COVID-19 Evidence Reviews
as of 10/4/22
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Diagnostics
 
= living review
= draft/preprint   |  
= meets mimimum quality standards   |  

A review with this mark was peer-reviewed, described systematic search and study selection, and included critical appraisal of primary studies.
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9/26/22
Ricco M, Zaniboni A, Satta E, et al. | Diagnostics
Aim: To explore the reliability of EBC as a way to collect respiratory specimens for RT-qPCR for diagnosis of COVID-19.
DIAGNOSTICS
9/23/22
Tsang NNY, So HC, Cowling BJ, et al. | Eur Respir Rev
Aim: To assess the performance of saline and water gargling for SARS-CoV-2 RT-PCR testing in the settings of diagnosing and monitoring viral shedding.
DIAGNOSTICS
9/20/22
Kumar R, Misra AK, Dutta S, et al. | J Family Med Prim Care
Aim: To conduct a systematic analysis of the cases involving presence of mucormycosis and to find out its association with COVID-19, diabetes mellitus, and corticosteroids.
DIAGNOSTICS
9/19/22
Xie J, He Y, Zheng Y, et al. | Microbiol Res
Aim: To assess the diagnostic accuracy of the rapid antigen test (RAT) compared with RT-PCR (reference standard) for SARS-CoV-2.
UPDATED
DIAGNOSTICS
9/19/22
Liu E, Smyth RL, Li Q, et al. | Eur J Pediatr
Aim: To review the evidence on the diagnosis and management of children with COVID-19.
DIAGNOSTICS
8/29/22
Maia R, Carvalho V, Faria B, et al. | Micromachines
Aim: To provide an overview of the COVID-19 diagnosis methods and tests already available, as well as their evolution in recent months.
DIAGNOSTICS
8/29/22
Mei F, Rota M, Bonifazi M, et al. | J Clin Med
Aim: To summarize data from the literature on the diagnostic yield of BAL for the detection of SARS-CoV-2 in cases with high clinical suspicion for COVID-19 and at least one negative NPS.
DIAGNOSTICS
8/24/22
Jia LL, Zhao JX, Pan NN, et al. | Eur J Radiol Open
Aim: To provide an overview of radiomics studies identifying COVID-19 from other pneumonias and evaluate the efficacy of prediction models.
UPDATED
DIAGNOSTICS
8/24/22
Wynants L, Van Calster B, Bonten MMJ | BMJ
Aim: To review and critically appraise published and preprint reports of models that aim to predict either (i) presence of existing COVID-19 infection, or (ii) future complications in individuals already diagnosed with COVID-19
UPDATED
DIAGNOSTICS
8/22/22
Dolatshahi Z, Nargesi S, Sadeghifar J, et al. | Int J Surg
Aim: To compare the economic evaluation of different laboratory diagnostic interventions with each other and also with implementing the conservative CDC & WHO guidelines.
DIAGNOSTICS
8/22/22
Martin C, Cheng N, Chang B, et al. | Pol J Radiol
Aim: To stratify studies investigating the sensitivities of RT-PCR and CT for COVID-19 based on bias, to see how biases affect the sensitivities reported.
DIAGNOSTICS
8/15/22
Gempeler A, Griswold DP, Rosseau G, et al. | Front Med
Aim: To identify, appraise, and summarize the available evidence on the diagnostic accuracy of chest CT for rapid diagnosis of COVID-19, and discuss important considerations for its use.
DIAGNOSTICS
8/15/22
Duncan DB, Mackett K, Ali MU, et al. | Clin Biochem
Aim: To assess the diagnostic performance of saliva compared with NPS for COVID-19
DIAGNOSTICS
8/2/22
Siddiqui S, Arifeen M, Hopgood A, et al. | SN Comput Sci
Aim: To demonstrate the analysis and performance of recently proposed methods based on DL to diagnose COVID-19. 
DIAGNOSTICS
7/28/22
Hung KC, Huang YT, Chang YJ, et al. | Diagnostics
Aim: To examine the association of the F/A ratio with prognostic outcomes among patients contracting COVID-19.
UPDATED
DIAGNOSTICS
7/28/22
Kim J, Sung H, Lee H, et al. | Viruses
Aim: To evaluate and compare the available evidence on the real-world diagnostic utility of RATs for detecting variants at the point of care.
DIAGNOSTICS
7/28/22
Shang W, Kang L, Cao G, et al. | Vaccines
Aim: To assess the percentage of asymptomatic infections among SARS-CoV-2 Omicron variant-positive individuals detected by gene sequencing or specific polymerase chain reaction (PCR).
DIAGNOSTICS
7/27/22
Marando M, Tamburello A, Gianella P, et al. | Caspian J Intern Med
Aim: To evaluate the sensitivity of RT-PCR assays specifically on nasopharyngeal specimens in a population of adults with a clinical suspicion of Coronavirus Disease – 2019 (COVID-19).
DIAGNOSTICS
7/12/22
Rangel-Ramírez VV, Macias-Pina KA, Servin-Garrido RR, et al. | Microbiol Res
Aim: To review the scientific literature on antibody IgA immunity to SARS-CoV-2 to determine if IgA could be useful as a diagnostic tool or as a biomarker of severity. 
DIAGNOSTICS
7/6/22
Araújo ST, Araújo CT, Silva E Castro R, et al. | Curr Med Chem
Aim: To investigate potential neuroimaging markers of early diagnosis and prognosis of neurologic manifestations in COVID-19.
UPDATED
DIAGNOSTICS
6/21/22
Susanna D, Pratiwi D, Purnama SG | F1000Res
Aim: To examine the variations in COVID-19 diagnostic testing and clinical characteristics across various studies.
DIAGNOSTICS
5/31/22
Brümmer LE, Katzenschlager S, McGrath S, et al. | PLoS Med
Aim: To review the accuracy of commercially available Ag-RDTs, further explore the impact of viral load, the presence of symptoms, and the testing procedure on the accuracy of Ag-RDTs.
DIAGNOSTICS
5/31/22
Jamiruddin MR, Meghla BA, Islam DZ, et al. | Life
Aim: To explore the different microfluidic-based diagnostics kits and how their amalgamation with the various detection techniques has spearheaded their availability throughout the world.
DIAGNOSTICS
5/20/22
Keskin AU, Ciragil P, Topkaya AE | Int J Microbiol
Aim: To collect and analyse current evidence on real-world performance based on clinical accuracy of instrument-read rapid antigen diagnostic tests (Ag-IRRDTs) for SARS-CoV-2 identification.
UPDATED
DIAGNOSTICS
5/16/22
Riccò M, Ranzieri S, Peruzzi S, et al. | Acta Biomed
Aim: To assess available evidence and to explore the reliability of antigenic tests in the management of the SARS-CoV-2 pandemic.
DIAGNOSTICS
4/14/22
Ghasemi S, Harmooshi NN, Rahim F | Diagn Pathol
Aim: To investigate the eligible studies for the sensitivity and specificity of rapid tests and explore the factors that influence the result to help better diagnose COVID-19 infection.
DIAGNOSTICS
4/7/22
Rahmani AM, Azhir E, Naserbakht M, et al. | Multimed Tools Appl
Aim: To review the evidence on the application of Machine Learning (ML) methods for the detection of COVID-19.
DIAGNOSTICS
4/4/22
Fomenko A, Weibel S, Moezi H, et al. | Rev Med Virol
Aim: To review the evidence on RT-PCR performance in detecting infectious SARS-CoV-2. 
UPDATED
DIAGNOSTICS
3/31/22
Liu G, Chen Y, Runa A, et al. | Eur Radiol
Aim: To provide an updated overview of the diagnostic performance of CO-RADS in COVID-19, with a focus on the possible practical application of CO-RADS.
DIAGNOSTICS
3/10/22
Jari R, Alfuraih AM, McLaughlan JR | J Clin Ultrasound
Aim: To investigate the use of lung ultrasound (LUS) on COVID-19 patients, in emergency point of care settings, and to determine its diagnostic value compared with lung computed tomography (LCT) diagnostic performance.
DIAGNOSTICS
3/7/22
Macedo ACL, Prestes GDS, Colonetti T, et al. | J Clin Virol
Aim: To evaluate the accuracy of serology for SARS-CoV-2 infections in cases confirmed or not by RT-PCR.
DIAGNOSTICS
3/4/22
Chua PEY, Gwee SXW, Wang MX, et al. | Front Med
Aim: To compare the accuracy of different diagnostic tests (molecular, serology, clinical features, point of care testing, and imaging) and assess their potential utility as border screening for infection and immunity against SARS-CoV-2.
DIAGNOSTICS
3/2/22
Ahmadieh A, Dincer S, Navazesh M | Oral Surg Oral Med Oral Pathol Oral Radiol
Aim: To assess the sensitivity rate of SARS-CoV-2 detection in the saliva of ambulatory asymptomatic and mildly symptomatic patients, with saliva being collected passively without any forceful coughing.
DIAGNOSTICS
2/28/22
Fragkou PC, De Angelis G, Menchinelli G, et al. | Clin Microbiol Infect
Aim: To identify the most appropriate diagnostic test and/or diagnostic approach for SARS-CoV-2. 
DIAGNOSTICS
2/18/22
Zhou JQ, Liu GX, Huang XL, et al. | J Med Virol
Aim: To review the evidence on the role of fecal nucleic acid detection of SARS-CoV-2 for quarantine and contact tracing.
DIAGNOSTICS
2/11/22
Sharif PM, Nematizadeh M, Saghazadeh M, et al. | Pol J Radiol
Aim: To summarize the available data regarding chest CT features in confirmed cases of COVID-19.
DIAGNOSTICS
2/9/22
Bhatt A, Bumbrah GS, Ruwali M, et al. | Pathog Glob Health
Aim: To assess the diagnostic efficiency of RT-LAMP integrated CRISPR-Cas technology.
DIAGNOSTICS
1/24/22
Khalid MF, Selvam K, Jeffry AJN, et al. | Diagnostics
Aim: To evaluate the pooled sensitivity and specificity of the commercially available RATs.
UPDATED
DIAGNOSTICS
1/20/22
Fujita-Rohwerder N, Beckmann L, Zens Y, et al. | BMJ Evid Based Med
Aim: To systematically assess the diagnostic accuracy of rapid point-of-care tests for diagnosis of current SARS-CoV-2 infections in children under real-life conditions.
UPDATED
DIAGNOSTICS
1/17/22
Cao XJ, Fang KY, Zhou J, et al. | J Virol Methods
Aim: To review the evidence on the performance of commercial Cepheid Xpert Xpress SARS-CoV-2 test for the identification of SARS-CoV-2.
DIAGNOSTICS
1/14/22
Kim DH, Basurrah MA, Han JH, et al. | Saudi Med J
Aim: To evaluate the diagnostic utility of self-collected saliva in coronavirus desease-19 (COVID-19) screening procedures.
DIAGNOSTICS
1/10/22
Aria H, Mahmoodi F, Ghaheh HS, et al. | Anal Biochem
Aim: To review research studies that have applied nanobodies to diagnose or neutralize SARS-CoV-2.
DIAGNOSTICS
12/27/21
Makoah NA, Tipih T, Litabe MM, et al. | Future Virol
Aim: To investigate the utility of serological tests for the diagnosis of COVID-19 during the first week of symptom onset in patients confirmed with the real-time RT-PCR.
DIAGNOSTICS
12/27/21
Pang KW, Tham SL, Ng LS | Life
Aim: To determine the pooled sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR-) and diagnostic odds ratio (DOR) of using GD as a triage symptom prior to RT-PCR.
DIAGNOSTICS
12/27/21
Stoicescu ER, Ciuca IM, Iacob R, et al. | Diagnostics
Aim: To assess the evidence on the utility of lung ultrasound (LUS) in neonates diagnosed with COVID-19.
DIAGNOSTICS
12/22/21
Agrawal S, Goel AD, Gupta N, et al. | Heart Lung
Aim: To assess the diagnostic yield of BAL for detection of SARS-CoV-2 in cases of non-diagnostic upper respiratory tract samples.
DIAGNOSTICS
12/13/21
Ishak A, Al Rawashdeh MM, Esagian SM, et al. | J Clin Med
Aim: To assess the diagnostic performance of droplet digital PCR (ddPCR), also to evaluate its potential role in prognosis and management of COVID-19 patients.
DIAGNOSTICS
12/6/21
Pu R, Liu S, Ren X, et al. | J Virols Methods
Aim: To evaluate the diagnostic accuracy of RT-PCR and RT-LAMP and the potential effects of reference methods on diagnostic accuracy.
DIAGNOSTICS
12/3/21
Curran J, Boulos L, Somerville M, et al. | SPOR
Aim: To review the evidence on the impacts of variants of concern on public health and health systems.
UPDATED
DIAGNOSTICS
11/26/21
Santura I, Kawalec P, Furman M, et al. | Pol J Radiol
Aim: To compare chest CT diagnostic test parameters with RT-PCR (reference) in the early diagnosis of COVID-19.
DIAGNOSTICS
11/24/21
Kaushal K, Kaur H, Sarma P, et al. | J Crit Care
Aim: To evaluate serum ferritin level in different severity levels in COVID-19.
UPDATED
DIAGNOSTICS
11/15/21
Chen CC, Lu SC, Bai CH, et al. | Int J Environ Res Public Health
Aim: To evaluate the diagnostic accuracy of antigen tests for SARS-CoV-2.
DIAGNOSTICS
11/8/21
Pecoraro V, Negro A, Pirotti T, et al. | Eur J Clin Invest
Aim: To estimate the rate of RT-PCR false-negatives at initial testing for COVID-19.
UPDATED
DIAGNOSTICS
11/1/21
Spick M, Lewis HM, Wilde MJ, et al. | Metabolism
Aim: To assess the accuracy of mass spectrometry diagnostic tests developed so far, across a wide range of biological matrices.
DIAGNOSTICS
10/25/21
Parvu V, Gary DS, Mann J, et al. | Front Microbiol
Aim: To assess the diagnostic accuracy of SARS-CoV-2 antigen detection in COVID-19 symptomatic and asymptomatic individuals compared to quantitative reverse transcription polymerase chain reaction (RT-qPCR) and summarizes antigen test sensitivity using meta-regression.
UPDATED
DIAGNOSTICS
10/20/21
Wang L, Zhang Y, Wang D, et al. | Front Med
Aim: To review the application of Artificial Intelligence (AI) techniques in COVID-19, especially for diagnosis, estimation of epidemic trends, prognosis, and exploration of effective and safe drugs and vaccines.
UPDATED
DIAGNOSTICS
10/20/21
Au WY, Cheung PPH | Lancet Microbe
Aim: To assess the performance of three common nucleic acid tests, namely digital PCR (dPCR), quantitative PCR (qPCR), and loop-mediated isothermal amplification (LAMP), to detect SARS-CoV-2 in clinical settings.
DIAGNOSTICS
10/20/21
Ouma OK, Ephraim K, Loyce N, et al. | BMJ Open
Aim: To determine the diagnostic test accuracy, cost-effectiveness and utility of laboratory test strategies for COVID-19 in low-income and middle-income countries.
UPDATED
DIAGNOSTICS
10/12/21
Musa MJ, Yousef M, Adam M, et al. | Curr Med Imaging
Aim: To conduct a systematic review reported from a number of studies to show the usefulness of [LUS] and point of care ultrasound for diagnosing COVID-19.
DIAGNOSTICS
10/6/21
Borges LP, Martins AF, Silva BM, et al. | Int Immunopharmacol
Aim: To analyze scientific articles published in the literature addressing the rapid tests available for COVID-19 diagnosis at the first year of the pandemic.
DIAGNOSTICS
10/4/21
Wang YH, Wu CC, Bai CH, et al. | J Chin Med Assoc
Aim: To evaluate the diagnostic accuracy of antigen tests for SARS-CoV-2.
DIAGNOSTICS
9/28/21
Perrone F, Balbi M, Casartelli C, et al. | World J Radiol
Aim: To collect, describe, and discuss all the clinical studies evaluating the different CT findings between COVID-19 infection and other infective or non-infective lung diseases.
DIAGNOSTICS
9/27/21
Lee J, Song JU, Shim SR | J Clin Virol
Aim: To investigate the diagnostic accuracy of rapid antigen detection tests (RADTs) in the diagnosis of SARS-CoV-2 infection.
DIAGNOSTICS
9/27/21
Wang JG, Mo YF, Su YH, et al. | Medicine
Aim: To systematically analyze the chest CT imaging features of children with COVID-19 and provide references for clinical practice. 
UPDATED
DIAGNOSTICS
9/13/21
Channa A, Popescu N, Skibinska J, et al. | Sensors
Aim: To review the evidence on ehealth wearables for COVID-19.
DIAGNOSTICS
8/30/21
Wang M, Luo X, Wang L, et al. | Diagnostics
Aim: To comprehensively identify the diagnostic agreement between LUS and CT in the diagnosis of interstitial pneumonia caused by COVID-19. 
DIAGNOSTICS
8/30/21
Khandker SS, Nik Hashim NHH, Deris ZZ, et al. | J Clin Med
Aim: To provide an update on the diagnostic accuracy in terms of estimating the specificity and sensitivity of RAT kits in patients with suspected COVID-19.
UPDATED
DIAGNOSTICS
8/26/21
Caroselli C, Blaivas M, Falzetti S | Ultrasound Med Biol
Aim: To evaluate COVID-19 imaging options in pediatric patients
DIAGNOSTICS
8/23/21
Mistry DA, Wang JY, Moeser M, et al. | BMC Infect Dis
Aim: To assess the sensitivity and specificity of LFDs.
DIAGNOSTICS
8/16/21
Brummer LE, Katzenschlager S, Geaddert M, et al.  | PLoS One
Aim: To assess the clinical accuracy (sensi-tivity and specificity) of commercially available Ag-RDTs.
UPDATED
DIAGNOSTICS
7/27/21
Adamidi ES, Mitsis K, Nikita KS, et al. | Comput Struct Biotechnol J
Aim: To review the evidence on Artificial Intelligence techniques developed and validated for screening, diagnosis, and prognosis of the coronavirus disease 2019. 
DIAGNOSTICS
7/23/21
Garcia-Fernandez FJ | Research Square
Aim: To review the evidence on the use of transcription-mediated amplification assay to diagnose COVID-19.
DIAGNOSTICS
7/22/21
Zhou Y, O'Leary TJ | PLoS One
Aim: To compare the sensitivity of nasal and nasopharyngeal swabs against a composite reference standard for the initial diagnosis of SARS-CoV-2 infection in ambulatory patients.
UPDATED
DIAGNOSTICS
7/20/21
Kepczynski CM, Genigeski JA, Koski RR, et al. | J Am Pharm Assoc
Aim: To identify and compare at-home diagnostic tests that have been granted Emergency Use Authorizations (EUAs) and convey details about COVID-19 diagnostic tests, including regulatory information, pertinent to pharmacy practice.
DIAGNOSTICS
7/6/21
Ali DM, Zake LG, El Kady NK, et al. | Interdiscip Perspect Infect Dis
Aim: To carry out a systematic review and meta-analysis to find out the role of chest CT scan versus RT-PCR for precise diagnosis of COVID-19 infection.
DIAGNOSTICS
6/21/21
Locquet M, Diep AN, Beaudart C, et al. | Arch Public Health
Aim: To identify, compare, and evaluate performances of prediction models for the diagnosis of COVID-19 in adult patients in a health care setting.
UPDATED
DIAGNOSTICS
6/21/21
Lopez-Verdin S, Prieto-Correa JR, Molina-Frechero N, et al. | Am J Dent
Aim: To review diverse tests that could serve as a screening tool for the dental community to identify patients with potential COVID-19.
DIAGNOSTICS
6/14/21
Ibrahimi N, Delaunay-Moisan A, Hill C, et al. | PLoS One
Aim: To compare saliva and nasopharyngeal/oropharyngeal samples for the detection of SARS-CoV-2.
UPDATED
DIAGNOSTICS
6/7/21
Subali AD, Wiyono L | Pathog Glob Health
Aim: To review the evidence on RT-LAMP application for rapid identification of SARS-CoV-2 infection compared to the RT-PCR assay.
DIAGNOSTICS
6/7/21
Atieh MA, Guirguis M, Alsabeeha NHM, et al. | Oral Dis
Aim: To systematically evaluate the current literature on the use of saliva test for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and carry out a meta-analysis to determine its diagnostic accuracy.
DIAGNOSTICS
6/3/21
Kao Y, Lin K | Diagnostics
Aim: To use computerized tomography (CT)-based radiomics models to differentiate COVID-19 pneumonia from other viral pneumonia infections.
DIAGNOSTICS
6/1/21
Ulhaq ZS, Soraya GV | Expert Rev Mol Diagn
Aim: To compare the accuracy parameters of seven commercial molecular in vitro diagnostic tests for detecting SARS-CoV-2.
DIAGNOSTICS
5/28/21
Karam M, Althuwaikh S, Alazemi M, et al. | JRSM Open
Aim: To compare the performance of chest computed tomography (CT) scan versus reverse transcription polymerase chain reaction (RT-PCR) as the reference standard in the initial diagnostic assessment of coronavirus disease 2019 (COVID-19) patients.
DIAGNOSTICS
5/26/21
Pang C, Hou Q, Yang Z, et al. | Clin Transl Imaging
Aim: To comprehensively assess the diagnostic value of chest CT for COVID-19.
DIAGNOSTICS
5/20/21
Wang J, Kaperak C, Sato T, et al. | J Investig Med
Aim: To identify cases infected with different genetic strains of SARS-CoV-2 confirmed by polymerase-chain reaction and viral genome sequencing.
UPDATED
DIAGNOSTICS
5/20/21
Ishfaq A, Farooq SMY, Goraya A, et al. | Eur J Radiol Open
Aim: To identify the role of High-Resolution Computed Tomography chest and summarize characteristics of chest CT imaging for the diagnosis and evaluation of SARS-CoV-2 patients.
DIAGNOSTICS
5/14/21
Kwee RM, Adams HJA, Kwee TC | Radiol Cardiothorac Imaging
Aim: To determine the diagnostic performance of the COVID-19 Reporting and Data System (CO-RADS) and the Radiological Society of North America (RSNA) categorizations in patients with clinically suspected coronavirus disease 2019 (COVID-19) infection.
DIAGNOSTICS
5/14/21
Zhan H, Chen H, Liu C, et al. | Clin Appl Thromb Hermost
Aim: To assess the predictive value of D-dimer for the severity, mortality and incidence of venous thromboembolism (VTE) events in COVID-19 patients.
DIAGNOSTICS
5/13/21
Moezzi M, Shirbandi K, Shahvandi HK, et al. | Inform Med Unlocked
Aim: To summarize all the data currently available on the AI-assisted CT-Scan prediction accuracy for COVID-19.
DIAGNOSTICS
5/11/21
Rachel JB, Gururaj N, Smitha T, et al. | J Oral Maxillofac Pathol
Aim: To understand study the strain variants, all possible modes of transmission, pathogenesis, and manifestations mentioned in predominant literature published during the pandemic.
DIAGNOSTICS
5/11/21
Born J, Beymer D, Rajan D, et al. | Patterns
Aim: To address the utility of AI in imaging for COVID-19 patient care.
DIAGNOSTICS
5/7/21
Watt JA, Lane NE, Veroniki AA, et al. | J Am Geriatr Soc
Aim: To compare the diagnostic accuracy of virtual to in-person cognitive assessments and tests and barriers to virtual cognitive assessment implementation.
DIAGNOSTICS
5/6/21
Chee ML, Ong MEH, Siddiqui FJ, et al. | Int J Environ Res Public Health
Aim: To systematically review and critically appraise the current evidence on AI applications for COVID-19 in intensive care and emergency settings.
DIAGNOSTICS
5/6/21
Suklan J, Cheaveau J, Hill S, et al. | Viruses
Aim: To statistically summarise routine laboratory biomarker measurements in COVID-19-positive and -negative patients to inform future work.
DIAGNOSTICS
4/30/21
Zhang L, Pan R, Cai Y, et al. | Psychiatry Investig
Aim: To investigate the prevalence of post-traumatic stress disorder (PTSD) in the general population during the COVID-19 pandemic.
DIAGNOSTICS
4/20/21
Pecho-Silva S, Navarro-Solsol AC, Taype-Rondan A, et al. | Ultrasound Med Biol
Aim: To systematize the evidence on pulmonary ultrasound (PU) use in diagnosis, monitorization or hospital discharge criteria for patients with coronavirus disease 2019 (COVID-19).
DIAGNOSTICS
4/13/21
Alkhatip AAAMM, Kamel MG, Hamza MK, et al. | Expert Rev Mol Diagn
Aim: To evaluate the diagnostic and prognostic accuracy of the NLR in COVID-19 patients.
DIAGNOSTICS
4/12/21
Tsang NNY, So HC, Ng KY, et al. | Lancet Infect Dis
Aim: To systematically compare the diagnostic performance of different clinical specimen collection methods.
DIAGNOSTICS
4/1/21
Fathi M, Vakili K, Sayehmiri F, et al. | Iran J Immunol
Aim: To analyze the effectiveness of the measurement of specific antibodies to SARS-CoV2 (IgM and IgG) for the diagnosis of COVID-19 and to analyze the rate of SARS-CoV2 seroprevalence in the population.
DIAGNOSTICS
3/30/21
Khiabani K, Amirzade-Iranaq MH | Am J Infect Control
Aim: To conduct a systemic review and meta-analysis on the reliability and sensitivity of SARS-CoV-2 detection in saliva and deep throat sputum (DTS) compared to nasopharyngeal, combined naso/oropharyngeal, and oropharyngeal swabs.
DIAGNOSTICS
3/30/21
Sucha D, van Hamersvelt RW, van den Hoven AF, et al. | Radiol Cardiothorac Imaging
Aim: To synthesize the literature on diagnostic test accuracy of chest radiography, CT, and US for the diagnosis of coronavirus disease 2019 (COVID-19) in patients suspected of having COVID-19 in a hospital setting and evaluate the extent of suboptimal reporting and risk of bias.
UPDATED
DIAGNOSTICS
3/25/21
Hassanipour S, Azadbakht O, Dehnavi Z, et al. | Egypt J Radiol Nucl Med
Aim: To determine the correct location of chest CT scan in the diagnosis of COVID-19.
DIAGNOSTICS
3/24/21
Ghaderzadeh M, Asadi F | J Healthc Eng
Aim: To provide an overview of the current state of all models for the detection and diagnosis of COVID-19 through radiology modalities and their processing based on deep learning. 
DIAGNOSTICS
3/22/21
Montazeri M, ZahediNasab R, Farahani A, et al. | JMIR Med Inform
Aim: To summarize information on the use of intelligent models for diagnosing and prognosing the COVID-19 to help early and timely diagnosis of the disease to help with health.
DIAGNOSTICS
3/18/21
Kalin A, Javid B, Knight M, et al. | Syst Rev
Aim: To summarise the literature on the performance of different rapid tests for exertional desaturation.
UPDATED
DIAGNOSTICS
3/8/21
Moreira VM, Mascarenhas P, Machado V, et al. | Diagnostics
Aim: To compare the overall accuracy of nucleic acid assays run with index specimens (saliva, deep-throat saliva/posterior oral samples (DTS/POS], sputum, urine, feces, and tears/CS), against standard NPS/OPS based test results.
DIAGNOSTICS
3/8/21
Johnson T, Bishoff T, Kremsreiter K, et al. | Med J
Aim: To perform a systematic review of the literature and to provide evidence-based algorithms for diagnosing or ruling out COVID-19.
DIAGNOSTICS
3/1/21
Zhou X, Pu Y, Zhang D, et al. | Acta Radiol
Aim: To explore the chest CT findings and dynamic CT changes of COVID-19 using systematic evaluation methods, instructing the clinical imaging diagnosis.
DIAGNOSTICS
3/1/21
Zang S, Han X, Cui Q, et al. | Transl Pediatr
Aim: To summarize a comprehensive review and meta-analysis with a complete evaluation of CT characteristics in pediatric COVID-19 cases. 
UPDATED
DIAGNOSTICS
3/1/21
Canete MG, Valenzuela IM, Garces PC, et al. | Oral Surg Oral Med Oral Pathol Oral Radiol
Aim: To describe the value of saliva as a noninvasive sample for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in comparison with the current method for sample collection, the nasopharyngeal swab.
DIAGNOSTICS
2/25/21
Struyf T, Deeks JJ, Dinnes J et al. | Cochrane Database Syst Rev
Aim: To assess the diagnostic accuracy of signs and symptoms to determine if a person presenting in primary care or to hospital outpatient settings, such as the emergency department or dedicated COVID?19 clinics, has COVID?19 disease or COVID?19 pneumonia.
UPDATED
DIAGNOSTICS
2/20/21
Zhang JJY, Lee KS, Ong CW, et al. | Influenza Other Respir Viruses
Aim: To evaluate the diagnostic performance of serological testing in COVID?19 by providing summary sensitivity and specificity estimates with time from symptom onset.
DIAGNOSTICS
2/20/21
Sagredo-Olivares K, Morales-Gomez C, Aitken-Saavedra J | Med Oral Patol Oral Cir Bucal
Aim: To evaluate saliva as a diagnostic technique for COVID-19.
UPDATED
DIAGNOSTICS
2/15/21
Udeh R, Advani S, de Guadiana Romualdo LG, et al. | J Clin Med
Aim: To carefully evaluate the levels of calprotectin (serum, plasma or fecal) in severe and non-severe COVID-19, and also identify the implications of raised levels of calprotectin.
DIAGNOSTICS
2/11/21
Nasiri K, Dimitrova A | J Dent Sci
Aim: To evaluate saliva specimen in comparison to nasopharyngeal swab (NPS) specimen.
DIAGNOSTICS
2/10/21
Hariyanto TI, Rizki NA, Kurniawan A | Int Arch Otorhinolaryngol
Aim: To analyze the potential usefulness of anosmia or hyposmia in the detection of the COVID-19 infection.
DIAGNOSTICS
2/8/21
Kim DH, Kim SW, Stybayeva G, et al. | Clin Exp Otorhinolaryngol
Aim: To evaluate the diagnostic value of the various symptoms of COVID-19 in the screening of this disease.
DIAGNOSTICS
2/4/21
Anderson G, Casasanta D, Cocchieri A, et al. | J Clin Nurs
Aim: To identify the main diagnostic features of SARS-CoV-2 positive patients at the time of hospitalization and their prevalence.
DIAGNOSTICS
2/1/21
Lee RA, Herigon JC, Benedetti A, et al. | J Clin Microbiol
Aim: To understand the performance of alternative sample types compared to NP swabs
UPDATED
DIAGNOSTICS
2/1/21
Yoon SH, Yang S, Cho H, et al.  | Eur Rev Med Pharmacol Sci
Aim: To evaluate the diagnostic accuracy of the Food and Drug Administration Emergency Use Authorization (FDA-EUA) authorized point-of-care tests (POCTs) for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
UPDATED
DIAGNOSTICS
2/1/21
Bastos ML, Perlman-Arrow S, Menzies D, et al. | Ann Intern Med
Aim: To determine the difference in sensitivity for SARS-CoV-2 detection between nasopharyngeal swabs and saliva and estimate the incremental cost per additional SARS-CoV-2 infection detected with nasopharyngeal swabs.
UPDATED
DIAGNOSTICS
1/29/21
Khatami F, Saatchi M, Zadeh SST, et al. | Sci Rep
Aim: To determine the diagnostic value of an initial chest CT scan in patients with COVID-19 infection in comparison with RT-PCR. 
DIAGNOSTICS
1/29/21
Chen M, Qin R, Mei J, et al. | Int J Infect Dis
Aim: To investigate the diagnostic effectiveness of SARS-CoV-2 specific antibodies stratified by different positive results.
DIAGNOSTICS
1/29/21
Butler-Laporte G, Lawandi A, Schiller I, et al. | JAMA Intern Med
Aim: To assess the diagnostic accuracy of saliva NAAT for COVID-19.
DIAGNOSTICS
1/28/21
Mair MDD, Hussain M, Siddiqui S, et al | Br J Radiol
Aim: To perform a systematic review and meta-analysis to compare the diagnostic accuracy of Computed tomography (CT) and initial Reverse transcriptase polymerase chain reaction (RT-PCR) for detecting COVID-19 infection.
DIAGNOSTICS
1/11/21
Syeda HB, Syed M, Sexton KW, et al. | JMIR Med Inform
Aim: To conduct a systematic literature review on the role of ML as a comprehensive and decisive technology to fight the COVID-19 crisis in the arena of epidemiology, diagnosis, and disease progression.
UPDATED
DIAGNOSTICS
1/1/21
O'Leary T | J Molecular Diag
Aim: To better understand the relative performance characteristics of saliva and upper airway samples.
DIAGNOSTICS
12/22/20
Subsoontorn P, Lohitnavy M, Kongkaew C | Sci Rep
Aim: To determine the accuracy of nucleic acid point-of-care diagnosis for human coronaviruses, particularly, SARS-CoV, MERS-CoV and SARS-CoV-2.
UPDATED
DIAGNOSTICS
12/22/20
Pillai K, Hewage S, Harky A | J Med Ultrasound
Aim: To review the evidence on the potential role of the lung ultrasound to evaluate its benefits and potential roles to compare it to the current gold standard of computed tomography.
DIAGNOSTICS
12/14/20
Arevalo Rodriguez I, Buitrago Garcia D, Simancas Racines D, et al.  | PLoS One
Aim: To review and critically appraise evidence about the proportion of RT-PCR false-negatives at initial testing for COVID-19. 
UPDATED
DIAGNOSTICS
11/30/20
Islam N, Salameh JP, Leeflang MMG, et al. | Cochrane Database Syst Rev
Aim: To determine the diagnostic accuracy of chest imaging (computed tomography (CT), X?ray and ultrasound) in people with suspected or confirmed COVID?19.
UPDATED
DIAGNOSTICS
11/25/20
Garg M, Gupta P, Maralakunte M, et al. | Clin Imaging
Aim: To evaluate pooled prevalence, sensitivity, and specificity of chest computed tomography (CT) and radiographic findings for novel coronavirus-2019 (COVID-19) pneumonia.
DIAGNOSTICS
11/19/20
Stegeman I, Ochodo EA, Guleid F, et al. | Cochrane Database Syst Rev
Aim: To assess the diagnostic accuracy of routine laboratory testing as a triage test to determine if a person has COVID?19.
UPDATED
DIAGNOSTICS
11/19/20
da Silva RCM, Marinho LCN, de Araujo Silva DN, et al. | Travel Med Infect Dis
Aim: To conduct an integrative literature review reporting saliva use as a sample for the SARS-CoV-2 diagnosis.
DIAGNOSTICS
11/12/20
Bellini D, Panvini N, Carbone I, et al. | J Comput Assist Tomogr
Aim: To perform a meta-analysis assessing the diagnostic yield of computed tomography (CT) for the identification of coronavirus disease 2019 (COVID-19) using repeated reverse transcriptase polymerase chain reaction testing or confirmed true-negative state as reference standard.
DIAGNOSTICS
11/11/20
Hellou MM, Gorska A, Mazzaferri F, et al. | Clin Microbiol Infect
Aim: To evaluate the diagnostic test accuracy (DTA) of nucleic acid amplification tests (NAATs) for the diagnosis of coronavirus infections.
DIAGNOSTICS
11/9/20
Mekonnen D, Mengist HM, Derbi A, et al.  | Rev Med Virol
Aim: To assess the diagnostic test accuracy (DTA) of severe acute respiratory syndrome coronavirus 2 (SARS?COV?2) serological test methods and the kinetics of antibody positivity. 
DIAGNOSTICS
10/30/20
Ebrahimi M, Malehi AS, Rahim F | Osong Public Health Res Perspect
Aim: To compare coronavirus disease 2019 (COVID-19) laboratory findings, comorbidities, and clinical outcomes in patients from the general population versus medical staff to aid diagnosis of COVID-19 in a more timely, efficient, and accurate way.
DIAGNOSTICS
10/26/20
Comber L, Walsh KA, Jordan K, et al. | Rev Med Virol
Aim: To synthesise the available evidence for detection of SARS?CoV?2 RNA using RT?PCR tested saliva or nasal specimens compared with RT?PCR tested nasopharyngeal specimens.
DIAGNOSTICS
10/26/20
Wang H, Ai J, Loeffelholz MJ, et al. | Emerg Microbes Infect
Aim: To evaluate the diagnostic accuracy of serologic methods for COVID-19 based on assay design and post-symptom-onset intervals.
DIAGNOSTICS
10/21/20
Yang H, Lan Y, Yao X, et al. | Virol J
Aim: To summarize the characteristics of chest CT imaging in Chinese hospitalized patients with Coronavirus Disease 2019 (COVID-19) to provide reliable evidence for further guiding clinical routine.
DIAGNOSTICS
10/20/20
Hossein H, Ali KM, Hosseini M, et al. | Clin Transl Imaging
Aim: To answer to the question whether CT scan can be used in diagnosis of COVID-19 or not.
DIAGNOSTICS
10/13/20
Aggarwal N, Garg M, Dwarakanathan V, et al. | J Travel Med
Aim: To review the evidence on the diagnostic accuracy of infrared thermal screening via handheld non-contact infrared thermometers and thermal scanners.
DIAGNOSTICS
10/13/20
Roshandel R, Nateqi M, Lak R, et al. | Cell Mol Biol
Aim: To review the evidence on the diagnostic and methodological evaluation of urinary shedding of SARS-CoV-2.
UPDATED
DIAGNOSTICS
10/5/20
Moutchia J, Pokharel P, Kerri A, et al. | PLoS One
Aim: To assess clinical laboratory parameters which may serve as markers or predictors of severe or critical COVID-19.
UPDATED
DIAGNOSTICS
10/5/20
Jarrom D, Elston L, Washington J, et al. | BMJ Evid Based Med
Aim: To identify evidence on: (1) the clinical effectiveness of tests that detect the presence of severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) to inform COVID?19 diagnosis? and (2) the clinical effectiveness of tests that detect the presence of antibodies to the SARS?CoV?2 virus to inform COVID?19 diagnosis.
UPDATED
DIAGNOSTICS
10/2/20
Li WT, Ma J, Shende N, et al. | BMC Med Inform Decis Mak
Aim: To investigate correlations between clinical variables, cluster COVID-19 patients into subtypes, and generate a computational classification model for discriminating between COVID-19 patients and influenza patients based on clinical variables alone.
DIAGNOSTICS
9/21/20
Chen J, See KC | J Med Internet Res
Aim: To review AI applications for COVID-19.
DIAGNOSTICS
9/18/20
Zahra SA, Iddawela S, Pillai K, et al. | Brain Behav
Aim: To investigate the diagnostic value of symptoms of anosmia and dysgeusia for COVID?19.
DIAGNOSTICS
9/18/20
Mojtabavi H, Saghazadeh A, Rezaei N | Eur Cytokine Netw
Aim: To investigate whether the circulating levels of IL-6 is a reliable indicator of disease severity among patients affected with COVID-19.
DIAGNOSTICS
9/15/20
Ricco M, Ranzieri S, Peruzzi S, et al. | Acta Biomed
Aim: To conduct a meta-analysis on the sensitivity and specificity of SARS-CoV-2 viral RNA detection through RT-qPCR based on salivary specimens compared to conventional nasopharyngeal swabs.
DIAGNOSTICS
9/11/20
Sun Z, Zhang N, Li Y, et al. | Quant Imaging Med Surg
Aim: To analyze the currently available studies documenting radiologic findings and aim to clarify the role of CT imaging in the diagnosis of patients with COVID-19.
DIAGNOSTICS
9/11/20
Czumbel LM, Kiss S, Farkas N, et al. | Front Med
Aim: To conduct a meta-analysis on the reliability and consistency of SARS-CoV-2 viral RNA detection in saliva specimens.
UPDATED
DIAGNOSTICS
9/10/20
Liu C, Yang J, Wang W, et al. | Eur J Gastroenterol Hepatol
Aim: To compare liver injury in severe vs. non-severe or dead vs. surviving patients and investigate whether livery injury can help predict clinical severity and mortality in patients with coroanvirus disease 2019.
DIAGNOSTICS
9/9/20
Chauhan N, Soni S, Gupta A, et al. | Expert Rev Mol Diagn
Aim: To review the evidence on diagnostic methods for COVID-19 detection.
DIAGNOSTICS
8/31/20
Almqvist J, Granberg T, Tzortzakakis A, et al. | Ann Clin Transl Neurol
Aim: To optimize diagnostic workup of the current severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) pandemic.
DIAGNOSTICS
8/31/20
Duarte ML, Dos Santos LR, de Souza Contencas AC, et al. | Sao Paulo Med J
Aim: To compare accuracy between RT-PCR and computed tomography (CT) for detecting COVID-19 in the first week of its symptoms during the pandemic.
DIAGNOSTICS
8/26/20
Dinnes J, Deeks JJ, Adriano A et al. | Cochrane Database Syst Rev
Aim: To assess the diagnostic accuracy of point-of-care antigen and molecular-based tests to determine if a person presenting in the community or in primary or secondary care has current SARS-CoV-2 infection
DIAGNOSTICS
8/25/20
van Doorn AS, Meijer B, Frampton CMA, et al. | Aliment Pharmacol Ther
Aim: To critically assess the clinical relevance of testing stool samples and anal swabs and provide an overview of the potential faecal-oral transmission of SARS-CoV-2.
DIAGNOSTICS
8/15/20
Lv H, Chen T, Pan Y, et al. | Ann Transl Med
Aim: To estimate the prevalence and identify the underlying differential diagnostic value of VES.
DIAGNOSTICS
8/14/20
de Moura DTH, McCarty TR, Ribeiro IB, et al. | Clinics (Sao Paulo)
Aim: To perform a structured systematic review and meta-analysis to evaluate the diagnostic characteristics of serological-based COVID-19 testing.
UPDATED
DIAGNOSTICS
7/27/20
Bwire GM, Majigo MV, Nijiro BJ, et al. | J Med Virol
Aim: To profile the positive detection rate from different clinical specimens using PCR to guide the selection of specimens for clinical diagnosis of COVID-19.
UPDATED
DIAGNOSTICS
7/14/20
Boger B, Fachi MM, Vilhena RO, et al. | Am J Infect Control
Aim: To collate the evidence on the accuracy parameters of all available diagnostic methods for detecting SARS-CoV-2.
DIAGNOSTICS
7/14/20
La Marca A, Capuzzo M, Paglia T, et al. | Reprod Biomed Online
Aim: To provide an overview of current diagnostic approaches for SARS-CoV-2 and in particular highlight issues with serological testing, with the objective of providing a clear guide to clinicians on the assays currently available.
DIAGNOSTICS
7/11/20
Albahri OS, Zaidan AA, Albahri AS, et al. | J Infect Public Health
Aim: To review the evidence on artificial intelligence (AI) techniques used in the detection and classification of coronavirus disease 2019 (COVID-19) medical images in terms of evaluation and benchmarking.
DIAGNOSTICS
7/9/20
Shao JM, Ayuso SA, Deerenberg EB, et al. | Colorectal Dis
Aim: To investigate the sensitivity and utility of computed tomography (CT) of the chest in diagnosing active Coronavirus 2019 (COVID?19) infection, and its potential application to the surgical setting.
DIAGNOSTICS
7/3/20
Bastos M, Tavaziva G, Abidi SK, et al. | BMJ
Aim: To determine the diagnostic accuracy of serological tests for coronavirus disease-2019 (covid-19).
UPDATED
DIAGNOSTICS
6/23/20
Lv M, Wang M, Yang N, et al. | Ann Transl Med
Aim: To understand the role of CT for the diagnosis and the main imaging manifestations of patients with COVID-19.
UPDATED
DIAGNOSTICS
6/1/20
Adams HJA, Kwee TC, Yakar D, et al. | AJR Am J Roentgenol
Aim: To systematically review and meta-analyze the diagnostic accuracy of chest CT in detecting coronavirus disease (COVID-19).
DIAGNOSTICS
5/24/20
Ricco M, Ferraro P, Gualerzi G, et al. | J Clin Med
Aim: To explore the feasibility of rapid diagnostic tests in the management of the COVID-19 outbreak.
DIAGNOSTICS
5/19/20
Mohammadi A, Esmaeilzadeh E, Li Y, et al. | EBioMedicine
Aim: To review the evidence on respiratory sampling strategies for the detection of SARS-CoV-2 RNA.
DIAGNOSTICS
5/18/20
Xu B, Xing Y, Peng J, et al. | Eur Radiol
Aim: To perform a systematic review and meta-analysis regarding the diagnostic test accuracy of chest CT for detecting coronavirus disease 2019 (COVID-19).
DIAGNOSTICS
5/3/20
Esbin MN, Whitney ON, Chong S, et al. | RNA
Aim: To present a collection of these recent advances in COVID-19 nucleic acid testing, including both peer-reviewed and preprint articles.
DIAGNOSTICS
4/28/20
Bachelet VC | Medwave
Aim: To find and discuss studies on laboratory diagnostic tests and rapid viral diagnosis. 
DIAGNOSTICS
4/24/20
Shormin M, Yusuf MA | Bangladesh J Infect Dis
Aim: To identify the different laboratory tests for detection of SARS Cov2 from Covid19 patients.
DIAGNOSTICS