COVID-19 Evidence Reviews
as of 12/1/20
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Updated Reviews
 
= living review
= draft/preprint   |  
= meets mimimum quality standards   |  

A review with this mark was peer-reviewed, described systematic search and study selection, and included critical appraisal of primary studies.
latest update
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11/30/20
Graber K, Byrne E, Goodacre E, et al. | Child Care Health Dev
Aim: To review of the impact of quarantine, isolation, or other restrictive environments on children’s play and whether play may mitigate the adverse effects of such restrictions.
RECENTLY UPDATED
11/30/20
Bell V, Wade D | Soc Psychiatr Epidemiol
Aim: To estimate the additional burden of working directly with infected patients during epidemic and pandemic health emergencies.
RECENTLY UPDATED
11/30/20
Hannum ME, Ramirez VA, Lipson SJ, et al. | Chem Senses
Aim: To provide a comprehensive assessment of methodologies currently employed to quantify smell loss in COVID-19–positive patients and examine whether method type affects reported prevalence of smell loss in COVID-19 patients.
RECENTLY UPDATED
11/30/20
Bareeqa SB, Ahmed SI, Samar SS, et al. | Int J Psychiatry Med
Aim: To quantify COVID-19 mental health issues and its prevalence in China during the early period of the COVID-19 crisis.
RECENTLY UPDATED
11/30/20
Azam M, Sulistiana R, Ratnawati M, et al. | Sci Rep
Aim: To estimate the incidence of recurrent SARS-CoV-2 RNA positivity after recovery from COVID-19 and to determine the factors associated with recurrent positivity. 
RECENTLY UPDATED
11/30/20
Jammu A, Chasen M, Lofters A, et al. | Support Care Cancer
Aim: To synthesise the available knowledge regarding the impact of the COVID-19 pandemic.
RECENTLY UPDATED
11/30/20
Allan SM, Bealey R, Birch J, et al. | Eur J Psychotraumatol
Aim: To estimate the prevalence of common mental health disorders in HCWs based in hospitals where pandemic-affected patients were treated.
RECENTLY UPDATED
11/30/20
Islam N, Salameh JP, Leeflang MMG, et al. | Cochrane Database Syst Rev
Aim: To determine the diagnostic accuracy of chest imaging (computed tomography (CT), X?ray and ultrasound) in people with suspected or confirmed COVID?19.
RECENTLY UPDATED
DIAGNOSTICS
11/27/20
Wang Z, Deng H, Ou C, et al. | Medicine (Baltimore)
Aim: To compare the differences in the field of demographic, comorbidities, clinical symptoms, complications and outcomes between severe and non-severe COVID-19. To conclude the potential risk factors to severe COVID-19 patients.
RECENTLY UPDATED
11/27/20
Griffin J, Casey M, Collins Á, et al. | BMJ Open
Aim: To conduct a review of available evidence to advise on appropriate parameter values for serial interval and generation time in national COVID-19 transmission models for Ireland and on methodological issues relating to those parameters.
RECENTLY UPDATED
11/25/20
Karabay M, Ç?nar N, Karakaya Suzan Ö, et al. | J Matern Fetal Neonatal Med
Aim: To investigate the available evidence describing neonatal outcomes in newborns who have SARS-CoV-2 infection in order to guide prevention of COVID-19 in newborns.
RECENTLY UPDATED
INFECTION CONTROL
11/25/20
Kiss S, Gede N, Hegyi P, et al. | Med Microbiol Immunol
Aim: To review the evidence on the correlation between early changes in the laboratory parameters and the clinical outcomes of COVID-19 patients.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
11/25/20
Li B, Zhang S, Zhang R, et al. | Front Pediatr
Aim: To evaluate the epidemiological spectrum and clinical characteristics of children infected with SARS-CoV-2.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
11/25/20
Paul D, Gupta A, Maurya AK | PLoS One
Aim: To evaluate research done, prior to COVID-19 pandemic, on various decontamination methods for reprocessing of N95-FFRs.
RECENTLY UPDATED
INFECTION CONTROL
11/25/20
Nearchou F, Flinn C, Hennessy E, et al  | Int J Environ Res Public Health
Aim: To provide a systematic review of the evidence on the COVID-19 pandemic's impact on youth mental health.
RECENTLY UPDATED
MENTAL HEALTH
11/25/20
Jiménez D, García-Sanchez A, Rali P, et al. | Chest
Aim: To review the evidence on the incidence of VTE and bleeding among hospitalized patients with COVID-19?
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
11/25/20
Saniasiaya J, Islam MA, Abdullah B | Laryngoscope
Aim: To estimate the overall pooled prevalence of olfactory dysfunction in COVID-19 patients.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
11/25/20
Galanis P, Vraka I, Fragkou D, et al. | J Hosp Infect
Aim: To determine the seroprevalence of SARS-CoV-2 antibodies among HCWs, and to find out the factors that are associated with this seroprevalence.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
11/24/20
Novoa RH, Quintana W, Llancarí P, et al. | Travel Med Infect Dis
Aim: To review all cases from the current literature and provide up-to-date scientific evidence on the clinical characteristics, maternal outcomes, perinatal outcomes and the possibility of vertical transmission in the infected pregnant women.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
11/19/20
Sze S, Pan D, Nevill CR, et al. | EClinicalMedicine
Aim: To determine whether the risk of SARS-CoV-2 infection, COVID-19 intensive care unit (ICU) admission and mortality are associated with ethnicity. 
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
11/19/20
Goldstein KM, Ghadimi K, Mystakelis H, et al. | VA Evidence Synthesis Program
Aim: To review the evidence on the risk of transmitting SARS-CoV-2, SARS, MERS, and influenza with administration of drugs via nebulizer
RECENTLY UPDATED
VA ESP
11/19/20
Beaudry G, Zhong S, Whiting D, et al. | BMJ Glob Health
Aim: To synthesise the evidence on outbreaks of highly contagious diseases in prison.
RECENTLY UPDATED
INFECTION CONTROL
11/19/20
Yang J, Tian C, Chen Y, et al. | J Med Virol
Aim: To explore the relationship between obesity and COVID-19.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
11/19/20
Li X, Liu C, Mao Z, et al. | Crit Care
Aim: To evaluate the predictive values of NLR on disease severity and mortality in COVID-19 patients.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
11/19/20
Wu T, Zou Z, Yang D, et al. | Age Aging
Aim: To explore the factors associated with prevalence of venous thromboembolism (VTE) in COVID-19 patients.
RECENTLY UPDATED
CLINICAL CHARACTERISTICS
11/18/20
Serafim RB, Póvoa P, Souza-Dantas V, et al. | Clin Microbiol Infect
Aim: To describe the clinical course and outcomes of COVID-19 pneumonia in critically ill patients.
RECENTLY UPDATED
11/18/20
Kaye A, Siegel R | PeerJ
Aim: To investigate and synthesize existing evidence for the efficacy of TCZ in reducing COVID-19 mortality.
RECENTLY UPDATED
CANDIDATE THERAPEUTICS
11/16/20
Raharja A, Tamara A, Kok LT | J Racial Ethn Health Disparities
Aim: To review the association between ethnicity and poor Covid-19 outcomes including all-cause mortality, hospitalisation, critical care admission, respiratory and kidney failure.
UPDATED
CLINICAL CHARACTERISTICS
11/16/20
Wong CKH, Wong JYH, Tang EHM, et al. | Sci Rep
Aim: To investigate the comorbidities, symptoms, clinical characteristics and treatment of COVID-19 patients. 
UPDATED
CLINICAL CHARACTERISTICS
11/16/20
Juhasz MF, Ocskay K, Kiss S, et al. | World J Gastroenterol
Aim: To assess all the available evidence in the literature relating to coronavirus disease 2019 (COVID-19) and AP.
CLINICAL CHARACTERISTICS
11/16/20
Pant S, Perras C | CADTH
Aim: To describe the trial characteristics and estimated primary completion dates of the ongoing phase II, phase III, and phase IV studies evaluating drugs to prevent or treat COVID-19.
UPDATED
11/16/20
Pinedo-Torres I, Flores-Fernandez M, Yovera-Aldana M, et al. | Clin Med Insights Endocrinol Diabetes
Aim: To determine the prevalence of diabetes comorbidity and its associated unfavorable health outcomes in patients with acute respiratory syndromes for coronavirus disease according to virus types.
UPDATED
CLINICAL CHARACTERISTICS
11/11/20
Mahalingasivam V, Carik A, Tomlinson LA, et al. | Kidney Int Rep
Aim: To synthesise, analyse and appraise what has been learnt so far to help clinicians and policy makers better understand the risks to kidney transplant recipients, as well as identify gaps for future collaborative research for this global health challenge.
UPDATED
INFECTION CONTROL
11/11/20
Tleyjeh I, Kashour Z, Al Dosary O, et al. | Mayo Clin Proc Innov Qual Outcomes
Aim: To systematically review the literature and estimate the risk of cardiac toxicity in patients receiving CQ or HCQ for COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
11/9/20
Ren L, Xu W, Overton JL, et al. | Front Pharmacol
Aim: To examine the safety profiles of these medications, we systematically evaluated the adverse events (AEs) of these medications from published randomized controlled trials (RCTs).
UPDATED
CANDIDATE THERAPEUTICS
11/9/20
Jeevananthan C, Muhamed NA, Jafaar MH, et al. | BMJ Open
Aim: To identify the effects of temperature, humidity and air quality in the transmission of SARS-CoV-2 and to determine if the effects are linked to anthropic activities.
UPDATED
INFECTION CONTROL
11/9/20
Lebrasseur A, Fortin-Bedard N, Lettre J, et al.  | Disabil Health J
Aim: To review the impact of the COVID-19 pandemic, and associated isolation and protective measures, among people with physical disabilities.
UPDATED
MENTAL HEALTH
11/9/20
Aggarwal K, Agarwall A, Jaiswal N, et al.  | PLoS ONE
Aim: To evaluate the epidemiology and clinical features of ocular surface manifestations and complications related to COVID-19 infection, to assess the risk of transmission to patients and healthcare workers through ocular secretions and to determine whether ocular involvement has any correlation with the severity of respiratory symptoms and overall prognosis.
UPDATED
CLINICAL CHARACTERISTICS
11/9/20
Ssentongo A, Ssentongo P, Heilbrunn E, et al | Open Heart
Aim: To explore the association of RAAS inhibitors, including angiotensin-converting inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) with COVID-19 mortality in patients with hypertension. 
UPDATED
CLINICAL CHARACTERISTICS
11/9/20
Matsushita K, Ding N, Kou M, et al. | Glob Heart
Aim: To explore pre-existing CVD and its traditional risk factors as risk factors of severe COVID-19 (defined as death, acute respiratory distress syndrome, mechanical ventilation, or intensive care unit admission). 
UPDATED
CLINICAL CHARACTERISTICS
11/6/20
Mallett S, Allen J, Graziadio S, et al. | BMC Med
Aim: To examine at what time points during SARS?CoV?2 infection it is detectable at different anatomical sites using RT?PCR based tests.  
UPDATED
11/5/20
Mirza FN, Malik AA, Omer SB, et al. | Int J Dermatol
Aim: To collate the available information on the dermatologic manifestations in COVID?19 patients to inform current practice and further research.
UPDATED
11/4/20
Park R, Lee S, Kim SY, et al  | Acta Oncol
Aim: To summarize the existing evidence for the effect of active oncologic treatment on COVID-19 outcomes.
UPDATED
11/3/20
O'Neil M, Veazie S, LaFavor B | VA Evidence Synthesis Program
Aim: To compare the prevalence of mental health disorders among adults who have been hospitalized for COVID-19 to relevant comparison groups, assess whether the prevalence of mental health disorders varies by patient and disease characteristics, and ascertain mental health care utilization and resource needs for adults following hospitalization for COVID-19.
UPDATED
VA ESP
MENTAL HEALTH
11/2/20
Boregowda U, Perisetti A, Nanjappa A, et al. | Front Med
Aim: To compare the efficacy of tocilizumab in severe COVID-19 cases vs. standard of care alone.
UPDATED
11/2/20
Palaiodimos L, Chamorro-Pareja N, Karamanis D, et al. | Hormones
Aim: To systematically review and synthesize with a meta-analysis the available observational studies reporting the effect of diabetes in mortality among hospitalized patients with COVID-19.
UPDATED
11/2/20
Elsawah H, Elsokary M, Abdallah MS, et al. | Rev Med Virol
Aim: To systematically review the use of remdesivir in Covid?19 among the available clinical trials and summarise remdesivir efficacy.
UPDATED
11/2/20
Del Riccio M, Lorini C, Bonaccorsi G, et al. | Int J Environ Res Public Health
Aim: To review the association between seasonal influenza vaccination and the risk of SARS-CoV-2 infection or complicated illness or poor outcome (e.g. severe disease, need for hospitalization or ventilatory support, or death) among COVID-19 patients.
UPDATED
10/30/20
Andrenelli E, Negrini F, De Sire A, et al. | Eur J Phys Rehabil Med
Aim: To report data of a systematic search performed on papers published in July 2020.
UPDATED
CLINICAL CHARACTERISTICS
10/30/20
Arora T, Grey I, Ostlundh L, et al. | J Health Psychol
Aim: To examine the overall prevalence of psychological health outcomes during COVID-19. 
UPDATED
MENTAL HEALTH
10/29/20
Khan M, Khan N, Mustagir G, et al. | J Glob Health
Aim: To summarize pre-existing comorbidities in patients with COVID-19, and to estimate the likelihood of mortality from COVID-19 with each category of pre-existing comorbidities.
UPDATED
CLINICAL CHARACTERISTICS
10/29/20
Milby KM, Atallah AN, Rocha-Filho CR, et al. | Sao Paulo Med J
Aim: To understand and summarize the evidence relating to clinical manifestations, disease severity and prognoses among patients coinfected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and arboviruses.
UPDATED
CLINICAL CHARACTERISTICS
10/28/20
Chou R, Dana T, Jungbauer R, et al. | Ann Intern Med
Aim: To examine the effectiveness of N95, surgical, and cloth masks in community and health care settings for preventing respiratory virus infections, and effects of reuse or extended use of N95 masks.
UPDATED
10/27/20
Budhathoki P, Shrestha DB, Rawal E, et al. | SN Compr Clin Med
Aim: To assess the rationality on the use of corticosteroids in COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
10/27/20
Mackey K, King VJ, Gurley S, et al. | VA Evidence Synthesis Program
Aim: To synthesize evidence on the role of ACE inhibitor and ARB use on patient outcomes in COVID-19 as well as evidence on the benefits and harms of initiating these medications to treat patients with COVID-19.
UPDATED
WHO COLLABORATIVE
VA ESP
10/26/20
Weatherald J, Solverson K, Zuege DJ, et al. | J Crit Care
Aim: To quickly identify and synthesize studies examining the effect of awake prone positioning on patients with hypoxemic respiratory failure (including those with ARDS and/or COVID-19).
UPDATED
CANDIDATE THERAPEUTICS
10/26/20
Yee JY, Kim WK, Han JMH, et al. | Sci Rep
Aim: To evaluate the impact of COVID-19 on pregnant women.
UPDATED
CLINICAL CHARACTERISTICS
10/26/20
Javanmardi F, Keshavarzi A, Akbari A, et al. | PLoS One
Aim: To evaluate the prevalence of underlying disease in died people with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/23/20
Wang JG, Cui HR, Tang HB, et al. | Sci Rep
Aim: To understand the clinical manifestations and incidence of gastrointestinal symptoms of Coronavirus disease (COVID-19) in children and discuss the importance of fecal nucleic acid testing.
UPDATED
CLINICAL CHARACTERISTICS
10/23/20
Raymond C, Loshak H | CADTH
Aim: To describe the trial characteristics and estimated primary completion dates of the ongoing phase II, phase III, and phase IV studies evaluating IVIg and hyperimmune globulin to treat COVID-19.
UPDATED
10/22/20
Fong V, Iarocci G | J Pediatr Psychol
Aim: To evaluate the quality of existing studies on this topic, determine what is known about mental health outcomes and needs of children and families, and provide recommendations for how COVID-19 policies can best support children and families
UPDATED
MENTAL HEALTH
10/22/20
Perras C, Pohar S, Manoharan A, et al. | CADTH
Aim: To review the current scientific evidence on the potential benefits and harms of remdesivir.
UPDATED
10/22/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on the role of daycares and schools in the transmission of COVID-19.
UPDATED
10/21/20
Leisman DE, Ronner L, Pinotti R, et al. | Lancet Respir Med
Aim: To synthesise and describe the reported pattern of inflammatory cytokines in COVID-19-induced respiratory failure and to compare this profile with those of other acute inflammatory syndromes.
UPDATED
CLINICAL CHARACTERISTICS
10/21/20
Kefale B, Tegegne GT, Degu A, et al. | Clin Appl Thromb Hemost
Aim: To investigate the extent and risk factors of thromboembolism among COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
10/21/20
Xu J, Teng Y, Shang L, et al. | Clin Infect Dis
Aim: To provide a comprehensive summarization of current evidence to answer two major clinical questions: (1) Does the prior treatment of ACEI/ARB alter the susceptibility of SARS-CoV-2 infection in general population? (2) Does the prior treatment of ACEI/ARB affect risk of mortality and severe outcomes in COVID-19 patients?
UPDATED
CLINICAL CHARACTERISTICS
10/20/20
Chou R, Dana T, Buckley D, et al. | Ann Intern Med
Aim: To examine the burden of SARS-CoV-2, SARS-CoV-1, and Middle Eastern respiratory syndrome (MERS)-CoV on HCWs and risk factors for infection, using rapid and living review methods.
UPDATED
WHO COLLABORATIVE
10/20/20
Kotecha P, Light A, Checcucci E, et al. | Panminerva Med
Aim: To evaluate the data currently available regarding the repurposing of different drugs for Covid-19 treatment. 
UPDATED
CANDIDATE THERAPEUTICS
10/19/20
Liu Y, Lu H, Wang W, et al. | Expert Rev Anticancer Ther
Aim: To identify the risk factors for death in patients with cancer and COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/19/20
Mulchandani R, Lyngdoh T, Kakkar AK | Eur J Clin Invest
Aim: To quantify the differences in the circulating levels of major inflammatory and immunological markers between severe and non?severe COVID?19 patients.
UPDATED
CLINICAL CHARACTERISTICS
10/19/20
Ortega KL, Rech BO, El Haje GLC, et al. | J Hosp Infect
Aim: To review the evidence on whether hydrogen peroxide mouthwash has a virucidal effect.
UPDATED
INFECTION CONTROL
10/19/20
Abate SM, Mantefardo B, Basu B | Patient Saf Surg
Aim: To provide the global prevalence of perioperative outcomes of patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/19/20
Chamseddine RS, Wahbeh F, Chervenak F, et al. | J Pregnancy
Aim: To review the evidence on preinatal and obstetric management in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/19/20
Raschetti R, Vivanti AJ, Vauloup-Fellous C, et al. | Nat Commun
Aim: To clarify the main transmission route, clinical features and outcomes of neonatal SARS-CoV-2 infections
UPDATED
CLINICAL CHARACTERISTICS
10/19/20
Ramaraj P, Super JT, Doyle R, et al. | BMJ Open
Aim: To review the evidence behind UK Government PPE guidance on surgical masks versus respirators for SARS-CoV-2 protection.
UPDATED
INFECTION CONTROL
10/15/20
Gonzalez-Rubio J, Navarro-Lopez C, Lopez-Najera E, et al. | Int J Environ Res Public Health
Aim: To review the evidence on the epidemiologic relationship between smoking and COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/15/20
Chu IY, Alam P, Larson H, et al. | J Travel Med
Aim: To identify: 1) the social consequences of mass quarantine—community-wide movement restrictions—during previous and current infectious disease outbreaks, and 2) recommended strategies to mitigate the negative social implications of COVID-19 lockdowns. 
UPDATED
MENTAL HEALTH
10/13/20
Bansal A, Singh AD, Jain V, et al. | Heart Lung
Aim: To determine if D-dimers are elevated in individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who have adverse clinical outcomes including all-cause mortality, intensive care unit (ICU) admission or acute respiratory distress syndrome (ARDS).
UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Chai KL, Valk SJ, Piechotta V, et al. | Cochrane Database Syst Rev
Aim: To assess whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in the treatment of people with COVID?19.
UPDATED
CANDIDATE THERAPEUTICS
10/13/20
Banakar M, Lankarani KB, Jafarpour D, et al. | BMC Oral Health
Aim: To examine the risk of the transmission of the COVID–19 during dental treatments and provides pathways and protective protocols to minimize them, bearing in mind the long-term necessity of actions and realistic, practical measures.
UPDATED
INFECTION CONTROL
10/13/20
Roshandel R, Nateqi M, Lak R, et al. | Cell Mol Biol
Aim: To review the evidence on the diagnostic and methodological evaluation of urinary shedding of SARS-CoV-2.
UPDATED
DIAGNOSTICS
10/13/20
Kashour ZT, Riaz M, Garbati M, et al. | J Antimicrob Chemother
Aim: To systematically evaluate the effect of CQ and HCQ with or without azithromycin (AZ) on outcomes of COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
10/13/20
Tamuzi JL, Ayele BT, Shumba CS, et al. | BMC Infect Dis
Aim: To review different studies on SARS-CoV, MERS-CoV or COVID-19 associated with HIV/TB co-infection or only TB and to understand the interactions between HIV, TB and COVID-19 and its implications on the burden of the COVID-19 among HIV/TB co-infected or TB patients, screening algorithm and clinical management.
UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Malaty M, Kayes T, Amarasekera AT, et al. | Eur J Clin Invest
Aim: To examine the current incidence and available treatment for arrhythmias in hospitalized patients with SARS-CoV-2 infection.
UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Nopp S, Moik F, Jilma B, et al. | Res Pract Thromb Haemost
Aim: To evaluate available data and estimating the prevalence of VTE in COVID?19 patients.
UPDATED
CLINICAL CHARACTERISTICS
10/13/20
Elsayed S, Reddy M, Murthy PM, et al. | Cureus
Aim: To identify the trends of COVID-19 relapse, the effects of co-morbidities on it, and associated mortality rates.
UPDATED
CLINICAL CHARACTERISTICS
10/8/20
Henssler J, Stock F, van Bohemen J, et al. | Eur Arch Psychiatry Clin Neurosci
Aim: To assess the psychological effects in both quarantined and isolated persons compared to non-quarantined and non-isolated persons. 
UPDATED
MENTAL HEALTH
10/8/20
Choi GJ, Kim HM, Kang H, et al. | J Lipid Atheroscler
Aim: To analyze the available knowledge about the potential association between dyslipidemia and the severity of coronavirus disease 2019 (COVID-19) as reported in previous published systematic reviews.
UPDATED
CLINICAL CHARACTERISTICS
10/7/20
Setiati S, Harimurti K, Safitri ED, et al | Acta Med Indones
Aim: To systematically review all relevant studies related to the risk factors and laboratory test results associated with severe illness and mortality in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
10/6/20
Cheng W, Li Y, Cui L, et al. | Front Pharmacol
Aim: To evaluate the efficacy and safety of corticosteroid therapy in patients with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
10/5/20
Meyerowitz-Katz G, Merone L | Int J Infect Dis
Aim: To review the evidence on infection-fatality rates for COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
10/5/20
Tlayjeh H, Mhish O, Enani M, et al. | J Infect Public Health
Aim: To systematically review the literature about the association between systemic corticosteroid therapy (CST) and outcomes of COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
10/5/20
Moutchia J, Pokharel P, Kerri A, et al. | PLoS One
Aim: To assess clinical laboratory parameters which may serve as markers or predictors of severe or critical COVID-19.
UPDATED
DIAGNOSTICS
10/5/20
Soeroto AY, Soetedjo NN, Purwiga A, et al. | Diabetes Metab Syndr
Aim: To evaluate the association between obesity and composite poor outcome in coronavirus disease 2019 (COVID-19) patients.
UPDATED
CLINICAL CHARACTERISTICS
10/5/20
Jarrom D, Elston L, Washington J, et al. | BMJ Evid Based Med
Aim: To identify evidence on: (1) the clinical effectiveness of tests that detect the presence of severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) to inform COVID?19 diagnosis? and (2) the clinical effectiveness of tests that detect the presence of antibodies to the SARS?CoV?2 virus to inform COVID?19 diagnosis.
UPDATED
DIAGNOSTICS
10/2/20
Carrillo-Larco RM, Altez-Rodriguez C, Ravaglia S, et al. | Wellcome Open Res
Aim: To understand the characteristics of patients with COVID-19 and GBS, and to identify potential patterns.
UPDATED
CLINICAL CHARACTERISTICS
10/2/20
Oliviera Silva DF, Cunha Lima SC, Mauricio Sena-Evangelista KC, et al. | Nutrients
Aim: To identify the screening instruments that can be used to assess nutritional risk in older adults with COVID-19, and to clarify their measurement properties.
UPDATED
CLINICAL CHARACTERISTICS
10/2/20
Flumignan RLG, de Sa Tinoco JD, Pascoal PIF, et al. | Cochrane Database Syst Rev
Aim: To assess the effects of prophylactic anticoagulants versus active comparator, placebo or no intervention, on mortality and the need for respiratory support in people hospitalised with COVID?19.
UPDATED
CANDIDATE THERAPEUTICS
9/29/20
Morone G, Palomba A, Iosa M, et al.  | Front Med
Aim: To correlate the presence and the relevant temporal patterns of SARS-CoV-2 viral RNA in biological specimens (stool, urine, blood, and tears) of the transmission with clinical/epidemiological features in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/28/20
Shrestha DB, Pudhathoki P, Khadka S, et al. | Virol J
Aim: To review the efficacy and safety of favipiravir triphosphate as a treatment for COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
9/28/20
Rios P, Radhakrishnan A, Williams C, et al. | Syst Rev
Aim: to examine the current guidelines for infection prevention and control (IPAC) of coronavirus disease-19 (COVID-19) or other coronaviruses in adults 60 years or older living in long-term care facilities (LTCF).
UPDATED
INFECTION CONTROL
9/28/20
Viner RM, Mytton OT, Bonell C, et al. | JAMA Pediatr
Aim: To review the evidence on the susceptibility to and transmission of SARS-CoV-2 by children and adolescents compared with adults.
UPDATED
INFECTION CONTROL
9/24/20
Lim MA, Pranata R | J Clin Orthop Trauma
Aim: To evaluate the prevalence of coronavirus disease 2019 (COVID-19) and its impact on mortality in patients with hip fracture.
UPDATED
CLINICAL CHARACTERISTICS
9/24/20
Wang M, Wu T, Zuo Z, et al. | BMJ Support Palliat Care
Aim: To summarize the efficacy and safety of antiviral agents currently in use for COVID-19 treatment.
UPDATED
CANDIDATE THERAPEUTICS
9/24/20
Gulsen A, Yigitbas BA, Uslu B, et al. | Pulm Med
Aim: To determine the relationship between smoking and clinical COVID-19 severity via a systematic meta-analysis approach.
UPDATED
CLINICAL CHARACTERISTICS
9/23/20
O'Reilly A, Tibbs M, Booth A, et al. | Ir J Psychol Med
Aim: To summarise existing evidence on the potential impact of a pandemic on the mental health of 12-25-year-olds.
UPDATED
MENTAL HEALTH
9/21/20
Huang AT, Garcia Carreras B, Hitchings MDT, et al. | Nat Commun
Aim: To review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). 
UPDATED
CLINICAL CHARACTERISTICS
9/21/20
Mecenas P, da Rose Moreira Bastos RT, Vallinoto ACR, et al. | PLoS One
Aim: To describe current knowledge about the emergence and replicability of the virus and its connection with different weather factors such as temperature and relative humidity.
UPDATED
INFECTION CONTROL
9/17/20
Dambha-Miller H, Albasri A, Hodgson S, et al. | BMJ Open
Aim: To review evidence on routinely prescribed drugs in the UK that could upregulate or downregulate ACE2 and potentially affect COVID-19 disease.
UPDATED
CANDIDATE THERAPEUTICS
9/17/20
Juul S, Nielsen N, Feinberg J, et al. | PLoS Med
Aim: To compare the effects of all treatment interventions for participants in all age groups with COVID-19. 
UPDATED
CANDIDATE THERAPEUTICS
9/17/20
Wang Y, Ao G, Qi X, et al  | Clin Exp Allergy
Aim: To review the evidence on the association of asthma with risk of severe or fatal COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/17/20
Christophers B, Marin BG, Oliva R et al. | Pediatr Res
Aim: To describe the clinical presentation and outcomes of pediatric patients using an individual patient data approach to visualize trends by age.
UPDATED
CLINICAL CHARACTERISTICS
9/15/20
Cheruiyot I, Henry B, Lippi G, et al. | Acta Biomed
Aim: To assess whether AKI may be associated with worse prognosis and increased mortality in COVID-19 patients
UPDATED
9/15/20
Peres KC, Riera R, Martimbianco ALC, et al. | Front Endocrinol
Aim: To investigate a possible association between body weight and prognosis among patients diagnosed with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/15/20
Siepmann T, Sedghi A, Simon E, et al. | Eur J Neurol
Aim: To define the risk of acute stroke in patients with severe and non-severe COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/15/20
Ahmed M, Advani S, Moreira A, et al. | EClinicalMedicine
Aim: To describe the typical presentation and outcomes of children diagnosed with this hyperinflammatory condition.
UPDATED
CLINICAL CHARACTERISTICS
9/14/20
Siemieniuk RAC, Bartoszko JJ, Ge L, et al. | BMJ
Aim: To compare the effects of treatments for coronavirus disease 2019 (covid-19).
UPDATED
CANDIDATE THERAPEUTICS
9/14/20
Di Maria E, Latini A, Borgiani P, et al. | Human Genomics
Aim: To review the evidence on genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS, and COVID-19).
UPDATED
CLINICAL CHARACTERISTICS
9/14/20
Panda PK, Sharawat IK, Panda P, et al. | J Trop Pediatr
Aim: To review the evidence on the neurological manifestations of COVID-19 in children.
UPDATED
CLINICAL CHARACTERISTICS
9/14/20
Nussbaumer-Streit B, Mayr V, Dobrescu AI, et al. | Cochrane Database of Systematic Reviews
Aim: To assess the effects of quarantine (alone or in combination with other measures) of individuals who had contact with confirmed cases of COVID19, who travelled from countries with a declared outbreak, or who live in regions with high transmission of the disease.
UPDATED
WHO COLLABORATIVE
INFECTION CONTROL
9/11/20
Czumbel LM, Kiss S, Farkas N, et al. | Front Med
Aim: To conduct a meta-analysis on the reliability and consistency of SARS-CoV-2 viral RNA detection in saliva specimens.
UPDATED
DIAGNOSTICS
9/11/20
Seidu S, Gillies C, Zaccardi F, et al. | Endocrinol Diabetes Metab
Aim: To determine whether people with overweight or obesity and with SARS?CoV?2 have different outcomes compared to those within normal weight thresholds.
UPDATED
CLINICAL CHARACTERISTICS
9/9/20
Razmi M, Hashemi F, Gheytanchi E, et al. | Int Immunopharmacol
Aim: To assess the available data regarding the efficacy of the immunomodulatory drugs used to manage COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
9/8/20
Elavarasi A, Prasad M, Seth T, et al. | J Gen Intern Med
Aim: To synthesize the available data on the efficacy and safety of CQ and HCQ for the treatment of COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
9/4/20
Rees EM, Nightingale ES, Jafari Y, et al. | BMC Med
Aim: To review estimates of how long patients with COVID-19 need different levels of hospital care.
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
Martin A, Blom IM, Whyatt G, et al. | Disaster Med Public Health Prep
Aim: To explore the involvement of medical students in past global health emergencies, to help inform current and future scenarios.
UPDATED
9/3/20
Caldeira D, Alves M, Melo RGE, et al. | Int J Cardiol Heart Vasc
Aim: To systematically evaluate the risk of COVID-19 infection and the risk of severe COVID-19 disease associated with previous exposure to (ACEi) and/or ARB).
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
Liu C, He Y, Liu L, et al. | BMC Pediatr
Aim: To review the evidence on the characteristics of children with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
Allotey J, Stallings E, Bonet M, et al. | BMJ
Aim: To determine the clinical manifestations, risk factors, and maternal and perinatal outcomes in pregnant and recently pregnant women with suspected or confirmed coronavirus disease 2019 (covid-19).
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
Sergeant A, van Reekum EA, Sanger N, et al. | BMJ Open
Aim: To study the effect of pandemics and epidemics on mental health outcomes for people with premorbid mental disorders.
UPDATED
9/3/20
Costenaro P, Minotti C, Barbieri E, et al. | Rev Med Virol
Aim: To review the current knowledge on SARS-CoV-2 cases in PLWHA.
UPDATED
CLINICAL CHARACTERISTICS
9/3/20
de Almeida-Pititto B, Dualib PM, Zajdenverg L, et al. | Diabetol Metab Syndr
Aim: To evaluate the association of diabetes, hypertension, cardiovascular disease and ACEI/ARBs exposure with severity–intensive care unit treatment or mechanical ventilation necessity or O2 saturation?
UPDATED
CLINICAL CHARACTERISTICS
8/31/20
Ssentongo P, Ssentongo AE, Heilbrunn ES, et al. | PLoS ONE
Aim: To estimate the association of pre-existing comorbidities with COVID-19 mortality.
UPDATED
CLINICAL CHARACTERISTICS
8/31/20
Fiolet T, Guihur A, Rebeaud M, et al. | Clin Microbiol Infect
Aim: To assess whether chloroquine or hydroxychloroquine with or without azithromycin decreased COVID-19 mortality compared to the standard of care.
UPDATED
CANDIDATE THERAPEUTICS
8/29/20
Kelada M, Anto A, Dave K, et al. | Cureus
Aim: To assess the role of sex in the risk of mortality from COVID-19 in adult patients through comparison of clinical markers and inflammatory indexes.? 
UPDATED
CLINICAL CHARACTERISTICS
8/27/20
Braithwaite I, Callender T, Bullock M, et al. | Lancet Digit Health
Aim: To assess the effectiveness of automated and semi-automated digital tools for contact tracing, and identify key considerations for successful implementation, to inform the control of COVID-19. 
UPDATED
INFECTION CONTROL
8/27/20
Coomes EA, Haghbayan H | Rev Med Virol
Aim: To assess the evidence describing IL-6 response in patients with COVID-19 and the existing and planned studies investigating the efficacy of tocilizumab to guide patient management, clarify guideline development, and inform future trials in this field.
UPDATED
CLINICAL CHARACTERISTICS
8/27/20
Gertsman S, Agarwal A, O'Hearn K, et al. | J Hosp Infect
Aim: To collect and synthesize existing information on decontamination of N95 filtering facepiece respirators (FFRs) using microwave and heat-based treatments, with special attention to impact on mask function (aerosol penetration, airflow resistance), fit, and physical traits.
UPDATED
INFECTION CONTROL
8/25/20
Baral R, White M, Vassiliou VS | Curr Atheroscler Rep
Aim: To review the evidence on the impact RAAS inhibitor use has in antihypertensive COVID-19 hospitalised patients.
UPDATED
CANDIDATE THERAPEUTICS
8/23/20
Jovic TH, Ali SR, Ibrahim N, et al. | Nutrients
Aim: To investigate whether vitamin supplementation is beneficial in COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
8/21/20
Taneri PE, Ochoa S, Llanaj E, et al. | Eur J Epidemiol
Aim: To evaluate biomarkers of anemia and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and prevalence of anemia) in patients diagnosed with COVID-19, and explore their prognostic value. 
UPDATED
CLINICAL CHARACTERISTICS
8/15/20
Nasiri MJ, Haddadi S, Tahvildari A, et al.  | Front Med
Aim: To better understand role of the sex in mortality of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
8/14/20
de Moura DTH, McCarty TR, Ribeiro IB, et al. | Clinics (Sao Paulo)
Aim: To perform a structured systematic review and meta-analysis to evaluate the diagnostic characteristics of serological-based COVID-19 testing.
UPDATED
DIAGNOSTICS
8/12/20
Davalbhakta S, Advani S, Kumar S, et al. | J Med Syst
Aim: To provide an overview of mobile applications being currently utilized for COVID-19 related activities.
UPDATED
INFECTION CONTROL
8/12/20
Moosavi SA, Mashhadiagha A, Hashemazar A, et al. | Transpl Infect Dis
Aim: to conduct a systematic review on COVID?19 clinical manifestations and treatment strategies in SOT recipients.
UPDATED
CLINICAL CHARACTERISTICS
8/11/20
Jones L, Candy B, Roberts N, Ondruskova T, et al | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on the management of delirium in patients with COVID-19 and the use of non-pharmacological approaches outside of critical care settings.
UPDATED
8/11/20
Licina A, Silvers A, Stuart RL  | Syst Rev
Aim: To evaluate the effect of powered air-purifying respirators (PAPRs) as part of respiratory protection versus another device (egN95/FFP2) on HCW infection rates and contamination.
UPDATED
8/9/20
Cui X, Zhao Z, Zhang T, et al. | J Med Virol
Aim: To provide a comprehensive and systematic analysis of demographic characteristics, clinical symptoms, laboratory findings and imaging features of coronavirus disease 2019 (COVID-19) in pediatric patients.
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Jutzeler CR, Bourguignon L, Weis CV, et al. | Travel Med Infect Dis
Aim: To gather all available information regarding comorbidities, clinical signs and symptoms, outcomes, laboratory findings, imaging features, and treatments in patients with coronavirus disease 2019 (COVID-19).
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Hoang A, Chorath K, Moreira A, et al. | EClinicalMedicine
Aim: To characterize clinical symptoms, laboratory, and imaging findings, as well as therapies provided to confirmed pediatric cases of COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Wu T, Zuo Z, Deng M | Aging Dis
Aim: To provide systematic evidence for the association between multiorgan dysfunction and COVID-19 development.
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Samaranayake L, Fakhruddin K, Panduwawala C | Acta Odontol Scand
Aim: To evaluate the contemporary evidence on dysgeusia and anosmia as trigger prodromal symptoms, and their prevalence in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
8/9/20
Barochiner J, Martinez R | J Clin Pharm Ther
Aim: To compare the occurrence of severe and fatal COVID-19 in infected patients who were under treatment with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) vs no treatment or other antihypertensives.
UPDATED
CANDIDATE THERAPEUTICS
8/9/20
Baladia E, Pizarro AB, Ortiz-Munoz L, et al. | Medwave
Aim: To provide a timely, rigorous, and continuously updated summary of the available evidence on the role of vitamin C in treating patients with COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
8/7/20
Chi G, Lee JJ, Jamil A, et al. | J Clin Med
Aim: To offer benchmark data on the incidence of VTE and to examine the difference in D-dimer levels among anticoagulated COVID-19 patients with and without VTE incident. 
UPDATED
CANDIDATE THERAPEUTICS
8/6/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the extended use or re-use of personal protective equipment (PPE) during COVID-19.
UPDATED
8/5/20
Kumar A, Arora A, Sharma P, et al. | Indian J Gastroenterol
Aim: To determine the frequency of GI and hepatic manifestations of COVID-19 and to explore their relationship with severe clinical course.
UPDATED
8/5/20
Ghahramani S, Tabrizi R, Lankarani KB, et al. | Eur J Med Res
Aim: To understand the common laboratory features of COVID-19 in severe cases versus non-severe patients could be quite useful for clinicians and might help to predict the model of disease progression.
UPDATED
8/5/20
Reddy RK, Charles WN, Sklavounos A, et al. | J Med Virol
Aim: To rigorously and definitively quantify the effects of smoking on COVID-19 severity.
UPDATED
8/4/20
Gao Y, Ye L, Zhang J, et al. | BMC Infect Dis
Aim: To systematically review the clinical features and outcomes of pregnant women with COVID-19.
UPDATED
8/3/20
Sales-Peres SHC, de Azevedo-Silva LJ, Bonato RCS, et al. | Obes Res Clin Pract
Aim: To investigate the relationship between coronavirus disease 2019 (COVID-19) and obesity in critically ill patients admitted to the intensive care unit (ICU).
UPDATED
CLINICAL CHARACTERISTICS
8/3/20
Carlo D, Montemurro N, Petrella G, et al. | J Neurol
Aim: To review the evidence on the spectrum of neurological symptoms experienced by COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
8/1/20
Akbari H, Tabrizi R, Lankarani KB, et al. | Life Sci
Aim: To make a comparison between the clinical laboratory-related factors, complete blood count (CBC) indices, cytokines, and lymphocyte subsets in order to distinguish severe coronavirus disease 2019 (COVID-19) cases from the non-severe ones.
UPDATED
CLINICAL CHARACTERISTICS
8/1/20
Monaghesh E, Hajizadeh A | BMC Public Health
Aim: To identify the role of telehealth services during COVID-19 outbreak.
UPDATED
INFECTION CONTROL
7/31/20
 | National Collaborating Centre for Methods and Tools
Aim: To review the evidence on how long the virus can survive with potential for infection on surfaces.
UPDATED
7/31/20
Mitchell S, Maynard V, Lyons V, et al | Palliat Med
Aim: To synthesise existing evidence related to the delivery of palliative and end-of-life care by primary healthcare professionals in epidemics and pandemics.
UPDATED
7/30/20
Figliozzi S, Masci P, Ahmadi N, et al. | Eur J Clin Invest
Aim: To review available evidence and provide pooled estimates on predictors of clinical outcomes in patients with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/28/20
Radulesco T, Lechien JR, Sowerby L, et al. | Eur Arch Otorhinolaryngol
Aim: To summarize recommendations for sinus and anterior skull base surgery during the COVID-19 pandemic.
UPDATED
INFECTION CONTROL
7/27/20
Bwire GM, Majigo MV, Nijiro BJ, et al. | J Med Virol
Aim: To profile the positive detection rate from different clinical specimens using PCR to guide the selection of specimens for clinical diagnosis of COVID-19.
UPDATED
DIAGNOSTICS
7/24/20
Venkatesulu BP, Chandrasekar VT, Giridhar P, et al. | J Med Virol
Aim: To do a systematic review and critical appraisal of the ongoing clinical trials that are assessing various therapeutic interventions against SARS-CoV-2 with an aim to provide insight into the various interventions tested, clinical rationale, geographical distribution of the trials as well as the endpoints assessed in the studies.
UPDATED
CANDIDATE THERAPEUTICS
7/21/20
Wynants L, Van Calster B, Bonten MMJ | BMJ
Aim: To review and critically appraise published and preprint reports of models that aim to predict either (i) presence of existing COVID-19 infection, or (ii) future complications in individuals already diagnosed with COVID-19
UPDATED
7/20/20
Cortegiani A, Ingoglia G, Ippolito M, et al. | J Crit Care
Aim: To evaluate the efficacy and safety of chloroquine and chloroquine-related formulations in patients with SARS-CoV-2 pneumonia and articles describing related in-vitro studies.
UPDATED
CANDIDATE THERAPEUTICS
7/20/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the efficacy of face masks in helping to prevent the spread of COVID-19.
UPDATED
7/19/20
Pormohammad A, Ghorbani S, Baradaran B, et al. | Microb Pathog
Aim: To evaluate the clinical features and laboratory findings using a large sample size of COVID-19 infected patients in order to assist in its understanding, prevention and treatment.
UPDATED
CLINICAL CHARACTERISTICS
7/18/20
Verdugo-Paiva F, Izcovich A, Ragusa M, et al. | Medwave
Aim: To provide a timely, rigorous, and continuously updated summary of the evidence on the role of lopinavir/ritonavir in the treatment of patients with COVID-19.
UPDATED
7/17/20
Greco A, Buccheri S, D'Arrigo P, et al. | Eur Heart J Cardiovasc Pharmacother
Aim: To review the evidence on the impact of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on the clinical outcomes of COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
7/17/20
Galbadage T, Peterson BM, Awada J, et al. | Front Med
Aim: To examine the association between male sex and COVID-19 severity.
UPDATED
CLINICAL CHARACTERISTICS
7/16/20
Shah S, Shah K, Patel SB, et al. | Cardiol Rev
Aim: To investigate the prognostic role of D-dimer in COVID-19 infected patients. 
UPDATED
CLINICAL CHARACTERISTICS
7/15/20
Chandrasekar VT, Venkatesalu B, Patel HK, et al. | J Med Virol
Aim: To assess if any intervention provides mortality benefit, other clinically relevant outcomes and also ascertain the safety profile.
UPDATED
CANDIDATE THERAPEUTICS
7/14/20
de Pablo GS, Vaquerizo-Serrano J, Catalan A, et al. | J Affect Disord
Aim: To review the evidence on the impact of SARS/MERS/COVID-19 on physical and mental health outcomes of health care workers.
UPDATED
INFECTION CONTROL
7/11/20
Abate S, Ali S, Mantedafro B, et al. | PLoS One
Aim: To investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus.
UPDATED
CLINICAL CHARACTERISTICS
7/10/20
Kunutsor S, Laukkanen J | Ann Med
Aim: To evaluate renal complications of COVID-19 and their incidence using a systematic meta-analysis.
UPDATED
CLINICAL CHARACTERISTICS
7/10/20
Kernohan A, Calderon M | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on risk factors or management of VTE.
UPDATED
7/8/20
Lvliang L, Zhong W, Bian Z, et al. | J Infect
Aim: To compare mortality risk factors of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) to provide new strategies for COVID-19 prevention and treatment.
CLINICAL CHARACTERISTICS
7/8/20
Kulkarni A, Kumar P, Tevethia HV, et al. | Aliment Pharmacol Ther
Aim: To assess the prevalence of CLD, the incidence of elevated liver chemistries and the outcomes of patients with and without underlying CLD/elevated liver chemistries in COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/8/20
Pan D, Sze S, Minhas J, et al. | EClinicalMedicine
Aim: To assess whether ethnicity has been reported in patients with COVID-19 and its relation to clinical outcomes.
UPDATED
CLINICAL CHARACTERISTICS
7/6/20
Kumar-M P, Mishra S, Jha DK, et al. | Hepatol Int
Aim: To systematically study the occurrence of liver injury in COVID-19 and also determine the frequency of liver involvement in COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
7/3/20
Bastos M, Tavaziva G, Abidi SK, et al. | BMJ
Aim: To determine the diagnostic accuracy of serological tests for coronavirus disease-2019 (covid-19).
UPDATED
DIAGNOSTICS
7/3/20
Spencer EA, Brassey J, Jefferson T, et al. | Oxford COVID-19 Evidence Service Team
Aim: To explore if climate conditions may influence the spread of SARS-CoV-2.
UPDATED
6/30/20
Armstrong RA, Kane AD, Cook TM | Anaesthesia
Aim: To assess the reported ICU mortality for patients with confirmed COVID?19.
UPDATED
CLINICAL CHARACTERISTICS
6/26/20
Duan-Porter W | VA Evidence Synthesis Program
Aim: To explore the length of stay in the intensive care unit (ICU) and time on invasive mechanical ventilation for adult patients with COVID-19.
UPDATED
VA ESP
6/25/20
Tahvildari A, Arbabi M, Farsi Y, et al. | Front Med
Aim: To characterize the clinical, diagnostic, and treatment characteristics of patients presenting with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
6/25/20
Qureshi Z, Jones N, et al. | Oxford COVID-19 Evidence Service Team
Aim: To identify the evidence behind the 2-metre social distancing rule in the context of the still used large vs. small (droplet vs airborne) droplet size dichotomy in route of transmission.
UPDATED
6/23/20
Gao Y, Liu R, Zhou Q, et al. | Ann Transl Med
Aim: To assess the effectiveness of telemedicine in reducing transmission of COVID-19 and reducing pressure on medical institutions.
UPDATED
6/23/20
Yang N, Che S, Zhang J, et al. | Ann Transl Med
Aim: To conduct a rapid review of mother-to-child transmission of COVID-19 during breastfeeding.
UPDATED
6/23/20
Lv M, Wang M, Yang N, et al. | Ann Transl Med
Aim: To understand the role of CT for the diagnosis and the main imaging manifestations of patients with COVID-19.
UPDATED
DIAGNOSTICS
6/23/20
Wang Z, Zhou Q, Wang C, et al. | Ann Transl Med
Aim: To review the clinical characteristics of children with COVID-19.
UPDATED
CLINICAL CHARACTERISTICS
6/23/20
Lu S, Zhou Q, Huang L, et al. | Ann Transl Med
Aim: To review the evidence on the use of glucocorticoids in treating COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Zhang J, Yang Y, Yang N, et al. | Ann Transl Med
Aim: To explore the clinical effectiveness and safety of IVIG in the treatment of children with severe COVID-19.
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Wang J, Tang Y, Ma Y, et al. | Ann Transl Med
Aim: To evaluate the efficacy and safety of antibiotic agents in children with COVID-19, as well as to introduce the present situation of antibiotics use and bacterial coinfections in COVID-19 patients. 
UPDATED
CANDIDATE THERAPEUTICS
6/23/20
Zhou Q, Gao Y, Wang X, et al. | Ann Transl Med
Aim: To understand nosocomial infection in patients with COVID-19, SARS, and MERS.
UPDATED
6/23/20
Shi Q, Zhou Q, Wang X, et al. | Ann Transl Med
Aim: To assess the potential effectiveness and safety of antiviral agents for COVID-19 in children. 
UPDATED
CANDIDATE THERAPEUTICS
6/22/20
Goodarzi Z, Watt J, Kirkham J, et al | CIHR IRSC
Aim: To review the evidence on the effect of telehealth interventions on depression or depressive symptoms in older adults.
UPDATED
6/21/20
Ghannam MG, Alshaer QA, Al-Chalabi MAC, et al. | J Neurol
Aim: To clarify the neurological complications of SARS-CoV-2 infection including the potential mechanisms and therapeutic options.
UPDATED
6/20/20
Maldonado E, Tao D, Mackey K | J Gen Intern Med
Aim: To synthesize evidence on thromboembolism incidence and outcomes with antithrombotic therapies in COVID-19.
UPDATED
VA ESP
CANDIDATE THERAPEUTICS
6/20/20
Castro-Rodriguez JA, Forno E | Pediatr Pulmonol
Aim: To review the evidence on the role of asthma in children with COVID-19 and the risk of infection.
UPDATED
6/18/20
Tabari P, Amini M, Moghadami M, et al. | Iran J Med Sci
Aim: To determine countries’ public responses to the epidemic of COVID-19 and how they developed administrative approaches towards the outbreak.
UPDATED
6/18/20
Novara G, Checcucci E, Crestani A, et al. | Eur Urol
Aim: To perform a systematic review of the literature and evaluate all the available studies on urological applications of telehealth.
INFECTION CONTROL
6/17/20
Grover A, Oberoi M | Eur Heart J Cardiovasc Pharmacother
Aim: To review the evidence on the continued use of angiotensin converting enzyme inhibitors (ACEI) and angtiotensin receptor blockers (ARBs) in patients with COVID-19.
UPDATED
6/17/20
Agarwal A, Basmaji J, Muttalib F, et al. | Can J Anaesth
Aim: To describe the efficacy and safety of HFNC in acute hypoxemic respiratory failure; and to determine the risk of dispersion, aerosol generation and associated transmission of COVID-19 with HFNC.
UPDATED
WHO COLLABORATIVE
6/14/20
Bonilla-Aldana DK, Cardona-Trujillo MC, García-Barco A, et al. | Infez Med
Aim: To review the evidence on the role of animals as potential reservoirs for MERS-CoV and SARS-CoV.
UPDATED
6/12/20
Almufarrij I, Uus K, Munro KJ | Int J Audiol
Aim: To investigate audio-vestibular symptoms associated with coronavirus.
UPDATED
CLINICAL CHARACTERISTICS
6/12/20
Chiesa-Estomba CM, Lechien JR, Calvo-Henriquez C, et al. | Oral Oncol
Aim: To summarize in a systematic way the available recommendations from 18 guidelines from all over the world.
UPDATED
6/10/20
Marra DE, Hamlet KM, Bauer RM, et al. | Clin Neuropsychol
Aim: To review the evidence on the effectiveness of teleneuropsychology for older adults.
UPDATED
INFECTION CONTROL
6/9/20
 | Health Information and Quality Authority, Ireland
Aim: To review the international evidence on immunity and the spread of the virus by children.
UPDATED
6/9/20
Huntley BJF, Huntley ES, Di Mascio D, et al. | Obstet Gynecol
Aim: To ascertain the frequency of maternal and neonatal complications, as well as maternal disease severity, in pregnancies affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
UPDATED
6/8/20
Parohan M, Yaghoubi S, Seraj A, et al. | Aging Male
Aim: To summarize available findings on the association between age, gender, comorbidities and risk of death from COVID-19 infection.
UPDATED
6/7/20
Kunutsor S, Laukkanen | J Infect
Aim: To review the evidence on cardiovascular complications associated with COVID-19.
UPDATED
6/5/20
Pormohammad A, Ghorbani S, Baradaran B, et al. | Rev Med Virol
Aim: To review the evidence on clinical and laboratory characteristics of COVID-19 infected patients.
UPDATED
CLINICAL CHARACTERISTICS
6/5/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence regarding temporary workforce reconfigurations such as splitting of teams and establishing social distancing protocols within teams to minimise staff exposure to COVID-19.
UPDATED
6/3/20
Iannone P, Castellini G, Coclite D, et al. | PLoS One
Aim: To assess the efficacy of N95 respirators versus surgical masks for the prevention of respiratory tract infections transmission among HCWs.
UPDATED
6/2/20
Raymond M, Ching-A-Sue G, Van Hecke O | Oxford COVID-19 Evidence Service Team
Aim: To review the evidence on mast cell stabilizers, leukotriene antagonists, and antihistimines in COVID-19.
UPDATED
6/2/20
Hossain M, Sultana A, Purohit N | Epidemiol Health
Aim: To synthesize the available evidence on mental health outcomes of quarantine and isolation for preventing infectious diseases.
UPDATED
MENTAL HEALTH
6/1/20
Kunutsor S, Laukkanen J | J Infect
Aim: To review the evidence on clinical characteristics and outcomes of liver injury in COVID-19 patients.
UPDATED
CLINICAL CHARACTERISTICS
6/1/20
Chu DK, Akl EA, Duda S, et al. | Lancet
Aim: To investigate the effects of physical distance, face masks, and eye protection on virus transmission in health-care and non-health-care (eg, community) settings.
UPDATED
5/31/20
Lansbury L, Lim WS, Baskaran V, et al. | J Infect
Aim: To evaluate the burden of co-infections in patients with COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on risk stratification approaches to identify risk level in diabetes patients and clinical pathways to support diabetes management and service delivery.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of domestic and family violence during the COVID-19 pandemic.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on fibrinolysis versus primary percutaneous coronary intervention in the treatment of ST-Elevation Myocardial Infarction (STEMI).
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the available guidelines on inpatient management of COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on safe practice of intubation in the emergency department during the COVID-19 pandemic.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk of newborn babies developing COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on how the increasing use of NIPPV to manage suspected or confirmed COVID-19 patients led to any additional guidance regarding the physical requirements and engineering services.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the guidance for the provision of pulmonary rehabilitation for people recovering from COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the rehabilitation needs of post-acute COVID-19 patients and the appropriate timing of rehabilitation interventions.
UPDATED
5/28/20
Dagens A, Sigfrid L, Cai E, et al. | BMJ
Aim: To appraise the availability, quality, and inclusivity of clinical guidelines produced in the early stage of the coronavirus disease 2019 (covid-19) pandemic.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on spirometry and whether it's an aerosol generating procedure, and the risk this procedure carries during the COVID-19 pandemic.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the available guidelines on temporary shared accomodations, particularly for people experiencing homelessness.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the effectiveness of mass thermal imaging in identifying people with COVID-19.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on which tools are validated to diagnose respiratory illness via telehealth.
UPDATED
5/28/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the proportion of COVID-19 cases in intensive care units that require ventilation.
UPDATED
5/27/20
Jain V, Yuan JM  | Int J Public Health
Aim: To identify specific symptoms and comorbidities predicting severe COVID-19 and intensive care unit (ICU) admission.
UPDATED
5/27/20
Fajgenbaum DC, Khor JS, Gorzewski A, et al. | Infect Dis Ther
Aim: To systematically evaluate the treatments adminstered to COVID-19 patients.
UPDATED
CANDIDATE THERAPEUTICS
5/19/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on the risk and management of people with immunosuppression and COVID-19.
UPDATED
5/19/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence or published standards on telehealth implementation during the COVID-19 pandemic.
UPDATED
5/15/20
Verbeek  JH, Rajamaki  B, Ijaz  S, et al. | Cochrane Database Syst Rev
Aim: To evaluate which type of full?body PPE and which method of donning or doffing PPE have the least risk of contamination or infection for HCW, and which training methods increase compliance with PPE protocols.
INFECTION CONTROL
5/14/20
Yaacoub S, Schunemann H, Khabasa J, et al. | BMJ Global Health
Aim: To systematically review the literature to scope and assess the effects of specific strategies for the management of the bodies.
UPDATED
WHO COLLABORATIVE
5/6/20
LeBlanc A | medRxiv
UPDATED
4/21/20
 | NSW Health COVID-19 Critical Intelligence Unit
Aim: To review the evidence on preoperative testing of COVID-19 for patients undergoing surgery.
UPDATED
4/18/20
Della Gatta A, Rizzo R, Pilu G, et al. | Am J Obstet Gynecol
Aim: To conduct a systematic review of the clinical outcomes reported for pregnant patients with coronavirus disease 2019.
UPDATED
4/15/20
Zorko D, Gertsman S, O'Hearn K, et al. | J Hosp Infect
Aim: To identify and synthesize data from original research evaluating interventions to decontaminate surgical masks for the purpose of reuse.
UPDATED
INFECTION CONTROL
1/11/00
Di Toro F, Gjoka M, Di Lorenzo G, et al | Clin Microbiol Infect
Aim: To assess the impact of coronavirus disease 19 (COVID-19) on maternal and neonatal outcomes.
UPDATED
CLINICAL CHARACTERISTICS