coronary intervention in the treatment of ST-Elevation Myocardial Infarction (STEMI).
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence and guidelines on the use of PPE in COVID-19.
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the available guidelines on inpatient management of COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on safe practice of intubation in the emergency department during the COVID-19 pandemic.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on large vessel occlusion stroke in patients with COVID-19.
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of newborn babies developing COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on how the increasing use of NIPPV to manage suspected or confirmed COVID-19 patients led to any additional guidance regarding the physical requirements and engineering services.
UPDATED
5/28/20
Kumar VCS, Mukherjee S, Harne PS, et al. | BMJ Open Gastroenterol
Aim: To perform a systematic review and meta-analysis on the GI symptoms of COVID-19.
CLINICAL CHARACTERISTICS
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on preservingc onsumer and patient partnership approaches during COVID-19.
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the guidance for the provision of pulmonary rehabilitation for people recovering from COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on supporting health systems to reduce adverse impacts on people with a lived experience of mental health issues during the COVID-19 pandemic.
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the rehabilitation needs of post-acute COVID-19 patients and the appropriate timing of rehabilitation interventions.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the use of renal replacement therapies in intensive care units for patients with COVID-19?
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effectiveness of santising and covering large medical equipment for COVID-19.
5/28/20
Dagens A, Sigfrid L, Cai E, et al. | BMJ
Aim: To appraise the availability, quality, and inclusivity of clinical guidelines produced in the early stage of the coronavirus disease 2019 (covid-19) pandemic.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on spirometry and whether it's an aerosol generating procedure, and the risk this procedure carries during the COVID-19 pandemic.
UPDATED
5/28/20
Keeley P, Buchanan D, Carolan C, et al. | BMJ Palliat Care
Aim: To review the evidence on symptom prevalence and intensity, resistance or susceptibility to symptom control, and mode of death in COVID-19 patients to inform palliative and end-of-life care.
CLINICAL CHARACTERISTICS
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the available guidelines on temporary shared accomodations, particularly for people experiencing homelessness.
UPDATED
5/28/20
Checcucci E, Piramide F, Pecoraro A, et al. | Panminerva Med
Aim: To summarize the preliminary experiences and ongoing clinical trials of the major candidates and challenges of the vaccine strategies in humans.
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effectiveness of mass thermal imaging in identifying people with COVID-19.
UPDATED
5/28/20
Zhen J, Chan C, Schoonees A, et al. | South African Med J
Aim: To assess the abilities of different interventions to decrease the incidence of droplet-based infections among people using public ground transport.
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on which tools are validated to diagnose respiratory illness via telehealth.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the proportion of COVID-19 cases in intensive care units that require ventilation.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effective use of telemedicine or virtual care in different clinical areas.
5/27/20
Chan VW, Chiu PK, Yee CH, et al. | World J Urol
Aim: To review the evidence on COVID-19 and its potential urological manifestations.
CLINICAL CHARACTERISTICS
5/27/20
Duran P, Berman S, Niermeyer S, et al. | Rev Panam Salud Publica
Aim: To describe perinatal and neonatal outcomes in newborns exposed to SARS-CoV-2.
5/27/20
Hernandez AV, Roman YM, Pasupuleti V, et al. | Ann Intern Med
Aim: To summarize evidence about the benefits and harms of hydroxychloroquine or chloroquine for the treatment or prophylaxis of coronavirus disease 2019 (COVID-19).
CANDIDATE THERAPEUTICS
5/27/20
Bergeron-Longpre M, Bertrand-Deschenes A | Center for Research in Public Health
Aim: To review the evidence on the impact of the pandemic on people and workers bereaved or confronted with death.
5/27/20
Moletta L, Peirobon ES, Capovilla G, et al. | Int J Surg
Aim: To review the available recommendations published by general Surgery Societies and Health Institutions and evaluate the underlying Literature.
5/27/20
Yousefifard M, Zali A, Zarghi A, et al. | Int J Clin Pract
Aim: To evaluate the efficacy and safety of various NSAIDs in viral respiratory infections so that we can reach a conclusion on which NSAID is best choice for COVID-19.
CLINICAL CHARACTERISTICS
5/27/20
Jain V, Yuan JM  | Int J Public Health
Aim: To identify specific symptoms and comorbidities predicting severe COVID-19 and intensive care unit (ICU) admission.
UPDATED
5/27/20
Albahri AS, Hamid RA, Alwan JK, et al. | J Med Syst
Aim: To obtain an overview of this critical virus, address the limitations of utilising data mining and ML algorithms, and provide the health sector with the benefits of this technique. 
5/27/20
Fajgenbaum DC, Khor JS, Gorzewski A, et al. | Infect Dis Ther
Aim: To systematically evaluate the treatments adminstered to COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
5/27/20
Durand-Moreau Q, Adisesh A, et al. | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the transmission of SARS-CoV-2 in meat and poultry facilities.
5/26/20
Rodrigo C, Fernando SD, Rajapakse S | Clin Microbiol Infect
Aim: To summarize evidence from human clinical studies for using HCQ or CQ as antiviral agents for any viral infection.
CANDIDATE THERAPEUTICS
5/26/20
Hartmann-Boyce J, Lindson N | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the role of nicotine in COVID-19.
5/25/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the assessment and management of suspected or confirmed COVID-19 patients presenting to the Emergency Department (ED).
5/25/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the guidance to support health systems response to COVID-19 and associated risks for people experiencing homelessness.
5/25/20
Ahmed H, Patel K, Greenwood D, et al. | J Rehabil Med
Aim: To determine long-term clinical outcomes in survivors of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus infections after hospitalization or intensive care unit admission.
5/25/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on using wastewater surveillance to monitor the COVID-19 pandemic in the community.
5/24/20
Ricco M, Ferraro P, Gualerzi G, et al. | J Clin Med
Aim: To explore the feasibility of rapid diagnostic tests in the management of the COVID-19 outbreak.
DIAGNOSTICS
5/23/20
Youssef M, Hussein M, Attia AS, et al. | J Med Virol
Aim: To find the association between liver injuries and the severity of COVID?19 disease.
5/23/20
Ang L, Song E, Lee HW, et al. | J Clin Med
Aim: To evaluate the effectiveness and adverse events of herbal medicines for the treatment of COVID-19.
CANDIDATE THERAPEUTICS
5/23/20
Zhang Z, Hou Y, Li D, et al. | Scand J Clin Lab Invest
Aim: To assess laboratory findings in patients with COVID-19.
CLINICAL CHARACTERISTICS
5/22/20
Devasenapathy N, Ye Z, Loeb M, et al. | CMAJ
Aim: To review the safety and efficacy of convalescent plasma in severe coronavirus disease 2019 (COVID-19) patients for guideline development
CANDIDATE THERAPEUTICS
5/22/20
Pranata R, Huang I, Lukito AA, et al. | Postgrad Med J
Aim: To assess the association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and mortality in patients with COVID-19.
CLINICAL CHARACTERISTICS
5/22/20
Tian W, Jiang W, Yao J, et al. | J Med Virol
Aim: To evaluate the risk factors associated with mortality in COVID?19.
5/22/20
Kania-Richmond A, Sharpe H | Alberta Health Services
Aim: To review the evidence on the risk of transmission of COVID-19 via singing for aysmptomatic/presymptomatic and symptomatic people with COVID-19.
5/22/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on stigmatization related to COVID-19 in Canada.
5/22/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the impact of the COVID-19 pandemic on Indigenous communitites in Canada.
5/21/20
Ludvigsson JF | Acta Paediatr
Aim: To review the evidence on the role of children in the transmission of SARS-CoV-2.
5/21/20
Antwi-Amoabeng D, Kanji Z, Ford B, et al. | J Med Virol
Aim: To summarize the baseline characteristics of COVID-19 patients who received tocilizumab in order to identify nuanced predictors of response to therapy and other clinical outcomes.
CANDIDATE THERAPEUTICS
5/21/20
Mackey S, Warren C, Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the approaches being taken to migitate the risks associated with reopening schools.
5/21/20
Noone C, McSharry J, Smalle M, et al. | Cochrane Database Syst Rev
Aim: To assess the effectiveness of video calls for reducing social isolation and loneliness in older adults. 
5/20/20
Salem JB | Center for Research in Public Health
Aim: To review the evidence on the expression of the angiotensin 2 converting enzyme (ACE2) in children and adults.
5/20/20
Aiello F, Afflitto GG, Mancino R, et al. | Eye
Aim: To review the evidence on the presence of SARS-CoV-2 in cornea, conjunctiva, lacrimal sac, and tears in patients with COVID-19.
5/20/20
Flodgren GM, Vestrheim DF, Brurberg KG | Norwegian Institute of Public Health
Aim: To review the evidence on the risk factors for severe COVID-19 disease.
5/20/20
 | Sante Publique France
5/20/20
Park M | Vancouver Coastal Health
Aim: To review the evidence on re-opening child-related facilities and gatherings.
5/20/20
Liguoro I, Pilotto C, Bonanni M, et al. | Eur J Pediatr
Aim: To systematically review main clinical characteristics and outcomes of SARS-CoV-2 infections in pediatric age.
CLINICAL CHARACTERISTICS
5/20/20
Hojaij FC, chinelatto LA, Book GHP, et al. | Clinics
Aim: To analyze different perspectives concerning the COVID-19 pandemic, aiming to provide recommendations that could guide surgeons and entities toward screening, elective and emergency surgeries, decision making, and operating room management. 
5/19/20
Kasraeian M, Zare M, Vafaei H, et al. | J Matern Fetal Neonatal Med
Aim: To review the evidence on pregnancy outcome and neonates regarding COVID-19 pneumonia.
5/19/20
Juan J, Gil MM, Rong Z, et al. | Ultrasound Obstet Gynecol
Aim: To evaluate the effects of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcomes by performing a systematic review of available published literature on pregnancies affected by COVID-19.
5/19/20
Sachdeva M, Mufti A, Maliyar K, et al. | J Am Acad Dermatol
Aim: To conduct a systematic review of previously reported cases of psoriasis onset, exacerbation, or relapse after HCQ treatment.
CANDIDATE THERAPEUTICS
5/19/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk and management of people with immunosuppression and COVID-19.
UPDATED
5/19/20
Tarassenko L, Greenhalgh T | Oxford COVID-19 Evidence Service Team
Aim: Can we use smartphones to measure oxygen saturation?
5/19/20
Parhar K, Weatherald J, Solverson K | Alberta Health Services
Aim: To review the evidence on the safety and efficacy of prone positioning in awake non-intubated patients with SARS-CoV-2 pneumonia.
5/19/20
Kania-Richmond A, Koning C, Manhas KP | Alberta Health Services
Aim: To review the evidence on the rehabilitation needs of COVID-19 patients in ICU and in-patient hospital settings.
5/19/20
Mohammadi A, Esmaeilzadeh E, Li Y, et al. | EBioMedicine
Aim: To review the evidence on respiratory sampling strategies for the detection of SARS-CoV-2 RNA.
DIAGNOSTICS
5/19/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence or published standards on telehealth implementation during the COVID-19 pandemic.
UPDATED
5/19/20
Wang H, Qiu P, Liu J, et al. | Clin Res Hepatol Gastroenterol
Aim: To evaluate the association of liver injury and gastrointestinal symptoms (GIS) with the progression of COVID-19.
CLINICAL CHARACTERISTICS
5/18/20
Mustafa NM, Selim LA | J Clin Virol
Aim: To analyse the disease characterisation in paediatric age group including the possibility of vertical transmission to the neonates.
CLINICAL CHARACTERISTICS
5/18/20
Xu B, Xing Y, Peng J, et al. | Eur Radiol
Aim: To perform a systematic review and meta-analysis regarding the diagnostic test accuracy of chest CT for detecting coronavirus disease 2019 (COVID-19).
DIAGNOSTICS
5/18/20
Mackey K, King VJ, Gurley S, et al. | VA Evidence Synthesis Program
Aim: To synthesize evidence on the role of ACE inhibitor and ARB use on patient outcomes in COVID-19 as well as evidence on the benefits and harms of initiating these medications to treat patients with COVID-19.
UPDATED
WHO COLLABORATIVE
VA ESP
5/18/20
Gupta S, Parker J, Smits S, et al. | Colorectal Dis
Aim: To establish the incidence and timing of positive faecal samples for SARS-CoV-2 in patients with COVID-19.
5/18/20
Rogers JP, Chesney E, Oliver D, et al. | Lancet Psychiatry
Aim: To examine the two previous coronavirus epidemics, SARS and MERS, to identify the possible psychiatric and neuropsychiatric implications for the current pandemic. 
5/18/20
Farsalinos K, Barbouni A, Niaura R | Intern Emerg Med
Aim: To systematically examine the prevalence of current smoking among hospitalized patients with COVID-19 in China, considering the high-population smoking prevalence in China (26.6%).
5/18/20
Rafiq D, Batool A, Bazaz MA | Rev Med Virol
Aim: To analyse information on progression of the pandemic in the past 3 months and systematically discusses the characteristics of SARS-CoV-2019 virus including its epidemiologic, pathophysiologic, and clinical manifestations.
CLINICAL CHARACTERISTICS
5/15/20
Zhang X, Yu J, Pan L, et al. | Pharmacol Res
Aim: To (1) determine whether use of ACRI/ARB is associated with an increase in likelihood of viral infectivity; (2) to investigate whether there are differences in severity and mortality between ACRI/ARB users and non- ACRI/ARB users; (3) and, in particular, to evaluate whether ACRI/ARB exposure was associated with a lower risk of mortality when compared to non-ACRI/ARB antihypertensive drug exposure. 
CANDIDATE THERAPEUTICS
5/15/20
Sultan S, Altayar O, Siddique SM, et al. | Gastroenterology
Aim: To summarize international data on the Gl and liver manifestations of COVID-19 infection and treatment.
CLINICAL CHARACTERISTICS
5/15/20
Montalvan V, Lee J, Bueso T, et al. | Clin Neurol Neurosurg
Aim: To review the neurological aspects of SARS-cov2 and other coronavirus, including transmission pathways, mechanisms of invasion into the nervous system, and mechanisms of neurological disease.
5/15/20
Verbeek  JH, Rajamaki  B, Ijaz  S, et al. | Cochrane Database Syst Rev
Aim: To evaluate which type of full?body PPE and which method of donning or doffing PPE have the least risk of contamination or infection for HCW, and which training methods increase compliance with PPE protocols.
INFECTION CONTROL
5/15/20
Oyelade T, Alqahtani J, Canciani G | Trop Med Infect Dis
Aim: To evaluate the severity and mortality in COVID-19 patients with underlying kidney and liver diseases.
CLINICAL CHARACTERISTICS
5/15/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on how physical distancing impacts mental health.
5/15/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the risk of adverse maternal or fetal outcomes in women diagnosed with COVID-19 during pregnancy.
5/15/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on indirect transmission in community settings.
5/14/20
Chauhan RP, Gordon ML | Pathogens
Aim: To summarize the original research articles and case reports of all the four types of influenza viruses reported in swine populations worldwide.
5/14/20
Yaacoub S, Schunemann H, Khabasa J, et al. | BMJ Global Health
Aim: To systematically review the literature to scope and assess the effects of specific strategies for the management of the bodies.
UPDATED
WHO COLLABORATIVE
5/14/20
Gbinigie K, Frie K | BJGP Open
Aim: To review the evidence for the effectiveness and safety of azithromycin in treating COVID-19.
CANDIDATE THERAPEUTICS
5/14/20
Yang Z, Liu Y | Am J Perinatol
Aim: To summarize currently available evidence on vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
5/13/20
Carrillo-Larco RM, Altez-Rodriguez C | Wellcome Open Res
Aim: To determine the frequency of anosmia and dysgeusia in COVID-19 patients, the association of anosmia or dysgeusia with COVID-19 diagnosis, and whether anosmia and dysgeusia are prognostic factors for impaired outcomes among COVID-19 patients.
CLINICAL CHARACTERISTICS
5/13/20
da Silveira Fleck A, Ouedraogo DJ | Center for Research in Public Health
Aim: To review the evidence on the effects of automated calls or live call to assess the mental and physical health needs of elderly and/or vulnerable populations.
5/13/20
Mackey S, Warren C, Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the resumption of health care services in community or acute care.
5/13/20
Mayland CR, Harding AJ, Preston N, et al. | J Pain Symptom Manage
Aim: To review and synthesise learning from previous literature focused on the impact on grief and bereavement during other infectious disease outbreaks.
5/13/20
Kermali M, Khalsa RK, Pillai K, et al. | Life Sci
Aim: To evaluate different biomarkers to discover if they are able to predict clinical outcomes and correlate with the severity of COVID-19 disease.
CLINICAL CHARACTERISTICS
5/12/20
Chowdhury MS, Rathod J, Gernsheimer,J | Acad Emerg Med
Aim: To examine the evidence on chloroquine and hydroxychloroquine as treatments for COVID-19.
CANDIDATE THERAPEUTICS
5/12/20
Singh AK, Singh A, Shaikh A, et al. | Diabets Metab Syndr
Aim: To review existing literature and relevant websites regarding these drugs and COVID-19, adverse effects related to drugs, and related guidelines.
CANDIDATE THERAPEUTICS
5/12/20
Rajendran K, Narayanasamy K, Rangarajan J, et al. | J Med Virol
Aim: To evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date.
CANDIDATE THERAPEUTICS
5/12/20
Yang Z, Wang M, Zhu Z, et al. | J Matern Fetal Neonatal Med
Aim: To summarize currently available evidence on maternal, fetal, and neonatal outcomes of pregnant women infected with Coronavirus Disease 2019 (COVID-19).
5/12/20
Streng A, Hartmann K, Armann J, et al. | Monatsschr Kinderheilkd
Aim: To summarize the current scientific evidence regarding the clinical presentation of COVID-19 in hospitalized children based on available case series from China.
CLINICAL CHARACTERISTICS
5/12/20
Tamara A, Tahapary DL | Diabetes Metab Syndr
Aim: To study the impact of obesity to the prognosis and disease severity of COVID-19.
5/12/20
Jessop ZM, Dobbs TD, Ali SR, et al. | Br J Surg
Aim: To inform surgeons of appropriate PPE requirements, and to discuss usage, availability, rationing and future solutions.
INFECTION CONTROL
5/12/20
Alqahtani JS, Oyelade T, Aldhahir AM, et al. | PLoS ONE
Aim: To summarize the evidence on the potential severity and mortality risks caused by COVID-19 in patients with COPD.
5/12/20
Ahmad E, Davies MJ, Khunti K | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on screening for and managing diabetic retinopathy during the COVID-19 pandemic.
5/12/20
Mehta MS, Mytton OT, Mullins EWS, et al. | Clin Infect Dis
Aim: To summarise current understanding of the epidemiology and transmission dynamics of this coronavirus in children, in order to inform decisions regarding clinical and public health measures for children in the UK.
5/12/20
 | Singapore Ministry of Health
Aim: To review the evidence on the use of baricitinib as a potential treatment for patients with COVID-19.
5/12/20
Abdelrahman T, Ansell J, Brown C, et al. | BJS Open
Aim: To identify contemporary evidence relating to OR practice in the context of COVID?19.
5/12/20
Li JW, Han TW, Woodward M, et al. | Prog Cardiovasc Dis
Aim: To summarize available data on severity differences in acute cardiac injury and acute cardiac injury with mortality during the COVID-19 outbreak.
5/12/20
Veronese N, Demurtas J, Yang L, et al. | Front Med
Aim: To investigate the effectiveness of glucocorticoid therapy in patients with COVID-19.
CANDIDATE THERAPEUTICS
5/11/20
Patil VM, Singhal S, Masand N | Life Sci
Aim: To review the evidence on the mechanism of action, safety (side effects, adverse effects, toxicity) and details of clinical trials for chloroquine and hydroxychloroquine.
CANDIDATE THERAPEUTICS
5/11/20
Williams S, Walsh C, Bornstein S, et al. | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the significance of asymptomatic/pre-symptomatic transmission of COVID-19.
5/11/20
 | Singapore Ministry of Health
Aim: To review the evidence on the use of antimalarials, particularly chloroquine or hydroxychloroquine, to treat patients with COVID-19.
5/11/20
Bobrovitz N, Lee J, Mahtani KR | Oxford COVID-19 Evidence Service Team
Aim: To identify a priority list of evidence-based medications for use in the community or emergency department that could prevent emergency hospital admissions among non-COVID patients.  
5/11/20
Modayil M, Cook C, Cook L, et al. | Alberta Health Services
Aim: To review the evidence on the impact of virtual visits compared with or in addition to in-person visits on process outcomes, patient and provider satisfaction, quality of care, and access to provider.
5/11/20
 | Singapore Ministry of Health
Aim: To review the evidence on the use of protease inhibitors for treating COVID-19.
5/11/20
Aziz M, Perisetti A, Lee-Smith WM, et al. | Gastroenterology
Aim: To assess the presence of ageusia/dysgeusia among COVID-19 patients.
CLINICAL CHARACTERISTICS
5/10/20
Neubeck L, Hansen T, Jaarsma T | Eur J Cardiovasc Nurs
Aim: To bring together the evidence for remote healthcare during a quarantine situation period to support people living with cardiovascular disease during COVID-19 isolation.
5/10/20
Liu M, Gao Y, Yuan Y, et al. | Pharmacol Res
Aim: To assess the efficacy and safety of Integrated Traditional Chinese and Western Medicine to corona virus disease 2019 (COVID-19). 
CANDIDATE THERAPEUTICS
5/10/20
Parohan M, Yaghoubi S, Seraj A | Hepatol Res
Aim: To summarize available findings on the association between liver injury and severity of COVID-19 infection.
5/10/20
Jankelson L, Karam G, Becker ML, et al. | Heart Rhythm
Aim: To conduct a systematic review of the arrhythmogenic effect of short courses of chloroquine or hydroxychloroquine.
CANDIDATE THERAPEUTICS
5/9/20
Lechner M, Chandrasekharan D, Jumani K, et al. | Rhinology
Aim: To review the literature of SARS-CoV2 infection/COVID-19 and anosmia to help inform management of anosmia in healthcare works. 
CLINICAL CHARACTERISTICS
5/8/20
Pappa S, Ntella V, Giannakas T, et al. | Brain Behav Immun
Aim: To synthesize and analyze existing evidence on the prevalence of depression, anxiety and insomnia among HCWs during the Covid-19 outbreak.
5/8/20
Li Z, Wang X, Cao D, et al. | Drug Discov Ther
Aim: To critically assess the potential anti-coronavirus effect of remdesivir on COVID-19 and other coronaviruses based on the most up-to-date evidence.
CANDIDATE THERAPEUTICS
5/8/20
Juvet LK, Lauvrak V | Norwegian Institute of Public Health
Aim: To investigate if there are studies supporting the use of salivary samples for detection of SARS-CoV-2, and if there are studies that can be used to calculate the diagnostic accuracy of salivary testing compared to nasopharyngeal or oropharyngeal swab samples.
5/8/20
McQuillan R, Dozier M, Nundy R, et al. | UNCOVER
Aim: To review the evidence on the outdoor transmission of SARS-CoV-2 under the following different approaches: epidemiological, microbiological, mechanistic, and environmental.
5/7/20
Lloyd-Williams M, Mogan C, Karen SR, et al. | Oxford COVID-19 Evidence Service Team
Aim: To establish the evidence for which non-technology based activities that can be delivered at home by family carers, are effective in maintaining cognitive function in people with dementia who are socially isolating during COVID-19
5/7/20
Lloyd-Williams M, Mogan C, Russel S, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To establish the evidence for which non-technology based activities that can be delivered at home by family carers, are effective in maintaining cognitive function in people with dementia who are socially isolating during COVID-19.
5/7/20
Park M | Vancouver Coastal Health
5/7/20
Allsop M, Ziegler L, Fu Y, et al. | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the evidence for oxygen as a treatment option to alleviate the symptoms of breathlessness for patients dying with COVID-19 and to identify potential harms.
5/7/20
Kisely S, Warren N, McMahon L, et al. | BMJ
Aim: To examine the psychological effects on clinicians of working to manage novel viral outbreaks, and successful measures to manage stress and psychological distress.
5/7/20
Brurberg KG | Norwegian Institute of Public Health
Aim: To review the evidence on the transmission of SARS-CoV-2 via contact or droplets.
5/6/20
LeBlanc A | medRxiv
UPDATED
5/6/20
da Silveira Fleck A, Ouedraogo DJ | Center for Research in Public Health
Aim: To review the evidence on the effectiveness of disinfection methods for disposable filtering face pieces of type N95.
5/6/20
Chou R, Dana T, Buckley D, et al. | Ann Intern Med
Aim: To examine the burden of SARS-CoV-2, SARS-CoV-1, and Middle Eastern respiratory syndrome (MERS)-CoV on HCWs and risk factors for infection, using rapid and living review methods.
WHO COLLABORATIVE
5/6/20
Chen J | Alberta Health Services
Aim: To review the evidence on the use of antibacterial therapy upon admission for patients with respiratory symptoms who have suspected or confirmed COVID-19.
5/6/20
 | Singapore Ministry of Health
Aim: To review the evidence on the use of interleukin-6 (IL-6) inhibitors, particularly tocilizumab, to manage symptoms of patients with COVID-19.
5/6/20
Theodoratou E, Dozier M, Li X, et al. | UNCOVER
Aim: To review the evidence on COVID-19 transmission routes among infected children and adolescents.
5/5/20
Biro S | KFL&A Public Health
Aim: To review the evidence on the factors, considerations, and criteria that should be in place to limit infection risk while lifting restrictions at a regional level in Canada.
5/5/20
Razaq A, Harrison D, Karunanithi S, et al. | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the evidence on plausible associations between ethnicity and COVID-19 incidence and adverse health outcomes in the general population and people working in health and social care.
5/5/20
Balla M, Merugu GP, Patel M, et al. | J Clin Med Res
Aim: To provide a comprehensive clinical summary of all the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19, thus increasing awareness in health care providers. 
5/5/20
Martins-Filho PR, Tavares CSS, Santos VS | Eur J Intern Med
Aim: To comprehensively review studies of clinical and laboratory features of hospitalized patients with COVID-19.
CLINICAL CHARACTERISTICS
5/5/20
Li H, Chen C, Hu F, et al. | Leukemia
Aim: To determine safety and efficacy of corticosteroids in SARS-CoV-2, SARS-CoV, and MERS-CoV infections.
CANDIDATE THERAPEUTICS
5/5/20
Biro S | KFL&A Public Health
5/5/20
 | Health Information and Quality Authority, Ireland
Aim: To identify a wide range of diagnostic tests for detecting and confirming COVID-19 cases.
5/5/20
 | Sante Publique France
5/4/20
Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the transmission of COVID-19 in outdoor settings.
5/4/20
Juvet LK, Laake I, Vestrheim DF | Norwegian Institute of Public Health
Aim: To review the literature on the case fatality rate and infection fatality rate for serious cases of COVID-19.
5/4/20
Flodgren GM | Norwegian Institute of Public Health
Aim: To review the evidence on immunity to COVID-19 after infection by SARS-CoV-2.
5/4/20
Tarassenko LJ, McManus R, Greenhalgh T | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the accuracy of the Lifelight app to measure blood pressure.
5/4/20
 | Singapore Ministry of Health
Aim: To review the evidence on the use of remdesivir as a potential treatment for patients with COVID-19.
5/4/20
Mackey S, Warren C | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the role of children in the transmission of COVID-19.
5/3/20
Esbin MN, Whitney ON, Chong S, et al. | RNA
Aim: To present a collection of these recent advances in COVID-19 nucleic acid testing, including both peer-reviewed and preprint articles.
DIAGNOSTICS
5/2/20
Chowdhury M, Rathod J, Gernsheimer J | Acad Emerg Med
Aim: To review literature currently available regarding the clinical use of CQ and HCQ as treatment in COVID-19 patients in an effort to catalog their recommendations and assess drug efficacy.
CANDIDATE THERAPEUTICS
5/2/20
Rawson TM, Moore L, Zhu N, et al. | Clin Infect Dis
Aim: To explore and describe the current literature surrounding bacterial/fungal co-infection in patients with coronavirus infection.
5/1/20
 | INESSS, Quebec
Aim: To evaluate the safety and efficacy of cholorquine and hydroxychloroquine in COVID-19.
5/1/20
Li Y, Nair H, Kulkarni D, et al. | UNCOVER
Aim: To review the evidence on how population-level non-pharmaceutical interventions to reduce the transmission of COVID-19 is related to the reproduction number R.
5/1/20
Williams S, Walsh C, Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on the liklihood of reinfection and the significance of sustained viral detection after incubation period is complete.
5/1/20
Lee J, van Hecke O, Roberts N | Oxford COVID-19 Evidence Service Team
Aim: To review the clinical evidence that vitamin D has a role in preventing or treating COVID-19.
4/30/20
Shiozawa P, Uchida RR | Braz J Psychiatry
Aim: To review the evidence on emergency psychological crisis intervention during the COVID-19 outbreak.
4/30/20
Zhong H, Wang Y, Zhang Z, et al. | Pharmacol Res
Aim: To evaluate the efficacy and safety of current option of therapies for severe acute respiratory syndrome (SARS), Middle Eastern respiratory syndrome (MERS) besides COVID-19, in an attempt to identify promising therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients.
CANDIDATE THERAPEUTICS
4/30/20
Hartmann-Boyce J, Lindson N | Oxford COVID-19 Evidence Service Team
4/30/20
Brurberg KG | Norwegian Institute of Public Health
Aim: To review the evidence on the role of children in the transmission of SARS-CoV-2.
4/29/20
Janssens GO, Mandeville HC, Timmermann B, et al. | Radiother Oncol
Aim: To derive evidence-based recommendations for the optimal utilisation of resources during unexpected shortage of radiotherapy capacity.
4/29/20
 | INESSS, Quebec
Aim: To identify alternative drugs to propofol currently used in the constitution of marketing authorization kits while taking into account current and anticipated stock-outs of alternative drugs.
4/29/20
Hoang U, Jones NR | Oxford COVID-19 Evidence Service Team
Aim: To determine if there is an association between ambient air pollution and severity of COVID-19 infection.
4/29/20
Hoang U, Jones NR | Oxford COVID-19 Evidence Service Team
Aim: To determine if there is an association between ambient air pollution and severity of COVID-19 infection.
4/29/20
Hoang U, Jones NR | Oxford COVID-19 Evidence Service Team
Aim: To determine if there is an association between ambient air pollution and severity of COVID-19 infection. 
4/29/20
Checkley S, Rogers L, Caffrey N, et al. | Alberta Health Services
Aim: To review the evidence that centralized voluntary isolation/quarantine centers (CVICs) reduce transmission and spread.
4/29/20
Asadi L | Alberta Health Services
Aim: To explore evidence based strategies beyond home self-isolation and use of centralized voluntary isolation centers (eg: wearing masks within the home; additional cleaning; testing, other) that have been used to successfully control focal COVID-19 outbreaks in other settings.
4/29/20
Boyd J | Alberta Health Services
Aim: To review the evidence on whether there are populations of asymptomatic individuals (e.g., population sampling; congregate living including LTC, vulnerable populations; patients being hospitalized, those associated with outbreaks, HCWs) that should be considered priority for screening for COVID 19 infection (with RTPCR), with the goal of surveillance and preventing spread within these populations.
4/29/20
McQuillan R, Dozier M, Theodoratou E, et al. | UNCOVER
Aim: To review the evidence on differences in COVID-19 incidence and outcomes based on ethnic variation.
4/28/20
Bachelet VC | Medwave
Aim: To find and discuss studies on laboratory diagnostic tests and rapid viral diagnosis. 
DIAGNOSTICS
4/28/20
Park M | Vancouver Coastal Health
Aim: To review the evidence on lockdown de-escalation measures in response to COVID-19.
4/28/20
 | ECRI
Aim: To review evidence and guidelines on interventions to supplement standard weaning practices to reduce ventilator time and avoid repeat intubation in patients with COVID-19.
4/28/20
Paludan-Müller  AS, Boesen  K, Klerings  I, et al. | Cochrane Database Syst Rev
Aim: To assess the benefits and harms of hand cleaning with ash compared with hand cleaning using soap or other materials for reducing the spread of viral and bacterial infections.
INFECTION CONTROL
4/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the guidance on the management of acute behavioural disturbance during COVID-19.
4/28/20
Rohr S, Muller F, Jung F, et al. | Psychiatr Prax
Aim: To collect evidence on the psychosocial consequences of quarantine measures in severe coronavirus outbreaks prior to COVID-19. 
4/28/20
 | Singapore Ministry of Health
Aim: To review the evidence on the use of favipiravir for treating COVID-19.
4/28/20
 | Singapore Ministry of Health
Aim: To review the evidence on the use of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly ibuprofen, to manage symptoms of COVID-19.
4/28/20
Gbinigie K, Frie K | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the evidence for the safety and effectiveness of using macrolides to treat COVID-19.
4/27/20
Thombs BD, Bonardi O, Rice DB, et al. | J Psychosomatic Res
Aim: To evaluate (1) levels of mental health symptoms, prioritizing studies that assess changes in symptoms from pre-COVID-19 or compare concurrent samples between participants with different experiences with COVID-19 (e.g., those infected versus healthy comparison sample); (2) factors associated with levels or changes in symptoms during COVID-19, and (3) the effect of interventions on mental health symptoms during COVID-19.
4/27/20
 | ECRI
Aim: To examine the effectiveness of triage systems for identifying disease severity and mortality risk to inform decisions on scarce resource allocation during pandemics.
4/27/20
Minotti C, Tirelli F, Barbieri E, et al. | J Infect
Aim: To systematically review the current knowledge on SARS-CoV-2 cases in children and adults with immunosuppression, to evaluate outcomes in this special population.
4/27/20
Halpin D, Singh D, Hadfield RM | Eur Respir J
Aim: To evaluate whether pre-morbid use or continued administration of inhaled steroids is a risk factor for adverse outcomes in acute respiratory infections due to COVID-19, SARS or MERS. 
WHO COLLABORATIVE
CANDIDATE THERAPEUTICS
4/27/20
Kernohan A, Boath A, Calderon M, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify relevant studies to inform evidence-based patient management and care pathway development.
4/27/20
Wilson, MG, Waddell K, Gauvin FP, et al. | McMaster Health Forum
Aim: To identify evidence on international and Canadian experiences with asymptomatic screening to identify COVID-19 cases and to prevent transmission.
4/26/20
Williams S, Walsh C, Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on cohorting of residents in long-term care facilities who test positive for COVID-19.
4/25/20
Chauhan R, Dessie ZG, Noreddin A, et al. | Pathogens
Aim: To highlight the available information about viral diseases, including zoonotic and vector-borne diseases, reported in Africa to better understand the trend of emerging and re-emerging virus diseases within the African continent.
4/24/20
Couper K, Taylor-Phillips S, Grove A, et al. | Resuscitation
Aim: To identify the potential risk of transmission associated with key interventions (chest compressions, defibrillation, cardiopulmonary resuscitation) to inform international treatment recommendations.
4/24/20
 | INESSS, Quebec
Aim: To examine the evidence on COVID-19 in pediatric clinical care.
4/24/20
Soliman R, Brassey J, Pluddemann A, et al. | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the current evidence about the protective effects of BCG vaccine against acute respiratory infections and COVID-19.
4/24/20
Brett K, Walter M | CADTH
Aim: To examine the evidence regarding the clinical effectiveness of plastic or reusable aerochambers in multi-dose inhalers for patients requiring medication administration, as well as any evidence-based guidelines on the topic.
4/24/20
Kumar D, Severn M | CADTH
Aim: To identify available evidence on the clinical effectiveness of portable or temporary negative pressure rooms and related evidence-based guidelines for the management of people with active tuberculosis.
4/23/20
Castagnoli R, Votto M, Licari A, et al. | JAMA Pediatr
Aim: To evaluate currently reported pediatric cases of SARS-CoV-2 infection.
4/22/20
Erdmann R, Kania-Richmond A | Alberta Health Services
Aim: To review the evidence on whether patients who are on prescribed NSAIDS as chronic therapy should stop taking these drugs if they develop COVID-19.
4/22/20
Houghton C, Meskell P, Delaney H, et al. | Cochrane Database of Systematic Reviews
Aim: To identify barriers and facilitators to healthcare workers' adherence to IPC guidelines for respiratory infectious diseases.
INFECTION CONTROL
4/22/20
Moujaess E, Kourie HR, Ghosn M | Crit Rev Oncol Hematol
Aim: To expose the challenges of cancer management in the era of SARS-CoV-2, the epidemiological, clinical, pathological and radiological characteristics of the disease in cancer patients and its outcomes on this population.
CLINICAL CHARACTERISTICS
4/22/20
Chastenay M | INESSS, Quebec
Aim: To review the evidence on social and mental health services to promote a return to normal life during the recovery phase of a pandemic or similar crisis.
4/22/20
Zhu J, Zhong Z, Li H, et al. | J Med Virol
Aim: To systematically review the CT imaging features of COVID-19 in order to provide reference for clinical practice.
CLINICAL CHARACTERISTICS
4/22/20
Kalin A, Waqar S, Ghouri N, et al. | Oxford COVID-19 Evidence Service Team
Aim: To provide guidance to clinicians looking after patients with symptoms of COVID-19 who are thinking about fasting in Ramadan.
4/22/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on community or home-based non-invasive ventilation (NIV) and inspiratory muscle training (IMT) for people with spinal cord injuries during COVID-19.
4/22/20
Hu Y, Sun J, Dai Z, et al. | J Clin Virol
Aim: To evaluate the risk factors of COVID-19. 
4/22/20
Jelinski S, Mackay E | Alberta Health Services
Aim: To review the evidence on patient demographic or clinical factors that are associated with positive COVID-19 test results.
4/22/20
Clement F  | University of Calgary
Aim: To review the clinical evidence for the risk of transmission of acute respiratory infections to health care workers caring for patients undergoing aerosol-generating medical procedures.
4/22/20
Stravropoulou C, Palmer VJ, Burls A, et al. | Oxford COVID-19 Evidence Service Team
Aim: To examine the evidence on the conditions that most often lead to potentially preventable unplanned hospital admissions that are manageable in primary care.
4/22/20
Urwin SG, Kandola G, Graziado S | Oxford COVID-19 Evidence Service Team
Aim: To provide a quick reference summary of prognostic clinical risk prediction scores that are currently available in an accessible format and methodologically suitable for use in the community following a potential infection with the SARS-CoV-2 virus causing COVID-19, or people with suspected or confirmed COVID-19.
4/22/20
Sharpe H, McLane P | Alberta Health Services
Aim: To review the evidence on criteria or simple tools that can be used to determine which patients with suspected/confirmed COVID-19 are stable and appropriate for safe discharge from hospital or an alternate care centre.
4/22/20
Carver C, Guyan M, Pierre M | UNCOVER
Aim: To review the evidence on which high proximity activites in the UK would benefit from mask wearing to reduce the transmission of COVID-19.
4/21/20
Strict A, Hartmann K, Armann J, et al. | Übersichten
Aim: To summarize the current scientific evidence on the clinical course of COVID-19 in hospitalized children.
4/21/20
Yousefifard M, Zali A, Mohamed A, et al. | Arch Acad Emerg Med
Aim: To evaluate the efficacy of antiviral therapies in treatment of COVID-19.
CANDIDATE THERAPEUTICS
4/21/20
Chang T, Wu J, Chang L | J Formos Med Assoc
Aim: To collect current evidence about COVID-19 in children.
4/21/20
 | INESSS, Quebec
Aim: To examine the evidence on COVID-19 and breastfeeding.
4/21/20
Alzghari SK, Acuna VS | J Clin Virol
Aim: To evaluate outcomes associated with TCZ treatment in patients with COVID-19.
CANDIDATE THERAPEUTICS
4/21/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on preoperative testing of COVID-19 for patients undergoing surgery.
UPDATED
4/21/20
Greenhalgh T, Javid B, Knight M, et al. | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on tests to confirm or exclude exertional desaturation.
4/20/20
Jones N, Carver C | Oxford COVID-19 Evidence Service Team
Aim: Does current evidence support social distancing of asymptomatic healthcare workers from other household members or other interventions specific to healthcare workers to reduce the risk of transmitting COVID-19?
4/20/20
 | ECRI
Aim: To review the evidence on the general public’s use of these face coverings for reducing the transmission risk of viral respiratory infection.
4/20/20
Roncon L, Zuin M, Rigatelli G, et al. | J Clin Virol
Aim: To assess the risk of ICU admission and morality risk in diabetic COVID-19 patients.
4/20/20
 | ECRI
Aim: To examine the accuracy of external infrared temperature screening devices for identifying infected people.
4/20/20
Asadi L | Alberta Health Services
Aim: To review the evidence on the effectiveness of wearing medical masks, including home-made masks, to reduce the spread of COVID-19 in the community.
4/20/20
 | Health Technology Wales
Aim: To review the evidence on the effectiveness of virus and antibody tests to inform COVID-19 diagnosis.
4/20/20
Greenhalgh T, Treadwell J, Burrow R, et al. | Oxford COVID-19 Evidence Service Team
Aim: In people in the community with suspected or confirmed COVID-19, are there demographic features, other conditions, symptoms, or signs that are prognostic factors for 30-day all-cause mortality, ventilation, or ICU care?
4/20/20
Waddell K, Gauvin FP, Wilson MG, et al. | McMaster Health Forum
Aim: To identify evidence on the spread and management of COVID-19 in non-health workplaces, including workplaces where light-touch services are offered such as government administration offices (e.g., Service Canada or Service Ontario) and social services (e.g., group homes for high-needs individuals).
4/20/20
Theodoratou E, Dozier M, Guyan M, et al. | UNCOVER
Aim: To review the evidence on the efficacy of face masks in preventing respiratory transmission in the community.
4/20/20
Cunningham C, Cook C | Alberta Health Services
Aim: To review the evidence on predictive tools or tests that can assist in deciding who is at risk of clinical deterioration and should be assessed in the emergency department.
4/19/20
McQuillan R, Narain A, Dozier M | UNCOVER
Aim: To review the evidence on the efficacy of homemade facemaks at reducing transmission of COVID-19 in community settings.
4/19/20
Santoso A, Pranata R, Wibowo A, et al. | Am J Emerg Med
Aim: To explore the association between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory distress syndrome (ARDS), and severe coronavirus disease 2019 (COVID-19) in patients with COVID-19 pneumonia
4/19/20
 | UNCOVER
Aim: To review the evidence on the effect of face masks in the general population in reducing the spread of infection.
4/18/20
Della Gatta A, Rizzo R, Pilu G, et al. | Am J Obstet Gynecol
Aim: To conduct a systematic review of the clinical outcomes reported for pregnant patients with coronavirus disease 2019.
UPDATED
4/18/20
Panahi L, Amiri M, Pouy S | Arch Acad Emerg Med
Aim: To review articles published on clinical manifestations and characteristics of children and infants with COVID-19.
CLINICAL CHARACTERISTICS
4/18/20
Gatta D, Nunzia A, Rizzo R, et al. | Am J Obstet Gynecol
Aim: To conduct a systematic review of the outcomes reported for pregnant patients with COVID 19. 
4/17/20
Romney D, Fox H, Carlson S, et al. | Disaster Med Public Health Prep
Aim: To locate and analyze U.S. State Crisis Standards of Care (CSC) documents to determine their prevalence and quality.
4/17/20
Song Y, Ren F, Sun D, et al. | Int J Environ Res Public Health
Aim: To summarize the recent scientific evidence that outlines the effects of exercise on influenza or pneumonia in older adults.
4/17/20
Asadi-Pooya AA, Simani L | J Neruol Sci
Aim: To discuss the evidence on the occurrence of central nervous system (CNS) involvement and neurological manifestations in patients with COVID-19.
CLINICAL CHARACTERISTICS
4/17/20
 | National Collaborating Centre for Environmental Health
Aim: To review the evidence on precautions needed to mitigate community spread of SARS-CoV-2 in outdoor environment
4/17/20
 | INESSS, Quebec
Aim: To evaluate the efficacy of remdesivir in post-exposure prophylaxis of SARS-Cov2 infection.
4/17/20
Brurberg KG, Fretheim A | Norwegian Institute of Public Health
Aim: To review the evidence on the association between age, comorbidity, and disease severity in patients with COVID-19.
4/17/20
Huang I, Lim MA, Pranata R | Diabetes Metab Syndr
Aim: To investigate the association between DM and poor outcome in patients with COVID-19 pneumonia.
4/17/20
Dulong C, Frey N, Walter M | CADTH
Aim: To summarize studies on the clinical effectiveness of using pre-dental treatment mouth rinses for patients with suspected SARS or COVID-19 in order to prevent virus transmission from patients to oral health care providers.
4/17/20
 | Singapore Ministry of Health
Aim: To review the evidence on the use of convalescent plasma in patients with COVID-19.
4/17/20
Tobaigy M, Qashgary M, Al-Dahery S, et al. | Infect Prev Pract
Aim: To report any evidence of therapeutics used for the management of COVID-19 patients in clinical practice since the emergence of the virus.
CANDIDATE THERAPEUTICS
4/17/20
Sarma P, Kaur H, Kumar H, et al. | J Med Virol
Aim: To examine the evidence for the safety and efficacy of hydroxycholorquine in COVID-19.
CANDIDATE THERAPEUTICS
4/16/20
 | INESSS, Quebec
Aim: To evaluate the safety and efficacy of using biotherapies directed againts IL-6 or its receptor in COVID-19.
4/16/20
Zhu J, Ji P, Pang J, et al. | J Med Virol
Aim: To systematically review the clinical characteristics of Coronavirus disease 2019 (COVID?19).
CLINICAL CHARACTERISTICS
4/16/20
 | INESSS, Quebec
Aim: To review the evidence on palliative care and drug shortages during the COVID-19 pandemic.
4/16/20
 | INESSS, Quebec
Aim: To review the evidence on alternative drugs for sedation during the COVID-19 pandemic.
4/16/20
McCall MC, Heneghan C, Nunan D | Oxford COVID-19 Evidence Service Team
Aim: To examine the current evidence about the effectiveness of physical exercise in preventing or treating acute respiratory infection.
4/16/20
McCall MC, Heneghan C, Nunan D | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the effectiveness of physical exercise in preventing or treating acute respiratory infection.
4/16/20
Hastings S, et al. | Alberta Health Services
Aim: To explore the evidence for and risks of using hydroxychloroquine (HQ) as a treatment and prophylaxis for SARS-CoV-2.
4/16/20
 | ECRI
Aim: To review the evidence on the safety of extending the use of N95 respirator masks.
4/16/20
Pujadas-Botey A | Alberta Health Services
Aim: To review the evidence on strategies for assessing patients who were infected with COVID-19 for suitability for starting or resuming cancer treatment.
4/16/20
Kostaras X | Alberta Health Services
4/16/20
Coles B, Burton C, Khunti K, et al. | Oxford COVID-19 Evidence Service Team
Aim: What is the efficacy of aprons compared to gowns in primary care settings?
4/16/20
Coles B, Burton C, Khunti K, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To review the efficacy of protective gowns versus aprons in primary care settings.
4/15/20
Muhidin S, Moghadam ZB, Vizheh M | Arch Acad Emerg Med
Aim: To clarify the impact of novel coronavirus disease (COVID-19) on pregnant patients and maternal and neonatal outcomes.
4/15/20
Lovato A, de Filippis C | Ear Nose Throat J
Aim: To perform a systematic review of current evidences on clinical presentation of COVID-19, focusing on upper airway symptoms in order to help otolaryngologists identifying suspected cases. 
CLINICAL CHARACTERISTICS
4/15/20
Hastings S, et al. | Alberta Health Services
Aim: To explore how the testing characteristics for the Alberta Health Services lab-developed test for COVID-19 differ between samples collected from nasal, nasopharyngeal, and throat swabs.
4/15/20
MacPherson F | BC Ministry of Health
Aim: To identify which infection prevention and control interventions, programs, infrastructure are most effective at reducing health care associated infections in Long Term Care facilities.
4/15/20
 | INESSS, Quebec
Aim: To review the evidence on general considerations for cancer treatment in patients with COVID-19.
4/15/20
Zorko D, Gertsman S, O'Hearn K, et al. | J Hosp Infect
Aim: To identify and synthesize data from original research evaluating interventions to decontaminate surgical masks for the purpose of reuse.
UPDATED
INFECTION CONTROL
4/15/20
 | Ontario Health Quality
Aim: To examine the recommendations and literature on the extended use and layering of N95 respirators and use of expired personal protective equipment during the COVID-19 pandemic.
4/15/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the pyschological impact of COVID-19 on healthcare workers.
4/15/20
Zhou M, Qi J, Li X, et al. | Br J Haematol
Aim: To analyse the proportion of patients with thrombocytopenia in SARS?CoV, MERS?CoV and 2019?nCoV infections.
CLINICAL CHARACTERISTICS
4/14/20
Shah S, Das S, Jain A, et al. | Int J Rheum Dis
Aim: To systematically review the role of CQ and HCQ in preventing the spread of COVID-19.
CANDIDATE THERAPEUTICS
4/14/20
Zuin M, Rigatelli G, Zuliani G, et al. | J Infect
Aim: To evaluate the risk of death in COVID-19 infection patients with and without HT.
4/14/20
Fu L, Wang B, Yuan T, et al. | J Infect
Aim: To better inform efforts to treat and control the current outbreak with a comprehensive characterization of COVID-19.
CLINICAL CHARACTERISTICS
4/14/20
Bao C, Liu X, Zhang H, et al. | J Am Coll Radiol
Aim: To provide a summary of evidence on detection of COVID-19 by chest CT and the expected CT imaging manifestations.
CLINICAL CHARACTERISTICS
4/14/20
 | NICE
Aim: To assess the best available evidence to determine the risk of developing COVID-19 due to acute use of NSAIDs and if doing so can lead to increased risk of developing more severe symptoms of COVID-19.
4/14/20
Koshkouei M, Abel L, Pilbeam C | Oxford COVID-19 Evidence Service Team
Aim: To evaluate available measures to minimise the risk of infection spread among residents and staff within care home settings.
4/14/20
Ferner RE, Aronson JK | Oxford COVID-19 Evidence Service Team
Aim: To examine the protocols and preliminary trial reports of early clinical trials involving hyroxychloroquine.
4/14/20
Dorward J, Gbinigie K | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence for the use of Lopinavir/ritonavir (LPVr) as a treatment for COVID-19.
4/14/20
Van Hecke O, Lee J | Oxford COVID-19 Evidence Service Team
Aim: To conduct a rapid review of NAC with specific emphasis on its potential for early administration in the community for patients at greater risk of severe COVID-19.
4/14/20
 | CADTH
Aim: To summarize current recommendations about the use of N95 respirator masks.
4/14/20
Yang Z, Liu J, Zhou Y, et al. | J Infect
Aim: To further evaluate the influence of corticosteroids on patients with coronavirus infection.
CANDIDATE THERAPEUTICS
4/14/20
Wilson MG, Gauvin FP, Waddell K, et al. | McMaster Health Forum
Aim: To identify evidence on strategies for conserving, re-using, and repurposing different kinds of masks.
4/13/20
Hastings S, et al. | Alberta Health Services
Aim: To explore the evidence supporting the possibility of asymptomatic transmission of SARS-CoV-2.
4/13/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on emerging tools that are being used to support communication between patients and their loved ones during the COVID-19 pandemic.
4/13/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the triage tools that are available to guide decisions about admission to ICU during COVID-19.
4/12/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the use of dedicated hospitals and wards exclusively for the use of COVID-19 patients.
4/12/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the organization of palliative care services during COVID-19 (or previous pandemics).
4/12/20
Etkind SN, Bone AE, Lovell N, et al. | J Pain Symptom Manage
Aim: To synthesise evidence for the role and response of palliative care and hospice teams to viral epi/pandemics, to inform the COVID-19 pandemic response.
CLINICAL CHARACTERISTICS
4/11/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence about COVID-19 modes of transmission?
4/10/20
Jelinski S | Alberta Health Services
Aim: To review the evidence on risk prediction tools to guide admission disposition and management decisions for patients with COVID-19 who are admitted to the hospital.
4/10/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on whether continuous positive airway pressure (CPAP) and/or Bilevel Positive Airway Pressure (BiPAP) are aerosol generating, and to locate guidelines on the use of CPAP as a substitute for ventilators during the COVID-19 pandemic.
4/10/20
Sharpe H | Alberta Health Services
Aim: To review the evidence on clinical features that reliably indicate need for intubation or mechanical ventilation.
4/10/20
McLane P | Alberta Health Services
Aim: To review the evidence on admission or safe discharge of patients with suspected or confirmed COVID-19 from the emergency department
4/10/20
Viner RM, Russell SJ, Croker H, et al. | Lancet Child Adolesc Health
Aim: To identify what is known about the effectiveness of school closures and other school social distancing practices during coronavirus outbreaks.
INFECTION CONTROL
4/10/20
Aminjafari A, Ghasemi S | Int Immunopharmacol
Aim: To evaluate the existing evidence and experience related to immunotherapy for 2019-nCoV.
CANDIDATE THERAPEUTICS
4/9/20
 | INESSS, Quebec
Aim: To evaluate the use of the lopinavir-ritonavir combination in post-exposure prophylaxis of SARS-Cov2 infection.
4/9/20
Chastenay M | INESSS, Quebec
Aim: To review the evidence on maintaining a community safety net for children and youth at risk of being abused during a pandemic.
4/9/20
Dulong C, MacDougall D | CADTH
Aim: To search for evidence-based guidelines related to the use of digital stethoscopes for pulmonary auscultation in patients with suspected or confirmed infectious disease.
4/9/20
Nussbaumer-Streit B, Mayr V, Dobrescu AI, et al. | Cochrane Database of Systematic Reviews
Aim: To assess the effects of quarantine (alone or in combination with other measures) of individuals who had contact with confirmed cases of COVID19, who travelled from countries with a declared outbreak, or who live in regions with high transmission of the disease.
WHO COLLABORATIVE
INFECTION CONTROL
4/9/20
Stern D, Lopez-Olmedo N, Perez-Ferrer C, et al. | Salud publica de Mexico
Aim: To assess the effectiveness of using surgical masks in community settings to reduce the probability of infection by SARS-CoV-2 or other acute viral respiratory infection, compared to not using surgical masks
INFECTION CONTROL
4/9/20
Kumar D, Walter M, Frey N | CADTH
Aim: To review the available evidence on the lifespan of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on different materials, as well as its potential for transmission via these materials
4/9/20
Gbinigie K, Kerstin F | BJGP Open
Aim: To establish the current evidence for the effectiveness of CQ and HCQ in treating COVID-19.
CANDIDATE THERAPEUTICS
4/8/20
Russel B, Moss C, George G, et al. | Ecancermedicalscience
Aim: To examine the effects of immuno-suppressive and stimulating drugs on host immunity against COVID-19.
4/8/20
Chastenay MH | INESSS, Quebec
Aim: To review the evidence on the effectiveness and feasibility of assessing autism spectrum disorder in children remotely in the context of the COVID-19 pandemic.
4/8/20
Hartmann-Boyce J, Morris E, Goyder C, et al. | Oxford COVID-19 Evidence Service Team
4/8/20
Heneghan C, Pluddemann A, Mahtani KR | Oxford COVID-19 Evidence Service Team
4/8/20
Hartmann-Boyce J, Morris E, Goyder C, et al. | Oxford COVID-19 Evidence Service Team
4/8/20
Zaigham M, Andersson O | Acta Obstet Gynecol Scand
Aim: To summarize the clinical manifestations and maternal and perinatal outcomes of COVID-19 during pregnancy
CLINICAL CHARACTERISTICS
4/8/20
Greenhalgh T, Treadwell J, Burrow R, et al. | Oxford COVID-19 Evidence Service Team
Aim: To establish the state of knowledge, ignorance and uncertainty in relation to the use of NEWS2 in the context of COVID-19 in primary care.
4/8/20
Chastenay MH | INESSS, Quebec
Aim: To review the evidence on psychological distress and mental health in healthcare workers during the COVID-19 pandemic.
4/8/20
Hastings S | Alberta Health Services
Aim: To review the evidence on whether people with previous COVID-19 infection can become re-infected by the SARS-CoV-2 virus.
4/8/20
Kalin A | Oxford COVID-19 Evidence Service Team
4/8/20
El-Jardali F, Fadlallah R, Daher N, et al. | Knowledge to Policy Center
Aim: To provide guidance for suppressing COVID-19 through community-centered care approach.
4/8/20
Rios P, Radhakrishnan A, Antony J, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify safe and effective medical countermeasures to address the current outbreak of a novel coronavirus (COVID-19).
4/8/20
Green K, Allen AJ, Suklan J | Oxford COVID-19 Evidence Service Team
Aim: To describe the approaches to clinical investigations following a negative RT-PCR results as described in guidelines from China, Italy, Spain, UK and US. 
4/7/20
 | Ontario Health Quality
Aim: To examine the recommendations and literature on cloth (fabric) masks during the COVID-19 pandemic.
4/7/20
Cheung KS, Hung IF, Chan PP, et al. | Gastroenterology
Aim: To review the published gastrointestinal symptoms and detection of virus in stool, and also summarize data from a cohort of patients with COVID-19 in Hong Kong.
CLINICAL CHARACTERISTICS
4/7/20
Green K, Graziadio S, Turner P, et al. | Oxford COVID-19 Evidence Service Team
Aim: To summarize the characteristics of current molecular and antibody diagnostic tests available to support the diagnosis and management of patients with suspected COVID-19.
4/7/20
 | Ontario Health Quality
Aim: To examine the recommendations and literature on N95 equivalents from other countries during the COVID-19 pandemic.
4/7/20
 | Ontario Health Quality
Aim: To examine the guidelines and published literature on 3D printing of N95 respirators and face shields during the COVID-19 pandemic.
4/7/20
Khunti K | Oxford COVID-19 Evidence Service Team
4/6/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on whether cardiopulmonary resuscitation is aerosol generating.
4/6/20
Navarro P | Newfoundland and Laborador Centre for Applied Health Research
Aim: To review the evidence on effective interventions for homeless people during the COVID-19 pandemic.
4/6/20
 | INESSS, Quebec
Aim: To document the ethical guidelines for demonstrating treatment effectiveness by clinical research.
4/6/20
Heneghan C, Brassey J, Jefferson T | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the proportion of COVID-19 cases that are asymptomatic.
4/6/20
McCall MC, Nunan D, Heneghan C | Oxford COVID-19 Evidence Service Team
4/4/20
 | INESSS, Quebec
Aim: To review the evidence on the use of NSAIDS in pediatric patients with confirmed or suspected COVID-19.
4/4/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on appropriate PPE for healthcare workers providing routine intrapartum care during the COVID-19 outbreak and other respiratory pandemics.
4/3/20
 | Ontario Health Quality
Aim: To examine the guidelines and published literature on the use of PAPRs as an alternative to N95 respirators in a health care setting.
4/3/20
Berg C, Nokleby H | Norwegian Institute of Public Health
Aim: To review the evidence on electronic follow-up of children and youth in childcare institutions.
4/3/20
McLane P, Leal J | Alberta Health Services
Aim: To review the evidence on managing the clothing and personal items of healthcare workers across various health care settings to reduce the risk of self-contamination and to reduce the risk of transmitting the virus outside the hospital.
4/3/20
Sharpe H, Kania-Richmond A, Leal J | Alberta Health Services
Aim: To review the evidence on the risk of COVID-19 transmission associated with oxygen therapy.
4/3/20
Cao Y, Liu X, Xiong L, et al. | J Med Virol
Aim: To explore reliable evidences for the diagnosis and treatment of the COVID-19 by analyzing all the published studies by Chinese scholars on the clinical and imaging features in novel coronavirus pneumonia (NCP) caused by SARS-CoV-2.
CLINICAL CHARACTERISTICS
4/3/20
Chastenay MH | INESSS, Quebec
Aim: To review the evidence on effective approaches with patients requiring psychiatric care and who have or are at risk of having COVID-19.
4/3/20
Khunti K, et al. | Oxford COVID-19 Evidence Service Team
4/2/20
Bartoszko JJ, Farooqi MAM, Alhazzani W, et al. | Influenza Other Respir Viruses
Aim: To compare medical masks to N95 respirators in preventing laboratory confirmed viral infection and respiratory illness including coronavirus specifically in health care workers.
INFECTION CONTROL
4/2/20
Greenhalgh, T | Oxford COVID-19 Evidence Service Team
4/2/20
McQuillan R, Dozier M, Harpur A, et al. | UNCOVER
Aim: To review the evidence on the importance of outdoor transmission and of indoor transmission of COVID-19.
4/1/20
Brurberg KG, Fretheim A | Norwegian Institute of Public Health
Aim: To review the evidence on the risk of aerosol-related transmission of SARS-CoV-2.
4/1/20
Carver C, Jones N | Oxford COVID-19 Evidence Service Team
Aim: What is the comparative accuracy of oropharyngeal and nasopharyngeal swabs for diagnosis of COVID-19?
4/1/20
Seyedi SJ, Shojaeian R, Hiradfar M, et al. | Iran J Pediatr
Aim: To investigate different aspects of COVID-19 infection in pediatrics
CLINICAL CHARACTERISTICS
4/1/20
 | INESSS, Quebec
Aim: To review the evidence on the use of nitrous oxide during childbirth in women with confirmed or suspected COVID-19.
4/1/20
 | Health Technology Wales
Aim: To review evidence on the Jafron device or other haemoperfusion adsorption cartridges for the treatment of cytokine storm, particularly in people with COVID-19.
4/1/20
 | Health Technology Wales
Aim: To review evidence that reported levels of residual hydrogen peroxide (HP) after use of HP vapour to decontaminate PPE, in particular respirators and isolation/surgical gowns.
4/1/20
Sharpe H | Alberta Health Services
Aim: To review the evidence on the recommendeduse of non-invasive ventilation in AHS acute care facilities during the COVID-19 pandemic.
4/1/20
Michelen M, Jones N, Stavropoulou C | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the symptoms and clinical features of mild and moderate cases of COVID-19.
4/1/20
Michelen M, Jones N, Stavropoulou C | Oxford COVID-19 Evidence Service Team
4/1/20
 | ECRI
Aim: To examine the safety and effectiveness of off-label use of these intermittent BiPAP and CPAP machines as temporary ventilator support for critically ill patients during ventilator shortages.
4/1/20
 | ECRI
Aim: To review the safety and efficacy of sharing a ventilator between multiple patients.
4/1/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on how seasonal changes could impact the COVID-19 pandemic.
3/31/20
Park M, Cook AR, Lim JT, et al. | J Clin Med
Aim: To summarize the available evidence on transmission dynamics, severity, susceptibility and control measures to inform policymakers and leaders in formulating management guidelines and to provide directions for future research
3/31/20
Brassey J, Heneghan C | Oxford COVID-19 Evidence Service Team
Aim: Are strip-like thermometers accurate?
3/31/20
Chastenay M | INESSS, Quebec
Aim: To review the evidence on current intervention practices with children with ID, ASD, or PD internationally in the context of a pandemic.
3/31/20
Chastenay MH | INESSS, Quebec
Aim: To shed light on the identification of useful means or potential means to promote the maintenance of social interactions between caregivers and vulnerable people.
3/31/20
 | INESSS, Quebec
Aim: To evaluate the use of assive antibody therapy (convalescent plasma) for the treatment of COVID-19.
3/31/20
Chastenay MH | INESSS, Quebec
Aim: To document the harmful effects of the COVID-19 pandemic on the mental health of the population and the measures to put in place to counter these effects.
3/31/20
Kumar D, Loshak H | CADTH
Aim: To compare hand washing with soap and water to hand sanitation solutions, and to review handwashing guidelines for health care workers that come in contact with patients.
3/31/20
Bashir N | Lancet
Aim: To collate the available data documenting the radiographic features of COVID-19, and document their prevalence amongst the existing literature
CLINICAL CHARACTERISTICS
3/31/20
Chastenay MH | INESSS, Quebec
Aim: To review the evidence on the criteria and the precautions to be implemented in the case of a load shedding in a psychiatric environment in the context of the health emergency linked to COVID-19 and the alternative measures to be implemented if necessary.
3/31/20
Fadlallah R, Daher N, El-Jardali F | Knowledge to Policy Center
Aim: To promote and strengthen the role of local and international NGOs in the COVID-19 response.
3/30/20
Hafizi D, Walter M, MacDougall D | CADTH
Aim: To examine the clinical effectiveness of masks for clinicians and health care workers exposed to bioaerosols or infectious agents during ears, nose and throat (ENT) procedures.
3/30/20
Kalin, A  | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on oral long-term immunosuppression in patients with respiratory disease.
3/30/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effects of the COVID-19 pandemic on healthcare workers in terms of infections.
3/29/20
Lin A, Hye W, Jun Y, et al.  | Integr Med Res
Aim: To summarize and analyze the herbal formulae provided by the guidelines for their pattern identifications (PIs) and compositions of herbs to treat patients with COVID-19
CANDIDATE THERAPEUTICS
3/29/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on existing models for redeploying staff during the COVID-19 pandemic.
3/28/20
Hartmann-Boyce J, Davies N, Frost R, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To evaluate the evidence for interventions to maximise mobility in older people, and minimise deterioration in activity and frailty levels.
3/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence for the prone position in patients with COVID-19.
3/27/20
 | INESSS, Quebec
Aim: To review the safety and effiacy of abortion methods during the COVID-19 pandemic.
3/27/20
Rios P, Radhakrishnan A, Thomas SM, et al. | Oxford COVID-19 Evidence Service Team
3/26/20
Tierney S, Mahtani KR, Turk A | Oxford COVID-19 Evidence Service Team
3/26/20
Frie K, Gbinigie K | Oxford COVID-19 Evidence Service Team
3/26/20
Carver C, Jones N | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the comparative accuracy of oropharyngeal and nasopharyngeal swabs to diagnose COVID-19.
3/26/20
Aronson JK | Oxford COVID-19 Evidence Service Team
3/26/20
Carver C, Jones N | Oxford COVID-19 Evidence Service Team
3/26/20
Heneghan C, Brassey J, Jefferson T | Oxford COVID-19 Evidence Service Team
3/25/20
Tierney s, Mahtani KR, Turk A | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on how social prescribing can be best implemented within the current COVID-19 pandemic.
3/25/20
Frie K, Gbinigie K | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the effectiveness of chloroquine and hydroxychloroquine in treating COVID-19.
3/25/20
 | INESSS, Quebec
Aim: To document the effect of colchicine on the inflammatory cascade accompanying certain severe forms of severe acute respiratory syndrome caused by coronaviruses.
3/25/20
Bao C, Liu X, Zhang H, et al. | J Am Coll Radiol
Aim: To provide a more precise estimate of detection of COVID-19 by chest CT and report on the most common imaging findings on chest CT imaging.
CLINICAL CHARACTERISTICS
3/25/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the safety of laparoscopy during the COVID-19 pandemic.
3/25/20
Mascio DD, Khalil A, Saccone G, et al. | Am J Obs Gynecol
CLINICAL CHARACTERISTICS
3/25/20
Di Mascio D, Khalil A, Saccone G, et al. | Am J Obstet Gynecol
Aim: To report pregnancy and perinatal outcomes of Coronavirus (CoV) spectrum infections, and particularly COVID-19 disease due to SARS-COV-2 infection during pregnancy
CLINICAL CHARACTERISTICS
3/25/20
Rios P, Radhakrishnan A, Thomas SM, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify evidence on infection protection and control measures for adults aged 60 years and older in long-term care settings from systematic reviews.
3/25/20
Mahtani KR, MacKenna B, Spencer E | Oxford COVID-19 Evidence Service Team
3/25/20
Mahtani KR, MacKenna B, Spencer E | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on prescribing longer repeat prescriptions for patients with long-term conditions during a pandemic.
3/25/20
Hartmann-Boyce J, Mahtani KR | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on management of LTCs during pandemics and national emergencies, to evaluate the indirect risks posed by these situations, and to summarise the strategies proposed to mitigate these risks.
3/25/20
Hartmann-Boyce J, Mahtani KR | Oxford COVID-19 Evidence Service Team
3/24/20
Emami A, Javanmardi F, Pirbonyeh N, et al. | Arch Acad Emerg Med
Aim: To estimate the prevalence of underlying disorders in hospitalized COVID-19 patients.
CLINICAL CHARACTERISTICS
3/24/20
Greenhalgh T, Chan XH, Khunti K, et al. | Oxford COVID-19 Evidence Service Team
3/24/20
Greenhalgh T, Chan XH, Khunti K, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on respiratory protective measures e.g. use of face masks as PPE, to reduce droplet and airborne spread. 
3/23/20
Aronson JK, Ferner RE | Oxford COVID-19 Evidence Service Team
3/23/20
Greenhalgh T, Kotze K, Van Der Westhuizen H | Oxford COVID-19 Evidence Service Team
3/23/20
 | INESSS, Quebec
Aim: To evaluate the safety and efficacy of using Amantadine/Rimantadine in COVID-19 patients.
3/23/20
 | INESSS, Quebec
Aim: To evaluate the administration of an interferon as monotherapy for the treatment of patients with a confirmed or suspected diagnosis of COVID-19.
3/23/20
 | INESSS, Quebec
Aim: To evaluate the use of oseltamivir for the treatment of patients with a confirmed or suspected diagnosis of COVID-19.
3/23/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on drug therapies being used to combat COVID-19.
3/23/20
Brassey J, Heneghan C | Oxford COVID-19 Evidence Service Team
3/23/20
Hoang U | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the accuracy of wrist style BP cuffs.
3/23/20
Hoang U | Oxford COVID-19 Evidence Service Team
3/23/20
Brurberg KG | Norwegian Institute of Public Health
Aim: To review the evidence on the risk of airborne transmission of SARS-CoV-2, MERS-CoV, and SARS-CoV.
3/23/20
Ludvigsson JF | Acta Paediatr
Aim: To review the evidence on COVID-19 incidence and disease course in children
CLINICAL CHARACTERISTICS
3/23/20
O’Donovan J, Tanveer S, Jones N, et al. | Oxford COVID-19 Evidence Service Team
3/22/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the advice being provided by medical colleges regarding the COVID-19 pandemic.
3/22/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the advice being provided by international medical colleges regarding the COVID-19 pandemic.
3/22/20
 | Singapore Ministry of Health
Aim: To review the evidence on the effect of ACE inhibitors and angiotensin II receptor blockers on patients with COVID-19.
3/22/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the advice being provided by surgical specialities regarding COVID-19.
3/20/20
 | INESSS, Quebec
Aim: To review the evidence on the use of ACE inhibitors and ARBs in the context of the COVID-19 pandemic.
3/20/20
 | INESSS, Quebec
Aim: To review the evidence on the use of NSAIDS in patients with confirmed or suspected COVID-19.
3/20/20
Vardavas CI, Nikitara K | Tob Induc Dis
Aim: To evaluate the association between smoking and COVID-19 outcomes including the severity of the disease, the need for mechanical ventilation, the need for intensive care unit (ICU) hospitalization and death.
CLINICAL CHARACTERISTICS
3/20/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence and expert advice regarding the use of ECMO for COVID-19 patients.
3/20/20
Hartmann-Boyce J, Davies N, Frost R, Bussey J, Park S | Oxford COVID-19 Evidence Service Team
3/20/20
Pluddemann A, Hobbs R, Mahtani KR, Heneghan C | Oxford COVID-19 Evidence Service Team
3/20/20
Ferner RE, Murray PI, Aronson JK | Oxford COVID-19 Evidence Service Team
3/20/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on telemedicine models or interventions associated with improved outcomes for people in the ICU.
3/20/20
Nunan D, Brassey J | Oxford COVID-19 Evidence Service Team
3/20/20
Nunan D, Brassey J | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the effect of restricting and cancelling mass gatherings and sporting events on infectious diseases.
3/20/20
Mahtani KR, Heneghan C, Aronson JK | Oxford COVID-19 Evidence Service Team
3/18/20
Brassey J, Heneghn C | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the accuracy of strip-like forehead thermometers in detecting fevers.
3/18/20
Mullins E, Evans D, Viner RM, et al. | Ultrasound Obstet Gynecol
Aim: To guide treatment and prevention in women affected by COVID-19 during pregnancy in the current outbreak.
CLINICAL CHARACTERISTICS
3/18/20
Hartmann-Boyce J, Hobbs R | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the relationship between the use of inhaled corticosteroids and COVID-19 infection.
3/18/20
Hartmann-Boyce J, Hobbs R | Oxford COVID-19 Evidence Service Team
3/18/20
Park S, Brassey J, Heneghan C, Mahtani K | Oxford COVID-19 Evidence Service Team
3/18/20
Park S, Brassey J, Heneghan C, et al.  | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on managing fever in adults with possible or confirmed COVID-19 in primary care.
3/17/20
Aronson JK, Ferner RE, DeVito N, Heneghan C | Oxford COVID-19 Evidence Service Team
3/17/20
Ferner R | Oxford COVID-19 Evidence Service Team
3/16/20
Heneghan C, Brassey J | Oxford COVID-19 Evidence Service Team
3/16/20
Heneghan C, Brassey J | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence using NSAIDs in patients with acute respiratory infection.
3/16/20
Heneghan C, Aronson J, Hobbs R, Mahtani K | Oxford COVID-19 Evidence Service Team
3/14/20
Salehi S, Abedi A, Balakrishnan S, et al. | AJR Am J Roentgenol
Aim: To identify the CT characteristics of this life-threatening and rapidly spreading viral pneumonia, summarize key imaging findings in different stages of the disease, and define the evolution of CT findings associated with disease progression or clinical improvement. We also aim to investigate how CT findings correlate with patients’ age, severity of clinical symptoms, laboratory testing, and disease prognosis.
CLINICAL CHARACTERISTICS
3/13/20
Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, et al. | Travel Med Infect Dis
Aim: To summarize the clinical, laboratory, and image features of COVID-19; to examine the outcome of COVID-19 cases, including risk factors, the proportion of patients requiring ICU and those with fatal outcomes; and to assess the prevalence of comorbidities among COVID-19 confirmed cases.
CLINICAL CHARACTERISTICS
3/13/20
Long Y, Hu T, Liu L, et al. | J Evid Based Med
Aim: To assess the effectiveness of N95 respirators versus surgical masks for prevention of influenza by collecting randomized controlled trials (RCTs)
INFECTION CONTROL
3/12/20
Yang J, Zheng Y, Gou X, et al. | Int J Infect Dis
Aim: To assess the prevalence of comorbidities in the COVID-19 infection patients and the risk of underlying diseases in severe patients compared to non-severe patients.
CLINICAL CHARACTERISTICS
3/1/20
 | ECRI
Aim: To review the evidence on the effectiveness of antimicrobial copper surfaces in reducing health-associated infection risk.
3/1/20
 | Health Technology Wales
Aim: To review the evidence on digital applications for the diagnosis of actue respiratory disease.
3/1/20
Brooks SK, Webster RK, Smith LE, et al.  | Lancet
Aim: To review of the psychological impact of quarantine
INFECTION CONTROL
3/1/20
Chughtai AA, Khan W | J Infect Pub Health
Aim: To examine the use of PPE for respiratory infections in healthcare settings in Pakistan
INFECTION CONTROL
2/26/20
Pang J, Wang MX, Ang IYH, et al. | J Clin Med
Aim: To describe and assess the potential rapid diagnostics, vaccines and therapeutics for 2019-nCoV, based in part on the developments for MERS-CoV and SARS-CoV
CLINICAL CHARACTERISTICS
2/25/20
Rios P, Radhakrishnan A, Antony J, et al. | Public Health Agency of Canada
Aim: To identify safe and effective medical countermeasures (e.g., antivirals/antibodies) to address the current outbreak of a novel coronavirus (COVID-19)
CANDIDATE THERAPEUTICS
2/14/20
Zhang L, Liu Y | J Med Virol
Aim: To summarize therapeutic options available for the treatment of COVID-19
CANDIDATE THERAPEUTICS
2/6/20
Cupertino M, Rsende MB, Mayer NAJ, et al. | Asian Pacific Journal of Tropical Medicine
Aim: To review studies on the role of wild animals as reservoirs and/or dispersers of etiological agents of human infectious diseases in order to compile data on the main wild animals and etiological agents involved in zoonotic outbreaks
2/1/20
Prajapat M, Sarma P, Shekhar N, et al. | Indian J Pharmacol
Aim: To describe protein structures that are potential targets for the development of CoV therapies
CANDIDATE THERAPEUTICS
2/1/20
 | ECRI
Aim: To review the efficacy of SafeHaven for reducing healthcare-associated infections.
2/1/20
 | ECRI
Aim: To review the evidence that the use of SilvaClean reduces healthcare-associated infections (HAIs).