COVID-19 Evidence Reviews
as of 7/30/21
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Updated Reviews
 
= living review
= draft/preprint   |  
= meets mimimum quality standards   |  

A review with this mark was peer-reviewed, described systematic search and study selection, and included critical appraisal of primary studies.
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7/29/21
Ceban F, Nogo D, Carvalho IP, et al. | JAMA Psychiatry
Aim: To assess whether preexisting mood disorders are associated with a higher risk of COVID-19 susceptibility, hospitalization, severe complications, and death.
RECENTLY UPDATED
7/29/21
Zinellu A, Paliogiannis P, Carru C, et al. | Adv Med Sci
Aim: To review the evidence on the international normalized ratio (INR) in COVID-19.
RECENTLY UPDATED
7/29/21
Mohsenpour A, Bozorgmehr K, Rohleder S, et al. | EClinicalMedicine
Aim: To review the evidence on SARS-Cov-2 infection, transmission, outcomes of disease, effects of non-pharmaceutical interventions (NPI), and the effectiveness of strategies for infection prevention and control (IPC).
RECENTLY UPDATED
7/28/21
Raoofi S, Pashazadeh Kan F, Rafiei S, et al. | BMJ Support Palliat Care
Aim: To systematically review the existing literature examining the prevalence of anxiety among hospital staff and identifying the contributing factors to address the complications of this disorder.
RECENTLY UPDATED
7/28/21
Fond G, Nemani K, Etchecopar-Etchart D, et al.  | JAMA Psychiatry
Aim: To determine whether patients with mental health disorders were at increased risk of COVID-19 mortality compared with patients without mental health disorders.
RECENTLY UPDATED
7/27/21
Xu H, Stjernswärd S, Glasdam S, et al. | Int J Nurs Stud Adv
Aim: To explore the psychosocial experiences of frontline nurses working in hospital-based settings during the COVID-19 pandemic.
RECENTLY UPDATED
7/27/21
Zhang K, Zhang X, Ding W, et al. | Front Med
Aim: To evaluate the prognostic accuracy of the NEWS2 on predicting clinical deterioration for patients with COVID-19. 
RECENTLY UPDATED
7/26/21
Karimi A, Nowroozi A, Alilou S, et al. | Urol J
Aim: To study the effect of androgen deprivation therapy (ADT) on COVID-19 in patients with prostate cancer.
RECENTLY UPDATED
7/26/21
Chen X, Chen Z, Azman AS, et al.  | Clin Infect Dis
Aim: To summarize the evidence on neutralization ability against various SARS-CoV-2 variants among those previously infected with strains from the original SARSCoV-2 lineage and those who have been vaccinated
RECENTLY UPDATED
7/26/21
Conde-Agudelo A, Romero R | Am J Obstet Gynecol
Aim: To examine the relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and the risk of preeclampsia.
RECENTLY UPDATED
7/22/21
McGrowder DA, Miller F, Cross MA, et al. | Diseases
Aim: To review the evidence on abnormal liver biochemistry tests in COVID-19 and the possible pathogenesis involved.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
7/22/21
Zhou Y, O'Leary TJ | PLoS One
Aim: To compare the sensitivity of nasal and nasopharyngeal swabs against a composite reference standard for the initial diagnosis of SARS-CoV-2 infection in ambulatory patients.
RECENTLY UPDATED
DIAGNOSTICS
7/20/21
Vai B, Mazza MG, Delli Colli C, et al. | Lancet Psychiatry
Aim: To assess the specific risks of COVID-19-related mortality, hospitalisation, and intensive care unit (ICU) admission associated with any pre-existing mental disorder, and specific diagnostic categories of mental disorders, and exposure to psychopharmacological drug classes.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
7/20/21
Cirillo N | J Infect Public Health
Aim: To facilitate a timely understanding of the differences in the prevalence of gustatory disturbances (GD) in individuals infected with SARS-CoV-2.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
7/19/21
Andrianto, Al-Farabi MJ, Nugraha RA, et al. | Microvasc Res
Aim: To assess biomarkers of endothelial cells in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/19/21
Harder T, Koch J, Vygen-Bonnet S, et al. | Euro Surveill
Aim: To assess the extent to which COVID-19 vaccines are able to prevent symptomatic and asymptomatic infections to guide public health recommendations and develop strategies for fully vaccinated people.
UPDATED
INFECTION CONTROL
7/19/21
Saragih ID, Tonapa SI, Saragih IS, et al. | Int J Nurs Stud
Aim: To systematically identify the mental health problems among healthcare workers in various countries during the COVID-19 pandemic.
UPDATED
MENTAL HEALTH
7/19/21
Luo C, Yang Y, Liu Y, et al.  | Am J Infect Control
Aim: To gain insight into willingness and its influencing factors to vaccinate against COVID-19 among health care workers (HCWs).
UPDATED
INFECTION CONTROL
7/19/21
Alkofide H, Almohaizeie A, Almuhaini S, et al. | Int J Infect Dis
Aim: To systematically review the literature on the association between the combination of tocilizumab (TCZ) and systemic corticosteroid therapy (SCT) on outcomes of COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
7/17/21
John A, Eyles E, Webb RT, et al.  | F1000Research
Aim: To identify and appraise any newly published evidence from around the world that assesses the impact of the COVID-19 pandemic on suicide deaths, suicidal behaviours, self-harm and suicidal thoughts, or that assesses the effectiveness of strategies to reduce the risk of suicide deaths, suicidal behaviours, self-harm and suicidal thoughts, resulting from the COVID-19 pandemic.
UPDATED
MENTAL HEALTH
7/16/21
Franceschi VB, Santos AS, Glaeser AB, et al. | Rev Med Virol
Aim: To evaluate the qualitative aspects of population-based seroprevalence surveys of COVID-19, including their reliability and biases.
UPDATED
7/16/21
Agarwal L, Agarwal A, Advani S, et al. | BR J Radiol
Aim: To scope the existing literature on the abdominal imaging findings in COVID-19.
UPDATED
7/15/21
Jiang F, Xu N, Zhou Y, et al. | Phytother Res
Aim: To review the efficacy and safety of treating COVID-19 with combined traditional Chinese medicine (TCM) and conventional western medicine (CWM).
UPDATED
CANDIDATE THERAPEUTICS
7/15/21
Karakike E, Giamarellos-Bourboulis EJ, Kyprianou M, et al. | Crit Care Med
Aim: To describe the prevalence of coronavirus disease 2019-related sepsis.
UPDATED
CLINICAL CHARACTERISTICS
7/15/21
Aeen FB, Pakzad R, Rad MG, et al. | Sci Rep
Aim: To determine the effects of PP on respiratory parameters and outcomes.
UPDATED
CANDIDATE THERAPEUTICS
7/15/21
Saragih ID, Advani S, Saragih IS, et al. | Geriatr Nurs
Aim: To study the impacts of frailty on COVID-19 outcomes.
UPDATED
CLINICAL CHARACTERISTICS
7/15/21
Yetmar Z, Chesdachai S, Kashour T, et al. | Open Forum Infect Dis
Aim: To examine the association between prior statin use and outcomes of patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/15/21
Low JM, Low YW, Zhong Y, et al. | Arch Dis Child Fetal Neonatal Ed
Aim: To review the evidence on the production of SARS-CoV-2 antibodies in human milk of individuals who had COVID-19, and antibodies' ability to neutralise SARS-CoV-2 infectivity.
UPDATED
INFECTION CONTROL
7/13/21
Pashazadeh Kan F, Raoofi S, et al. | J Affect Disord
Aim: To identify the individuals at higher risk of anxiety with a view to provide targeted mental health services during this outbreak.
UPDATED
MENTAL HEALTH
7/13/21
Viswanatha GL, Anjana Male CKVLSN, Shylaja H, et al. | Clin Exp Rheumatol
Aim: To evaluate the therapeutic benefits and safety of tocilizumab (TCZ) in treating severe coronavirus disease 2019 (COVID-19) and associated health complications.
UPDATED
CANDIDATE THERAPEUTICS
7/13/21
Akobeng AK, Grafton-Clarke C, Abdelgadir I, et al. | Frontline Gastroenterol
Aim: To summarise the published evidence on the gastrointestinal manifestations of COVID-19 in children and to determine the prevalence of gastrointestinal symptoms.
UPDATED
CLINICAL CHARACTERISTICS
7/13/21
Tegegne GT, Kefale B, Engidaw MT, et al. | Front Public Health
Aim: To investigate the level of KAP and associated factors among HCPs about COVID-19. 
UPDATED
INFECTION CONTROL
7/12/21
Zein AFMZ, Sulistiyana CS, Raffaelo WM, et al. | Diabetes Metab Syndr
Aim: To investigate the effect of ivermectin on mortality in patients with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
7/12/21
Mansory E, Srigunapalan S, Lazo-Langner A | TH Open
Aim: To evaluate the epidemiology of VTE in hospitalized intensive care unit (ICU) and non-ICU patients.
UPDATED
CLINICAL CHARACTERISTICS
7/9/21
Schwartzberg L, Advani S, Clancy DC, et al. | Skin Health Dis
Aim: To summarize cutaneous manifestations associated with COVID?19.
UPDATED
CLINICAL CHARACTERISTICS
7/9/21
Pavlov I, He H, McNicholas B, et al. | Respir Care
Aim: To synthesize the available evidence on the efficacy of APP.
UPDATED
CANDIDATE THERAPEUTICS
7/8/21
Najt P, Richards HL, Fortune D | Brain Behav Immun Health
Aim: To synthesise the potential evidence of the brain correlates of SARS-CoV-2.
UPDATED
CLINICAL CHARACTERISTICS
7/8/21
Gaythorpe K, Bhatia S, Mangal T, et al. | Sci Rep
Aim: To review the evidence on the susceptibility of children to SARS-CoV-2 infection, the severity and clinical outcomes in children with SARS-CoV-2 infection, and the transmissibility of SARS-CoV-2 by children.
UPDATED
CLINICAL CHARACTERISTICS
7/8/21
Ulloque-Badaracco JR, Salas-Tello WI, Al-Kassab-Cordova A, et al. | Int J Clin Pract
Aim: To evaluate the prognostic value of the NLR in patients diagnosed with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/8/21
Chisale MRO, Ramazanu S, Mwale SE, et al. | Rev Med Virol
Aim: To estimate the seroprevalence of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in residents of African countries and explore its associated factors.
UPDATED
CLINICAL CHARACTERISTICS
7/8/21
Egunsola O, Mastikhina L, Dowsett L, et al. | SPOR
Aim: To identify comparative observational studies and randomized controlled trials (RCTs) evaluating the effectiveness or efficacy of COVID-19 vaccination in reducing infection transmission, asymptomatic viral carriage and other proxies of possible transmission, such as cycle threshold (Ct) values and viral load.
UPDATED
7/7/21
Al-Amer R, Maneze D, Everett B, et al. | J Clin Nurs
Aim: To synthesise evidence regarding vaccination intention, identify factors contributing to vaccine hesitancy among healthcare professionals and the general populations globally.
UPDATED
INFECTION CONTROL
7/7/21
Pardhan S, Wood S, Vaughan M, et al. | Front Med
Aim: To examine the adjusted risk of COVID-19 related hospitalsation, intensive care unit (ICU) admission, and mortality in patients with vs. without asthma or COPD.
UPDATED
CLINICAL CHARACTERISTICS
7/6/21
Kremer D, Pieters TT, Verhaar MC, et al. | Am J Transplant
Aim: To assess all current evidence to provide an updated and robust insight in the clinical course and outcome of COVID-19 in KTR.
UPDATED
CLINICAL CHARACTERISTICS
7/6/21
Lassi ZS, Ana A, Das JK, et al. | J Glob Health
Aim: To determine the clinical presentation, risk factors, and pregnancy and perinatal outcomes in pregnant women with confirmed COVID-19 and identify if these are different based on COVID-19 severity.
UPDATED
CLINICAL CHARACTERISTICS
7/6/21
Franchini M, Prefumo F, Grisolia G, et al. | Viruses
Aim: To systematically examine the current evidence on the clinical use of convalescent plasma during pregnancy.
UPDATED
CANDIDATE THERAPEUTICS
7/6/21
Wibowo A, Pranata R, Lim MA, et al. | Int J Infect Dis
Aim: To compare the level of von Willebrand Factor (vWF) antigen in patients with poor outcome compared to those without. 
UPDATED
CLINICAL CHARACTERISTICS
7/6/21
Serrano-Ripoll MJ, Zamanillo-Campos R, Castro A, et al. | Actas Esp Psiquiatr
Aim: To examine the impact of the current health pandemic produced by COVID-19 on insomnia and sleep quality of health professionals, and to identify risk factors associated with insomnia.
UPDATED
MENTAL HEALTH
7/6/21
Romiti GF, Corica B, Lip GYH, et al. | J Clin Med
Aim: To investigate the epidemiology of AF in COVID-19 patients and its impact on all-cause mortality.
UPDATED
CANDIDATE THERAPEUTICS
7/6/21
Hao Q, Wang D, Xie M, et al. | Front Psychiatry
Aim: To review the evidence on the prevalence of mental health problems and risk factors among HCWs during the COVID-19 pandemic to identify at-risk HCWs and provide timely assistance and intervention.
UPDATED
MENTAL HEALTH
7/6/21
Bertuzzi V, Semonella M, Bruno D, et al. | Int J Environ Res Public Health
Aim: To review the evidence on the content and efficacy of the psychological support interventions in increasing mental health among healthcare providers and informal caregivers during the COVID-19 pandemic.
UPDATED
MENTAL HEALTH
7/6/21
Romero Starke K, Mauer R, Karskens E, et al. | Int J Environ Res Public Health
Aim: To collect evidence on the impact of temperature and humidity on COVID-19 mortality. 
UPDATED
CLINICAL CHARACTERISTICS
7/6/21
Beukes E, Ulep AJ, Eubank T, et al. | J Clin Med
Aim: To systematically review what has been published regarding tinnitus during the coronavirus disease 2019 (COVID-19) pandemic up to March 2021.
UPDATED
CLINICAL CHARACTERISTICS
7/6/21
Chigwedere OC, Sadath A, Kabir Z, et al. | Int J Environ Res Public Health
Aim: To examine the impact of epidemics and pandemics on the mental health of HCWs.
UPDATED
MENTAL HEALTH
7/6/21
Akbar MR, Pranata R, Wibowo A, et al. | Front Med
Aim: To assess the prognostic value of hyponatremia in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/2/21
Zein AFMZ, Sulistiyana CS, Khasanah U, et al. | Postgrad Med J
UPDATED
CLINICAL CHARACTERISTICS
7/1/21
Melo AKG, Milby KM, Caparroz ALMA, et al. | PLoS One
Aim: To describe the laboratory parameters and biomarkers of the cytokine storm syndrome associated with severe and fatal COVID-19 cases.
UPDATED
CLINICAL CHARACTERISTICS
7/1/21
Abeldaño Zuñiga RA, González-Villoria RAM, Elizondo MV, et al. | Ther Adv Respir Dis
Aim: To determine the clinical effectiveness of convalescent plasma employed in the treatment of hospitalized patients with diagnosis of COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
7/1/21
Ciapponi A, Bardach A, Comande D, et al.  | PLoS One
Aim: To summarize the best evidence regarding the effect of COVID-19 on maternal and child health.
UPDATED
CLINICAL CHARACTERISTICS
7/1/21
Kula B, Clancy CJ, Nguyen MG, et al. | Lancet Microbe
Aim: To establish the prevalence of autopsy-proven tissue-invasive IMD and analyse individual-level data to assess potential risk factors.
UPDATED
CLINICAL CHARACTERISTICS
6/30/21
Chua EX, Zahir SMISM, Ng KT, et al. | J Clin Anesth
Aim: To investigate the effect of prone position on partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio.
UPDATED
CANDIDATE THERAPEUTICS
6/30/21
Sharma M, Aggarwal S, Madaan P, et al. | Sleep Med
Aim: To study the prevalence and pattern of sleep disturbances in children and adolescents during the COVID-19 pandemic.
UPDATED
MENTAL HEALTH
6/30/21
Sharma M, Aggarwal S, Madaan P, et al. | Sleep Med
Aim: To study the prevalence and pattern of sleep disturbances in children and adolescents during the COVID-19 pandemic.
UPDATED
MENTAL HEALTH
6/29/21
Crafa A, Cannarella R, Condorelli RA, et al. | EClinicalMedicine
Aim: To assess whether hypovitaminosis D is a risk factor for developing SARS-CoV-2 infection and whether it affects the worsening of the clinical course of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
6/29/21
Vindrola-Padros C, Singh KE, Sidhu MS, et al. | EClinicalMedicine
Aim: To analyse the implementation and impact of remote home monitoring models (virtual wards) during COVID-19, identifying their main components, processes of implementation, target patient populations, impact on outcomes, costs and lessons learnt.
UPDATED
INFECTION CONTROL
6/28/21
Kulkarni MS, Kakodkar P, Nesari TM, et al. | J Ayurveda Integr Med
Aim: To summarise the evidence from different systematic reviews of distinct yoga interventions used to improve mental health and recommend yoga practices for the same. 
UPDATED
MENTAL HEALTH
6/28/21
Lazarus G, Budiman RA, Rinaldi I, et al. | Cancer Immunol Immunother
Aim: To investigate the effects of ICI treatment on COVID-19 prognosis, including mortality, severity, and any other prognosis-related outcomes.
UPDATED
CANDIDATE THERAPEUTICS
6/28/21
Chow R, Im J, Chiu N, et al. | PLoS One
Aim: To conduct a systematic review and meta-analysis to report on adverse outcomes among COVID-19 patients by statin usage. 
UPDATED
CANDIDATE THERAPEUTICS
6/25/21
Drury J, Mao G, John A, et al. | BMC Public Health
Aim: To describe public attitudes towards certification, and its possible impact on uptake of testing and vaccination, protective behaviours, and crime.
UPDATED
INFECTION CONTROL
6/25/21
Ren X, Wang X, Ge Z, et al. | Int J Immunopathol Pharmacol
Aim: To examine immune function status-related manifestations and laboratory indicators of COVID-19 patients with recurrent virus PCR positivity.
UPDATED
CLINICAL CHARACTERISTICS
6/25/21
Nawangsih EN, Kusmala YY, Rakhmat II, et al. | Int Immunopharmacol
Aim: To evaluate the effect of colchicine administration on mortality in patients with COVID-19 and factors affecting the association.
UPDATED
CANDIDATE THERAPEUTICS
6/25/21
Bobrovitz N, Arora R, Cao C, et al.  | PLoS ONE
Aim: To synthesize seroprevalence data to better estimate the burden of SARS-CoV-2 infection, identify high-risk groups, and inform public health decision making.
UPDATED
CLINICAL CHARACTERISTICS
6/25/21
Zinellu A, Mangoni A | Front Immunol
Aim: To investigate possible differences in the serum concentrations of two routinely measured complement components, C3 and C4, in COVID-19 patients with different severity and survival status.
UPDATED
CLINICAL CHARACTERISTICS
6/25/21
Yamamoto S, Saito M, Tamura A, et al. | PLoS One
Aim: To evaluate existing evidence on the association between the microbiome and COVID-19 in humans and summarize this data in the pandemic era.
UPDATED
CLINICAL CHARACTERISTICS
6/25/21
Pal R, Banerjee M, Bhadada SK, et al. | J Endocrinol Invest
Aim: To provide a precise summary and collate the hitherto available clinical evidence on the effect of vitamin D supplementation on clinical outcomes in COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
6/23/21
Tripathy SK, Varghese P, Panigrahi S, et al. | Chin J Traumatol
Aim: To evaluate the 30-day mortality and complications in COVID-19 + and COVID-19 ? patients with hip fractures.
UPDATED
CLINICAL CHARACTERISTICS
6/22/21
 | Pan American Health Organization
Aim: To review the evidence on the therapeutic options for COVID-19.
UPDATED
6/21/21
Locquet M, Diep AN, Beaudart C, et al. | Arch Public Health
Aim: To identify, compare, and evaluate performances of prediction models for the diagnosis of COVID-19 in adult patients in a health care setting.
UPDATED
DIAGNOSTICS
6/21/21
Bryant A, Lawrie TA, Dowswell T, et al. | Am J Ther
Aim: To assess the efficacy of ivermectin treatment among people with covid-19 infection and as a prophylaxis among people at higher risk of COVID-19 infection.
UPDATED
CANDIDATE THERAPEUTICS
6/18/21
Adibi A, Golitaleb M, Farrahi-Ashtiani I, et al. | Front Psychiatry
Aim: To investigate GAD's prevalence among HCWs during the COVID-19 pandemic by systematic review and meta-analysis.
UPDATED
MENTAL HEALTH
6/17/21
Nopsopon T, Kittrakulrat J, Takkavatakarn K, et al. | PLoS Negl Trop Dis
Aim: To evaluate the prevalence and case fatality rate of COVID-19 in patients with ESRD with RRT.
UPDATED
CLINICAL CHARACTERISTICS
6/17/21
Yusuf F, Fahriani M, Mamada SS, et al. | F1000Res
Aim: To determine the cumulative prevalence of prolonged gastrointestinal (GI) symptoms, including nausea, vomiting, diarrhea, lack of appetite, abdominal pain, and dysgeusia, in survivors of both mild and severe COVID-19 worldwide and to discuss the potential pathogenesis.  
UPDATED
CLINICAL CHARACTERISTICS
6/17/21
Alimoradi Z, Brostrom A, Tsang HWH, et al. | EClinicalMedicine
Aim: To estimate the magnitude of sleep problems during the COVID-19 pandemic and its relationship with psychological distress.
UPDATED
MENTAL HEALTH
6/16/21
Taheri L, Gheiasi SF, Taher M, et al. | Compr Child Adolesc Nurs
Aim: To identify and summarize the existing evidence on clinical characteristics of COVID-19 in pediatric patients. 
UPDATED
CLINICAL CHARACTERISTICS
6/16/21
Ramanathan K, Shekar K, Ling RR, et al. | Crit Care
Aim: To summarise outcome data during the first year of the pandemic and identify risk factors for an unfavourable outcomes in order to guide clinical decision-making and further research.
UPDATED
CLINICAL CHARACTERISTICS
6/16/21
Negrini F, de Sire A, Andrenelli E, et al. | Eur J Phys Rehabil Med
Aim: To investigate the literature on rehabilitation services for COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
6/14/21
Chan KW, Yu KY, Lee PW, et al. | Front Med
Aim: To assess the association between AKI, mortality, underlying non-communicable diseases, and clinical risk factors.
UPDATED
CLINICAL CHARACTERISTICS
6/14/21
Ibrahimi N, Delaunay-Moisan A, Hill C, et al. | PLoS One
Aim: To compare saliva and nasopharyngeal/oropharyngeal samples for the detection of SARS-CoV-2.
UPDATED
DIAGNOSTICS
6/14/21
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the role of daycares and schools in the transmission of COVID-19.
UPDATED
6/11/21
Akbar M, Pranata R, Wibowo A, et al | Eur Rev Med Pharmacol Sci
Aim: To evaluate the association between the prealbumin and severity and mortality in COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
6/10/21
Hughes MC, Liu Y, Baumbach A | Gerontol Geriatr Med
Aim: To examine the current literature on the impact of COVID-19 on the health and well-being of informal caregivers for people with dementia. 
UPDATED
MENTAL HEALTH
6/10/21
Zein AFMZ, Sulistiyana CS, Raffaello WM, et al. | Postgrad Med J
Aim: To evaluate the effect of sofosbuvir/daclatasvir (SOF/DCV) on mortality, the need for intensive care unit (ICU) admission or invasive mechanical ventilation (IMV) and clinical recovery in patients with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/9/21
Asiimwe IG, Pushpakom S, Turner R, et al | Br J Clin Pharmacol
Aim: To continually evaluate the rapidly evolving evidence base on the role of cardiovascular drugs in COVID-19 clinical outcomes (susceptibility to infection, hospitalization, hospitalization length, disease severity, and all-cause mortality).
UPDATED
CLINICAL CHARACTERISTICS
6/9/21
Amani B, Khanijahani A, Amani B | Sci Rep
Aim: To examine the efficacy and safety of HCQ in addition to standard of care (SOC) in COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/9/21
Matli K, Farah R, Maalouf M, et al. | Open Heart
Aim: To highlight the role of thrombosis in COVID-19 and provide new insights on the use of antithrombotic therapy in its management. 
UPDATED
CANDIDATE THERAPEUTICS
6/8/21
Yang J, D'souza R, Kharrat A, et al. | Acta Obstet Gynecol Scand
Aim: To conduct a living systematic review and meta-analyses of studies reporting pregnancy and neonatal outcomes by comparing the pandemic and pre-pandemic periods.
UPDATED
CLINICAL CHARACTERISTICS
6/8/21
Sarkar S, Kannan S, Khanna P, et al. | Rev Med Virol
Aim: To explore the utility of RDW in the prognosis of COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
6/7/21
Liu X, Wang H, Shi S, et al. | Postgrad Med J
Aim: To evaluate the association between IL-6 and severe disease and mortality in COVID-19 disease.
UPDATED
CLINICAL CHARACTERISTICS
6/7/21
Guerrero JI, Barragan LA, Martinez JD, et al. | BMC Infect Dis
Aim: To describe the features of the central and peripheral nervous system involvement by COVID-19 in terms of pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings.
UPDATED
CLINICAL CHARACTERISTICS
6/7/21
Nascimento I, O Mathuna DP, von Groote TC, et al. | BMC Infect Med
Aim: To collate and summarize all published systematic reviews on the coronavirus disease (COVID-19).
UPDATED
6/7/21
Messina A, Sanfilippo F, Milani A, et al. | J Crit Care
Aim: To summarise the current knowledge regarding cardiac dysfunction in COVID-19 as assessed by echocardiography, both in ICU and non-ICU subjects.
UPDATED
CLINICAL CHARACTERISTICS
6/7/21
Seidu S, Kunutsor SK, Cos X, et al. | Prim Care Diabetes
Aim: To assess the indirect impact of the COVID-19 pandemic on hospitalisations for cardiovascular diseases and their management.
UPDATED
INFECTION CONTROL
6/7/21
Rogers JP, Watson CJ, Badenoch J, et al. | J Neurol Neurosurg Psychiatry
Aim: To describe the characteristics of the early literature and estimate point prevalences for neurological and neuropsychiatric manifestations.
UPDATED
CLINICAL CHARACTERISTICS
6/7/21
Ao G, Wang Y, Qi X, et al. | Transplant Rev
Aim: To investigate the association between severe or fatal COVID-19 and SOT.
UPDATED
6/7/21
Elsayed HH, Hassaballa AS, Ahmed TA, et al. | PLoS One
Aim: To review the evidence on IMV for COVID-associated ARDS to study its outcome among different countries.
UPDATED
CANDIDATE THERAPEUTICS
6/3/21
Jimenez-Cebrian AM, Castro-Mendez A, Garcia-Podadera B, et a;/ | J Clin Med
Aim: To analyze and synthesize the published reviews on manifestations of COVID-19 at the foot level. 
UPDATED
CLINICAL CHARACTERISTICS
6/3/21
Wang R, Liu M, Liu J | Vaccines
Aim: To assess the association between influenza vaccination and SARS-CoV-2 infection and clinical outcomes.
UPDATED
CLINICAL CHARACTERISTICS
6/3/21
Khan DSA, Pirzada AN, Ali A, et al. | Int J Environ Res Public Health
Aim: To investigate the differences in clinical presentation, management, and prognosis of COVID-19 infection in pregnant and non-pregnant women.
UPDATED
CLINICAL CHARACTERISTICS
6/3/21
Stroehlein JK, Wallqvist J, Iannizzi C, et al.  | Cochrane Database Syst Rev
Aim: To assess whether vitamin D supplementation is effective and safe for the treatment of COVID?19 in comparison to an active comparator, placebo, or standard of care alone, and to maintain the currency of the evidence, using a living systematic review approach.
UPDATED
CANDIDATE THERAPEUTICS
6/2/21
Wilt T, Kaka AS, MacDonald R, et al. | VA Evidence Synthesis Program
Aim: To assess the clinical effectiveness and harms of remdesivir in hospitalized adults with COVID-19.
UPDATED
VA ESP
6/2/21
Wang MX, Gwee SXW, Pang J | Nutrients
Aim: To systematically assess the associations between micronutrient supplementation or deficiency, with novel coronavirus incidence and disease severity.
UPDATED
CLINICAL CHARACTERISTICS
6/1/21
Grove A, Osokogu O, Al-Khudairy L, et al. | BMJ Open
Aim: To systemically review and critically appraise published studies of the association between vitamin D supplementation or serum vitamin D level and susceptibility to SARS-CoV-2 infection or COVID-19, including clinical course, morbidity and mortality outcomes.
UPDATED
CLINICAL CHARACTERISTICS
6/1/21
Ayouni I, Maatoug J, Dhouib W, et al.  | BMC Public Health
Aim: To evaluate the implemented public health interventions to control the spread of the outbreak of COVID-19.
UPDATED
INFECTION CONTROL
6/1/21
Chou R, Dana T, Buckley D, et al. | Ann Intern Med
Aim: To examine the burden of SARS-CoV-2, SARS-CoV-1, and Middle Eastern respiratory syndrome (MERS)-CoV on HCWs and risk factors for infection, using rapid and living review methods.
UPDATED
WHO COLLABORATIVE
6/1/21
Lee Y, Lui LMW, Chen-Li D, et al. | J Affect Disord
Aim: To evaluate the impact of the COVID-19 pandemic and government response on measures of depressive symptom presence and severity based on published studies.
UPDATED
MENTAL HEALTH
6/1/21
Kaur H, Thakur JS, Paika R, et al. | Asian Pac J Cancer Prev
Aim: To explore the prevalence of comorbidities among cancer patients with SARS CoV-2 infection and their impact on mortality.
UPDATED
CLINICAL CHARACTERISTICS
6/1/21
Muehlschlegel P, Parkinson E, Chan RYL, et al. | J Glob Health
Aim: To comprehensively evaluate biopsychosocial consequences after lockdown measures are lifted and identify strategies to successfully negotiate the transition out of COVID-19 related lockdowns.
UPDATED
MENTAL HEALTH
6/1/21
Amani B, Khanijahani A, Amani B, et al. | J Pharm Pharm Sci
Aim: To provide the latest evidence on the efficacy and safety of lopinavir/ritonavir compared to other treatment options for COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/1/21
Zawawi A, Naser AY, Alwafi H, et al. | Front Immunol
Aim: To evaluate the inflammatory cytokines profile associated with severe human coronavirus diseases, including three stains: MERS-CoV, SARS-CoV SARS-CoV-2, in severe patients.
UPDATED
CLINICAL CHARACTERISTICS
5/28/21
Staibano P, Levin M, McHugh T, et al. | JAMA Otolaryngol Head Neck Surg
Aim: To evaluate the association of tracheostomy with COVID-19 patient outcomes and the risk of SARS-CoV-2 transmission among health care professionals (HCPs).
UPDATED
INFECTION CONTROL
5/28/21
Iqbal FM, Lam K, Sounderajah V, et al. | EClinicalMedicine
Aim: To characterise the clinical features between acute and chronic post-COVID syndrome.
UPDATED
CLINICAL CHARACTERISTICS
5/28/21
Sahilu T, Sheleme T, Melaku T | Interdiscip Perspect Infect Dis
Aim: To summarize the current evidence of the severity and mortality associated with steroid therapy for patients with COVID-19. 
UPDATED
CANDIDATE THERAPEUTICS
5/24/21
Mangkuliguna G, Glendardi G, Susanto N, et al. | Tuberc Respir Dis
Aim: To investigate the efficacy and safety of Azithromycin in COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
5/24/21
Abate SM, Chekole YA, Estifanos MB, et al. | Clin Nutr ESPEN
Aim: To investigate the prevalence and outcome of malnutrition among patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
5/24/21
Li W, Zhang H, Zhang C, et al. | Front Psychol
Aim: To review the evidence on the prevalence of different psychological states during the early stage of the COVID-19 epidemic in China.
UPDATED
MENTAL HEALTH
5/24/21
Snow TAC, Saleem N, Ambler G, et al. | Intensive Care Med
Aim: To ascertain the benefit of IL-6 blockade with tocilizumab for COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
5/21/21
Singhal S, Kumar P, Singh S, et al. | BMC Geriatr
Aim: To review the evidence on the clinical characteristics of older COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
5/21/21
Piechotta V, Iannizzi C, Chai KL, et al. | Cochrane Database Syst Rev
Aim: To assess whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in the treatment of people with COVID?19.
UPDATED
CANDIDATE THERAPEUTICS
5/21/21
Bzeizi K, Abdulia M, Mohammed N, et al. | Sci Rep
Aim: To assess the available evidence on the clinical effects of SARS-CoV-2 on liver function laboratory tests and coagulation profile in affected individuals. 
UPDATED
CLINICAL CHARACTERISTICS
5/21/21
Xiong X, Chi J, Gao Q | Thromb J
Aim: To determine the prevalence and risk factors of thrombotic events on COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
5/20/21
Wang J, Kaperak C, Sato T, et al. | J Investig Med
Aim: To identify cases infected with different genetic strains of SARS-CoV-2 confirmed by polymerase-chain reaction and viral genome sequencing.
UPDATED
DIAGNOSTICS
5/20/21
Pannone G, Caponio VCA, De Stefano IS, et al. | Infect Agent Cancer
Aim: To summarize lung histopathological characteristics of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
5/17/21
Nochaiwong S, Ruengorn C, Thavorn K, et al. | Sci Rep
Aim: To provide a contemporary global prevalence of mental health issues among the general population amid the coronavirus disease-2019 (COVID-19) pandemic. 
UPDATED
MENTAL HEALTH
5/17/21
Lei H, Yang Y, Zhou W, et al. | Lung Cancer
Aim: To provide precise estimates of the mortality rate of COVID-19 patients with lung cancer and other tumors.
UPDATED
5/17/21
Shao SC, Lai CC, Chen YH, et al. | Age Aging
Aim: To summarize the evidence on prevalence, incidence and mortality of delirium in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
5/14/21
De Crescenzo F, Amato L, Cruciani F, et al. | Front Pharmacol
Aim: To assess the comparative efficacy and safety of pharmacological interventions for COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
5/14/21
Siow I, Lee KS, Zhang JJY, et al. | Eur J Neurol
Aim: To describe the incidence, clinical course and outcomes of patients who suffer from encephalitis as a complication of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
5/14/21
Chambergo-Michilot D, Barros-Sevillano S, Rivera-Torrejon O, et al. | Eur J Neurol
Aim: To systematically review the factors associated with COVID-19 in people with PD.
UPDATED
CLINICAL CHARACTERISTICS
5/14/21
Heath L, Carey M, Lowney AC, et al.  | Palliat Med
Aim: To determine the dose ranges of pharmacological interventions commonly used to manage symptoms in adult patients dying of COVID-19, establish how effectiveness of these interventions was measured, and whether the pharmacological interventions were effective.
UPDATED
CANDIDATE THERAPEUTICS
5/14/21
Paternoster G, Bertini P, Innelli P, et al. | J Cardiothorac Vasc Anesth
Aim: To describe the features of right ventricular impairment and pulmonary hypertension in coronavirus disease (COVID-19) and assess their effect on mortality.
UPDATED
CLINICAL CHARACTERISTICS
5/13/21
Kang S, Gong X, Yuan Y | Epidemiol Infect
Aim: To systematically assess the association between smoking and cardiovascular disease and disease progression among novel coronavirus pneumonia (COVID-19) cases.
UPDATED
CLINICAL CHARACTERISTICS
5/13/21
Ahammed T, Anjum A, Rahman MM, et al. | Health Sci Rep
Aim: To estimate the R0 and CFR of COVID-19 and assess whether the parameters vary in different regions of the world.
UPDATED
INFECTION CONTROL
5/13/21
Martimbianco ALC, Pacheco RL, Bagattini AM, et al. | Int J Clin Pract
Aim: To identify, systematically evaluate and summarise the best available evidence on the frequency of long COVID (post-acute COVID-19 syndrome), its clinical manifestations and the criteria used for diagnosis.
UPDATED
CLINICAL CHARACTERISTICS
5/11/21
Wijaya I, Andhika R, Huang I, et al. | Clin Epidemiol Glob Health
Aim: To assess the efficacy of JAK inhibitors in terms of clinical outcome, including mortality, clinical improvement, and clinical deterioration among hospitalized COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
5/10/21
Turner S, Botero-Tovar N, Herrera MA, et al. | Implement Sci
Aim: To depict the experiences and perceptions of organisations and actors at multiple levels of health systems internationally in responding to COVID-19.
UPDATED
INFECTION CONTROL
5/7/21
Gulsen A, Konig I, Jappe U, et al. | Respirology
Aim: To examine in detail whether the underlying chronic obstructive pulmonary diseases (COPD), asthma and chronic respiratory diseases (CRDs) were associated with an increased risk of more severe COVID-19. 
UPDATED
CLINICAL CHARACTERISTICS
5/7/21
Dembrovszky F, Váncsa S, Farkas N, et al. | Viruses
Aim: To evaluate which prognostic factors may impact repeated SARS-CoV-2 positivity (RSP) and their association with immunoglobulin detectability among recovered patients. 
UPDATED
CLINICAL CHARACTERISTICS
5/7/21
Cosco TD, Best J, Davis D, et al. | Age Aging
Aim: To quantify the association between frailty and COVID-19 in relation to mortality in hospitalised patients.
UPDATED
CLINICAL CHARACTERISTICS
5/4/21
Dos Santos ACM, Dos Santos BRC, Dos Santos BB, et al. | Infect Genet Evol
Aim: to review the effect of single nucleotide polymorphisms in the development of severe acute respiratory syndrome (SARS).
UPDATED
CLINICAL CHARACTERISTICS
5/4/21
Liang M, Luo N, Chen M, et al. | Infect Dis Ther
Aim: To investigate the prevalence and mortality in PLWHA co-infected with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
5/3/21
Neira C, Godinho R, Rincon F, et al. | Nutrients
Aim: To evaluate the current evidence about the impact that preventive measures of physical contact restriction causes in healthy nutrition.
UPDATED
5/3/21
Tleyjeh IM, Kashour Z, Riaz M, et al. | Clin Microbiol Infect
Aim: To perform a living systematic review of the literature about the efficacy and toxicity of the IL-6 receptor antagonist, tocilizumab, in COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
5/3/21
La Verde M, Riemma G, Torella M, et al. | Int J Gynaecol Obstet
Aim: To evaluate the characteristics of pregnant women deceased due to COVID-19.
UPDATED
5/3/21
Dramé M, Cofais C, Hentzien M, et al. | Nutrients
Aim: To identify and synthesize the best available evidence on the association between vitamin D level and risk of COVID-19, adverse outcomes and possible benefits of supplementation aged 60 years or over.
UPDATED
5/1/21
Tharmarajah E, Buazon A, Patel V, et al. | J Infect
Aim: To assess the impact of IL-6 inhibition on mortality in the treatment of COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
4/29/21
Choudary MC, Crain CR, Qiu X, et al.  | Clin Infect Dis
Aim: To characterize the hallmarks of reinfecting sequences and the rate of viral evolution in persistent infection.
UPDATED
CLINICAL CHARACTERISTICS
4/29/21
Hammond A, Khalid T, Thornton HV, et al. | PLoS One
Aim: To investigate whether modern portable, commercially available air filters reduce the incidence of respiratory infections and/or remove bacteria and viruses from indoor air.
UPDATED
INFECTION CONTROL
4/28/21
Hayward SE, Deal A, Cheng C, et al. | J Migr Health
Aim: To assess clinical outcomes of COVID-19 in migrant populations (cases, hospitalisations, deaths), indirect health and social impacts, and to determine key risk factors.
UPDATED
CLINICAL CHARACTERISTICS
4/28/21
Bartoszko JJ, Siemieniuk RAC, Kum E, et al. | BMJ
Aim: To determine and compare the effects of drug prophylaxis on severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (covid-19).
UPDATED
4/27/21
Sheikh AB, Chourasia PK, Javed N, et al. | J Neuroimmunol
Aim: To determine demographic characteristics, clinical features, lab evaluation, management and complications of the studies focusing on Guillain-Barre syndrome (GBS) as a sequele of novel coronavirus (COVID-19) infection.
UPDATED
CLINICAL CHARACTERISTICS
4/27/21
Siemieniuk RAC, Bartoszko JJ, Ge L, et al. | BMJ
Aim: To compare the effects of treatments for coronavirus disease 2019 (covid-19).
UPDATED
CANDIDATE THERAPEUTICS
4/27/21
Patralekh MK, Jain V, Iyengar K, et al.  | J Clin Orthop Trauma
Aim: To evaluate the impact of COVID-19 on patients with PFF and assessed associated mortality.
UPDATED
CLINICAL CHARACTERISTICS
4/27/21
Wu Y, Li H, Zhang Z, et al. | Ann Palliat Med
Aim: To evaluate the in-hospital mortality and risk factors of death in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
4/27/21
Mackey K, Kansagara D, Vela K | Ann Intern Med
Aim: To synthesize evidence on the role of ACE inhibitor and ARB use on patient outcomes in COVID-19 as well as evidence on the benefits and harms of initiating these medications to treat patients with COVID-19.
UPDATED
WHO COLLABORATIVE
VA ESP
4/26/21
Varghese A, George G, Kondaguli SV, et al. | J Glob Health
Aim: To explore the prevalence and determinants of mental health outcomes (anxiety, stress, depression, PTSD, insomnia) among nurses across the globe due to the COVID-19.
UPDATED
MENTAL HEALTH
4/26/21
Muller AE, Himmels JPW, Van de Velde S | BMC Med Res Methodol
Aim: To review the diagnostic tests developed to assess or diagnose COVID-19-related fear or phobia.
UPDATED
MENTAL HEALTH
4/16/21
Damiano RF, Di Santi D, Beach S, et al. | Braz J Psychiatry
Aim: To review the most common mental health strategies aimed at alleviating and/or preventing mental health problems in individuals during the coronavirus disease 2019 (COVID-19) and other coronavirus pandemics.
UPDATED
MENTAL HEALTH
4/14/21
Mondal R, Deb S, Shome G, et al. | Mult Scler Relat Disord
Aim: To summarize so far available pieces of evidence documenting de novo novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) mediated spinal cord demyelinating diseases.
UPDATED
CLINICAL CHARACTERISTICS
4/14/21
Flook M, Jackson C, Vasileiou E, et al. | BMC Infect Dis
Aim: To review the evidence on the risk factors for severity, disease, and mortality for COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
4/13/21
Handayani DR, Juliastuti H, Nawangsih EN, et al. | Obes Med
Aim: To assess the prognostic value of fasting hyperglycemia in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
4/13/21
Pranata R, Huang I, Lawrensia S, et al. | Pharmacol Rep
Aim: To address the current interest of whether the administration of PPI could increase the susceptibility and risk of poor outcome in COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
4/12/21
Phiri P, Ramakrishnan R, Rathod S, et al. | EClinicalMedicine
Aim: To review the evidence on the mental health impacts of the COVID-19 pandemic on healthcare professionals, patients, and the general public.
UPDATED
MENTAL HEALTH
4/12/21
Meza N, Perez-Bracchiglione J, Perez I, et al. | Medwave
Aim: To provide a timely, rigorous, and continuously updated summary of the evidence available on the role of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) in the treatment of patients with COVID-19.
UPDATED
4/12/21
Barboza JJ, Chambergo-Michilot D, Velasquez-Sotomayor M, et al. | Travel Med Infect Dis
Aim: To describe the assessment and treatment of asymptomatic infection in patients with a confirmed diagnosis of COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
4/12/21
Tomfohr-Madsen L, Racine N, Giesbrecht GF, et al.  | Psychiatry Res
Aim: To analyze the worldwide prevalence of depression and anxiety among pregnant women during the COVID-19 pandemic.
UPDATED
MENTAL HEALTH
4/12/21
Rakhmat II, Kusmala YY, Handayani DR, et al. | Diabetes Metab Syndr
Aim: To synthesize evidence on dipeptidyl peptidase-4 (DPP-4) inhibitor and mortality in COVID-19 patients and factors affecting it.
UPDATED
CANDIDATE THERAPEUTICS
4/12/21
Qiu D, Li Y, Li L, et al. | Eur Psychiatry
Aim: To examine the pooled prevalence of post-traumatic stress symptoms among people exposed to the trauma resulting from COVID-19 outbreak.
UPDATED
MENTAL HEALTH
4/12/21
Palaiodimou L, Stefanou MI, Katsanos AH, et al. | Eur J Neurol
Aim: To critically appraise the published literature related to GBSs and COVID-19, and evaluate prevalence, clinical features and outcomes of GBSs in pateints with COVID-19 compared to non-COVID-19 contemporary or historical controls.
UPDATED
CLINICAL CHARACTERISTICS
4/12/21
Dhouib W, Maatoug J, Ayouni I, et al. | Syst Rev
Aim: To identify studies that recruited symptomatic patients, regardless of sex or age diagnosed with COVID-19, and calculated or estimated the incubation period between December 2019 and December 2020.
UPDATED
CLINICAL CHARACTERISTICS
4/9/21
Morales-Cane I, del Rocio Valverde-Leon M, Gonzalez-Gancedo J, et al. | Eur Rev Med Pharmacol Sci
Aim: To synthesize and analyze the scientific publications related to ventilatory therapies used in patients with COVID-19 in Intensive Care Units (ICUs), the parameters of invasive mechanical ventilation prescribed for these patients, and the clinical characteristics of patients admitted to the ICU.
UPDATED
CANDIDATE THERAPEUTICS
4/8/21
Mutiawati E, Fahriani M, Mamada SS, et al. | F1000Res
Aim: To determine the global prevalence of anosmia and dysgeusia in coronavirus disease 2019 (COVID-19) patients and to assess their association with severity and mortality of COVID-19. 
UPDATED
CLINICAL CHARACTERISTICS
4/8/21
Saragih ID, Saragih IS, Batubara SO, et al. | Geriatr Nurs
Aim: To systematically examine the association between dementia and mortality among older adults with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
4/8/21
Rezaei S, Fatemi B, Majd ZK, et al. | Expert Rev Clin Immunol
Aim: To combine the results of clinical studies of different designs to investigate the efficacy and safety of tocilizumab in severely-to-critically ill COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
4/8/21
Islam MA, Kundu S, Alam SS, et al. | PLoS One
Aim: To conduct a systematic review and meta-analysis to estimate the overall pooled prevalence of fever and chills in addition to fever characteristics (low, medium, and high temperature) in both adult and paediatric COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
4/7/21
Saha S, Al-Rifai RH, Saha S | J Diabetes Metab Disord
Aim: To quantify the overall and subgroup weighted prevalence of mortality among diabetic (primary outcome) and non-diabetic (secondary outcome) and the weighted prevalence of DM (secondary outcome), in hospitalized COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
4/6/21
Hoang T | Ann Glob Health
Aim: To examine the characteristics of repositive COVID-19 cases.
UPDATED
CLINICAL CHARACTERISTICS
4/6/21
Yan H, Ding Y, Guo W | Psychosom Med
Aim: To quantify the prevalence of the adverse mental health outcomes in medical staff working in the hospital settings during the COVID-19 pandemic and explore the relative distribution of anxiety and depressive symptoms.
UPDATED
MENTAL HEALTH
4/6/21
Kollias A, Kyrikoulis KG, Lagou S, et al. | Vasc Med
Aim: To review the current evidence regarding the prevalence of VTE in patients with COVID-19 screened/assessed with lower limb ultrasonography or computed tomography pulmonary angiography.
UPDATED
CLINICAL CHARACTERISTICS
4/5/21
Lee KW, Yap SF, Ngeow YF, et al.  | Int J Environ Res Public Health
Aim: To determine the epidemiological characteristics, clinical signs and symptoms, blood parameters, and clinical outcomes among PLHIV who contracted COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
4/5/21
Chmielewska B, Barratt I, Townsend R, et al. | Lancet Glob Health
Aim: To assess the collective evidence on the effects on maternal, fetal, and neonatal outcomes of the pandemic.
UPDATED
CLINICAL CHARACTERISTICS
4/5/21
Meherali S, Punjani N, Louie-Poon S, et al. | Int J Environ Res Public Health
Aim: To identify the impact of the pandemic on children's and adolescent's mental health and to evaluate the effectiveness of different interventions employed during previous and the current pandemic to promote children's and adolescents' mental health. 
UPDATED
MENTAL HEALTH
4/5/21
Li YC, Lai T, Lin S, et al. | Ther Adv Chronic Dis
Aim: To evaluate the influence of pre-existing CKD on risks of all-cause mortality, hospitalization, and critically ill condition among patients with COVID-19 infection.
UPDATED
4/5/21
Váncsa S, Dembrovsky F, Farkas N, et al.  | Viruses
Aim: To evaluate the clinical significance of repeatedly positive testing after coronavirus disease 2019 (COVID-19) recovery.
UPDATED
CLINICAL CHARACTERISTICS
4/5/21
Lin W, Hung S, Lai C, et al. | Int Immunopharmacol
Aim: To investigate the clinical efficacy and safety of tocilizumab for treating patients with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
4/5/21
Zhao Y, Jin Y, Rao W, et al. | J Affect Disord
Aim: To compare the prevalence of psychiatric comorbidities in all subpopulations during the SARS and COVID-19 epidemics.
UPDATED
CLINICAL CHARACTERISTICS
4/5/21
Marchi R, Sugita B, Centa A, et al. | Infect Genet Evol
Aim: To describe the role, function, and association of miRNAs in SARS-CoV-2 human infection and COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
4/5/21
Wang Z, Wang Y, Yang Z, et al. | Int J Infect Dis
Aim: To appraise the quality and availability of guidelines stated and whether non-invasive ventilation in the early stage of the pandemic is of importance.
UPDATED
CANDIDATE THERAPEUTICS
4/5/21
Gisondi P, Di Leo S, Bellinato F, et al. | Dermatol Ther
Aim: To systematically review the studies reporting the time of onset of selected skin lesions with respect to the reported onset of the COVID-19 core symptoms.
UPDATED
CLINICAL CHARACTERISTICS
4/2/21
Jacob S, Hammed A, Lam V, et al. | ANZ J Surg
Aim: To assess the consistency of national and international surgical society recommendations regarding the choice of surgical approach; assess the quality of evidence of viral emission in surgical aerosol; and assess the quality of evidence comparing aerosol generation by different surgical energy devices.
UPDATED
INFECTION CONTROL
4/2/21
Ayers CK, Kondo KK, Williams BE, et al. | J Gen Intern Med
Aim: To understand disparities in H1N1 vaccine uptake by race/ethnicity, socioeconomic status (SES), rural/urban residence, population density, and disability status, and factors associated with unequal uptake, as well as the benefits and harms of interventions designed to attenuate inequities in H1N1 vaccine uptake
UPDATED
VA ESP
INFECTION CONTROL
4/2/21
Abdelrahman Z, Liu Q, Jiang S, et al. | Front Pharmacol
Aim: To estimate the impact of current treatments on the efficacy and safety of COVID-19 by a meta-analysis.
UPDATED
CANDIDATE THERAPEUTICS
4/2/21
Upshaw TL, Brown C, Smith R, et al. | PLoS One
Aim: To review the early reports on the social determinants of COVID-19 infection, health service use and health outcomes.
UPDATED
INFECTION CONTROL
4/2/21
Zhang L, Hou J, Ma FZ, et al. | Arch Virol
Aim: To identify risk factors for COVID-19 severity and mortality. 
UPDATED
CLINICAL CHARACTERISTICS
4/1/21
Calzetta L, Ritondo BL, Coppola A, et al. | Vaccines
Aim: To identify the factors that may potentially influence the clinical efficacy of COVID-19 vaccines for which data from Phase III trials are currently available.
UPDATED
INFECTION CONTROL
4/1/21
Yassin A, Nawaiseh M, Shaban A, et al.  | BMC Neurol
Aim: To address the neurological aspects of COVID-19 including NM, NC, and ND findings.
UPDATED
CLINICAL CHARACTERISTICS
3/31/21
Kunzler AM, Rothke N, Gunthner L, et al. | Global Health
Aim: To assess its impact on mental health during the early phase by comparing pandemic with prepandemic data and to identify potential risk and protective factors.
UPDATED
MENTAL HEALTH
3/30/21
Papadopoulos V, Koutroulos MV, Zikoudi DG, et al. | Diabetol Int
Aim: To examine diabetes-related acute metabolic emergencies in COVID-19 patients
UPDATED
CLINICAL CHARACTERISTICS
3/30/21
Peter HJ, Vancsa S, Ocskay K, et al. | Front Med
Aim: To evaluate if MAFLD or NAFLD are associated with a more severe disease course of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
3/30/21
Sucha D, van Hamersvelt RW, van den Hoven AF, et al. | Radiol Cardiothorac Imaging
Aim: To synthesize the literature on diagnostic test accuracy of chest radiography, CT, and US for the diagnosis of coronavirus disease 2019 (COVID-19) in patients suspected of having COVID-19 in a hospital setting and evaluate the extent of suboptimal reporting and risk of bias.
UPDATED
DIAGNOSTICS
3/30/21
Mahat RK, Panda S, Rathore V, et al. | Clin Epidemiol Glob Health
Aim: To evaluate the association of inflammatory parameters with the severity and mortality in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
3/30/21
Bassatne A, Basbous M, Chakhtoura M, et al.  | Metabolism
Aim: To assess the impact of vitamin D status and supplementation on COVID-19 related mortality and health outcomes.
UPDATED
CANDIDATE THERAPEUTICS
3/29/21
Abeldano RA, Coca SM, Abeldano GF, et al. | Ther Adv Respir Dis
Aim: To assess the clinical effectiveness of drugs used in hospitalized patients with COVID-19 infection.
UPDATED
CANDIDATE THERAPEUTICS
3/29/21
Gabbai-Armelin PR, de Oliveira AB, Ferrisse TM, et al. | Eur J Clin Invest
Aim: To review the evidence on the relation of COVID-19 and thrombotic events and identify prognostic factors.
UPDATED
CLINICAL CHARACTERISTICS
3/29/21
Papotsi E, Giannakoulis VG, Xourgia E, et al.  | Crit Care
Aim: To investigate the effect (if any) of timing of intubation on clinical outcomes of critically ill patients with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
3/29/21
Emile S, Hamid HKS, Khan SM, et al. | J Gastrointest Surg
Aim: To assess the extent of adoption, efficacy, and safety of NOM of acute appendicitis in the setting of COVID-19.
UPDATED
INFECTION CONTROL
3/29/21
Li Y, Ashcroft T, Chung A, et al. | J Glob Health
Aim: To synthesise all available evidence regarding the risk factors for poor outcomes in hospitalised COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
3/26/21
Castiello T, Georgiopoulous G, Finocchiaro G, et al. | Heart Fail Rev
Aim: To review the challenges in the early diagnosis and management of myocarditis in patients with COVID-19 infection.
UPDATED
CLINICAL CHARACTERISTICS
3/26/21
Burns J, Movsisyan A, Stratil JM, et al. | Cochrane Database Syst Rev
Aim: To assess the effectiveness of travel?related control measures during the COVID?19 pandemic on infectious disease and screening?related outcomes.
UPDATED
WHO COLLABORATIVE
INFECTION CONTROL
3/26/21
Galanis P, Vraka I, Fragkou D, et al. | J Adv Nurs
Aim: To examine the impact of the COVID-19 pandemic on nurses’ burnout and to identify associated risk factors.
UPDATED
MENTAL HEALTH
3/25/21
Lai C, Chen C, Wang C, et al. | J Antimicrob Chemother
Aim: To provide updated information regarding the clinical efficacy of remdesivir in treating coronavirus disease 2019 (COVID-19).
UPDATED
CANDIDATE THERAPEUTICS
3/25/21
Gerayeli FV, Milne S, Cheung C, et al. | EClinicalMedicine
Aim:  To determine whether COPD is a risk factor for poor outcomes in COVID-19, focusing on the specific endpoints of hospitalization, severe disease, and mortality.
UPDATED
CLINICAL CHARACTERISTICS
3/25/21
Kong X, Qi Y, Huang J, et al.  | Cancer Lett
Aim: To review the evidence on the prevalence of cancer in coronavirus disease 2019 (COVID-19)-infected patients and the severe illness incidence and mortality of COVID-19 patients with cancer.
UPDATED
CLINICAL CHARACTERISTICS
3/24/21
Kasemi A, Mohammadi V, Aghababaee SK, et al. | Adv Nutr
Aim: To summarize and clarify the evidence on the association between 25(OH)D concentrations and COVID-19 risk and outcomes.
UPDATED
CLINICAL CHARACTERISTICS
3/24/21
Almufarrij I, Munro K | Int J Audiol
Aim: To systematically review the literature to December 2020, in order to provide a timely summary of evidence on SARS-CoV-2, COVID-19 and audio-vestibular symptoms.
UPDATED
CLINICAL CHARACTERISTICS
3/24/21
Longchamp G, Manzocchi-Besson S, Longchamp A, et al. | Thromb J
Aim: To systematically review and meta-analyze the risk of clinically relevant VTE in patients hospitalized for COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
3/23/21
Prasad M, Seth T, Elavarasi A | Indian J Hematol Blood Transfus
Aim: To study the efficacy and safety of convalescent plasma in patients with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
3/23/21
Tiruneh SA, Tesema ZT, Azanaw MM, et al. | Syst Rev
Aim: To assess the pooled incidence of COVID-19 complications and to identify the association between the incidence of complications and age.
UPDATED
CLINICAL CHARACTERISTICS
3/22/21
Ssentongo P, Heilbrunn ES, Ssentongo A, et al. | Sci Rep
Aim: To conduct a systematic review and meta-analysis of the prevalence of HIV in patients hospitalized for COVID-19 and delineating clinical outcomes including mortality.
UPDATED
CLINICAL CHARACTERISTICS
3/22/21
Dono F, Nucera B, Lanzone J, et al. | Epilepsy Behav
Aim: To summarize the available data on clinical features, diagnosis, and therapy of SE associated with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
3/22/21
Zhao Y, Yin L, Jenil P, et al. | J Med Virol
Aim: To characterize inflammatory markers of MIS-C patients with COVID-19, Kawasaki disease (KD), and coronary artery abnormalities. 
UPDATED
CLINICAL CHARACTERISTICS
3/19/21
Welte T, Ambrose LJ, Sibbring GC, et al. | Eur Respir Rev
Aim: To identify clinical trials of pharmacological interventions for COVID-19 and evaluate for effectiveness.
UPDATED
CANDIDATE THERAPEUTICS
3/19/21
Zhang XM, Jiao J, Cao J, et al. | BMC Geriatr
Aim: To systematically review and quantify the results of the associations between frailty and mortality.
UPDATED
CLINICAL CHARACTERISTICS
3/19/21
Ghosn L, Chaimani A, Evrenoglou T, et al. | Cochrane Database Syst Rev
Aim: To assess the effect of IL?6 blocking agents compared to standard care alone or with placebo on efficacy and safety outcomes in COVID?19.
UPDATED
CANDIDATE THERAPEUTICS
3/18/21
Kalin A, Javid B, Knight M, et al. | Syst Rev
Aim: To summarise the literature on the performance of different rapid tests for exertional desaturation.
UPDATED
DIAGNOSTICS
3/18/21
Moynihan R, Sanders S, Michaleff Z, et al.  | BMJ Open
Aim: To determine the extent and nature of changes in utilisation of healthcare services during COVID-19 pandemic. 
UPDATED
INFECTION CONTROL
3/18/21
Cares-Marambio K, Montenegro-Jimenez Y, Torres-Castro R, et al. | Chron Respir Dis
Aim: To determine the prevalence of respiratory symptoms in survivors of hospital admission after COVID-19 infection.
UPDATED
CLINICAL CHARACTERISTICS
3/17/21
Grepin KA, Ho T, Liu Z, et al. | BMJ Glob Health
Aim: To review evidence of the effectiveness of travel measures implemented during the early stages of the COVID-19 pandemic in order to recommend change on how evidence is incorporated in the International Health Regulations (2005) (IHR).
UPDATED
INFECTION CONTROL
3/17/21
Lebrasseur A, Fortin-Bedard N, Lettre J, et al.  | JMIR Aging
Aim: To synthesize the existing research on the impact of the COVID-19 pandemic, and associated isolation and protective measures, on older adults. 
UPDATED
MENTAL HEALTH
3/17/21
Robinson E, Jones A, Lesser I, et al. | Vaccine
Aim: To address the current lack of consensus on; i) the proportion of the population willing to be vaccinated against COVID-19 when a vaccine become available and how this differs across countries, ii) whether vaccination intentions have declined as the pandemic has progressed, iii) socio-demographic inequalities in intended vaccine uptake.
UPDATED
INFECTION CONTROL
3/16/21
Meena JP, Gupta AK, Tanwar P, et al. | Pediatr Blood Cancer
Aim: To review the evidence on pediatric cancer patients affected by COVID-19 and analyze the clinical manifestations and outcomes.
UPDATED
3/16/21
Helvaci N, Eyupoglu ND, Karabulut E, et al.  | Front Endocrinol
Aim: To evaluate the prevalence of obesity in patients with COVID-19 and to stratify the estimates by illness severity.
UPDATED
3/16/21
Hossain A, Nasrullah SM, Tasnim Z, et al. | EClinicalMedicine
Aim: To estimate pooled seroprevalence of SARS-CoV-2 IgG antibodies across geographic regions and to investigate the pattern by age-group, gender, infection risk of HCWs, and study period.
UPDATED
3/15/21
Lim ZJ, Reddy MP, Curtis JR, et al. | Crit Care Med
Aim: To investigate the incidence, characteristics, and outcomes of in-hospital cardiac arrest in patients with coronavirus disease 2019 and to describe the characteristics and outcomes for patients with in-hospital cardiac arrest within the ICU, compared with non-ICU patients with in-hospital cardiac arrest. 
UPDATED
3/15/21
Huntley B, Mulder IA, Di Mascio D, et al. | Obstet Gynecol
Aim: To compare the risk of intrauterine fetal death (20 weeks of gestation or later) and neonatal death among individuals who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared with those who tested negative for SARS-CoV-2 on admission for delivery.
UPDATED
3/15/21
Karimian M, Azami M | Pol J Radiol
Aim: To evaluate CT scan findings of COVID-19 at the time of admission.
UPDATED
3/15/21
Allotey J, Stallings E, Bonet M, et al. | BMJ
Aim: To determine the clinical manifestations, risk factors, and maternal and perinatal outcomes in pregnant and recently pregnant women with suspected or confirmed coronavirus disease 2019 (covid-19).
UPDATED
CLINICAL CHARACTERISTICS
3/15/21
Pranata R, Huang I, Lim MA, et al. | Arch Gerontol Geriatr
Aim: To establish the association between delirium and mortality in older adults with COVID-19.
UPDATED
3/15/21
Syahrul S, Maliga HA, Ilmawan M, et al. | F1000Research
Aim: To determine the global prevalence, chronological order of symptom appearance, and mortality rates with regard to hemorrhagic and ischemic stroke in patients with coronavirus disease 2019 (COVID-19) and to discuss possible pathogeneses of hemorrhagic and ischemic stroke in individuals with the disease.
UPDATED
3/15/21
Juul S, Nielsen N, Feinberg J, et al. | PLoS Med
Aim: To compare the effects of all treatment interventions for participants in all age groups with COVID-19. 
UPDATED
CANDIDATE THERAPEUTICS
3/12/21
Oltean I, Tran J, Lawrence S, et al. | Heliyon
Aim: To illustrate findings in a narrative fashion pertaining to SARS-CoV-2 on placental pathology, maternal, and neonatal outcomes.
UPDATED
CLINICAL CHARACTERISTICS
3/11/21
Pellicori P, Doolub G, Wong CM, et al. | Cochrane Database Syst Rev
Aim: To assess the prevalence of pre?existing cardiovascular comorbidities associated with suspected or confirmed cases of COVID?19 in a variety of settings, including the community, care homes and hospitals. 
UPDATED
CLINICAL CHARACTERISTICS
3/11/21
Alkhathami M, Advani SM, Abalkhail AA, et al. | Lung India
Aim: To determine the prelavence and mortality of chronic lung diseases which include COPD, lung cancer, asthma, and cystic fibrosis in confirmed COVID-19 cases.
UPDATED
CLINICAL CHARACTERISTICS
3/11/21
Wang Q, Liu J, Shao R, et al.  | Rheumatol Int
Aim: To integrate data on the epidemiology of COVID-19 in the RD population and to analyze the risk of COVID-19 infection and its complications in RD patients compared with the general population.
UPDATED
CLINICAL CHARACTERISTICS
3/10/21
Cai J, Tang M, Gao Y, et al. | Front Med
Aim: To determine which mode of delivery is better for preventing possible vertical transmission from COVID-19 positive pregnant women to the neonate.
UPDATED
INFECTION CONTROL
3/10/21
Pal R, Banerjee M, Mukherjee S, et al. | Ther Adv Endocrinol Metab
Aim: To provide a precise summary of the effect of DPP4i use (preadmission or in-hospital) and mortality in COVID-19 patients with diabetes mellitus (DM).
UPDATED
CLINICAL CHARACTERISTICS
3/10/21
Meena J, Jain S, Kumar j, et al.  | J Infect Chemother
Aim: To systematically synthesize the evidence over the efficacy and safety of HCQ or CQ alone as compared to placebo or no active intervention in adults with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
3/10/21
Hashan MR, Smoll N, King C, et al. | EClinicalMedicine
Aim: To define the epidemiology of COVID-19 outbreaks in RACFs to estimate the epidemiological index of the disease for these vulnerable populations.
UPDATED
CLINICAL CHARACTERISTICS
3/10/21
Chou R, Dana T, Jungbauer R, et al. | Ann Intern Med
Aim: To examine the effectiveness of N95, surgical, and cloth masks in community and health care settings for preventing respiratory virus infections, and effects of reuse or extended use of N95 masks.
UPDATED
3/10/21
Li Y, Scherer N, Felix L, et al. | PLoS ONE
Aim: To provide updated estimates of the prevalence of depression, anxiety and post-traumatic stress disorder (PTSD) among health care workers during the COVID-19 pandemic.
UPDATED
MENTAL HEALTH
3/10/21
Xia L, Chen C, Liu Z, et al. | Front Psychiatry
Aim: To explore the prevalence of sleep disturbances and sleep quality in Chinese HWs during the COVID-19 pandemic.
UPDATED
MENTAL HEALTH
3/9/21
Veazie S, O'Neil M, LaFavor B, et al.  | VA Evidence Synthesis Program
Aim: To compare the prevalence of mental health disorders among adults who have been hospitalized for COVID-19 to relevant comparison groups, assess whether the prevalence of mental health disorders varies by patient and disease characteristics, and ascertain mental health care utilization and resource needs for adults following hospitalization for COVID-19.
UPDATED
VA ESP
MENTAL HEALTH
3/9/21
Deng J, Zhou F, Hou W, et al. | Psychiatry Res
Aim: To examine the prevalence of depressive symptoms, anxiety symptoms, and sleep disturbances in higher education students to better understand the impact of the COVID-19 pandemic on the mental health of higher education students.
UPDATED
MENTAL HEALTH
3/8/21
Sarma P, Bhattacharyya A, Kaur H, et al. | Indian J Pharmacol
Aim: To evaluate the efficacy and safety of steroid therapy among all severity categories of patients with COVID-19 (mild to moderate and severe to critical category) in terms of "mortality," "requirement of mechanical ventilation," "requirement of ICU" and clinical cure parameters.
UPDATED
CLINICAL CHARACTERISTICS
3/8/21
Shehab M, Alrashed F, Shuaibi S, et al. | BMJ Open Gastroenterol
Aim: To evaluate the prevalence of GI, liver function test (LFT) abnormalities, and mortality of COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
3/8/21
Booth A, Reed AB, Ponzo S, et al. | PLoS One
Aim: To systematically map all the available evidence on the association of various clinical, demographic, and lifestyle variables with the risk of specific adverse outcomes in patients with COVID?19.
UPDATED
CLINICAL CHARACTERISTICS
3/8/21
Jamshidi P, Hajikhani B, Mirsaeidi M, et al. | Front Med
Aim: To investigate the prevalence and characteristics of cutaneous manifestations in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
3/8/21
Akbar MR, Pranata R, Wibowo A, et al. | Diabetes Metab Syndr
Aim: To evaluate the association between the elevated CK and severity and mortality in COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
3/2/21
Simons D, Shahab L, Brown J, et al. | Addiction
Aim: To estimate the association of smoking status with rates of i) infection, ii) hospitalisation, iii) disease severity, and iv) mortality from SARS?CoV?2/COVID?19 disease.
UPDATED
CLINICAL CHARACTERISTICS
3/1/21
Diallo A, Carlos-Bolumbu M, Traore M, et al. | J Public Health Res
Aim: To compare and rank the efficacy and safety of treatments tested in patients with SARSCoV- 2 virus.
UPDATED
CANDIDATE THERAPEUTICS
3/1/21
Gupta N, Balcom S, Gulliver A, et al. | Int J Health Planning Manag
Aim: To assess the state of the evidence on policy and planning responses to HRH surge capacity during the coronavirus disease (COVID?19) pandemic and other viral respiratory disease outbreaks of global significance in the 21st century.
UPDATED
3/1/21
Zang S, Han X, Cui Q, et al. | Transl Pediatr
Aim: To summarize a comprehensive review and meta-analysis with a complete evaluation of CT characteristics in pediatric COVID-19 cases. 
UPDATED
DIAGNOSTICS
2/26/21
Tan BK, Mainbourg S, Friggeri A, et al. | Thorax
Aim: To review the evidence on the prevalence of venous thromboembolic event (VTE) and arterial thromboembolic event (ATE) thromboembolic events in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
2/26/21
Sun C, Chen Y, Hu L, et al.  | Dig Dis Sci
Aim: To assess effects of famotidine on improving the outcome of those suffered COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
2/26/21
Bentivegna M, Hulme C, Ebell MH | J Am Board Fam Med
Aim: To summarize the best available evidence regarding individual risk factors, simple risk scores, and multivariate models that use patient characteristics, vital signs, comorbidities, and laboratory tests in inpatients.
UPDATED
CLINICAL CHARACTERISTICS
2/25/21
Yin TX, Li Y, Ying Y, et al. | BMC Infect Dis
Aim: To provide systematic evaluation and detailed estimation of prevalence rates of different kinds of common comorbidities in severe and non-severe COVID-19 patients and tries to illustrate the outcomes by combination with underlying pathogenesis to better understand how basic diseases contribute to the aggravation of SARS-CoV-2 infection.
UPDATED
CLINICAL CHARACTERISTICS
2/25/21
Struyf T, Deeks JJ, Dinnes J et al. | Cochrane Database Syst Rev
Aim: To assess the diagnostic accuracy of signs and symptoms to determine if a person presenting in primary care or to hospital outpatient settings, such as the emergency department or dedicated COVID?19 clinics, has COVID?19 disease or COVID?19 pneumonia.
UPDATED
DIAGNOSTICS
2/25/21
Ng JJ, Liang ZC, Choong A | J Intensive Care
Aim: To quantitatively synthesize available literature by using meta-analysis of proportions to estimate the weighted average incidence of PTE in critically ill COVID-19 patients admitted to the intensive care unit (ICU).
UPDATED
CLINICAL CHARACTERISTICS
2/24/21
Corona G, Pizzocaro A, Vena W, et al. | Rev Endocr Metab Disord
Aim: To provide an overview and a meta-analysis of main predictors and of country differences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-associated mortality rate (MR) in hospitalized patients. 
UPDATED
CLINICAL CHARACTERISTICS
2/24/21
Ma S, Xu C, Liu S, et al. | Signal Transduct Target Ther
Aim: To address the efficacy and safety of corticosteroids among severe COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
2/24/21
Bulfone TC, Malekinejad M, Rutherford GW, et al. | J Infect Dis
Aim: To quantify the risk of SAR-CoV-2 transmission in outdoor settings. 
UPDATED
INFECTION CONTROL
2/23/21
Avianai JK, Halim D, Soeroto AY, et al. | Rev Med Virol
Aim: To evaluate CPT potentials in COVID-19 treatment, by performing systematic review and meta-analysis of studies in COVID-19 and other similar viral respiratory diseases, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and Influenza.
UPDATED
CANDIDATE THERAPEUTICS
2/22/21
Hoste L, Van Paemel R, Haerynck F | Eur J Pediatr
Aim: To perform a systematic review of published cases of this novel multisystem inflammatory syndrome in children associated with COVID-19. 
UPDATED
CLINICAL CHARACTERISTICS
2/20/21
Sagredo-Olivares K, Morales-Gomez C, Aitken-Saavedra J | Med Oral Patol Oral Cir Bucal
Aim: To evaluate saliva as a diagnostic technique for COVID-19.
UPDATED
DIAGNOSTICS
2/19/21
Irfan O, Muttalib F, Tang K, et al. | Arch Dis Child
Aim: To compare paediatric COVID-19 disease characteristics, management and outcomes according to World Bank country income level and disease severity.
UPDATED
CLINICAL CHARACTERISTICS
2/18/21
Xu C, Yi Z, Cai R, et al. | Autoimmun Rev
Aim: To summarize the published and preprint literature that described the clinical characteristics and outcomes of COVID-19 patients with rheumatic diseases, and to provide a higher level of evidence for better clinical decision making.
UPDATED
CLINICAL CHARACTERISTICS
2/17/21
Roshdy A, Zaher S, Fayed H, et al. | Front Cardiovasc Med
Aim: To report the cardiac tissue autopsy findings in coronavirus disease 2019 (COVID-19) decedents.
UPDATED
CLINICAL CHARACTERISTICS
2/17/21
Atmosudigdo I, Pranata R, Anthonius M, et al.  | J Clin Exp Hepatol
Aim: To evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association.
UPDATED
CLINICAL CHARACTERISTICS
2/17/21
Sirois F, Owens J | Front Psychiatry
Aim: To examine the factors associated with psychological distress among HCW during an outbreak.
UPDATED
MENTAL HEALTH
2/17/21
Gao Y, Chen Y, Liu M, et al. | Epidemiol Infect
Aim: To clarify the association between nervous system diseases and severity or mortality in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
2/17/21
Mohamed MFH, A-Shokri S, Yousaf Z, et al. | Front Cardiovasc Med
Aim: To systematically review the literature and explore the pooled prevalence of VTE, PE, and DVT in critically ill COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
2/16/21
Labad J, Gonzalez-Rodriguez A, Cobo J, et al.  | PeerJ
Aim: To explore whether the coronavirus disease 2019 (COVID-19) pandemic is associated with toilet paper hoarding and to assess which risk factors are associated with the risk of toilet paper hoarding.
UPDATED
2/16/21
Chang R, Elhusseiny KM, Yeh Y, et al. | PLoS One
Aim: To review the evidence on COVID-19 intensive care unit (ICU) patient characteristics, rates and risks of invasive mechanical ventilation (IMV) and associated outcomes.
UPDATED
CLINICAL CHARACTERISTICS
2/16/21
Wang J, Zhong Z, Mo Y, et al. | Eur Rev Med Pharmacol Sci
Aim: To determine the incidence of the clinical manifestations of COVID-19 in children.
UPDATED
CLINICAL CHARACTERISTICS
2/16/21
Cavalcante-Leao BL, de Araujo C, Basso I, et al. | J Clin Exp Dent
Aim: To verify whether there is evidence in the literature regarding the decrease in viral load present in saliva after using three types of mouthwashes.
UPDATED
INFECTION CONTROL
2/16/21
Khan FA, Stewart I, Fabbri L, et al. | Thorax
Aim: To systematically review and assess the effectiveness of specific interleukin-1 and -6 inhibitors for the treatment of coronavirus-related infections. 
UPDATED
CANDIDATE THERAPEUTICS
2/13/21
Zace D, Hoxhaj I, Orfino A, et al.  | J Psychiatr Res
Aim: To identify and summarize the implemented interventions to deal with mental health issues of HCWs during infectious disease outbreaks, and report their effectiveness.
UPDATED
MENTAL HEALTH
2/12/21
Singh B, Ryan H, Kredo T, et al. | Cochrane Database Syst Rev
Aim: To evaluate the effects of chloroquine or hydroxychloroquine for treatment people with COVID-19 and for preventing infection in people at risk of exposure or exposed to SARS-CoV-2.
UPDATED
CANDIDATE THERAPEUTICS
2/11/21
Thompson H, Mousa A, Dighe A, et al.  | Clin Infect Dis
Aim: To estimate secondary attack rates (SAR) and observed reproduction numbers (Robs) in different settings exploring differences by age, symptom status, and duration of exposure.
UPDATED
INFECTION CONTROL
2/10/21
Syangtan G, Bista S, Dawadi P, et al. | Front Public Health
Aim: To review the evidence on the frequency of asymptomatic individuals and estimated occurrence by age group and gender.
UPDATED
CLINICAL CHARACTERISTICS
2/10/21
Jayant K, Reccia I, Virdis F, et al. | Clin Transplant
Aim: To determine the pooled prevalence of outcomes among hospitalized LTx recipients with COVID-19. 
UPDATED
CLINICAL CHARACTERISTICS
2/10/21
Marafini I, Troncone E, Rocchetti I, et al. | Front Pharmacol
Aim: To determine the risk of RTIs with vedolizumab in patients with IBD.
UPDATED
CLINICAL CHARACTERISTICS
2/10/21
Kumar J, Meena J, Yadav A, et al.  | J Matern Fetal Neonatal Med
Aim: To synthesize the current evidence for the presence of SARS-CoV-2 RNA in the human milk of mothers with confirmed COVID-19 and its potential role in neonatal SARS-CoV-2 infection.
UPDATED
CLINICAL CHARACTERISTICS
2/10/21
Umnuaypornlert A, Kanchanasurakit S, Lucero-Prisno DE, et al. | Tob Induc Dis
Aim: To determine the association between smoking and disease severity in COVID-19 infected patients.
UPDATED
CLINICAL CHARACTERISTICS
2/5/21
Xu Z, Tang Y, Huang Q, et al. | BMC Nephrol
Aim: To evaluate the incidence of AKI in hospitalized COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
2/3/21
Li J, Liao X, Zhou Y, et al. | Shock
Aim: To review the evidence on the response to glucocorticioids treatment in COVID-19 and SARS patients.
UPDATED
CANDIDATE THERAPEUTICS
2/3/21
Castaneda CA, Castillo M, Rojas JL, et al. | Rev Peru Med Exp Salud Publica
Aim: To describe the risk of infection and developing severe COVID-19 in cancer patients.
UPDATED
CLINICAL CHARACTERISTICS
2/3/21
Pourmalek F, Hemami MR, Janani L, et al. | BMC Public Health
Aim: To inform the researchers about the methodology and results of epidemic estimation studies performed for COVID-19 epidemic in Iran, we aimed to perform a rapid review.
UPDATED
2/3/21
Cevik M, Tate M, Lloyd O, et al. | Lancet Microbe
Aim: To characterise the viral load dynamics of SARS-CoV-2, duration of viral RNA shedding by RT-PCR, and viable virus shedding in various body fluids, and to compare SARS-CoV-2 viral dynamics with those of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV).
UPDATED
CLINICAL CHARACTERISTICS
2/1/21
Xiang G, Li X, Chen Z, et al. | Ann Palliat Med
Aim: To systematically review the clinical risk factors for fatal outcome of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
2/1/21
Pijls BG, Jolani S, Atherley A, et al. | BMJ Open
Aim: To describe the associations of age and sex with the risk of COVID-19 in different severity stages ranging from infection to death.
UPDATED
CLINICAL CHARACTERISTICS
2/1/21
Yisak H, Ewunetei A, Kefale B, et al. | Risk Manag Healthc Policy
Aim: To summarize and decide if there were a link between vitamin D status and COVID-19 infection and prognosis.
UPDATED
CLINICAL CHARACTERISTICS
2/1/21
Diaz LA, Idalsoaga F, Cannistra M, et al. | World J Gastroenterol
Aim: To characterize hepatic pathological findings in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
2/1/21
Wibowo A, Pranata R, Astuti A, et al. | J Intensive Care
Aim: To assess whether ventricular longitudinal strain can be used as a prognostication tool in patients with coronavirus disease 2019 (COVID-19).
UPDATED
CLINICAL CHARACTERISTICS
2/1/21
Lee RA, Herigon JC, Benedetti A, et al. | J Clin Microbiol
Aim: To understand the performance of alternative sample types compared to NP swabs
UPDATED
DIAGNOSTICS
2/1/21
Yoon SH, Yang S, Cho H, et al.  | Eur Rev Med Pharmacol Sci
Aim: To evaluate the diagnostic accuracy of the Food and Drug Administration Emergency Use Authorization (FDA-EUA) authorized point-of-care tests (POCTs) for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
UPDATED
DIAGNOSTICS
2/1/21
Martha JW, Wibowo A, Pranata R | Postgrad Med J
Aim: To evaluate the prognostic performance of elevated lactate dehydrogenase (LDH) in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
2/1/21
Gronholm P, Nose M, van Brakel WH, et al. | Epidemiol Psychiatr Sci
Aim: To develop recommendations for strategies and interventions to reduce stigma and discrimination related to COVID-19.
UPDATED
MENTAL HEALTH
2/1/21
Al-abdouh A, Bizanti A, Barbarawi M, et al. | Contemp Clin Trials
Aim: To evaluate the effect of remdesivir in the treatment of moderate and severe COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
2/1/21
Lee HW, Yoon C, Jang EJ, et al. | Thorax
Aim: To investigate if ACEI/ARB use is associated with the risk of mortality and severe disease in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
2/1/21
Bastos ML, Perlman-Arrow S, Menzies D, et al. | Ann Intern Med
Aim: To determine the difference in sensitivity for SARS-CoV-2 detection between nasopharyngeal swabs and saliva and estimate the incremental cost per additional SARS-CoV-2 infection detected with nasopharyngeal swabs.
UPDATED
DIAGNOSTICS
1/29/21
Lawes-Wickwar S, Ghio D, Tang MY, et al. | Vaccines
Aim: To identify and synthesise evidence relating to effective messaging for encouraging vaccination in order to prevent virus transmission during pandemics or epidemics.
UPDATED
INFECTION CONTROL
1/29/21
Lee JJ, Montazerin SM, Jamil A, et al. | J Med Virol
Aim: To review and synthesize the current evidence on the association of RDW levels with COVID?19 mortality and severity.
UPDATED
CLINICAL CHARACTERISTICS
1/29/21
Baldini T, Asioli GM, Romoli M, et al. | Eur J Neurol
Aim: To systematically review the available evidence in the literature for cerebral venous thrombosis (CVT) in association with coronavirus disease-2019 (COVID-19).
UPDATED
CLINICAL CHARACTERISTICS
1/29/21
Anglemyer A, Moore TH, Parker L, et al. | Cochrane Database Syst Rev
Aim: To assess the benefits, harms, and acceptability of personal digital contact tracing solutions for identifying contacts of an identified positive case of an infectious disease.
UPDATED
INFECTION CONTROL
1/29/21
Kitano T, Kitano M, Krueger C, et al. | PLoS One
Aim: To better understand the global epidemiology of COVID-19 in children and differences in outcome across countries.
UPDATED
CLINICAL CHARACTERISTICS
1/29/21
Lassi Z, Naseem R, Salam RA, et al. | Int J Environ Res Public Health
Aim: To review the evidence on the impact of the COVID-19 pandemic on immunization campaigns and programs.
UPDATED
INFECTION CONTROL
1/27/21
Hoogenes B, Queree M, Townson A, et al.  | J Neurotrauma
Aim: To provide an overview of the clinical presentation, course, and outcomes of COVID-19 in persons with SCI and identify risk factors for severe disease- and COVID-19-related mortality.
UPDATED
CLINICAL CHARACTERISTICS
1/27/21
Tian C, Lovrics O, Vaisman A, et al. | Infect Control Hosp Epidemiol
Aim: To investigate risk factors for HCW infection in viral respiratory pandemics (SARS-CoV-2, MERS, SARS CoV-1, influenza A H1N1, influenza H5N1) and improve understanding of HCW risk management amidst the COVID-19 pandemic.
UPDATED
INFECTION CONTROL
1/25/21
Shrotri M, van Schalkwyk MCI, Post N, et al. | PLoS One
Aim: To summarize current understanding of the cellular response to SARSCoV-2 infection, specifically exploring the role that T cell-mediated immunity might play in resistance to severe infection, clinical and virological recovery, and long-term protection.
UPDATED
INFECTION CONTROL
1/22/21
Pajo AT, Espiritu AI, Apor ADAO, et al. | Neurol Sci
Aim: To review the currently available neuropathological data on COVID-19 including post-mortem findings of patients following a death from COVID-19 infection.
UPDATED
CLINICAL CHARACTERISTICS
1/19/21
Sahebi A, Nejati-Zarnaqi B, Moayedi S, et al. | Prog Neuropsychopharmacol Biol Psychiatry
Aim: To review the evidence on the prevalence of anxiety and depression among healthcare workers during the COVID-19 pandemic.
UPDATED
MENTAL HEALTH
1/19/21
Cunarro-Lopez Y, Pintado-Recarte P, Cueto-Hernandez I, et al. | J Clin Med
Aim: To describe and analyze the profile of the obstetric patients according to the country of origin of the publication.
UPDATED
CLINICAL CHARACTERISTICS
1/18/21
Zeng W, Qi K, Ye M, et al. | Eur J Gastroenterol Hepatol
Aim: To explore the relationship between gastrointestinal symptoms and the severity of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
1/18/21
Martha JW, Wibowo A, Pranata R | Diabetes Metab Syndr
Aim: To evaluate the prognostic performance of hypocalcemia in patients with coronavirus disease 2019 (COVID-19).
UPDATED
CLINICAL CHARACTERISTICS
1/15/21
Goldstein KM, Ghadimi K, Mystakelis H, et al. | VA Evidence Synthesis Program
Aim: To review the evidence on the risk of transmitting SARS-CoV-2, SARS, MERS, and influenza with administration of drugs via nebulizer
UPDATED
VA ESP
1/15/21
Xu W, Li X, Dozier M, et al. | J Glob Health
Aim: To investigate the extent of SARS-CoV-2 transmission in schools. 
UPDATED
INFECTION CONTROL
1/13/21
Hassanipour S, Faradonbeh SB, Momeni K, et al. | Int J Reprod Biomed
Aim: To investigate the clinical manifestation include signs and symptoms, laboratory results, and perinatal outcomes in pregnant women with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
1/11/21
Johanna N, Citrawijaya H, Wangge G | J Public Health Res
Aim: To evaluate the effectiveness of mass testing, lockdown, or a combination of both to control COVID-19 pandemic.
UPDATED
INFECTION CONTROL
1/11/21
Zhao X, Gang X, He G, et al. | Front Endocrinol
Aim: To compare the impacts of obesity on the severity and mortality of influenza and COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
1/11/21
Syeda HB, Syed M, Sexton KW, et al. | JMIR Med Inform
Aim: To conduct a systematic literature review on the role of ML as a comprehensive and decisive technology to fight the COVID-19 crisis in the arena of epidemiology, diagnosis, and disease progression.
UPDATED
DIAGNOSTICS
1/8/21
Joo JY, Liu M | Int Nurs Rev
Aim: To identify and synthesize qualitative studies of frontline nurses’ experiences and challenges when caring for patients with COVID?19 in hospitals.
UPDATED
MENTAL HEALTH
1/7/21
Lukito AA, Pranata R, Henrina J, et al. | Diabetes Metab Syndr
Aim: To review the evidence on metformin consumption and mortality in COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
1/4/21
Post N, Eddy D, Huntley C, et al. | PLoS One
Aim: To comprehensively evaluate the evidence describing the antibody response to SARS-CoV-2.
UPDATED
CLINICAL CHARACTERISTICS
1/4/21
Rada G, Corbalan J, Rojas P, et al. | Medwave
Aim: To provide a timely, rigorous and continuously updated summary of the available evidence on the role of cell-based therapies in the treatment of patients with COVID-19. 
UPDATED
CANDIDATE THERAPEUTICS
1/4/21
Khamis AH, Jaber M, Azar A, et al. | J Formos Med Assoc
Aim: To systematically review all COVID-19 publications to summarize the clinical features, assess comorbidities, prevalence, and disease outcomes.
UPDATED
CLINICAL CHARACTERISTICS
1/4/21
Kim MS, An MH, Kim WJ, et al. | PLoS One
Aim: To evaluate the comparative efficacy and safety of pharmacological interventions used in treating COVID-19 and form a basis for an evidence-based guideline of COVID-19 management by evaluating the level of evidence behind each treatment regimen in different clinical settings. 
UPDATED
CANDIDATE THERAPEUTICS
1/4/21
Choupoo NS, Das SK, Haldar R, et al. | Indian J Crit Care Med
Aim:  To test the efficacy of different therapeutic options currently available for treating COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
1/4/21
Cascino F, Hoxhaj I, Zace D, et al.  | BMJ Glob Health
Aim: To identify healthcare systems interventions, experiences and recommendations that have been used to manage different respiratory viral infections outbreaks in the past.
UPDATED
1/4/21
Desai A, Gupta R, Advani S, et al. | Cancer
Aim: To assess the overall mortality in this population through a meta?analysis of published data on COVID?19 and cancer.
UPDATED
CLINICAL CHARACTERISTICS
1/4/21
Liu H, Yang D, Chen X, et al.  | Cancer Med
Aim: To qualify the potential effects of anticancer therapies on the clinical outcomes, such as mortality, admission to the intensive care unit (ICU), and the severity of COVID?19, in patients with cancer infected with COVID?19.
UPDATED
CLINICAL CHARACTERISTICS
1/3/21
Cheruiyot I, Sehmi P, Ngure B, et al.  | Langenbecks Arch Surg
Aim: To determine the presence of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in abdominal tissues or fluids and in surgical smoke.
UPDATED
INFECTION CONTROL
1/2/21
Liu N, Sun J, Wang X, et al. | Int J Infect Dis
Aim: To assess the association between low vitamin D status and COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
1/2/21
Wynants L, Van Calster B, Bonten MMJ | BMJ
Aim: To review and critically appraise published and preprint reports of models that aim to predict either (i) presence of existing COVID-19 infection, or (ii) future complications in individuals already diagnosed with COVID-19
UPDATED
12/30/20
Lai X, Liu J, Zhang T, et al. | BMJ Open
Aim: To systematically assess the clinical, laboratory and imaging predictors as well as prediction models for severe or critical illness and mortality in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
12/30/20
Dorrell R, Dourgherty MK, Barash EL, et al. | JGH Open
Aim: To characterize the prevalence of gastrointestinal (GI) and hepatic involvement in COVID?19 and specifically assess the prevalence of GI symptoms in isolation.
UPDATED
CLINICAL CHARACTERISTICS
12/30/20
Verdejo C, Vergara-Merino L, Meza N, et al. | Medwave
Aim: To provide a timely, rigorous, and continuously updated summary of the evidence available on the role of macrolides for treating patients with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
12/30/20
Mondal R, Ganguly U, Deb S, et al. | J Neurovirol
Aim: To summarise the clinical profile, investigations and radiological findings among patients with SARS-CoV-2 associated meningoencephalitis.
UPDATED
CLINICAL CHARACTERISTICS
12/30/20
Al Maqbali M, Al Sinani M, Al-Lenjawi B | J Psychosom Res
Aim: To ascertain the present impact of the COVID-19 outbreak on the prevalence of stress, anxiety, depression and sleep disturbance among nurses.
UPDATED
MENTAL HEALTH
12/30/20
Callus E, Bassola B, Fiolo V, et al. | Front Psychol
Aim: To identify the most effective stress reduction techniques for health care providers dealing with patients infected with severe coronavirus (SARS, MERS, and COVID-19).
UPDATED
MENTAL HEALTH
12/23/20
Prendki V, Tau N, Avni T, et al. | BMC Geriatr
Aim: To examine the participation of elderly patients in therapeutic or prophylactic trials on COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
12/23/20
Bhuiyan MU, Stiboy E, Hassan MZ, et al. | Vaccine
Aim: To review the evidence on the epidemiological and clinical characteristics of COVID-19 infection in children under five years.
UPDATED
CLINICAL CHARACTERISTICS
12/22/20
Rattka M, Dreyhaupt J, Winsauer C, et al. | Heart
Aim: To assess the mortality of patients with STEMI admitted during the COVID-19 pandemic.
UPDATED
CLINICAL CHARACTERISTICS
12/22/20
Bae S, Kim SR, Kim M, et al.  | Heart
Aim: To estimate the prevalence and risk factors for CVD among patients with COVID-19 in different age groups.
UPDATED
CLINICAL CHARACTERISTICS
12/22/20
Sarkar S, Khanna P, Singh A | J Med Virol
Aim: To evaluate the consequence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in patients with concurrent co-infections based on the publications reported to date.
UPDATED
CLINICAL CHARACTERISTICS
12/22/20
Tyrrell CSB, Mytton OT, Gentry SV, et al. | Thorax
Aim: To provide acute insights into the guidance on which patients are treated in ICU and receive ventilation during periods of high demand for ICU capacity during the COVID-19 pandemic.
UPDATED
CLINICAL CHARACTERISTICS
12/22/20
Raymond C, Loshak H | CADTH
Aim: To describe the trial characteristics and estimated primary completion dates of the ongoing phase II, phase III, and phase IV studies evaluating IVIg and hyperimmune globulin to treat COVID-19.
UPDATED
12/22/20
Mathioudakis AG, Fally M, Hashad R, et al. | Life
Aim: To describe the outcomes evaluated in 415 RCTs on the management of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
12/22/20
Rabbani G, Islam SMS, Rahman MA, et al. | Expert Rev Respir Med
Aim: To investigate COVID-19 mortality and severity among patients with pre-existing COPD.
UPDATED
CLINICAL CHARACTERISTICS
12/22/20
Rodrigues C, Baía I, Domingues R, et al. | Front Public Health
Aim: To review knowledge on the impact of COVID-19 on pregnancy and describe the outcome of published cases of pregnant women diagnosed with COVID-19, as well as the characteristics of COVID-19 positive women who delivered in Portugal by 31 of March 2020. 
UPDATED
CLINICAL CHARACTERISTICS
12/22/20
July J, Pranata R | Geriatr Gerontol Int
Aim: To discover whether age, sex and other comorbidities might affect the association between dementia and mortality.
UPDATED
CLINICAL CHARACTERISTICS
12/22/20
Islam MA, Alam SS, Kundu S, et al. | Front Neurol
Aim: To conduct a comprehensive systematic review and meta-analysis to estimate the overall pooled prevalence of headache in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
12/22/20
Viner RM, Ward J, Hudson L, et al. | Arch Dis Child
Aim: To undertake a systematic review of reviews of the prevalence of symptoms and signs of COVID-19 in those aged under 20 years.
UPDATED
CLINICAL CHARACTERISTICS
12/22/20
Subsoontorn P, Lohitnavy M, Kongkaew C | Sci Rep
Aim: To determine the accuracy of nucleic acid point-of-care diagnosis for human coronaviruses, particularly, SARS-CoV, MERS-CoV and SARS-CoV-2.
UPDATED
DIAGNOSTICS
12/18/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the impact of COVID-19 and related public health measures on household food security.
UPDATED
12/18/20
Yan H, Ding Y, Guo W | Front Psychol
Aim: To quantify the influence of the COVID-19 pandemic on the mental health of pregnant and postpartum women, and to explore the specific vulnerable groups among this population of women.
UPDATED
MENTAL HEALTH
12/17/20
van Paassen J, Vos JS, Hoekstra EM, et al. | Crit Care
Aim: To evaluate the effect of corticosteroids on mortality, viral clearance and secondary outcomes in COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
12/17/20
Arieta-Miranda J, Alcaychahua ABS, Santos GMP, et al  | Heliyon
Aim: To evaluate the quality of the CPG for the management of paediatric dental emergencies, published in the period 2000–2020 and applicable to the context of pandemic, by using the AGREE II tool.
UPDATED
INFECTION CONTROL
12/16/20
Madewell ZJ, Yang Y, Longini IM, et al. | JAMA Netw Open
Aim: To examine evidence for household transmission of SARS-CoV-2, disaggregated by several covariates, and to compare it with other coronaviruses.
UPDATED
INFECTION CONTROL
12/16/20
Liu S, Cao Y, Du T, et al. | J Allergy Clin Immunol Pract
Aim: To investigate the asthma prevalence among COVID-19 patients and compare outcomes between asthma and non-asthma patients.
UPDATED
CLINICAL CHARACTERISTICS
12/16/20
Wu T, Jia X, Shi H, et al. | J Affect Disord
Aim: To provide a comprehensive perspective of the prevalence mental health problems during the COVID-19 pandemic and identify high risk groups of mental health problems related to COVID-19 pandemic.
UPDATED
MENTAL HEALTH
12/14/20
Gallagher JE, Sukriti KC, Johnson IG, et al. | BDJ Open
Aim: To review the evidence on the pattern of aerosol spread and settle relevant to oral surgery in dental surgery.
UPDATED
12/14/20
Ojha V, Verma M, Pandey NN, et al.  | J Thorac Imaging
Aim: To assess the important imaging features on CMR in patients diagnosed with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
12/14/20
Piscoya A, Ng-Sueng LF, del Riego AP, et al. | PLoS One
Aim: To evaluate the efficacy and safety of remesdivir for the treatment of COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
12/14/20
Arevalo Rodriguez I, Buitrago Garcia D, Simancas Racines D, et al.  | PLoS One
Aim: To review and critically appraise evidence about the proportion of RT-PCR false-negatives at initial testing for COVID-19. 
UPDATED
DIAGNOSTICS
12/11/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on risk factors are associated with COVID-19 outbreaks and mortality in LTC facilities and what strategies mitigate risk.
UPDATED
12/10/20
Levin AT, Hanage WP, Owusu-Boaitey N, et al. | Eur J Epidemiol
Aim: To assess the age specificity of the infection fatality rate (IFR) for COVID-19 using seroprevalence results from eight national studies (Belgium, England, Hungary, Italy, Netherlands, Portugal, Spain, and Sweden), fifteen seroprevalence studies of specific locations in Europe and the United States, and three countries (Iceland, New Zealand, and Republic of Korea) that have engaged in comprehensive tracking and tracing of COVID-19 infections.
UPDATED
12/9/20
Vancsa S, Hegyi PJ, Zadori N, et al. | Front Med
Aim: To evaluate the prognostic value of on-admission liver function tests and pre-existing liver diseases on the clinical course of coronavirus disease 2019 (COVID-19).
UPDATED
12/9/20
Shamshirian A, Hessami A, Heydari K, et al. | Ann Acad Med Singap
Aim: To examine the effectiveness of hydroxychloroquine in treatment of COVID-19.
UPDATED
12/8/20
Wilkinson R, Hines L, Holland A, et al.  | Harm Reduct J
Aim: To explore what harm reduction interventions and messaging are most effective during a pandemic-type situation.
UPDATED
12/7/20
Puyat J, Ahmad H, Avina-Galindo AM, et al | PLoS One
Aim: To review the evidence on home-based activities that have potential beneficial effects on mental health.
UPDATED
12/7/20
Hessami A, Shamshirian A, Heydari K, et al. | Am J Emerg Med
Aim: To study cardiovascular disease burden among COVID-19 patients.
UPDATED
12/7/20
Jefferson T, Spencer EA, Brassey J, et al. | Clin Infect Dis
Aim: To review the evidence from studies relating SARS-CoV-2 culture with the results of reverse transcriptase polymerase chain reaction (RT-PCR) and other variables which may influence the interpretation of the test, such as time from symptom onset.
UPDATED
12/4/20
Zarifkar P, Kamath A, Robinson C, et al. | Clin Oncol
Aim: To review the current evidence base pertaining to the prevalence, presentation and outcome of COVID-19 in cancer patients, in order to inform policy and practice going forwards.
UPDATED
12/4/20
Alhumaid S, Al Mutair A, Al Alawi Z, et al. | Trop Med Infect Dis
Aim: To assess the efficacy and safety of lopinavir/ritonavir in COVID-19 patients in the extant published research.
UPDATED
12/4/20
Komolafe TE, Agbo J, Olaniyi EO, et al. | Diagnostics
Aim: To perform a meta-analysis to evaluate the diagnostic performance of chest CT, common CT morphological abnormalities, disease prevalence, biodata information, and gender prevalence of patients.
UPDATED
12/4/20
Zuercher SJ, Kerksieck P, Adamus C, et al. | Front Public Health
Aim: To review the evidence on MHP prevalence rates published since 2000, during and after epidemics, including the general public, health care workers, and survivors.
UPDATED
12/4/20
Torres-Castro R, Vasconcello-Castillo L, Alsina-Restoy X, et al. | Pulmonology
Aim: To determine the prevalence of restrictive pattern, obstructive pattern and altered diffusion in patients post-COVID-19 infection and to describe the different evaluations of respiratory function used with these patients.
UPDATED
12/3/20
Zhou S, Xu J, Xue C, et al. | Ren Fail
Aim: To review the evidence on kidney-related outcomes of three recent pandemics: SARS, MERS, and COVID-19, which were associated with potentially fatal acute respiratory distress syndrome (ARDS).
UPDATED
12/2/20
Zhou L, Wang J, Xie R, et al. | J Altern Complement Med
Aim: To assess the effects of TCM as an auxiliary treatment for COVID-19 through a systematic review of randomized-controlled trials (RCTs).
UPDATED
12/1/20
Yang J, Tian C, Chen Y, et al. | J Med Virol
Aim: To evaluate the impact of obesity on the onset, exacerbation, and mortality of coronavirus disease 2019 (COVID?19); and compare the effects of different degrees of obesity. 
UPDATED
CLINICAL CHARACTERISTICS
12/1/20
Schunemann HJ, Khabsa J, Solo K, et al. | Ann Intern Med
Aim: To review multiple streams of evidence regarding the benefits and harms of ventilation techniques for coronavirus infections, including that causing COVID-19.
UPDATED
11/30/20
Graber K, Byrne E, Goodacre E, et al. | Child Care Health Dev
Aim: To review of the impact of quarantine, isolation, or other restrictive environments on children’s play and whether play may mitigate the adverse effects of such restrictions.
UPDATED
11/30/20
Bell V, Wade D | Soc Psychiatr Epidemiol
Aim: To estimate the additional burden of working directly with infected patients during epidemic and pandemic health emergencies.
UPDATED
11/30/20
Hannum ME, Ramirez VA, Lipson SJ, et al. | Chem Senses
Aim: To provide a comprehensive assessment of methodologies currently employed to quantify smell loss in COVID-19–positive patients and examine whether method type affects reported prevalence of smell loss in COVID-19 patients.
UPDATED
11/30/20
Bareeqa SB, Ahmed SI, Samar SS, et al. | Int J Psychiatry Med
Aim: To quantify COVID-19 mental health issues and its prevalence in China during the early period of the COVID-19 crisis.
UPDATED
11/30/20
Azam M, Sulistiana R, Ratnawati M, et al. | Sci Rep
Aim: To estimate the incidence of recurrent SARS-CoV-2 RNA positivity after recovery from COVID-19 and to determine the factors associated with recurrent positivity. 
UPDATED
11/30/20
Jammu A, Chasen M, Lofters A, et al. | Support Care Cancer
Aim: To synthesise the available knowledge regarding the impact of the COVID-19 pandemic.
UPDATED
11/30/20
Allan SM, Bealey R, Birch J, et al. | Eur J Psychotraumatol
Aim: To estimate the prevalence of common mental health disorders in HCWs based in hospitals where pandemic-affected patients were treated.
UPDATED
11/30/20
Islam N, Salameh JP, Leeflang MMG, et al. | Cochrane Database Syst Rev
Aim: To determine the diagnostic accuracy of chest imaging (computed tomography (CT), X?ray and ultrasound) in people with suspected or confirmed COVID?19.
UPDATED
DIAGNOSTICS
11/27/20
Griffin J, Casey M, Collins Á, et al. | BMJ Open
Aim: To conduct a review of available evidence to advise on appropriate parameter values for serial interval and generation time in national COVID-19 transmission models for Ireland and on methodological issues relating to those parameters.
UPDATED
11/25/20
Karabay M, Ç?nar N, Karakaya Suzan Ö, et al. | J Matern Fetal Neonatal Med
Aim: To investigate the available evidence describing neonatal outcomes in newborns who have SARS-CoV-2 infection in order to guide prevention of COVID-19 in newborns.
UPDATED
INFECTION CONTROL
11/25/20
Kiss S, Gede N, Hegyi P, et al. | Med Microbiol Immunol
Aim: To review the evidence on the correlation between early changes in the laboratory parameters and the clinical outcomes of COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
11/25/20
Li B, Zhang S, Zhang R, et al. | Front Pediatr
Aim: To evaluate the epidemiological spectrum and clinical characteristics of children infected with SARS-CoV-2.
UPDATED
CLINICAL CHARACTERISTICS
11/25/20
Paul D, Gupta A, Maurya AK | PLoS One
Aim: To evaluate research done, prior to COVID-19 pandemic, on various decontamination methods for reprocessing of N95-FFRs.
UPDATED
INFECTION CONTROL
11/25/20
Nearchou F, Flinn C, Hennessy E, et al  | Int J Environ Res Public Health
Aim: To provide a systematic review of the evidence on the COVID-19 pandemic's impact on youth mental health.
UPDATED
MENTAL HEALTH
11/25/20
Jiménez D, García-Sanchez A, Rali P, et al. | Chest
Aim: To review the evidence on the incidence of VTE and bleeding among hospitalized patients with COVID-19?
UPDATED
CLINICAL CHARACTERISTICS
11/25/20
Saniasiaya J, Islam MA, Abdullah B | Laryngoscope
Aim: To estimate the overall pooled prevalence of olfactory dysfunction in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
11/25/20
Galanis P, Vraka I, Fragkou D, et al. | J Hosp Infect
Aim: To determine the seroprevalence of SARS-CoV-2 antibodies among HCWs, and to find out the factors that are associated with this seroprevalence.
UPDATED
CLINICAL CHARACTERISTICS
11/24/20
Novoa RH, Quintana W, Llancarí P, et al. | Travel Med Infect Dis
Aim: To review all cases from the current literature and provide up-to-date scientific evidence on the clinical characteristics, maternal outcomes, perinatal outcomes and the possibility of vertical transmission in the infected pregnant women.
UPDATED
CLINICAL CHARACTERISTICS
11/19/20
Sze S, Pan D, Nevill CR, et al. | EClinicalMedicine
Aim: To determine whether the risk of SARS-CoV-2 infection, COVID-19 intensive care unit (ICU) admission and mortality are associated with ethnicity. 
UPDATED
CLINICAL CHARACTERISTICS
11/19/20
Beaudry G, Zhong S, Whiting D, et al. | BMJ Glob Health
Aim: To synthesise the evidence on outbreaks of highly contagious diseases in prison.
UPDATED
INFECTION CONTROL
11/19/20
Yang J, Tian C, Chen Y, et al. | J Med Virol
Aim: To explore the relationship between obesity and COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
11/19/20
Li X, Liu C, Mao Z, et al. | Crit Care
Aim: To evaluate the predictive values of NLR on disease severity and mortality in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
11/19/20
Stegeman I, Ochodo EA, Guleid F, et al. | Cochrane Database Syst Rev
Aim: To assess the diagnostic accuracy of routine laboratory testing as a triage test to determine if a person has COVID?19.
UPDATED
DIAGNOSTICS
11/19/20
Wu T, Zou Z, Yang D, et al. | Age Aging
Aim: To explore the factors associated with prevalence of venous thromboembolism (VTE) in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
11/18/20
Serafim RB, Póvoa P, Souza-Dantas V, et al. | Clin Microbiol Infect
Aim: To describe the clinical course and outcomes of COVID-19 pneumonia in critically ill patients.
UPDATED
11/18/20
Kaye A, Siegel R | PeerJ
Aim: To investigate and synthesize existing evidence for the efficacy of TCZ in reducing COVID-19 mortality.
UPDATED
CANDIDATE THERAPEUTICS
11/16/20
Raharja A, Tamara A, Kok LT | J Racial Ethn Health Disparities
Aim: To review the association between ethnicity and poor Covid-19 outcomes including all-cause mortality, hospitalisation, critical care admission, respiratory and kidney failure.
UPDATED
CLINICAL CHARACTERISTICS
11/16/20
Wong CKH, Wong JYH, Tang EHM, et al. | Sci Rep
Aim: To investigate the comorbidities, symptoms, clinical characteristics and treatment of COVID-19 patients. 
UPDATED
CLINICAL CHARACTERISTICS
11/16/20
Juhasz MF, Ocskay K, Kiss S, et al. | World J Gastroenterol
Aim: To assess all the available evidence in the literature relating to coronavirus disease 2019 (COVID-19) and AP.
UPDATED
CLINICAL CHARACTERISTICS
11/16/20
Pant S, Perras C | CADTH
Aim: To describe the trial characteristics and estimated primary completion dates of the ongoing phase II, phase III, and phase IV studies evaluating drugs to prevent or treat COVID-19.
UPDATED
11/16/20
Pinedo-Torres I, Flores-Fernandez M, Yovera-Aldana M, et al. | Clin Med Insights Endocrinol Diabetes
Aim: To determine the prevalence of diabetes comorbidity and its associated unfavorable health outcomes in patients with acute respiratory syndromes for coronavirus disease according to virus types.
UPDATED
CLINICAL CHARACTERISTICS
11/11/20
Mahalingasivam V, Carik A, Tomlinson LA, et al. | Kidney Int Rep
Aim: To synthesise, analyse and appraise what has been learnt so far to help clinicians and policy makers better understand the risks to kidney transplant recipients, as well as identify gaps for future collaborative research for this global health challenge.
UPDATED
INFECTION CONTROL
11/11/20
Tleyjeh I, Kashour Z, Al Dosary O, et al. | Mayo Clin Proc Innov Qual Outcomes
Aim: To systematically review the literature and estimate the risk of cardiac toxicity in patients receiving CQ or HCQ for COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
11/9/20
Ren L, Xu W, Overton JL, et al. | Front Pharmacol
Aim: To examine the safety profiles of these medications, we systematically evaluated the adverse events (AEs) of these medications from published randomized controlled trials (RCTs).
UPDATED
CANDIDATE THERAPEUTICS
11/9/20
Pollock A, Campbell P, Cheyne J, et al | Cochrane Database Syst Rev
Aim: To assess the effects of interventions, and identify barriers and facilitators to implementing said interventions, aimed at supporting the resilience and mental health of frontline health and social care professionals during and after a disease outbreak, epidemic or pandemic.
UPDATED
MENTAL HEALTH
11/9/20
Jeevananthan C, Muhamed NA, Jafaar MH, et al. | BMJ Open
Aim: To identify the effects of temperature, humidity and air quality in the transmission of SARS-CoV-2 and to determine if the effects are linked to anthropic activities.
UPDATED
INFECTION CONTROL
11/9/20
Lebrasseur A, Fortin-Bedard N, Lettre J, et al.  | Disabil Health J
Aim: To review the impact of the COVID-19 pandemic, and associated isolation and protective measures, among people with physical disabilities.
UPDATED
MENTAL HEALTH
11/9/20
Aggarwal K, Agarwall A, Jaiswal N, et al.  | PLoS ONE
Aim: To evaluate the epidemiology and clinical features of ocular surface manifestations and complications related to COVID-19 infection, to assess the risk of transmission to patients and healthcare workers through ocular secretions and to determine whether ocular involvement has any correlation with the severity of respiratory symptoms and overall prognosis.
UPDATED
CLINICAL CHARACTERISTICS
11/9/20
Ssentongo A, Ssentongo P, Heilbrunn E, et al | Open Heart
Aim: To explore the association of RAAS inhibitors, including angiotensin-converting inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) with COVID-19 mortality in patients with hypertension. 
UPDATED
CLINICAL CHARACTERISTICS
11/9/20
Matsushita K, Ding N, Kou M, et al. | Glob Heart
Aim: To explore pre-existing CVD and its traditional risk factors as risk factors of severe COVID-19 (defined as death, acute respiratory distress syndrome, mechanical ventilation, or intensive care unit admission). 
UPDATED
CLINICAL CHARACTERISTICS
11/6/20
Mallett S, Allen J, Graziadio S, et al. | BMC Med
Aim: To examine at what time points during SARS?CoV?2 infection it is detectable at different anatomical sites using RT?PCR based tests.  
UPDATED
11/5/20
Mirza FN, Malik AA, Omer SB, et al. | Int J Dermatol
Aim: To collate the available information on the dermatologic manifestations in COVID?19 patients to inform current practice and further research.
UPDATED
11/4/20
Park R, Lee S, Kim SY, et al  | Acta Oncol
Aim: To summarize the existing evidence for the effect of active oncologic treatment on COVID-19 outcomes.
UPDATED
11/3/20
Mesas AE, Cavero-Redondo I, Alvarez-Bueno C, et al. | PLoS One
Aim: To synthesize the results of primary studies and provide pooled effect size estimators for a comprehensive set of potential predictors of in-hospital mortality in patients with confirmed COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
11/3/20
Lane MY, Winters N, Fregonese F, et al. | PLoS One
Aim: To conduct a systematic review and meta-analysis on the proportion of asymptomatic infection among coronavirus disease 2019 (COVID-19) positive persons and their transmission potential.
UPDATED
CLINICAL CHARACTERISTICS
11/2/20
Boregowda U, Perisetti A, Nanjappa A, et al. | Front Med
Aim: To compare the efficacy of tocilizumab in severe COVID-19 cases vs. standard of care alone.
UPDATED
11/2/20
Palaiodimos L, Chamorro-Pareja N, Karamanis D, et al. | Hormones
Aim: To systematically review and synthesize with a meta-analysis the available observational studies reporting the effect of diabetes in mortality among hospitalized patients with COVID-19.
UPDATED
11/2/20
Elsawah H, Elsokary M, Abdallah MS, et al. | Rev Med Virol
Aim: To systematically review the use of remdesivir in Covid?19 among the available clinical trials and summarise remdesivir efficacy.
UPDATED
11/2/20
Del Riccio M, Lorini C, Bonaccorsi G, et al. | Int J Environ Res Public Health
Aim: To review the association between seasonal influenza vaccination and the risk of SARS-CoV-2 infection or complicated illness or poor outcome (e.g. severe disease, need for hospitalization or ventilatory support, or death) among COVID-19 patients.
UPDATED
11/1/20
Lim JL, Reddy MP, Afroz A, et al. | Resuscitation
Aim: To evaluate the influence of the COVID-19 pandemic on the incidence, process, and outcomes of OHCA.
UPDATED
CLINICAL CHARACTERISTICS
10/31/20
Sanghera J, Pattani N, Hashmi Y, et al. | J Occup Health
Aim: To determine the impact of SARS?CoV?2 on mental health outcomes of hospital?based HCWs and formulate recommendations for future action.
UPDATED
MENTAL HEALTH
10/30/20
Arora T, Grey I, Ostlundh L, et al. | J Health Psychol
Aim: To examine the overall prevalence of psychological health outcomes during COVID-19. 
UPDATED
MENTAL HEALTH
10/29/20
Khan M, Khan N, Mustagir G, et al. | J Glob Health
Aim: To summarize pre-existing comorbidities in patients with COVID-19, and to estimate the likelihood of mortality from COVID-19 with each category of pre-existing comorbidities.
UPDATED
CLINICAL CHARACTERISTICS
10/29/20
Milby KM, Atallah AN, Rocha-Filho CR, et al. | Sao Paulo Med J
Aim: To understand and summarize the evidence relating to clinical manifestations, disease severity and prognoses among patients coinfected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and arboviruses.
UPDATED
CLINICAL CHARACTERISTICS
10/27/20
Budhathoki P, Shrestha DB, Rawal E, et al. | SN Compr Clin Med
Aim: To assess the rationality on the use of corticosteroids in COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
10/26/20
Weatherald J, Solverson K, Zuege DJ, et al. | J Crit Care
Aim: To quickly identify and synthesize studies examining the effect of awake prone positioning on patients with hypoxemic respiratory failure (including those with ARDS and/or COVID-19).
UPDATED
CANDIDATE THERAPEUTICS
10/26/20
Yee JY, Kim WK, Han JMH, et al. | Sci Rep
Aim: To evaluate the impact of COVID-19 on pregnant women.
UPDATED
CLINICAL CHARACTERISTICS
10/26/20
Javanmardi F, Keshavarzi A, Akbari A, et al. | PLoS One
Aim: To evaluate the prevalence of underlying disease in died people with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/23/20
Wang JG, Cui HR, Tang HB, et al. | Sci Rep
Aim: To understand the clinical manifestations and incidence of gastrointestinal symptoms of Coronavirus disease (COVID-19) in children and discuss the importance of fecal nucleic acid testing.
UPDATED
CLINICAL CHARACTERISTICS
10/22/20
Fong V, Iarocci G | J Pediatr Psychol
Aim: To evaluate the quality of existing studies on this topic, determine what is known about mental health outcomes and needs of children and families, and provide recommendations for how COVID-19 policies can best support children and families
UPDATED
MENTAL HEALTH
10/22/20
Hernandez AV, Roman YM, Pasupuleti V, et al. | Ann Intern Med
Aim: To summarize evidence about the benefits and harms of hydroxychloroquine or chloroquine for the treatment or prophylaxis of coronavirus disease 2019 (COVID-19).
UPDATED
CANDIDATE THERAPEUTICS
10/22/20
Perras C, Pohar S, Manoharan A, et al. | CADTH
Aim: To review the current scientific evidence on the potential benefits and harms of remdesivir.
UPDATED
10/21/20
Leisman DE, Ronner L, Pinotti R, et al. | Lancet Respir Med
Aim: To synthesise and describe the reported pattern of inflammatory cytokines in COVID-19-induced respiratory failure and to compare this profile with those of other acute inflammatory syndromes.
UPDATED
CLINICAL CHARACTERISTICS
10/21/20
Kefale B, Tegegne GT, Degu A, et al. | Clin Appl Thromb Hemost
Aim: To investigate the extent and risk factors of thromboembolism among COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
10/21/20
Xu J, Teng Y, Shang L, et al. | Clin Infect Dis
Aim: To provide a comprehensive summarization of current evidence to answer two major clinical questions: (1) Does the prior treatment of ACEI/ARB alter the susceptibility of SARS-CoV-2 infection in general population? (2) Does the prior treatment of ACEI/ARB affect risk of mortality and severe outcomes in COVID-19 patients?
UPDATED
CLINICAL CHARACTERISTICS
10/20/20
Kotecha P, Light A, Checcucci E, et al. | Panminerva Med
Aim: To evaluate the data currently available regarding the repurposing of different drugs for Covid-19 treatment. 
UPDATED
CANDIDATE THERAPEUTICS
10/19/20
Liu Y, Lu H, Wang W, et al. | Expert Rev Anticancer Ther
Aim: To identify the risk factors for death in patients with cancer and COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/19/20
Mulchandani R, Lyngdoh T, Kakkar AK | Eur J Clin Invest
Aim: To quantify the differences in the circulating levels of major inflammatory and immunological markers between severe and non?severe COVID?19 patients.
UPDATED
CLINICAL CHARACTERISTICS
10/19/20
Ortega KL, Rech BO, El Haje GLC, et al. | J Hosp Infect
Aim: To review the evidence on whether hydrogen peroxide mouthwash has a virucidal effect.
UPDATED
INFECTION CONTROL
10/19/20
Abate SM, Mantefardo B, Basu B | Patient Saf Surg
Aim: To provide the global prevalence of perioperative outcomes of patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/19/20
Chamseddine RS, Wahbeh F, Chervenak F, et al. | J Pregnancy
Aim: To review the evidence on preinatal and obstetric management in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/19/20
Raschetti R, Vivanti AJ, Vauloup-Fellous C, et al. | Nat Commun
Aim: To clarify the main transmission route, clinical features and outcomes of neonatal SARS-CoV-2 infections
UPDATED
CLINICAL CHARACTERISTICS
10/19/20
Ramaraj P, Super JT, Doyle R, et al. | BMJ Open
Aim: To review the evidence behind UK Government PPE guidance on surgical masks versus respirators for SARS-CoV-2 protection.
UPDATED
INFECTION CONTROL
10/15/20
Gonzalez-Rubio J, Navarro-Lopez C, Lopez-Najera E, et al. | Int J Environ Res Public Health
Aim: To review the evidence on the epidemiologic relationship between smoking and COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/15/20
Chu IY, Alam P, Larson H, et al. | J Travel Med
Aim: To identify: 1) the social consequences of mass quarantine—community-wide movement restrictions—during previous and current infectious disease outbreaks, and 2) recommended strategies to mitigate the negative social implications of COVID-19 lockdowns. 
UPDATED
MENTAL HEALTH
10/13/20
Bansal A, Singh AD, Jain V, et al. | Heart Lung
Aim: To determine if D-dimers are elevated in individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who have adverse clinical outcomes including all-cause mortality, intensive care unit (ICU) admission or acute respiratory distress syndrome (ARDS).
UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Banakar M, Lankarani KB, Jafarpour D, et al. | BMC Oral Health
Aim: To examine the risk of the transmission of the COVID–19 during dental treatments and provides pathways and protective protocols to minimize them, bearing in mind the long-term necessity of actions and realistic, practical measures.
UPDATED
INFECTION CONTROL
10/13/20
Roshandel R, Nateqi M, Lak R, et al. | Cell Mol Biol
Aim: To review the evidence on the diagnostic and methodological evaluation of urinary shedding of SARS-CoV-2.
UPDATED
DIAGNOSTICS
10/13/20
Kashour ZT, Riaz M, Garbati M, et al. | J Antimicrob Chemother
Aim: To systematically evaluate the effect of CQ and HCQ with or without azithromycin (AZ) on outcomes of COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
10/13/20
Tamuzi JL, Ayele BT, Shumba CS, et al. | BMC Infect Dis
Aim: To review different studies on SARS-CoV, MERS-CoV or COVID-19 associated with HIV/TB co-infection or only TB and to understand the interactions between HIV, TB and COVID-19 and its implications on the burden of the COVID-19 among HIV/TB co-infected or TB patients, screening algorithm and clinical management.
UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Malaty M, Kayes T, Amarasekera AT, et al. | Eur J Clin Invest
Aim: To examine the current incidence and available treatment for arrhythmias in hospitalized patients with SARS-CoV-2 infection.
UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Nopp S, Moik F, Jilma B, et al. | Res Pract Thromb Haemost
Aim: To evaluate available data and estimating the prevalence of VTE in COVID?19 patients.
UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Elsayed S, Reddy M, Murthy PM, et al. | Cureus
Aim: To identify the trends of COVID-19 relapse, the effects of co-morbidities on it, and associated mortality rates.
UPDATED
CLINICAL CHARACTERISTICS
10/8/20
Henssler J, Stock F, van Bohemen J, et al. | Eur Arch Psychiatry Clin Neurosci
Aim: To assess the psychological effects in both quarantined and isolated persons compared to non-quarantined and non-isolated persons. 
UPDATED
MENTAL HEALTH
10/8/20
Choi GJ, Kim HM, Kang H, et al. | J Lipid Atheroscler
Aim: To analyze the available knowledge about the potential association between dyslipidemia and the severity of coronavirus disease 2019 (COVID-19) as reported in previous published systematic reviews.
UPDATED
CLINICAL CHARACTERISTICS
10/7/20
Setiati S, Harimurti K, Safitri ED, et al | Acta Med Indones
Aim: To systematically review all relevant studies related to the risk factors and laboratory test results associated with severe illness and mortality in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
10/6/20
Cheng W, Li Y, Cui L, et al. | Front Pharmacol
Aim: To evaluate the efficacy and safety of corticosteroid therapy in patients with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
10/5/20
Meyerowitz-Katz G, Merone L | Int J Infect Dis
Aim: To review the evidence on infection-fatality rates for COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/5/20
Tlayjeh H, Mhish O, Enani M, et al. | J Infect Public Health
Aim: To systematically review the literature about the association between systemic corticosteroid therapy (CST) and outcomes of COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
10/5/20
Moutchia J, Pokharel P, Kerri A, et al. | PLoS One
Aim: To assess clinical laboratory parameters which may serve as markers or predictors of severe or critical COVID-19.
UPDATED
DIAGNOSTICS
10/5/20
Soeroto AY, Soetedjo NN, Purwiga A, et al. | Diabetes Metab Syndr
Aim: To evaluate the association between obesity and composite poor outcome in coronavirus disease 2019 (COVID-19) patients.
UPDATED
CLINICAL CHARACTERISTICS
10/5/20
Jarrom D, Elston L, Washington J, et al. | BMJ Evid Based Med
Aim: To identify evidence on: (1) the clinical effectiveness of tests that detect the presence of severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) to inform COVID?19 diagnosis? and (2) the clinical effectiveness of tests that detect the presence of antibodies to the SARS?CoV?2 virus to inform COVID?19 diagnosis.
UPDATED
DIAGNOSTICS
10/2/20
Carrillo-Larco RM, Altez-Rodriguez C, Ravaglia S, et al. | Wellcome Open Res
Aim: To understand the characteristics of patients with COVID-19 and GBS, and to identify potential patterns.
UPDATED
CLINICAL CHARACTERISTICS
10/2/20
Oliviera Silva DF, Cunha Lima SC, Mauricio Sena-Evangelista KC, et al. | Nutrients
Aim: To identify the screening instruments that can be used to assess nutritional risk in older adults with COVID-19, and to clarify their measurement properties.
UPDATED
CLINICAL CHARACTERISTICS
10/2/20
Flumignan RLG, de Sa Tinoco JD, Pascoal PIF, et al. | Cochrane Database Syst Rev
Aim: To assess the effects of prophylactic anticoagulants versus active comparator, placebo or no intervention, on mortality and the need for respiratory support in people hospitalised with COVID?19.
UPDATED
CANDIDATE THERAPEUTICS
9/29/20
Morone G, Palomba A, Iosa M, et al.  | Front Med
Aim: To correlate the presence and the relevant temporal patterns of SARS-CoV-2 viral RNA in biological specimens (stool, urine, blood, and tears) of the transmission with clinical/epidemiological features in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/28/20
Shrestha DB, Pudhathoki P, Khadka S, et al. | Virol J
Aim: To review the efficacy and safety of favipiravir triphosphate as a treatment for COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
9/28/20
Rios P, Radhakrishnan A, Williams C, et al. | Syst Rev
Aim: to examine the current guidelines for infection prevention and control (IPAC) of coronavirus disease-19 (COVID-19) or other coronaviruses in adults 60 years or older living in long-term care facilities (LTCF).
UPDATED
INFECTION CONTROL
9/28/20
Viner RM, Mytton OT, Bonell C, et al. | JAMA Pediatr
Aim: To review the evidence on the susceptibility to and transmission of SARS-CoV-2 by children and adolescents compared with adults.
UPDATED
INFECTION CONTROL
9/24/20
Lim MA, Pranata R | J Clin Orthop Trauma
Aim: To evaluate the prevalence of coronavirus disease 2019 (COVID-19) and its impact on mortality in patients with hip fracture.
UPDATED
CLINICAL CHARACTERISTICS
9/24/20
Wang M, Wu T, Zuo Z, et al. | BMJ Support Palliat Care
Aim: To summarize the efficacy and safety of antiviral agents currently in use for COVID-19 treatment.
UPDATED
CANDIDATE THERAPEUTICS
9/24/20
Gulsen A, Yigitbas BA, Uslu B, et al. | Pulm Med
Aim: To determine the relationship between smoking and clinical COVID-19 severity via a systematic meta-analysis approach.
UPDATED
CLINICAL CHARACTERISTICS
9/23/20
O'Reilly A, Tibbs M, Booth A, et al. | Ir J Psychol Med
Aim: To summarise existing evidence on the potential impact of a pandemic on the mental health of 12-25-year-olds.
UPDATED
MENTAL HEALTH
9/21/20
Huang AT, Garcia Carreras B, Hitchings MDT, et al. | Nat Commun
Aim: To review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). 
UPDATED
CLINICAL CHARACTERISTICS
9/21/20
Mecenas P, da Rose Moreira Bastos RT, Vallinoto ACR, et al. | PLoS One
Aim: To describe current knowledge about the emergence and replicability of the virus and its connection with different weather factors such as temperature and relative humidity.
UPDATED
INFECTION CONTROL
9/17/20
Dambha-Miller H, Albasri A, Hodgson S, et al. | BMJ Open
Aim: To review evidence on routinely prescribed drugs in the UK that could upregulate or downregulate ACE2 and potentially affect COVID-19 disease.
UPDATED
CANDIDATE THERAPEUTICS
9/17/20
Wang Y, Ao G, Qi X, et al  | Clin Exp Allergy
Aim: To review the evidence on the association of asthma with risk of severe or fatal COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/17/20
Christophers B, Marin BG, Oliva R et al. | Pediatr Res
Aim: To describe the clinical presentation and outcomes of pediatric patients using an individual patient data approach to visualize trends by age.
UPDATED
CLINICAL CHARACTERISTICS
9/15/20
Cheruiyot I, Henry B, Lippi G, et al. | Acta Biomed
Aim: To assess whether AKI may be associated with worse prognosis and increased mortality in COVID-19 patients
UPDATED
9/15/20
Peres KC, Riera R, Martimbianco ALC, et al. | Front Endocrinol
Aim: To investigate a possible association between body weight and prognosis among patients diagnosed with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/15/20
Siepmann T, Sedghi A, Simon E, et al. | Eur J Neurol
Aim: To define the risk of acute stroke in patients with severe and non-severe COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/15/20
Ahmed M, Advani S, Moreira A, et al. | EClinicalMedicine
Aim: To describe the typical presentation and outcomes of children diagnosed with this hyperinflammatory condition.
UPDATED
CLINICAL CHARACTERISTICS
9/14/20
Di Maria E, Latini A, Borgiani P, et al. | Human Genomics
Aim: To review the evidence on genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS, and COVID-19).
UPDATED
CLINICAL CHARACTERISTICS
9/14/20
Panda PK, Sharawat IK, Panda P, et al. | J Trop Pediatr
Aim: To review the evidence on the neurological manifestations of COVID-19 in children.
UPDATED
CLINICAL CHARACTERISTICS
9/14/20
Nussbaumer-Streit B, Mayr V, Dobrescu AI, et al. | Cochrane Database of Systematic Reviews
Aim: To assess the effects of quarantine (alone or in combination with other measures) of individuals who had contact with confirmed cases of COVID19, who travelled from countries with a declared outbreak, or who live in regions with high transmission of the disease.
UPDATED
WHO COLLABORATIVE
INFECTION CONTROL
9/11/20
Czumbel LM, Kiss S, Farkas N, et al. | Front Med
Aim: To conduct a meta-analysis on the reliability and consistency of SARS-CoV-2 viral RNA detection in saliva specimens.
UPDATED
DIAGNOSTICS
9/11/20
Seidu S, Gillies C, Zaccardi F, et al. | Endocrinol Diabetes Metab
Aim: To determine whether people with overweight or obesity and with SARS?CoV?2 have different outcomes compared to those within normal weight thresholds.
UPDATED
CLINICAL CHARACTERISTICS
9/9/20
Razmi M, Hashemi F, Gheytanchi E, et al. | Int Immunopharmacol
Aim: To assess the available data regarding the efficacy of the immunomodulatory drugs used to manage COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
9/8/20
Elavarasi A, Prasad M, Seth T, et al. | J Gen Intern Med
Aim: To synthesize the available data on the efficacy and safety of CQ and HCQ for the treatment of COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
9/4/20
Rees EM, Nightingale ES, Jafari Y, et al. | BMC Med
Aim: To review estimates of how long patients with COVID-19 need different levels of hospital care.
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
Martin A, Blom IM, Whyatt G, et al. | Disaster Med Public Health Prep
Aim: To explore the involvement of medical students in past global health emergencies, to help inform current and future scenarios.
UPDATED
9/3/20
Caldeira D, Alves M, Melo RGE, et al. | Int J Cardiol Heart Vasc
Aim: To systematically evaluate the risk of COVID-19 infection and the risk of severe COVID-19 disease associated with previous exposure to (ACEi) and/or ARB).
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
Liu C, He Y, Liu L, et al. | BMC Pediatr
Aim: To review the evidence on the characteristics of children with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
Sergeant A, van Reekum EA, Sanger N, et al. | BMJ Open
Aim: To study the effect of pandemics and epidemics on mental health outcomes for people with premorbid mental disorders.
UPDATED
9/3/20
Costenaro P, Minotti C, Barbieri E, et al. | Rev Med Virol
Aim: To review the current knowledge on SARS-CoV-2 cases in PLWHA.
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
de Almeida-Pititto B, Dualib PM, Zajdenverg L, et al. | Diabetol Metab Syndr
Aim: To evaluate the association of diabetes, hypertension, cardiovascular disease and ACEI/ARBs exposure with severity–intensive care unit treatment or mechanical ventilation necessity or O2 saturation?
UPDATED
CLINICAL CHARACTERISTICS
8/31/20
Ssentongo P, Ssentongo AE, Heilbrunn ES, et al. | PLoS ONE
Aim: To estimate the association of pre-existing comorbidities with COVID-19 mortality.
UPDATED
CLINICAL CHARACTERISTICS
8/31/20
Fiolet T, Guihur A, Rebeaud M, et al. | Clin Microbiol Infect
Aim: To assess whether chloroquine or hydroxychloroquine with or without azithromycin decreased COVID-19 mortality compared to the standard of care.
UPDATED
CANDIDATE THERAPEUTICS
8/29/20
Kelada M, Anto A, Dave K, et al. | Cureus
Aim: To assess the role of sex in the risk of mortality from COVID-19 in adult patients through comparison of clinical markers and inflammatory indexes.? 
UPDATED
CLINICAL CHARACTERISTICS
8/27/20
Braithwaite I, Callender T, Bullock M, et al. | Lancet Digit Health
Aim: To assess the effectiveness of automated and semi-automated digital tools for contact tracing, and identify key considerations for successful implementation, to inform the control of COVID-19. 
UPDATED
INFECTION CONTROL
8/27/20
Coomes EA, Haghbayan H | Rev Med Virol
Aim: To assess the evidence describing IL-6 response in patients with COVID-19 and the existing and planned studies investigating the efficacy of tocilizumab to guide patient management, clarify guideline development, and inform future trials in this field.
UPDATED
CLINICAL CHARACTERISTICS
8/27/20
Gertsman S, Agarwal A, O'Hearn K, et al. | J Hosp Infect
Aim: To collect and synthesize existing information on decontamination of N95 filtering facepiece respirators (FFRs) using microwave and heat-based treatments, with special attention to impact on mask function (aerosol penetration, airflow resistance), fit, and physical traits.
UPDATED
INFECTION CONTROL
8/25/20
Baral R, White M, Vassiliou VS | Curr Atheroscler Rep
Aim: To review the evidence on the impact RAAS inhibitor use has in antihypertensive COVID-19 hospitalised patients.
UPDATED
CANDIDATE THERAPEUTICS
8/23/20
Jovic TH, Ali SR, Ibrahim N, et al. | Nutrients
Aim: To investigate whether vitamin supplementation is beneficial in COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
8/21/20
Taneri PE, Ochoa S, Llanaj E, et al. | Eur J Epidemiol
Aim: To evaluate biomarkers of anemia and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and prevalence of anemia) in patients diagnosed with COVID-19, and explore their prognostic value. 
UPDATED
CLINICAL CHARACTERISTICS
8/15/20
Nasiri MJ, Haddadi S, Tahvildari A, et al.  | Front Med
Aim: To better understand role of the sex in mortality of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
8/14/20
de Moura DTH, McCarty TR, Ribeiro IB, et al. | Clinics (Sao Paulo)
Aim: To perform a structured systematic review and meta-analysis to evaluate the diagnostic characteristics of serological-based COVID-19 testing.
UPDATED
DIAGNOSTICS
8/12/20
Davalbhakta S, Advani S, Kumar S, et al. | J Med Syst
Aim: To provide an overview of mobile applications being currently utilized for COVID-19 related activities.
UPDATED
INFECTION CONTROL
8/12/20
Moosavi SA, Mashhadiagha A, Hashemazar A, et al. | Transpl Infect Dis
Aim: to conduct a systematic review on COVID?19 clinical manifestations and treatment strategies in SOT recipients.
UPDATED
CLINICAL CHARACTERISTICS
8/11/20
Jones L, Candy B, Roberts N, Ondruskova T, et al | Oxford COVID-19 Evidence Service
Aim: To review the evidence on the management of delirium in patients with COVID-19 and the use of non-pharmacological approaches outside of critical care settings.
UPDATED
8/11/20
Licina A, Silvers A, Stuart RL  | Syst Rev
Aim: To evaluate the effect of powered air-purifying respirators (PAPRs) as part of respiratory protection versus another device (egN95/FFP2) on HCW infection rates and contamination.
UPDATED
8/9/20
Cui X, Zhao Z, Zhang T, et al. | J Med Virol
Aim: To provide a comprehensive and systematic analysis of demographic characteristics, clinical symptoms, laboratory findings and imaging features of coronavirus disease 2019 (COVID-19) in pediatric patients.
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Jutzeler CR, Bourguignon L, Weis CV, et al. | Travel Med Infect Dis
Aim: To gather all available information regarding comorbidities, clinical signs and symptoms, outcomes, laboratory findings, imaging features, and treatments in patients with coronavirus disease 2019 (COVID-19).
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Hoang A, Chorath K, Moreira A, et al. | EClinicalMedicine
Aim: To characterize clinical symptoms, laboratory, and imaging findings, as well as therapies provided to confirmed pediatric cases of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Wu T, Zuo Z, Deng M | Aging Dis
Aim: To provide systematic evidence for the association between multiorgan dysfunction and COVID-19 development.
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Samaranayake L, Fakhruddin K, Panduwawala C | Acta Odontol Scand
Aim: To evaluate the contemporary evidence on dysgeusia and anosmia as trigger prodromal symptoms, and their prevalence in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Barochiner J, Martinez R | J Clin Pharm Ther
Aim: To compare the occurrence of severe and fatal COVID-19 in infected patients who were under treatment with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) vs no treatment or other antihypertensives.
UPDATED
CANDIDATE THERAPEUTICS
8/9/20
Baladia E, Pizarro AB, Ortiz-Munoz L, et al. | Medwave
Aim: To provide a timely, rigorous, and continuously updated summary of the available evidence on the role of vitamin C in treating patients with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
8/7/20
Chi G, Lee JJ, Jamil A, et al. | J Clin Med
Aim: To offer benchmark data on the incidence of VTE and to examine the difference in D-dimer levels among anticoagulated COVID-19 patients with and without VTE incident. 
UPDATED
CANDIDATE THERAPEUTICS
8/6/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the extended use or re-use of personal protective equipment (PPE) during COVID-19.
UPDATED
8/5/20
Kumar A, Arora A, Sharma P, et al. | Indian J Gastroenterol
Aim: To determine the frequency of GI and hepatic manifestations of COVID-19 and to explore their relationship with severe clinical course.
UPDATED
8/5/20
Ghahramani S, Tabrizi R, Lankarani KB, et al. | Eur J Med Res
Aim: To understand the common laboratory features of COVID-19 in severe cases versus non-severe patients could be quite useful for clinicians and might help to predict the model of disease progression.
UPDATED
8/5/20
Reddy RK, Charles WN, Sklavounos A, et al. | J Med Virol
Aim: To rigorously and definitively quantify the effects of smoking on COVID-19 severity.
UPDATED
8/4/20
Gao Y, Ye L, Zhang J, et al. | BMC Infect Dis
Aim: To systematically review the clinical features and outcomes of pregnant women with COVID-19.
UPDATED
8/3/20
Sales-Peres SHC, de Azevedo-Silva LJ, Bonato RCS, et al. | Obes Res Clin Pract
Aim: To investigate the relationship between coronavirus disease 2019 (COVID-19) and obesity in critically ill patients admitted to the intensive care unit (ICU).
UPDATED
CLINICAL CHARACTERISTICS
8/3/20
Carlo D, Montemurro N, Petrella G, et al. | J Neurol
Aim: To review the evidence on the spectrum of neurological symptoms experienced by COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
8/1/20
Akbari H, Tabrizi R, Lankarani KB, et al. | Life Sci
Aim: To make a comparison between the clinical laboratory-related factors, complete blood count (CBC) indices, cytokines, and lymphocyte subsets in order to distinguish severe coronavirus disease 2019 (COVID-19) cases from the non-severe ones.
UPDATED
CLINICAL CHARACTERISTICS
8/1/20
Monaghesh E, Hajizadeh A | BMC Public Health
Aim: To identify the role of telehealth services during COVID-19 outbreak.
UPDATED
INFECTION CONTROL
7/31/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on how long the virus can survive with potential for infection on surfaces.
UPDATED
7/31/20
Mitchell S, Maynard V, Lyons V, et al | Palliat Med
Aim: To synthesise existing evidence related to the delivery of palliative and end-of-life care by primary healthcare professionals in epidemics and pandemics.
UPDATED
7/30/20
Figliozzi S, Masci P, Ahmadi N, et al. | Eur J Clin Invest
Aim: To review available evidence and provide pooled estimates on predictors of clinical outcomes in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/28/20
Radulesco T, Lechien JR, Sowerby L, et al. | Eur Arch Otorhinolaryngol
Aim: To summarize recommendations for sinus and anterior skull base surgery during the COVID-19 pandemic.
UPDATED
INFECTION CONTROL
7/27/20
Bwire GM, Majigo MV, Nijiro BJ, et al. | J Med Virol
Aim: To profile the positive detection rate from different clinical specimens using PCR to guide the selection of specimens for clinical diagnosis of COVID-19.
UPDATED
DIAGNOSTICS
7/24/20
Venkatesulu BP, Chandrasekar VT, Giridhar P, et al. | J Med Virol
Aim: To do a systematic review and critical appraisal of the ongoing clinical trials that are assessing various therapeutic interventions against SARS-CoV-2 with an aim to provide insight into the various interventions tested, clinical rationale, geographical distribution of the trials as well as the endpoints assessed in the studies.
UPDATED
CANDIDATE THERAPEUTICS
7/20/20
Cortegiani A, Ingoglia G, Ippolito M, et al. | J Crit Care
Aim: To evaluate the efficacy and safety of chloroquine and chloroquine-related formulations in patients with SARS-CoV-2 pneumonia and articles describing related in-vitro studies.
UPDATED
CANDIDATE THERAPEUTICS
7/20/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the efficacy of face masks in helping to prevent the spread of COVID-19.
UPDATED
7/19/20
Pormohammad A, Ghorbani S, Baradaran B, et al. | Microb Pathog
Aim: To evaluate the clinical features and laboratory findings using a large sample size of COVID-19 infected patients in order to assist in its understanding, prevention and treatment.
UPDATED
CLINICAL CHARACTERISTICS
7/18/20
Verdugo-Paiva F, Izcovich A, Ragusa M, et al. | Medwave
Aim: To provide a timely, rigorous, and continuously updated summary of the evidence on the role of lopinavir/ritonavir in the treatment of patients with COVID-19.
UPDATED
7/17/20
Greco A, Buccheri S, D'Arrigo P, et al. | Eur Heart J Cardiovasc Pharmacother
Aim: To review the evidence on the impact of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on the clinical outcomes of COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
7/17/20
Galbadage T, Peterson BM, Awada J, et al. | Front Med
Aim: To examine the association between male sex and COVID-19 severity.
UPDATED
CLINICAL CHARACTERISTICS
7/16/20
Shah S, Shah K, Patel SB, et al. | Cardiol Rev
Aim: To investigate the prognostic role of D-dimer in COVID-19 infected patients. 
UPDATED
CLINICAL CHARACTERISTICS
7/15/20
Chandrasekar VT, Venkatesalu B, Patel HK, et al. | J Med Virol
Aim: To assess if any intervention provides mortality benefit, other clinically relevant outcomes and also ascertain the safety profile.
UPDATED
CANDIDATE THERAPEUTICS
7/14/20
de Pablo GS, Vaquerizo-Serrano J, Catalan A, et al. | J Affect Disord
Aim: To review the evidence on the impact of SARS/MERS/COVID-19 on physical and mental health outcomes of health care workers.
UPDATED
INFECTION CONTROL
7/11/20
Abate S, Ali S, Mantedafro B, et al. | PLoS One
Aim: To investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus.
UPDATED
CLINICAL CHARACTERISTICS
7/10/20
Kunutsor S, Laukkanen J | Ann Med
Aim: To evaluate renal complications of COVID-19 and their incidence using a systematic meta-analysis.
UPDATED
CLINICAL CHARACTERISTICS
7/10/20
Kernohan A, Calderon M | Oxford COVID-19 Evidence Service
Aim: To review the evidence on risk factors or management of VTE.
UPDATED
7/8/20
Lvliang L, Zhong W, Bian Z, et al. | J Infect
Aim: To compare mortality risk factors of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) to provide new strategies for COVID-19 prevention and treatment.
CLINICAL CHARACTERISTICS
7/8/20
Kulkarni A, Kumar P, Tevethia HV, et al. | Aliment Pharmacol Ther
Aim: To assess the prevalence of CLD, the incidence of elevated liver chemistries and the outcomes of patients with and without underlying CLD/elevated liver chemistries in COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/8/20
Pan D, Sze S, Minhas J, et al. | EClinicalMedicine
Aim: To assess whether ethnicity has been reported in patients with COVID-19 and its relation to clinical outcomes.
UPDATED
CLINICAL CHARACTERISTICS
7/6/20
Kumar-M P, Mishra S, Jha DK, et al. | Hepatol Int
Aim: To systematically study the occurrence of liver injury in COVID-19 and also determine the frequency of liver involvement in COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/3/20
Bastos M, Tavaziva G, Abidi SK, et al. | BMJ
Aim: To determine the diagnostic accuracy of serological tests for coronavirus disease-2019 (covid-19).
UPDATED
DIAGNOSTICS
7/3/20
Spencer EA, Brassey J, Jefferson T, et al. | Oxford COVID-19 Evidence Service
Aim: To explore if climate conditions may influence the spread of SARS-CoV-2.
UPDATED
6/30/20
Armstrong RA, Kane AD, Cook TM | Anaesthesia
Aim: To assess the reported ICU mortality for patients with confirmed COVID?19.
UPDATED
CLINICAL CHARACTERISTICS
6/26/20
Duan-Porter W | VA Evidence Synthesis Program
Aim: To explore the length of stay in the intensive care unit (ICU) and time on invasive mechanical ventilation for adult patients with COVID-19.
UPDATED
VA ESP
6/25/20
Tahvildari A, Arbabi M, Farsi Y, et al. | Front Med
Aim: To characterize the clinical, diagnostic, and treatment characteristics of patients presenting with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
6/25/20
Qureshi Z, Jones N, et al. | Oxford COVID-19 Evidence Service
Aim: To identify the evidence behind the 2-metre social distancing rule in the context of the still used large vs. small (droplet vs airborne) droplet size dichotomy in route of transmission.
UPDATED
6/23/20
Gao Y, Liu R, Zhou Q, et al. | Ann Transl Med
Aim: To assess the effectiveness of telemedicine in reducing transmission of COVID-19 and reducing pressure on medical institutions.
UPDATED
6/23/20
Yang N, Che S, Zhang J, et al. | Ann Transl Med
Aim: To conduct a rapid review of mother-to-child transmission of COVID-19 during breastfeeding.
UPDATED
6/23/20
Lv M, Wang M, Yang N, et al. | Ann Transl Med
Aim: To understand the role of CT for the diagnosis and the main imaging manifestations of patients with COVID-19.
UPDATED
DIAGNOSTICS
6/23/20
Wang Z, Zhou Q, Wang C, et al. | Ann Transl Med
Aim: To review the clinical characteristics of children with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
6/23/20
Lu S, Zhou Q, Huang L, et al. | Ann Transl Med
Aim: To review the evidence on the use of glucocorticoids in treating COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Zhang J, Yang Y, Yang N, et al. | Ann Transl Med
Aim: To explore the clinical effectiveness and safety of IVIG in the treatment of children with severe COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Wang J, Tang Y, Ma Y, et al. | Ann Transl Med
Aim: To evaluate the efficacy and safety of antibiotic agents in children with COVID-19, as well as to introduce the present situation of antibiotics use and bacterial coinfections in COVID-19 patients. 
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Zhou Q, Gao Y, Wang X, et al. | Ann Transl Med
Aim: To understand nosocomial infection in patients with COVID-19, SARS, and MERS.
UPDATED
6/23/20
Shi Q, Zhou Q, Wang X, et al. | Ann Transl Med
Aim: To assess the potential effectiveness and safety of antiviral agents for COVID-19 in children. 
UPDATED
CANDIDATE THERAPEUTICS
6/22/20
Goodarzi Z, Watt J, Kirkham J, et al | CIHR IRSC
Aim: To review the evidence on the effect of telehealth interventions on depression or depressive symptoms in older adults.
UPDATED
6/21/20
Ghannam MG, Alshaer QA, Al-Chalabi MAC, et al. | J Neurol
Aim: To clarify the neurological complications of SARS-CoV-2 infection including the potential mechanisms and therapeutic options.
UPDATED
6/20/20
Maldonado E, Tao D, Mackey K | J Gen Intern Med
Aim: To synthesize evidence on thromboembolism incidence and outcomes with antithrombotic therapies in COVID-19.
UPDATED
VA ESP
CANDIDATE THERAPEUTICS
6/20/20
Castro-Rodriguez JA, Forno E | Pediatr Pulmonol
Aim: To review the evidence on the role of asthma in children with COVID-19 and the risk of infection.
UPDATED
6/18/20
Tabari P, Amini M, Moghadami M, et al. | Iran J Med Sci
Aim: To determine countries’ public responses to the epidemic of COVID-19 and how they developed administrative approaches towards the outbreak.
UPDATED
6/18/20
Novara G, Checcucci E, Crestani A, et al. | Eur Urol
Aim: To perform a systematic review of the literature and evaluate all the available studies on urological applications of telehealth.
UPDATED
INFECTION CONTROL
6/17/20
Grover A, Oberoi M | Eur Heart J Cardiovasc Pharmacother
Aim: To review the evidence on the continued use of angiotensin converting enzyme inhibitors (ACEI) and angtiotensin receptor blockers (ARBs) in patients with COVID-19.
UPDATED
6/17/20
Agarwal A, Basmaji J, Muttalib F, et al. | Can J Anaesth
Aim: To describe the efficacy and safety of HFNC in acute hypoxemic respiratory failure; and to determine the risk of dispersion, aerosol generation and associated transmission of COVID-19 with HFNC.
UPDATED
WHO COLLABORATIVE
6/14/20
Bonilla-Aldana DK, Cardona-Trujillo MC, García-Barco A, et al. | Infez Med
Aim: To review the evidence on the role of animals as potential reservoirs for MERS-CoV and SARS-CoV.
UPDATED
6/12/20
Almufarrij I, Uus K, Munro KJ | Int J Audiol
Aim: To investigate audio-vestibular symptoms associated with coronavirus.
UPDATED
CLINICAL CHARACTERISTICS
6/12/20
Chiesa-Estomba CM, Lechien JR, Calvo-Henriquez C, et al. | Oral Oncol
Aim: To summarize in a systematic way the available recommendations from 18 guidelines from all over the world.
UPDATED
6/10/20
Marra DE, Hamlet KM, Bauer RM, et al. | Clin Neuropsychol
Aim: To review the evidence on the effectiveness of teleneuropsychology for older adults.
UPDATED
INFECTION CONTROL
6/9/20
 | Health Information and Quality Authority, Ireland
Aim: To review the international evidence on immunity and the spread of the virus by children.
UPDATED
6/9/20
Huntley BJF, Huntley ES, Di Mascio D, et al. | Obstet Gynecol
Aim: To ascertain the frequency of maternal and neonatal complications, as well as maternal disease severity, in pregnancies affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
UPDATED
6/8/20
Parohan M, Yaghoubi S, Seraj A, et al. | Aging Male
Aim: To summarize available findings on the association between age, gender, comorbidities and risk of death from COVID-19 infection.
UPDATED
6/7/20
Kunutsor S, Laukkanen | J Infect
Aim: To review the evidence on cardiovascular complications associated with COVID-19.
UPDATED
6/5/20
Pormohammad A, Ghorbani S, Baradaran B, et al. | Rev Med Virol
Aim: To review the evidence on clinical and laboratory characteristics of COVID-19 infected patients.
UPDATED
CLINICAL CHARACTERISTICS
6/5/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence regarding temporary workforce reconfigurations such as splitting of teams and establishing social distancing protocols within teams to minimise staff exposure to COVID-19.
UPDATED
6/3/20
Iannone P, Castellini G, Coclite D, et al. | PLoS One
Aim: To assess the efficacy of N95 respirators versus surgical masks for the prevention of respiratory tract infections transmission among HCWs.
UPDATED
6/2/20
Raymond M, Ching-A-Sue G, Van Hecke O | Oxford COVID-19 Evidence Service
Aim: To review the evidence on mast cell stabilizers, leukotriene antagonists, and antihistimines in COVID-19.
UPDATED
6/2/20
Hossain M, Sultana A, Purohit N | Epidemiol Health
Aim: To synthesize the available evidence on mental health outcomes of quarantine and isolation for preventing infectious diseases.
UPDATED
MENTAL HEALTH
6/1/20
Kunutsor S, Laukkanen J | J Infect
Aim: To review the evidence on clinical characteristics and outcomes of liver injury in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
6/1/20
Chu DK, Akl EA, Duda S, et al. | Lancet
Aim: To investigate the effects of physical distance, face masks, and eye protection on virus transmission in health-care and non-health-care (eg, community) settings.
UPDATED
5/31/20
Lansbury L, Lim WS, Baskaran V, et al. | J Infect
Aim: To evaluate the burden of co-infections in patients with COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on risk stratification approaches to identify risk level in diabetes patients and clinical pathways to support diabetes management and service delivery.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of domestic and family violence during the COVID-19 pandemic.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on fibrinolysis versus primary percutaneous coronary intervention in the treatment of ST-Elevation Myocardial Infarction (STEMI).
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the available guidelines on inpatient management of COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on safe practice of intubation in the emergency department during the COVID-19 pandemic.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of newborn babies developing COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on how the increasing use of NIPPV to manage suspected or confirmed COVID-19 patients led to any additional guidance regarding the physical requirements and engineering services.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the guidance for the provision of pulmonary rehabilitation for people recovering from COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the rehabilitation needs of post-acute COVID-19 patients and the appropriate timing of rehabilitation interventions.
UPDATED
5/28/20
Dagens A, Sigfrid L, Cai E, et al. | BMJ
Aim: To appraise the availability, quality, and inclusivity of clinical guidelines produced in the early stage of the coronavirus disease 2019 (covid-19) pandemic.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on spirometry and whether it's an aerosol generating procedure, and the risk this procedure carries during the COVID-19 pandemic.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the available guidelines on temporary shared accomodations, particularly for people experiencing homelessness.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effectiveness of mass thermal imaging in identifying people with COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on which tools are validated to diagnose respiratory illness via telehealth.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the proportion of COVID-19 cases in intensive care units that require ventilation.
UPDATED
5/27/20
Jain V, Yuan JM  | Int J Public Health
Aim: To identify specific symptoms and comorbidities predicting severe COVID-19 and intensive care unit (ICU) admission.
UPDATED
5/27/20
Fajgenbaum DC, Khor JS, Gorzewski A, et al. | Infect Dis Ther
Aim: To systematically evaluate the treatments adminstered to COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
5/19/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk and management of people with immunosuppression and COVID-19.
UPDATED
5/19/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence or published standards on telehealth implementation during the COVID-19 pandemic.
UPDATED
5/15/20
Verbeek  JH, Rajamaki  B, Ijaz  S, et al. | Cochrane Database Syst Rev
Aim: To evaluate which type of full?body PPE and which method of donning or doffing PPE have the least risk of contamination or infection for HCW, and which training methods increase compliance with PPE protocols.
UPDATED
INFECTION CONTROL
5/14/20
Yaacoub S, Schunemann H, Khabasa J, et al. | BMJ Global Health
Aim: To systematically review the literature to scope and assess the effects of specific strategies for the management of the bodies.
UPDATED
WHO COLLABORATIVE
5/6/20
LeBlanc A | medRxiv
UPDATED
4/28/20
Chan V, Ng H, Rahman L, et al. | Crit Care Med
Aim: To assess the risk of coronavirus transmission to healthcare workers performing aerosol-generating procedures and the potential benefits of personal protective equipment during these procedures.
UPDATED
INFECTION CONTROL
4/21/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on preoperative testing of COVID-19 for patients undergoing surgery.
UPDATED
4/18/20
Della Gatta A, Rizzo R, Pilu G, et al. | Am J Obstet Gynecol
Aim: To conduct a systematic review of the clinical outcomes reported for pregnant patients with coronavirus disease 2019.
UPDATED
4/17/20
Yin X, Wang X, Xu S, et al. | Public Health
Aim: To examine which type of mask and manner of wearing is the best suitable respiratory personal protective equipment for preventing the viral respiratory infectious diseases.
UPDATED
INFECTION CONTROL
4/15/20
Zorko D, Gertsman S, O'Hearn K, et al. | J Hosp Infect
Aim: To identify and synthesize data from original research evaluating interventions to decontaminate surgical masks for the purpose of reuse.
UPDATED
INFECTION CONTROL
1/11/00
Di Toro F, Gjoka M, Di Lorenzo G, et al | Clin Microbiol Infect
Aim: To assess the impact of coronavirus disease 19 (COVID-19) on maternal and neonatal outcomes.
UPDATED
CLINICAL CHARACTERISTICS